Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Thyrovate Ingredients & Drug Interactions

by Myokem

Thyrovate label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Thyrovate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Thyrovate is a dietary supplement by Myokem with 8 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,480 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril Ashwagandha extract, Bioperine Black Pepper extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Thyrovate by Myokem

Ask about any prescription or over-the-counter medication and we check it for interactions with Thyrovate by Myokem — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Thyrovate by Myokem

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 7 of its 8 active ingredients.
  • “Nutrient Bioavailability Enhancer” is listed as a grouped ingredient — the label gives one combined amount (5 mg) without saying how much of each component you get.
  • “Non-Stim Thermogenic Fat Loss Blend” is a proprietary blend — the label gives one combined amount (1.12 Gram(s)) without saying how much of each component you get.

Thyrovate contains 8 ingredients total. The active players are Bioperine Black Pepper extract (which enhances absorption of other substances), Sensoril Ashwagandha extract (traditionally used for stress and sleep), Japanese Mugwort extract, Olive leaf extract, Paradoxine Grains of Paradise extract, plus three ingredients we cannot fully evaluate: a Nutrient Bioavailability Enhancer blend, a Non-Stim Thermogenic Fat Loss Blend, iFAS503, and Weak Jumby Pepper extract.

The capsule also contains inactive ingredients including gelatin, magnesium stearate, and food colorings (FD&C Red #40 and FD&C Blue #1).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Burn fat and accelerate metabolism.
  • We looked for evidence on: Obesity, Metabolic syndrome, Antipsychotic-induced metabolic side effects, Fatigue, Stress, Anxiety — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Stress.
  • Also on file: Mugwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

The evidence for most ingredients in this product isn't established in our data. Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder — those are the strongest claims supported.

Black pepper, mugwort, olive leaf, and grains of paradise all show insufficient evidence to rate their effectiveness for the conditions listed in our data (which range from hay fever to arthritis). We don't hold effectiveness ratings for iFAS503, Weak Jumby Pepper extract, or Wakame extract.

The evidence, ingredient by ingredient Black Pepper Mugwort Olive Ashwagandha Grains Of Paradise

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black pepper is generally well tolerated in food amounts and as a single medicinal dose; concentrated supplements should be used cautiously. Common side effects from black pepper are burning aftertaste, indigestion, and reduced taste perception.

Rare allergic reactions have been reported in sensitive individuals. Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited.

Common side effects (which don't occur at typical doses) include diarrhea, stomach upset, nausea, and vomiting. Rare serious cases of liver damage and hepatitis have been reported.

Japanese Mugwort may trigger allergic reactions, especially in people sensitive to ragweed, with symptoms including asthma, rash, and anaphylaxis. Olive leaf extract commonly causes headache and stomach discomfort.

Grains of Paradise and Wakame — we have no adverse effect data on file. For pregnancy and breastfeeding: Japanese Mugwort and Ashwagandha are rated likely unsafe in pregnancy.

Ashwagandha is considered likely unsafe while breastfeeding, and Mugwort as well. Black pepper is rated likely safe in pregnancy but likely unsafe while breastfeeding.

Olive leaf and Grains of Paradise have insufficient data; talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Black Pepper Mugwort Olive Ashwagandha Grains Of Paradise

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Black Pepper, Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,481 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use thyroid hormone replacement, any sedative or anti-anxiety medication (including benzodiazepines like Valium or Xanax), blood pressure medications, blood sugar medications, immunosuppressants, propranolol, seizure medications, HIV drugs, tuberculosis drugs, cholesterol drugs, or asthma/breathing medications. Black pepper and ashwagandha together create a broad interaction profile affecting these and other drug classes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ashwagandha (which has research support for anxiety and stress) with black pepper (which boosts absorption of other substances) and several botanicals with limited evidence. It's not designed for thyroid disease treatment — anyone taking thyroid medication should check with their pharmacist first, especially because ashwagandha may amplify thyroid hormone effects.

If you take any prescription medications, sedatives, blood pressure drugs, blood sugar drugs, or immunosuppressants, verify your exact medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Thyrovate, straight from the product label.

Brand Myokem
Barcode (UPC) 850698006187
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214670
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Thyrovate by Myokem, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
850698006187
IngredientAmount% DV
Nutrient Bioavailability Enhancer5 mg--
Bioperine Black Pepper extract0 NP--
Non-Stim Thermogenic Fat Loss Blend1.115 Gram(s)--
Japanese Mugwort extract300 mg--
iFAS503250 mg--
Olive leaf extract200 mg--
Weak Jumby Pepper extract140 mg--
Sensoril Ashwagandha extract125 mg--
Paradoxine Grains of Paradise extract80 mg--
Wakame extract20 mg--

Other ingredients: Gelatin, Magnesium Stearate, FD&C Red #40, FD&C Blue #1, Sodium Lauryl Sulfate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Thyrovate represents the next evolution in non-stimulant weight loss research, with a revolutionary formula consisting of 7 scientifically researched ingredients that work synergistically to promote weight loss from multiple directions. Thyrovate's advanced multi-faceted formula is designed to dramatically increase metabolism, accelerate fat loss, inhibit fat production, suppress appetite, and eliminate stress- based weight gain.

Advanced stimulant-free thermogenic fat loss catalyst

Burn fat & accelerate metabolism Suppress appetite Reduce stress-related overeating Actively target midsection fat

Precautions

Important: While Thyrovate does not contain caffeine or stimulants, it is important to understand that it is still a powerful, clinical-strength fat burning formula and should be taken only as directed.

Do not use if pregnant or nursing. If you are taking prescription or over-the-counter medication, or have a medical condition, consult your physician or licensed healthcare professional before use.

Do not use if you are taking an MAO inhibitor. Before beginning any weight loss or fitness program, consult your healthcare professional.

Disclosure: Due to the unique restrictions of many organizations (Law Enforcement, Military, WADA, IOC, NCAA, NFL, MLB, NBA, etc) it is recommended that you consult with the appropriate governing body before taking this or any other dietary supplement.

May not be suitable for persons under the age of 18.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent an disease.

Formula

Clinically researched ingredients

iFAS503 Sensoril vitalizing mind & body BioPerine Paradoxine

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take two (2) capsules first thing in the morning with food (or with your first meal of the day). Take an additional two (2) capsules with your evening meal. Do not exceed two servings (4 total capsules) per day. Drink 8-10 glasses of water daily while taking Thyrovate. For best results, pair with an exercise program and healthy eating habits.

Brand IP Statement(s)

iFAS503 is a trademark of IN Ingredients. Sensoril is a trademark of Natrean, Inc. Bioperine is a registered trademark of the Sabinsa Corporation. Paradoxine is registered trademark under exclusive global distribution by Genobolix Lifescience Int'l Co., Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Thyrovate by Myokem label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Thyrovate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Thyrovate by Myokem

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nutrient Bioavailability Enhancer

5 mg per serving

Non-Stim Thermogenic Fat Loss Blend

1.115 Gram(s) per serving

Other (inactive) ingredients: Gelatin, Magnesium Stearate, FD&C Red #40, FD&C Blue #1, Sodium Lauryl Sulfate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Thyrovate by Myokem Drug Interactions

Want to check YOUR meds against Thyrovate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,480Drugs
1,430 Moderate 50 Minor

Ingredients driving the most interactions

Sensoril Ashwagandha extract 1,372
Bioperine Black Pepper extract 1,019

Individual Drug Interactions

The ingredients in Thyrovate interact with 1,480 drugs. Click any drug to see the details.

2 of the 8 ingredients in Thyrovate interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha extract Bioperine Black Pepper extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Thyrovate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril Ashwagandha extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril Ashwagandha extract full monograph & interactions

Bioperine Black Pepper extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine Black Pepper extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Thyrovate, from the product label.

Myokem

See all Myokem products
Name
Wellston-Lamont Holdings, LLC
Street Address
PO Box 67
City
Pen Argyl
State
PA
ZipCode
18072
Web Address
myokem.com
Pharmacist Counseling Corner

Thyrovate by Myokem: Common Questions

Does Thyrovate by Myokem interact with any medications?
Yes. Based on its ingredients, Thyrovate has a known interaction with 1,480 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Thyrovate contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my thyroid?
We don't have effectiveness data for Thyrovate as a complete product. Ashwagandha in it is possibly effective for anxiety and stress, but we don't hold evidence that it treats thyroid conditions. If you have a thyroid problem, talk with your doctor before starting this.
Is it safe to take while I'm pregnant?
Japanese Mugwort and Ashwagandha are rated likely unsafe during pregnancy — the data advises against them. Black pepper is rated likely safe in pregnancy. Because the product contains ingredients considered unsafe in pregnancy, you should avoid it and talk with your doctor.
What side effects might I get from the black pepper?
Black pepper is well tolerated in food and medicine doses. The most common side effects are burning aftertaste, indigestion, and reduced taste perception. Rare allergic reactions have been reported in sensitive people.
Can I take this if I have anxiety?
Ashwagandha in this product is possibly effective for anxiety and generalized anxiety disorder. But because Ashwagandha interacts with anti-anxiety medications and sedatives, you must talk with your pharmacist or doctor first if you take any of those drugs — the combination could be risky.
What is black pepper extract doing in here?
Black pepper extract (piperine) enhances how your body absorbs other substances. That's why it's called a bioavailability enhancer — it helps you absorb more of the other ingredients. But that same ability means it can increase blood levels of many medications, so it creates several drug interactions.
Is it safe if I'm breastfeeding?
Ashwagandha and Japanese Mugwort both have insufficient data for breastfeeding safety and the facts advise against them. Black pepper is rated likely safe while breastfeeding. Because two key ingredients lack safety data for nursing, talk with your doctor or pharmacist before taking this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Thyrovate label
Go deeper

The Full Monographs Behind Thyrovate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Mugwort

Mugwort is a traditional herb used for digestion, menstrual issues, and sleep, but there is very little high-quality human research to confirm these uses. It is closely related to ragweed an...

Read the full Mugwort monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Grains Of Paradise

Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at metabolism. Early human research suggests...

Read the full Grains Of Paradise monograph →
Sources

Sources & How We Checked

Thyrovate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 72 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
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Mugwort 7 references
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Olive 2 references
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Ashwagandha 32 references
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Grains Of Paradise 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Grains Of Paradise monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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