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Dietary supplement

Tivose Ingredients & Drug Interactions

by Nutramax Laboratories

Tivose label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tivose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tivose is a dietary supplement by Nutramax Laboratories with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are patented Maitake Mushroom extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tivose by Nutramax Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Tivose by Nutramax Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tivose by Nutramax Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tivose contains one active ingredient: a patented extract from maitake mushroom, a fungus used in traditional medicine. The capsule also holds inactive ingredients — microcrystalline cellulose, hydroxypropyl methylcellulose, silicon dioxide, and magnesium stearate — which are fillers and binders that help form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Immune system support.
  • We looked for evidence on: HIV/AIDS, Coronavirus disease 2019 (COVID-19), Immune function, Infection resistance, Defense mechanisms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Coronavirus disease 2019 (COVID-19).

The evidence we hold on maitake mushroom for most of its marketed uses — including hay fever (allergic rhinitis), cancer-related anemia, laryngeal cancer, diarrhea from chemotherapy, and chronic fatigue syndrome — is rated insufficient. That means the data we have isn't reliable enough to say whether it works or doesn't work for these conditions.

If you're considering Tivose for a specific health goal, it's worth talking it over with your doctor or pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom from the extract is generally well tolerated when taken by mouth. The most common side effects reported in clinical trials were gastrointestinal — a small number of trial participants experienced diarrhea, nausea, or stomach pain (epigastric pain).

One person developed a rash and itching (pruritus) after two doses, though it cleared on its own without treatment. During pregnancy and breastfeeding, there isn't enough safety data to know whether concentrated maitake supplements are safe.

The safety notes advise against use in both situations. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tivose, double-check with your doctor or pharmacist if you take warfarin or other blood thinners (a moderate risk that maitake may strengthen their effect), blood pressure medications (a moderate risk of blood pressure dropping too low), or diabetes medications (a moderate risk of blood sugar dropping too low).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Tivose might appeal to someone looking to support immune or general wellness, but the evidence for its specific health claims isn't well established in the data we hold. The bigger concern is if you take blood thinners, blood pressure pills, or diabetes medications — this product could affect how those drugs work.

Check your exact medications with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tivose, straight from the product label.

Brand Nutramax Laboratories
Barcode (UPC) 755970720129
Net contents 31 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2018
DSLD ID 173789
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tivose by Nutramax Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsules(s) Per Day
Maximum serving Sizes:
1 Capsules(s) Per Day
Servings per container
31
UPC/BARCODE
755970720129
IngredientAmount% DV
patented Maitake Mushroom extract15 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Help support your body's immune defenses

Immune system support 31 day supply

For more information, visit Tivose.com or call Customer Service at 1-888-886-6442.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule per day on an empty stomach, or as directed by your physician.

Precautions

Warnings: If you are pregnant or nursing, or taking prescription medications, consult your physician before taking this product.

If you have any condition that requires medical attention you should always consult your physician before taking any drug or dietary supplement.

10-1070-02

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Now with MaitakeGold 404

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

MaitakeGold 404 is a trademark of Tradeworks Group, Inc. and is protected under U.S. Patent 5,854,404.

2013 Nutramax Laboratories, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tivose by Nutramax Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tivose label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tivose by Nutramax Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsules(s) Per Day Dosage formCapsule Servings per container31 Amounts shown are per serving.

Patented Maitake Mushroom extract

Interacts with
260 drugs
15 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Patented Maitake Mushroom extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tivose by Nutramax Laboratories Drug Interactions

Want to check YOUR meds against Tivose?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

patented Maitake Mushroom extract 260

Individual Drug Interactions

The ingredients in Tivose interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tivose interact with drugs. Each result below shows which ingredient is responsible. patented Maitake Mushroom extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tivose with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

patented Maitake Mushroom extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
patented Maitake Mushroom extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tivose, from the product label.

Nutramax Laboratories

See all Nutramax Laboratories products
Name
Nutramax Laboratories, Inc.
Street Address
2208 Lakeside Boulevard
City
Edgewood
State
MD
ZipCode
21040
Phone Number
800-925-5187
Web Address
www.nutramaxlabs.com
Pharmacist Counseling Corner

Tivose by Nutramax Laboratories: Common Questions

Does Tivose by Nutramax Laboratories interact with any medications?
Yes. Based on its ingredients, Tivose has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tivose contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is maitake mushroom safe during pregnancy or while breastfeeding?
No — there isn't enough safety data, and the supplement should be avoided during both pregnancy and breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking Tivose.
What are the most common side effects?
Stomach-related issues are the most common — diarrhea, nausea, or stomach discomfort. A small number of people in trials reported these, and one person had a rash and itching that went away on its own.
Does maitake mushroom actually work for hay fever or chronic fatigue?
The evidence we have for those uses — and most others on the label — is rated insufficient, meaning we don't have reliable data to say whether it works or doesn't. That doesn't mean it's ineffective, just that more research is needed.
What is maitake mushroom used for in this supplement?
Maitake is a fungus traditionally used to support immune and general wellness. The extract in Tivose is a patented form, but for most health claims, the scientific evidence is still being established.
Will this interact with my blood pressure medication?
It might — research shows maitake mushroom can lower blood pressure, so combining it with blood pressure pills could push your pressure too low. Check with your doctor or pharmacist before taking Tivose alongside any blood pressure drugs.
Can I take this if I'm on warfarin (Coumadin)?
You shouldn't without checking first. There's limited evidence that maitake may increase warfarin's blood-thinning effect, and one case report showed a person's clotting marker spike after starting the supplement. Talk to your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tivose label
Go deeper

The Full Monographs Behind Tivose’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Tivose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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