Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Total CardioCover Ingredients & Drug Interactions

by Williams Nutrition

Total CardioCover label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Total CardioCover against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Total CardioCover is a dietary supplement by Williams Nutrition with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, cholesterol and heart health, immune support.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase, Amla extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Total CardioCover by Williams Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Total CardioCover by Williams Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Total CardioCover by Williams Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Total CardioCover contains 2 active ingredients: amla extract (from Indian gooseberry) and nattokinase. Amla is a traditional plant extract studied for its effects on cholesterol and acid reflux.

Nattokinase is an enzyme derived from fermented soybeans that works on blood clotting. The product also contains inactive ingredients including microcrystalline cellulose, gelatin, dicalcium phosphate, magnesium stearate, and silica — these are fillers and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Dyslipidemia, Hypercholesterolemia, Hyperlipidemia — and 4 related terms.
  • The strongest evidence on file: Indian Gooseberry is rated "Possibly Effective" for Dyslipidemia (Natural Medicines).
  • Also on file: Indian Gooseberry is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hypercholesterolemia, Hypertension.
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina, Atherosclerosis, Cardiovascular disease (CVD).

Amla extract has been rated possibly effective for acid reflux (GERD) and high cholesterol (dyslipidemia), but the evidence isn't strong enough to rate it for high cholesterol numbers (hypercholesterolemia) or hair loss. Nattokinase lacks established evidence for the conditions we have data on — angina, atherosclerosis, cancer, heart disease, and chronic fatigue syndrome all have insufficient reliable evidence.

The data we hold doesn't establish what either ingredient does for the overall 'heart support' the product name suggests.

The evidence, ingredient by ingredient Indian Gooseberry Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Amla extract is generally well tolerated as a food, but supplement safety at higher doses is less studied. The safety data advises against using it as a supplement and against using it while breastfeeding due to insufficient information.

A small number of trial participants reported mild stomach discomfort or indigestion, and rare cases of fatigue and muscle pain were reported. Nattokinase is generally tolerated short-term, but its blood-thinning effect means people with a bleeding risk should be cautious.

The safety data advises against it during pregnancy and breastfeeding due to lack of data. Rare reports of bleeding, including one documented case of brain hemorrhage, exist; additionally, people allergic to natto (fermented soybeans) can have severe reactions including anaphylaxis within 2 hours of taking it.

Side effects, ingredient by ingredient Indian Gooseberry Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Indian Gooseberry, Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on blood thinners (anticoagulants) like warfarin, antiplatelet drugs like clopidogrel (Plavix), aspirin, diabetes medications, or blood pressure drugs. The nattokinase plus aspirin combination has a documented case of serious bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at heart health, but the evidence for its ingredients' effectiveness on that goal isn't established in our data. More importantly, if you take blood thinners, aspirin, diabetes drugs, or blood pressure medications, talk to your pharmacist or doctor before starting — these ingredients interact with those drug types in ways that matter.

Avoid it during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total CardioCover, straight from the product label.

Brand Williams Nutrition
Barcode (UPC) 678829241456
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287849
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total CardioCover by Williams Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
678829241456
IngredientAmount% DV
Amla extract250 mg--
Nattokinase25 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-888-1415 or visit healthydirections.com Choose refill & save and never run out!

Formulation

Unconditionally guaranteed for purity and labeled potency.

Cardio health Blood pressure Cholesterol support Blood flow

GF Gluten Free

Storage

Store bottle with cap tightly closed in a cool, dry place.

Precautions

Precautions: Consult a health care practitioner before use if you take warfarin or other blood thinning products, or are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Contains: Soy

Brand IP Statement(s)

AmlaMax is a registered trademark of Dolcas Biotech, LLC. NSK-SD40 is a registered trademark of JBSL.

Formula

Each capsule provides 1,000 FU (fibrin units) of nattokinase activity.

Clinically validated AmlaMax + NSK-SD40

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Doctor’s Suggested Use: Take 2 capsules daily - 1 capsule with morning meal and 1 capsule before going to bed.

Seals/Symbols

GF Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Total CardioCover by Williams Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Total CardioCover label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Total CardioCover by Williams Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amla extract

Interacts with
208 drugs
250 mg per serving

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...

Amla extract monograph & interactions

Nattokinase

Interacts with
289 drugs
25 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Total CardioCover by Williams Nutrition Drug Interactions

Want to check YOUR meds against Total CardioCover?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Nattokinase 289
Amla extract 208

Individual Drug Interactions

The ingredients in Total CardioCover interact with 375 drugs. Click any drug to see the details.

2 of the 2 ingredients in Total CardioCover interact with drugs. Each result below shows which ingredient is responsible. Nattokinase Amla extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Total CardioCover with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions

Amla extract4 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Aspirin

Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.

Likelihood Possible Evidence B
Amla extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Total CardioCover, from the product label.

Williams Nutrition

See all Williams Nutrition products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-888-1415
Web Address
healthydirections.com
Pharmacist Counseling Corner

Total CardioCover by Williams Nutrition: Common Questions

Does Total CardioCover by Williams Nutrition interact with any medications?
Yes. Based on its ingredients, Total CardioCover has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total CardioCover contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Total CardioCover if I'm allergic to soy?
Nattokinase comes from fermented soybeans. People with natto allergy can have serious reactions including anaphylaxis within 2 hours. If you have a soy allergy, talk to your pharmacist before trying this product.
What side effects have been reported?
Amla extract has caused mild stomach discomfort or indigestion in a small number of trial participants, with rare reports of fatigue and muscle pain. Nattokinase rarely causes bleeding; one documented case involved brain hemorrhage when combined with aspirin.
Is Total CardioCover safe during pregnancy?
No. The safety data advises against both ingredients during pregnancy due to insufficient information. Talk with your doctor or pharmacist before considering this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
No. There isn't enough safety data for either ingredient while breastfeeding, so the safety information advises against it. Check with your doctor or pharmacist for alternatives.
Does amla extract really help with cholesterol?
Amla extract has been rated possibly effective for high cholesterol (dyslipidemia), but the evidence isn't strong. For high cholesterol numbers specifically, there's insufficient reliable evidence. Talk to your doctor about whether it's right for you.
What happens if I take this with my blood thinner?
Both ingredients in this product can increase bleeding risk when combined with blood thinners or aspirin. There's a documented case of serious brain bleeding when nattokinase was added to aspirin therapy — this is why you must check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Total CardioCover is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total CardioCover label
Go deeper

The Full Monographs Behind Total CardioCover’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Indian Gooseberry

Interacts with 208 drugs

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...

Read the full Indian Gooseberry monograph → Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Total CardioCover's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Indian Gooseberry 6 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

See these in context on the Indian Gooseberry monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team