Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Trehalose Complex Ingredients & Drug Interactions

by D'Adamo Personalized Nutrition

Trehalose Complex label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trehalose Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Trehalose Complex is a dietary supplement by D'Adamo Personalized Nutrition with 3 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 109 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioenergy Ribose, modified Citrus Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Trehalose Complex by D'Adamo Personalized Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Trehalose Complex by D'Adamo Personalized Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Trehalose Complex by D'Adamo Personalized Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Trehalose Complex contains three active ingredients: Bioenergy Ribose, Trehalose, and modified Citrus Pectin. Ribose is a simple sugar your cells use to make energy and may support muscle recovery or heart function, though the evidence for these uses is limited.

Trehalose is another type of sugar that may help with cellular protection. Modified Citrus Pectin is a soluble fiber derived from citrus peel.

The product has no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: maintain healthy brain metabolism and nerve function.
  • We looked for evidence on: Cognitive function, Brain health, Neurological function, Protein folding.
  • The closest evidence on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Cognitive function (Natural Medicines).

The evidence for Bioenergy Ribose is mixed. It's rated possibly ineffective for athletic performance and McArdle disease (a rare muscle disorder).

For other uses — restless legs syndrome, congestive heart failure, muscle soreness, and recovery after bypass surgery — there isn't enough reliable evidence to rate it either way. Modified Citrus Pectin is rated possibly effective for high cholesterol (hypercholesterolemia), but for prediabetes and radiation exposure, the evidence is insufficient to know.

Trehalose's effectiveness is not established in the data we hold.

The evidence, ingredient by ingredient Ribose Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated for short-term use (up to about a month), but long-term safety isn't well studied. Common side effects include diarrhea, gastrointestinal discomfort, headache, nausea, and low blood sugar.

Some people report anxiety or lightheadedness; lowering the dose has resolved these in some cases. Ribose is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Modified Citrus Pectin from food and typical supplement doses is generally well tolerated. Mild side effects may include diarrhea, gas, loose stools, and mild cramps.

Rarely, allergic reactions including anaphylaxis can occur in sensitive individuals. In pregnancy, pectin from food is fine, but supplement safety hasn't been well studied — check with your doctor.

The same caution applies to breastfeeding.

Side effects, ingredient by ingredient Ribose Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Pectin, Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 109 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Trehalose Complex, double-check with your doctor or pharmacist if you take insulin or any blood sugar medication (such as metformin or sulfonylureas) — moderate risk of low blood sugar. Also check if you use lovastatin, tetracycline antibiotics, or digoxin — moderate risk that this product may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in supporting muscle energy or cholesterol levels and have no blood sugar concerns or relevant medications. If you take insulin, any diabetes medication, lovastatin, tetracycline antibiotics, or digoxin, you need to check with your doctor or pharmacist before starting — interactions could affect how well your medications work or how low your blood sugar goes.

Talk it over with your healthcare provider to see if it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trehalose Complex, straight from the product label.

Brand D'Adamo Personalized Nutrition
Barcode (UPC) 17318010245
Net contents 240 Gram(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 27250
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trehalose Complex by D'Adamo Personalized Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
60
UPC/BARCODE
17318010245
IngredientAmount% DV
Bioenergy Ribose550 mg--
Trehalose3100 mg--
modified Citrus Pectin235 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Genoma Nutritionals(R) ALL Types

Bioenergy Ribose(TM) is a registered trademark of Bioenergy Life Science, Inc.

FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

An exceptional blend of three well-researched glyconutrients designed to maintain healthy brain metabolism by promoting proper protein folding.

Glyconutrient formula to promote healthy brain and nerve function

Formulation

This 100% vegetarian product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

This 100% vegetarian product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

Seals/Symbols

QUALITY ASSURED GMP(TM)

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take a level teaspoon of Trehalose complex twice daily or as recommended by physician. Mix a level teaspoon in a cup of warm water and some lemon.

General

SP2510-110411

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trehalose Complex by D'Adamo Personalized Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trehalose Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trehalose Complex by D'Adamo Personalized Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 tsp Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bioenergy Ribose

Interacts with
86 drugs
550 mg per serving Form: D-Ribose, Powder

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

Bioenergy Ribose monograph & interactions

Trehalose

3100 mg per serving

Modified Citrus Pectin

Interacts with
23 drugs
235 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Modified Citrus Pectin monograph & interactions
Interaction report

Trehalose Complex by D'Adamo Personalized Nutrition Drug Interactions

Want to check YOUR meds against Trehalose Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
109Drugs
109 Moderate

Ingredients driving the most interactions

Bioenergy Ribose 86
modified Citrus Pectin 23

Individual Drug Interactions

The ingredients in Trehalose Complex interact with 109 drugs. Click any drug to see the details.

2 of the 3 ingredients in Trehalose Complex interact with drugs. Each result below shows which ingredient is responsible. Bioenergy Ribose modified Citrus Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Trehalose Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioenergy Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
Bioenergy Ribose full monograph & interactions

modified Citrus Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
modified Citrus Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trehalose Complex, from the product label.

D'Adamo Personalized Nutrition

See all D'Adamo Personalized Nutrition products
Name
North American Pharmacal, Inc.
Street Address
213 Danbury Road
City
Wilton
State
CT
ZipCode
06897
Phone Number
1-877-226-8973
Web Address
www.4yourtype.com
Pharmacist Counseling Corner

Trehalose Complex by D'Adamo Personalized Nutrition: Common Questions

Does Trehalose Complex by D'Adamo Personalized Nutrition interact with any medications?
Yes. Based on its ingredients, Trehalose Complex has a known interaction with 109 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trehalose Complex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take blood sugar medication?
Not without checking first. Ribose in this product can lower blood sugar and boost insulin's effect, which could make your blood sugar drop too much. Talk to your doctor or pharmacist before starting — they can advise whether it's safe for you and how to monitor your blood sugar if you do take it.
What are the most common side effects?
From the ribose: diarrhea, nausea, gastrointestinal discomfort, and headache are the most frequent. From the pectin: diarrhea, gas, loose stools, and mild cramps. Some people also report anxiety, lightheadedness, or increased appetite from the ribose. Lowering the dose has helped resolve nausea and anxiety in some cases.
Is this safe to take during pregnancy or while breastfeeding?
Ribose is not recommended during pregnancy or breastfeeding — there isn't enough safety data. Pectin from food is fine during pregnancy, but supplement-level amounts haven't been well studied, so check with your doctor. The same applies to breastfeeding. Talk with your healthcare provider for personalized advice.
Can I take this with my cholesterol or heart medications?
It depends on the specific drug. Pectin in this product may reduce absorption of lovastatin (a cholesterol medication) and digoxin (a heart medication), potentially making them less effective. If you take either, ask your doctor or pharmacist whether this product is right for you or if you need to adjust timing.
Does this actually improve athletic performance or muscle soreness?
The evidence doesn't support it. Ribose is rated possibly ineffective for athletic performance. For muscle soreness, there isn't enough reliable evidence to say whether it helps. If that's your main reason for considering it, you may want to explore options with stronger evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Trehalose Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trehalose Complex label
Go deeper

The Full Monographs Behind Trehalose Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Trehalose Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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