Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Tri-Digestivas Ingredients & Drug Interactions

by GM Germa

Tri-Digestivas label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tri-Digestivas against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tri-Digestivas is a dietary supplement by GM Germa with 6 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betain HCl, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tri-Digestivas by GM Germa

Ask about any prescription or over-the-counter medication and we check it for interactions with Tri-Digestivas by GM Germa — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tri-Digestivas by GM Germa

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Tri-Digestivas contains 6 active ingredients aimed at digestion support. Pepsin and pancreatin are enzymes that help break down proteins and other nutrients in food.

Betaine HCl (betaine hydrochloride) is a stomach-acid booster. Papain is a protein-digesting enzyme from papaya.

Diastase is an enzyme that breaks down starches. Ox bile extract supports fat digestion.

The tablet also contains several inactive ingredients — dicalcium phosphate, FD&C Brown, magnesium stearate, methyl cellulose, microcrystalline cellulose, silica, stearic acid, and titanium dioxide — which are fillers, binders, and colorants.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: aid in digestion of carbohydrates, proteins and fats.
  • We looked for evidence on: Dyspepsia, indigestion, bloating, gas.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence we hold does not establish that any of these ingredients are effective for their purported uses. Betaine HCl is rated as having insufficient reliable evidence for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, and allergic rhinitis.

Papain similarly lacks sufficient evidence for cancer, dental cavities, radiation burns, exercise muscle soreness, shingles, and intestinal parasites. No effectiveness ratings are on file for pepsin, diastase, pancreatin, or ox bile extract in this product.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated in adults but may cause digestive upset or allergic reactions. Betaine HCl may irritate the stomach and is not safe for people with ulcers, gastritis, or true acid reflux — it can cause heartburn and theoretically worsen ulcers.

Papain is generally tolerated as a food but can irritate the digestive tract and trigger allergic reactions in sensitive people; high oral doses may be unsafe and rarely cause severe gastritis or esophageal damage. Occupational exposure to airborne papain or pepsin dust can cause respiratory allergies including asthma and rhinitis.

During pregnancy, betaine HCl is best avoided — safety data is insufficient. Papain from concentrated sources and unripe papaya products should be avoided in pregnancy due to safety concerns.

During breastfeeding, there is little safety data for pepsin and insufficient data for betaine HCl and papain, so medical advice is recommended before use.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (a blood thinner), do not start this product without checking with your pharmacist or doctor — papain may increase its blood-thinning effect. Also double-check if you use H2-blockers, antacids, or proton pump inhibitors (PPIs) for stomach acid, because betaine HCl may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Tri-Digestivas is a multienzyme digestive aid with no established effectiveness in our data and interactions with common medications, most notably blood thinners and acid-reduction drugs. If you take warfarin, H2-blockers, antacids, or PPIs, check with your doctor or pharmacist before starting this product.

Pregnant and breastfeeding people should also speak with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tri-Digestivas, straight from the product label.

Brand GM Germa
Barcode (UPC) 790933803303
Net contents 30 Tab(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 252968
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tri-Digestivas by GM Germa, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
790933803303
IngredientAmount% DV
Diastase60 mg--
Pepsin150 mg--
Betain HCl60 mg--
Ox Bile extract129 mg--
Pancreatin129 mg--
Papain30 mg--

Other ingredients: Dicalcium Phosphate, FD&C Brown, Magnesium Stearate Vegetable, Methyl Cellulose, Microcrystalline Cellulose, Silica, Stearic Acid, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

An aid in the digestion of starch (carbohydrate), protein and fat.

Digestive aid Promotes digestion health

Suggested/Recommended/Usage/Directions

Suggested Use: Use as a Dietary Supplement. Take 1 capsule a day, preferably with food or as directed by your doctor.

Precautions

Warning: Do not use If pregnant or nursing, ask a physician before use If taking any medication or have any medical condition

Warning: Do not use If allergic to any of the ingredients

Warning: Do not use If any adverse reactions occur.

Not intended for use by person under the age of 18.

In case of accidental overdose, get medical help or contact a Poison Control Center immediately. Do not use if either seal is torn, broken or missing.

Keep out of the reach of children

Food allergy notice: Do not use this product if prone to allergic reaction from any of the ingredients.

Storage

Store at controlled room temperature between 15 degrees and 30 degrees C (59 degrees-86 degrees F).

Seals/Symbols

Made in USA

General Statements

Questions or Comments: 1-305-278-0033, M-F, 9-5 Eastern Please Recycle

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tri-Digestivas by GM Germa label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tri-Digestivas label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tri-Digestivas by GM Germa

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diastase

60 mg per serving Form: Malt

Pepsin

No known
interactions
150 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betain HCl

Interacts with
36 drugs
60 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betain HCl monograph & interactions

Ox Bile extract

129 mg per serving

Pancreatin

129 mg per serving

Papain

Interacts with
2 drugs
30 mg per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, FD&C Brown, Magnesium Stearate Vegetable, Methyl Cellulose, Microcrystalline Cellulose, Silica, Stearic Acid, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tri-Digestivas by GM Germa Drug Interactions

Want to check YOUR meds against Tri-Digestivas?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betain HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Tri-Digestivas interact with 38 drugs. Click any drug to see the details.

2 of the 6 ingredients in Tri-Digestivas interact with drugs. Each result below shows which ingredient is responsible. Betain HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Tri-Digestivas with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betain HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betain HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tri-Digestivas, from the product label.

GM Germa

See all GM Germa products
Name
Germa Products, LLC
Street Address
13121 SW 122 Avenue
City
Miami
State
FL
ZipCode
33186
Phone Number
1-305-278-0033
Web Address
www.germa.net
Pharmacist Counseling Corner

Tri-Digestivas by GM Germa: Common Questions

Does Tri-Digestivas by GM Germa interact with any medications?
Yes. Based on its ingredients, Tri-Digestivas has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tri-Digestivas contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Tri-Digestivas while I'm on omeprazole (Prilosec)?
Not without checking with your doctor or pharmacist first. Betaine HCl in this product increases stomach acid, which may reduce omeprazole's effectiveness. Your healthcare provider can advise whether it's safe for your situation or if you need to adjust timing.
Is Tri-Digestivas safe during pregnancy?
No. Betaine HCl should be avoided in pregnancy due to insufficient safety data, and papain from concentrated sources and unripe papaya is also best avoided. Talk with your doctor before using this product if you're pregnant or planning to become pregnant.
What can I take Tri-Digestivas for?
The product contains enzymes intended to support digestion, but we don't hold evidence in our data that these ingredients are effective for any specific condition. If you have a digestive concern, discuss it with your doctor to find an option with proven benefit for your situation.
Will papain in this product affect my warfarin?
Possibly. A case report showed that papain from a supplement caused a patient's warfarin effect to become dangerously high. If you take warfarin, do not start Tri-Digestivas without clearing it with your pharmacist or doctor first.
Can I take this while breastfeeding?
There isn't enough safety data to recommend pepsin, betaine HCl, or papain during breastfeeding. Talk with your doctor or pharmacist before use if you're nursing.
Does Tri-Digestivas have any allergens?
Pepsin and papain can both trigger allergic reactions in sensitive individuals, including respiratory symptoms with occupational exposure to their airborne dust. If you have a history of allergies to these enzymes or papaya, avoid this product and discuss alternatives with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tri-Digestivas label
Go deeper

The Full Monographs Behind Tri-Digestivas’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Tri-Digestivas's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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