Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Tri-Digestivas Ingredients & Drug Interactions

by GM Germa

Tri-Digestivas label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tri-Digestivas against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tri-Digestivas is a dietary supplement by GM Germa with 6 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betain HCl, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tri-Digestivas by GM Germa

Ask about any prescription or over-the-counter medication and we check it for interactions with Tri-Digestivas by GM Germa — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Tri-Digestivas by GM Germa

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Tri-Digestivas contains six active ingredients designed to support digestion. Pepsin is a protease enzyme that helps break down protein; betaine HCl is a stomach acid booster; and papain is a plant enzyme that aids protein digestion.

The product also includes pancreatin (a blend of pancreatic enzymes), diastase (an enzyme that breaks down starches), and ox bile extract to help with fat digestion. There are eight inactive ingredients — fillers and binders — listed on the label.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Aid in digestion of starch, protein and fat.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Wound healing, Indigestion, Bloating, Maldigestion.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for these ingredients is limited. For betaine HCl and papain, we hold no reliable evidence that either works for the digestive or other conditions listed — the ratings all say insufficient evidence.

Pepsin and the other ingredients don't have effectiveness ratings on file. If you're thinking about this product to address a specific digestive concern, talk with your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin and papain are generally well tolerated when used as directed, though both can cause allergic reactions in sensitive people — including digestive upset, itchy eyes, sneezing, or even respiratory symptoms with airborne exposure. Betaine HCl may irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux (it could make heartburn worse).

During pregnancy, the safety data advises against betaine HCl and concentrated papain; pepsin safety has not been established during pregnancy, so medical advice is needed. During breastfeeding, betaine HCl and papain are not recommended without guidance from your doctor or pharmacist, and pepsin data is insufficient.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tri-Digestivas, double-check if you take warfarin (Coumadin) or other blood thinners — papain may increase its effects (Moderate severity). Also check if you use H2-blockers, antacids, or proton pump inhibitors for acid reflux or ulcers — betaine HCl could reduce how well they work (Minor severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Tri-Digestivas is a multi-enzyme digestive aid that may appeal to people looking for natural digestive support. If you take warfarin or any acid-reducing medication, check with your pharmacist before starting — this product could interfere.

Pregnant or breastfeeding? Talk to your doctor first, because safety data for these ingredients is thin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tri-Digestivas, straight from the product label.

Brand GM Germa
Barcode (UPC) 790933803303
Net contents 30 Tab(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 252968
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tri-Digestivas by GM Germa, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
790933803303
IngredientAmount% DV
Diastase60 mg--
Pepsin150 mg--
Betain HCl60 mg--
Ox Bile extract129 mg--
Pancreatin129 mg--
Papain30 mg--

Other ingredients: Dicalcium Phosphate, FD&C Brown, Magnesium Stearate Vegetable, Methyl Cellulose, Microcrystalline Cellulose, Silica, Stearic Acid, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

An aid in the digestion of starch (carbohydrate), protein and fat.

Digestive aid Promotes digestion health

Suggested/Recommended/Usage/Directions

Suggested Use: Use as a Dietary Supplement. Take 1 capsule a day, preferably with food or as directed by your doctor.

Precautions

Warning: Do not use If pregnant or nursing, ask a physician before use If taking any medication or have any medical condition

Warning: Do not use If allergic to any of the ingredients

Warning: Do not use If any adverse reactions occur.

Not intended for use by person under the age of 18.

In case of accidental overdose, get medical help or contact a Poison Control Center immediately. Do not use if either seal is torn, broken or missing.

Keep out of the reach of children

Food allergy notice: Do not use this product if prone to allergic reaction from any of the ingredients.

Storage

Store at controlled room temperature between 15 degrees and 30 degrees C (59 degrees-86 degrees F).

Seals/Symbols

Made in USA

General Statements

Questions or Comments: 1-305-278-0033, M-F, 9-5 Eastern Please Recycle

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tri-Digestivas by GM Germa label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tri-Digestivas label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tri-Digestivas by GM Germa

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diastase

60 mg per serving Form: Malt

Pepsin

No known
interactions
150 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betain HCl

Interacts with
36 drugs
60 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betain HCl monograph & interactions

Ox Bile extract

129 mg per serving

Pancreatin

129 mg per serving

Papain

Interacts with
2 drugs
30 mg per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, FD&C Brown, Magnesium Stearate Vegetable, Methyl Cellulose, Microcrystalline Cellulose, Silica, Stearic Acid, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tri-Digestivas by GM Germa Drug Interactions

Want to check YOUR meds against Tri-Digestivas?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betain HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Tri-Digestivas interact with 38 drugs. Click any drug to see the details.

2 of the 6 ingredients in Tri-Digestivas interact with drugs. Each result below shows which ingredient is responsible. Betain HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Tri-Digestivas with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betain HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betain HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tri-Digestivas, from the product label.

GM Germa

See all GM Germa products
Name
Germa Products, LLC
Street Address
13121 SW 122 Avenue
City
Miami
State
FL
ZipCode
33186
Phone Number
1-305-278-0033
Web Address
www.germa.net
Pharmacist Counseling Corner

Tri-Digestivas by GM Germa: Common Questions

Does Tri-Digestivas by GM Germa interact with any medications?
Yes. Based on its ingredients, Tri-Digestivas has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tri-Digestivas contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this upset my stomach?
Pepsin and papain can cause digestive upset in some people. Betaine HCl is tougher — it increases stomach acid, so it may cause heartburn and is not safe if you have ulcers, gastritis, or acid reflux already. If you have a sensitive stomach, start cautiously or talk to your pharmacist first.
Can I take this while pregnant or breastfeeding?
The safety data advises against betaine HCl and concentrated papain in pregnancy. Pepsin has not been studied enough to know. During breastfeeding, betaine HCl and papain are not recommended without medical advice. Talk to your doctor or pharmacist about your personal situation before starting.
What does each ingredient actually do?
Pepsin, papain, and pancreatin break down proteins and other nutrients to help digestion. Diastase breaks down starches. Betaine HCl boosts stomach acid. Ox bile helps your body digest fats. Together they're meant to support your digestive system.
Will this actually help my digestion?
The evidence is limited. We don't have reliable research showing betaine HCl or papain work for digestive problems — the data rates them as insufficient evidence. Pepsin and the other ingredients don't have published ratings. If you're treating a specific issue, ask your pharmacist what the science supports.
Is this safe to take long-term?
Pepsin and papain are generally well tolerated short-term, but we don't have long-term safety data on file. Betaine HCl is not designed for people with ulcers, gastritis, or acid reflux. If you're thinking long-term, talk with your pharmacist about what makes sense for you.
Could I be allergic to this?
Yes. Both pepsin and papain can trigger allergic reactions in sensitive people — anything from itchy eyes and sneezing to rash, stomach cramps, or respiratory symptoms. If you have a history of enzyme allergies or sensitivities, mention it to your pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tri-Digestivas is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tri-Digestivas label
Go deeper

The Full Monographs Behind Tri-Digestivas’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Tri-Digestivas's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team