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Dietary supplement

Tribulus 750 Ingredients & Drug Interactions

by MET-Rx

Tribulus 750 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 750 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 750 is a dietary supplement by MET-Rx with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus 750 by MET-Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 750 by MET-Rx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus 750 by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus 750 contains a single active ingredient: tribulus extract at 750 mg per capsule. Tribulus is a plant whose fruit and root have been used traditionally to support sexual function and athletic performance.

The capsule itself is made from gelatin and cellulose—standard inactive ingredients that hold the extract together.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: athletic performance and muscle building.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Strength, Endurance, Muscle recovery.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence for tribulus is mixed. For sexual dysfunction, the data suggests it's possibly effective—meaning there's some clinical support, but it's not ironclad.

For athletic performance, the evidence leans toward possibly ineffective. For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to say whether it works or not.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term in healthy adults, but long-term safety data are sparse and quality varies. Avoid this product during pregnancy because it may affect hormones and its safety hasn't been established.

Also skip it while breastfeeding—we don't have reliable safety information for nursing. Mild side effects like stomach upset, nausea, diarrhea, or cramping can occur, though in one study these rates matched placebo.

Rare serious effects including liver or kidney injury and seizures have been reported, and one case described a person who drank 2 liters of tribulus water daily and developed weakness, seizures, and kidney damage (which improved after stopping and getting dialysis).

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before combining this product with blood pressure medications, diabetes drugs, or lithium. Tribulus can lower blood pressure and blood sugar and may raise lithium levels, all of which could require dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus might help with sexual function, but the evidence is modest. If you take blood pressure medication, diabetes drugs, or lithium, talk to your pharmacist or doctor before starting—this supplement can amplify their effects.

Short-term use seems okay for most people, but we don't know much about long-term safety, so treat it as a trial rather than a forever habit.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 750, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560508681
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 63078
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 750 by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
786560508681
IngredientAmount% DV
Tribulus extract750 mg--

Other ingredients: Gelatin, Cellulose, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Formula

3X THE TRIBULUS

STANDARDIZED FOR 40% SAPONINS

LAB-TESTED FOR 40% SAPONINS PER SERVING, TO HELP ENSURE YOU RECEIVE THE ACTIVE COMPONENTS.

ORIGINALLY USED BY RUSSIAN POWERLIFTERS, TRIBULUS IS NOW USED BY ATHLETES AND BODYBUILDERS AROUND THE WORLD.

General Statements

THE ORIGINAL POWERLIFTERS SECRET

SPECIALTY SUPPLEMENT

Compared to our previous Tribulus 250 formula

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

You Can't Fake Strong

2015

General

50868 02A B50868

Suggested/Recommended/Usage/Directions

FOR MAXIMUM BENEFITS, TAKE ONE CAPSULE UP TO TWO TIMES DAILY WITH A MEAL.

Directions: For adult men, take one (1) capsule up to two times daily, preferably with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 750 by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 750 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 750 by MET-Rx

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Tribulus extract

Interacts with
259 drugs
750 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 750 by MET-Rx Drug Interactions

Want to check YOUR meds against Tribulus 750?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus extract 259

Individual Drug Interactions

The ingredients in Tribulus 750 interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus 750 interact with drugs. Each result below shows which ingredient is responsible. Tribulus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 750 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 750, from the product label.

MET-Rx

See all MET-Rx products
Name
MET-Rx Nutrition, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-556-3879
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

Tribulus 750 by MET-Rx: Common Questions

Does Tribulus 750 by MET-Rx interact with any medications?
Yes. Based on its ingredients, Tribulus 750 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 750 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Tribulus 750 if I'm pregnant or breastfeeding?
No. The safety data advise against tribulus during pregnancy because it may affect hormones. Skip it while breastfeeding too—we don't have enough safety information. Talk with your doctor or pharmacist if you're considering it during these times.
Does tribulus actually help with sexual function?
The evidence says it's possibly effective, meaning there's some clinical backing but it's not a proven home run. Results vary from person to person, and the quality of studies isn't perfect.
What are the most common side effects?
Mild stomach upset—nausea, cramping, diarrhea, or vomiting—can happen, though in one study these rates were the same as placebo. Most people tolerate it well in the short term.
Will tribulus help my athletic performance?
The evidence suggests it's possibly ineffective for athletic performance, so it's not a reliable choice if that's your main goal.
How long can I safely take this supplement?
The data show it's generally well tolerated short-term in healthy adults, but long-term safety information is limited. Treat it as a trial and chat with your pharmacist before taking it long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 750 is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 750 label
Go deeper

The Full Monographs Behind Tribulus 750’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 750's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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