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Dietary supplement

Tribulus Ingredients & Drug Interactions

by The Asylum Cabinet by Insane Labz

Tribulus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus is a dietary supplement by The Asylum Cabinet by Insane Labz with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus by The Asylum Cabinet by Insane Labz

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus by The Asylum Cabinet by Insane Labz — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus by The Asylum Cabinet by Insane Labz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus terrestris fruit extract, a plant-based compound traditionally used for sexual function and athletic performance. The capsule also contains two inactive ingredients—magnesium stearate and hypromellose—which are common binders and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Sexual function and athletic performance support.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Exercise-induced muscle damage, Male infertility, Premature ejaculation, Sexual dysfunction — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility, Exercise-induced muscle damage.

Tribulus shows possibly effective evidence for sexual dysfunction, suggesting some potential benefit, though the data isn't conclusive. For athletic performance, the evidence leans possibly ineffective.

The product hasn't been rated for benign prostatic hyperplasia (enlarged prostate), so we don't have enough reliable evidence to say how well it works for that purpose.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term in healthy adults, but long-term safety data are limited and quality varies across products. Serious side effects are rare but have been reported, including liver and kidney injury and seizures.

More commonly, people may experience gastrointestinal complaints like stomach pain, nausea, diarrhea, or constipation, though in one study these rates matched placebo. Avoid this product during pregnancy because it may affect hormones and safety hasn't been established.

You should also avoid it while breastfeeding due to lack of reliable safety information. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing before using this supplement.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check your exact blood pressure medications, diabetes medications, and any lithium prescription with the medication checker below. These are the main drug types that interact with tribulus.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus might help with sexual dysfunction, though the evidence is modest. If you take blood pressure medication, diabetes medication, or lithium, you'll need to check with your pharmacist first—this supplement can affect how those drugs work.

It's generally well tolerated short-term, but long-term safety data are sparse.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus, straight from the product label.

Brand The Asylum Cabinet by Insane Labz
Barcode (UPC) 051497274764
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 298696
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus by The Asylum Cabinet by Insane Labz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
051497274764
IngredientAmount% DV
Tribulus terrestris Fruit Extract750 mg--

Other ingredients: Magnesium Stearate, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement for adults, take 1 capsule daily.

Precautions

Read warnings and only use as directed.

Warning: This product is only intended to be consumed by healthy adults 18 years of age or older.

Before using product, seek advice from a physician if you are unaware of your current health condition or have any preexisting medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, difficulty urinating due to prostate enlargement, psychiatric disease or bipolar disease or if you are taking a MAO-B inhibitor or any other prescription or over-the-counter medication. Do not use if you are pregnant, nursing, prone to dehydration or exposed to excessive heat.

If you are a competitive athlete and/or subject to drug testing, consult with your sanctioning body prior to use to ensure compliance. Discontinue use immediately if you experience any adverse reactions.

Keep out of reach of children.

Seals/Symbols

Made in the USA Certified cGMP

Formula

Tribulus from the asylum

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Approved by Mad Chemist

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus by The Asylum Cabinet by Insane Labz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus by The Asylum Cabinet by Insane Labz

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Tribulus terrestris Fruit Extract

Interacts with
259 drugs
750 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris Fruit Extract monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus by The Asylum Cabinet by Insane Labz Drug Interactions

Want to check YOUR meds against Tribulus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris Fruit Extract 259

Individual Drug Interactions

The ingredients in Tribulus interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris Fruit Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus, from the product label.

The Asylum Cabinet by Insane Labz

See all The Asylum Cabinet by Insane Labz products
Name
Insane Labz
Street Address
675 East Highway 43
City
Harrison
State
AR
ZipCode
72601
Pharmacist Counseling Corner

Tribulus by The Asylum Cabinet by Insane Labz: Common Questions

Does Tribulus by The Asylum Cabinet by Insane Labz interact with any medications?
Yes. Based on its ingredients, Tribulus has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually work for sexual function?
The evidence shows possibly effective—meaning there's some support for it, but the data aren't strong enough to be certain. Results vary between people, and more research would help.
Can I take this if I'm on blood pressure medication?
Not without checking first. Tribulus lowers blood pressure on its own, so combining it with your medication could drop your pressure too far. Use the medication checker on this page, then talk with your pharmacist or doctor.
What side effects might I get?
Most people tolerate it well. Stomach pain, nausea, diarrhea, and constipation are the most common complaints, though in one study they occurred at rates similar to placebo. Serious effects like liver or kidney injury are rare but have been reported.
Is it safe to take while pregnant or breastfeeding?
No. You should avoid tribulus during pregnancy because it may affect hormones and safety isn't established. Avoid it while breastfeeding as well due to lack of reliable safety information. Talk with your doctor if you're pregnant or nursing.
Can I take this with my diabetes medication?
Check with your pharmacist first. Tribulus can lower blood sugar levels, so it might increase the risk of low blood sugar (hypoglycemia) when combined with diabetes drugs. You may need your medication dose adjusted.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus label
Go deeper

The Full Monographs Behind Tribulus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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