Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tribulus Terrestris 1,000 mg Ingredients & Drug Interactions

by Nature's Truth

Tribulus Terrestris 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Terrestris 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Terrestris 1,000 mg is a dietary supplement by Nature's Truth with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tribulus Terrestris 1,000 mg by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Terrestris 1,000 mg by Nature's Truth — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Tribulus Terrestris 1,000 mg by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: tribulus terrestris fruit extract at 1,000 mg per capsule. The capsule also holds inactive ingredients — rice powder, gelatin, and magnesium stearate — which are binders and fillers that help deliver the extract.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Male performance formula.
  • We looked for evidence on: Erectile dysfunction (ED), Premature ejaculation, Male infertility, Sexual dysfunction, Athletic performance, Exercise-induced muscle damage — and 2 related terms.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction, Erectile dysfunction (ED), Premature ejaculation, Male infertility, and more.

Tribulus terrestris is possibly effective for sexual dysfunction — though the evidence is limited. For athletic performance, the research suggests it's probably not effective.

The data we hold isn't robust enough to rate it for benign prostatic hyperplasia (enlarged prostate), so we can't say whether it helps with that condition.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term, tribulus is generally well tolerated in healthy adults, but quality and long-term safety data are sparse. The supplement should be avoided during pregnancy because it may affect hormones and safety hasn't been established.

It should also be avoided while breastfeeding due to lack of reliable safety information. Serious side effects are rare, but cases of liver and kidney injury, seizures, and painful erection have been reported.

More commonly, you might experience stomach pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these complaints happened at similar rates in people taking tribulus and those on placebo. One case report described severe complications (lower limb weakness, seizures, hepatitis, acute kidney injury) from consuming very high amounts (2 liters of tribulus water daily for two days), which improved after stopping and receiving dialysis.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood pressure medications, diabetes medications, or lithium. All three drug types have Moderate interactions with tribulus, and your doses or monitoring may need to change.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may be worth trying if you're interested in sexual function support, though the evidence is modest. If you take blood pressure or diabetes medications, or lithium, this product isn't a good match without checking with your doctor or pharmacist first — the interactions are real and may need dose adjustments.

Pregnant or breastfeeding? Skip it.

Talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Terrestris 1,000 mg, straight from the product label.

Brand Nature's Truth
Barcode (UPC) 840093113184
Net contents 100 Quick Release Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306834
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Terrestris 1,000 mg by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Quick Release Capsule(s)
Maximum serving Sizes:
2 Quick Release Capsule(s)
Servings per container
50
UPC/BARCODE
840093113184
IngredientAmount% DV
Tribulus terrestris Fruit Extract1000 mg--

Other ingredients: Rice, Powder, Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

100% Quality Satisfaction guarantee

Our non-GMO pledge Visit our website

Formula

Tribulus terrestris 1,000mg per serving

Exotic herb for men

Formulation

Male performance formula

Gluten free Non GMO

No gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non-GMO

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: for adults, take two (2) quick release capsules daily, preferably with a meal.

Precautions

Warning: This product is intended for use by men and is not intended for use by women. If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

If you are taking any medications or have any medical condition, consult your doctor before use.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2020 Nature's Truth LLC

General Statements

Vitamins

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Terrestris 1,000 mg by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Terrestris 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Terrestris 1,000 mg by Nature's Truth

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Quick Release Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Tribulus terrestris Fruit Extract

Interacts with
259 drugs
1000 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris Fruit Extract monograph & interactions

Other (inactive) ingredients: Rice, Powder, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Terrestris 1,000 mg by Nature's Truth Drug Interactions

Want to check YOUR meds against Tribulus Terrestris 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris Fruit Extract 259

Individual Drug Interactions

The ingredients in Tribulus Terrestris 1,000 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Terrestris 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Terrestris 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris Fruit Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Terrestris 1,000 mg, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-844-544-1030
Web Address
naturestruthproducts.com
Pharmacist Counseling Corner

Tribulus Terrestris 1,000 mg by Nature's Truth: Common Questions

Does Tribulus Terrestris 1,000 mg by Nature's Truth interact with any medications?
Yes. Based on its ingredients, Tribulus Terrestris 1,000 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Terrestris 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Tribulus if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because tribulus may affect hormones and safety isn't established. You should also avoid it while breastfeeding because there isn't reliable safety information. Talk to your doctor or pharmacist if you're pregnant or breastfeeding and interested in this supplement.
What does tribulus do for sexual function?
Research suggests tribulus is possibly effective for sexual dysfunction, meaning there is some evidence it may help — but the data isn't conclusive. If you're considering it for this reason, your own doctor or pharmacist can help you weigh the evidence and see if it's right for you.
Will this help my athletic performance?
The research we hold suggests tribulus is probably not effective for athletic performance. If boosting performance is your goal, this may not be the right supplement for you.
What are the common side effects?
Most people tolerate it well short-term. You might experience stomach pain, cramping, nausea, vomiting, diarrhea, or constipation, but in one study these happened at similar rates in people taking tribulus and those on placebo. Serious side effects like liver or kidney injury are rare but have been reported.
Is this supplement safe long-term?
Long-term safety data are limited. While it's generally well tolerated short-term in healthy adults, we don't have enough information to say how safe it is over months or years. If you're thinking of taking it regularly, run it by your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Terrestris 1,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Terrestris 1,000 mg label
Go deeper

The Full Monographs Behind Tribulus Terrestris 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Terrestris 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team