Triphala 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Triphala 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Triphala 500 mg is a dietary supplement by Planetary Herbals with 5 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,071 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, organic Amla. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Triphala 500 mg by Planetary Herbals
Ask about any prescription or over-the-counter medication and we check it for interactions with Triphala 500 mg by Planetary Herbals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Triphala 500 mg by Planetary Herbals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Triphala 500 mg contains three active ingredients in a proprietary blend: organic Amla (Indian gooseberry), organic Chebulic Myrobalan, and organic Belleric Myrobalan. The blend also includes inactive ingredients — gelatin, microcrystalline cellulose, silica, and magnesium stearate — which are capsule fillers and binders.
Does it work?
Strong evidence
Indian gooseberry shows Possibly Effective evidence for GERD (gastroesophageal reflux disease, or acid reflux) and for dyslipidemia (abnormal blood fat levels). The evidence is Insufficient for high cholesterol and for androgenic alopecia (pattern hair loss).
We hold no effectiveness data on the other two ingredients in the blend.
How safe is it?
Well-documented data
Indian gooseberry is generally well tolerated as a food, but safety research on supplement doses is limited. Safety data during breastfeeding is too sparse to know whether it's safe, so it's best to avoid it if you're nursing.
In clinical trials, a small number of people reported stomach discomfort or indigestion, and one person reported fatigue and three reported muscle or joint pain.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you're on blood thinners (anticoagulants), aspirin, antiplatelet drugs like clopidogrel (Plavix), or diabetes medications. Indian gooseberry may increase bleeding risk and lower blood sugar, which could change how these drugs work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Triphala may help with acid reflux or abnormal blood fat levels, but it's important to talk with your doctor or pharmacist before taking it — especially if you're on blood thinners, aspirin, or diabetes medications. If you're breastfeeding, ask your doctor or pharmacist about safety first.
Check your exact medications with the search tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Triphala 500 mg, straight from the product label.
| Brand | Planetary Herbals |
|---|---|
| Barcode (UPC) | 021078105022 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2017 |
| DSLD ID | 76086 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Triphala 500 mg by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Dietary Fiber | 1 Gram(s) | 4% |
| Protein | 1 Gram(s) | 2% |
| Proprietary Blend | 2 Gram(s) | -- |
| organic Amla | 0 NP | -- |
| organic Chebulic Myrobalan | 0 NP | -- |
| organic Belleric Myrobalan | 0 NP | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
GI tract wellness
Formulated by Michael Tierra L.Ac, O.M.D
Triphala is a potent yet gentle three-fruit herbal complex that uniquely supports GI (gastrointestinal) tract wellness. Supported by emerging science and traditional use, Triphala cleanses, tonifies, and revitalizes the tissues of the entire GI tract, setting the stage for better digestion and regular elimination to help you feel better. Triphala has been the cornerstone herbal formula for GI wellness in the East for more than 1,000 years.
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: 2 to 4 capsules twice daily between meals.
Storage
Store in a cool, dry place.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
PF0502 REV H143
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Triphala 500 mg by Planetary Herbals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Triphala 500 mg by Planetary Herbals
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container22 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsProtein
Proprietary Blend
- › Organic Amla
- › Organic Chebulic Myrobalan
- › Organic Belleric Myrobalan
Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Triphala 500 mg by Planetary Herbals Drug Interactions
HelloPharmacist Interaction Report
Triphala 500 mg by Planetary Herbals contains Indian gooseberry (amla), which has documented interactions with several medication types.
The most serious concern is a Moderate-severity interaction with blood thinners (anticoagulants) and antiplatelet drugs — Indian gooseberry may increase bleeding risk by reducing how easily blood clots form, though research on this remains mixed.
Read the full breakdown — every affected drug type, severity by severity
Indian gooseberry also interacts Moderately with diabetes medications and aspirin. If you take diabetes drugs, this ingredient may lower your blood sugar further, and your dose might need adjusting.
Aspirin carries the same bleeding-risk concern as other anticoagulants and antiplatelet drugs.
We could not check two of the three active ingredients — organic Chebulic Myrobalan and organic Belleric Myrobalan — because we hold no interaction data for them. Altogether, these interactions span 208 individual medications.
Before you start this product, search your exact medications in the tool below.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Triphala 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Triphala 500 mg interact with 2,071 drugs. Click any drug to see the details.
2 of the 5 ingredients in Triphala 500 mg interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber organic Amla
EptifibatideIntegrilin
How Eptifibatide interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Eptifibatide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Eptifibatide interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Ertugliflozin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Ertugliflozin, Metformin Hydrochloride interactionOrganic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Ertugliflozin, Metformin Hydrochloride interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Esomeprazole, Naproxen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Esomeprazole, Naproxen interactionExenatideBydureon, Byetta
How Exenatide interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Exenatide Synthetic interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Famotidine, Ibuprofen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Famotidine, Ibuprofen interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Fish Oil Triglycerides interactionFondaparinuxArixtra
How Fondaparinux interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Fondaparinux interactionGliclazideDiamicron
How Gliclazide interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Gliclazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glimepiride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glipizide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Glipizide, Metformin interactionOrganic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glucagon interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glucagon interactionGlucoseIV Glucose
How Glucose interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glucose interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glyburide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Glyburide, Metformin interactionOrganic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Glyburide, Metformin interactionHeparinHeparin
How Heparin interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Heparin interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Hydrocodone, Ibuprofen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Hydrocodone, Ibuprofen interactionIbrutinibImbruvica
How Ibrutinib interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibrutinib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibuprofen interactionIbuprofen LysineNeoProfen
How Ibuprofen Lysine interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen Lysine interactionIbuprofen, AcetaminophenAdvil Dual Action
How Ibuprofen, Acetaminophen interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen, Acetaminophen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
How Ibuprofen, Hydrocodone interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen, Hydrocodone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
How Ibuprofen, Oxycodone interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen, Oxycodone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibuprofen, Oxycodone interactionIbuprofen, PseudoephedrineDristan
How Ibuprofen, Pseudoephedrine interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Ibuprofen, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ibuprofen, Pseudoephedrine interactionIcosapent Ethyl (prescription Drug)Vascepa
How Icosapent Ethyl (prescription Drug) interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Icosapent Ethyl (prescription Drug) interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Icosapent Ethyl (prescription Drug) interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Iloprost interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Iloprost interactionInhaled InsulinExubera
How Inhaled Insulin interacts with Triphala 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Organic AmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Amla + Inhaled Insulin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Inhaled Insulin interactionInotersenTegsedi
How Inotersen interacts with Triphala 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic AmlaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Read the full Organic Amla + Inotersen interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Triphala 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
organic Amla
Anticoagulant/Antiplatelet Drugs
Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.
Aspirin
Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.
Clopidogrel (Plavix)
Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.
Brand information
Manufacturer and brand details for Triphala 500 mg, from the product label.
Planetary Herbals
See all Planetary Herbals products- Name
- Planetary Herbals, LLC
- Street Address
- P.O. Box 1760
- City
- Soquel
- State
- CA
- ZipCode
- 95073
- Web Address
- www.planetaryherbals.com
Triphala 500 mg by Planetary Herbals: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Triphala 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographIndian Gooseberry
Interacts with 208 drugsIndian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...
Read the full Indian Gooseberry monograph →Sources & How We Checked
Triphala 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Indian Gooseberry 6 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
- Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
- Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
- Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC