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Dietary supplement

Turkey Tail Mushroom 1000 mg Ingredients & Drug Interactions

by HMS Nutrition

Turkey Tail Mushroom 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Turkey Tail Mushroom 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Turkey Tail Mushroom 1000 mg is a dietary supplement by HMS Nutrition with 1 active ingredient. Its ingredients are commonly taken for immune support, used alongside cancer care, gut and digestive health.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Turkey Tail Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Turkey Tail Mushroom 1000 mg by HMS Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Turkey Tail Mushroom 1000 mg by HMS Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Turkey Tail Mushroom 1000 mg by HMS Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: turkey tail mushroom at 1000 mg per capsule. The capsule also includes two inactive ingredients — methylcellulose and brown rice powder — which are fillers and binders that help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Turkey Tail Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy immune system and overall well-being.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Hepatitis, Genital herpes, Urinary tract infections (UTIs), Chronic fatigue syndrome (CFS), General immunity — and 2 related terms.
  • The closest evidence on file: Turkey Tail Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Turkey Tail Mushroom is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Hepatitis, Urinary tract infections (UTIs), Genital herpes.

Turkey tail mushroom is rated possibly effective for cancer support based on the evidence we hold. For chronic fatigue syndrome, tinea corporis (a fungal skin infection), and upper respiratory tract infections, the evidence isn't established well enough to rate it either way.

If you're considering it for one of those less-studied uses, there's not enough reliable data to tell you whether it'll help.

The evidence, ingredient by ingredient Turkey Tail Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Turkey tail mushroom is generally well tolerated in healthy adults, though quality and potency can vary between products — talk with your healthcare provider or pharmacist before starting. Some people report gastrointestinal side effects like nausea, vomiting, appetite loss, stomach discomfort, diarrhea, or constipation, particularly when PSK (a component of turkey tail) is taken alongside chemotherapy, though it's unclear whether the mushroom, the cancer drugs, or both are responsible.

There isn't enough safety data to recommend turkey tail during pregnancy or while breastfeeding — the safety data advises against both. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Turkey Tail Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Turkey Tail Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before taking this product if you use chemotherapy drugs (especially cyclophosphamide), tamoxifen for cancer, antidiabetes medications, or drugs metabolized by the CYP2C9 enzyme (including certain blood thinners and other prescription drugs). The polysaccharide peptide component in turkey tail can increase drug levels or change how your body absorbs these medicines, raising your risk of side effects or reduced effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Turkey tail mushroom may be worth considering if you're interested in cancer support and your doctor approves. However, if you take antidiabetes drugs, chemotherapy, tamoxifen, or certain blood thinners, you need to check your exact medications with our tool before starting.

Talk with your pharmacist — especially if you're pregnant, breastfeeding, or on any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Turkey Tail Mushroom 1000 mg, straight from the product label.

Brand HMS Nutrition
Barcode (UPC) 860003543849
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255613
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Turkey Tail Mushroom 1000 mg by HMS Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
860003543849
IngredientAmount% DV
Turkey Tail Mushroom1000 mg--

Other ingredients: Methylcellulose, Brown Rice powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules daily with food, or as directed by a physician.

Precautions

Caution: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in the USA Manufactured in an FDA inspected facility GMP Good Manufacturing Practice Quality Assured

Formulation

Non GMO Soy free Dairy free

Vegan

Supports a healthy immune system and overall well-being

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Turkey Tail Mushroom 1000 mg by HMS Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Turkey Tail Mushroom 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Turkey Tail Mushroom 1000 mg by HMS Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Turkey Tail Mushroom

Interacts with
187 drugs
1000 mg per serving

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified...

Turkey Tail Mushroom monograph & interactions

Other (inactive) ingredients: Methylcellulose, Brown Rice powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Turkey Tail Mushroom 1000 mg by HMS Nutrition Drug Interactions

Want to check YOUR meds against Turkey Tail Mushroom 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
88 Moderate 99 Minor

Ingredients driving the most interactions

Turkey Tail Mushroom 187

Individual Drug Interactions

The ingredients in Turkey Tail Mushroom 1000 mg interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Turkey Tail Mushroom 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Turkey Tail Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Turkey Tail Mushroom 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Turkey Tail Mushroom4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Turkey Tail Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Turkey Tail Mushroom 1000 mg, from the product label.

HMS Nutrition

See all HMS Nutrition products
Name
HMS Nutrition LLC
Street Address
501 Silverside Rd, Suite 341
City
Wilmington
State
DE
ZipCode
19809
Pharmacist Counseling Corner

Turkey Tail Mushroom 1000 mg by HMS Nutrition: Common Questions

Does Turkey Tail Mushroom 1000 mg by HMS Nutrition interact with any medications?
Yes. Based on its ingredients, Turkey Tail Mushroom 1000 mg has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Turkey Tail Mushroom 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take turkey tail if I'm pregnant or breastfeeding?
No — there isn't enough safety data. The safety information advises against turkey tail during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's safe for you in those situations.
What side effects might I notice?
Most people tolerate it well. Some report stomach upset — nausea, vomiting, loss of appetite, stomach discomfort, diarrhea, or constipation — though these reports mostly come from people taking it alongside chemotherapy, and it's unclear what caused them.
Does turkey tail actually work for cancer?
It's rated possibly effective for cancer based on the evidence we hold, meaning there's some research support but it's not conclusive. Talk with your oncologist about whether it makes sense for your situation.
Will this lower my blood sugar?
Turkey tail's compounds can theoretically lower blood sugar further, so if you take antidiabetes drugs, there's a Moderate-severity risk of low blood sugar (hypoglycemia). Check with your pharmacist and doctor before adding it.
What is turkey tail mushroom and what does it do?
Turkey tail is an edible mushroom used traditionally and studied for immune and digestive support. The product here delivers 1000 mg per capsule of the mushroom itself, including active compounds like polysaccharides.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Turkey Tail Mushroom 1000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Turkey Tail Mushroom 1000 mg label
Go deeper

The Full Monographs Behind Turkey Tail Mushroom 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph →
Sources

Sources & How We Checked

Turkey Tail Mushroom 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Turkey Tail Mushroom 15 references
  1. Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
  2. Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
  3. Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
  4. Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
  5. Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
  6. Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
  7. Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
  8. Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
  9. Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
  10. Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
  11. Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
  12. Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
  13. Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
  14. Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
  15. Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed

See these in context on the Turkey Tail Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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