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Dietary supplement

Maitake Mushroom 1500 mg Ingredients & Drug Interactions

by HMS Nutrition

Maitake Mushroom 1500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake Mushroom 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake Mushroom 1500 mg is a dietary supplement by HMS Nutrition with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake Mushroom 1500 mg by HMS Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake Mushroom 1500 mg by HMS Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Maitake Mushroom 1500 mg by HMS Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Maitake Mushroom 1500 mg contains one active ingredient: maitake mushroom, a fungus that's been used in traditional medicine. Each capsule delivers 1500 mg of the mushroom.

The supplement also contains methylcellulose as an inactive ingredient — a binder that helps hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy immune system and overall well-being.
  • We looked for evidence on: Allergic rhinitis (hay fever), Chemotherapy-induced anemia, Chemotherapy-induced diarrhea, Chemotherapy-induced leukopenia, Chemotherapy-induced nausea and vomiting (CINV), Chemotherapy-related fatigue — and 4 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced anemia, Chemotherapy-induced diarrhea, Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue, and more.

The evidence for what maitake mushroom can do is still thin. The data we hold rates it as having insufficient reliable evidence for allergic rhinitis (hay fever), chemotherapy-related side effects including anemia and diarrhea, laryngeal cancer, and chronic fatigue syndrome.

That means either studies haven't been done yet, or the ones that exist aren't strong enough to say it works. Don't count on this for any of those uses without talking to your doctor.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when taken by mouth. The most common side effects are gastrointestinal — diarrhea and stomach pain — though these showed up in only a small number of trial participants.

One patient reported a rash and itching that cleared on its own. Because concentrated supplements haven't been fully studied in pregnancy and breastfeeding, the safety data advises against use during pregnancy and while breastfeeding.

As a food, maitake is considered safe, but as a concentrated supplement, we don't have enough data.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking maitake mushroom, double-check with your pharmacist if you're on warfarin or any blood thinner — the supplement may boost its blood-thinning effects. Blood pressure medications and diabetes drugs are also a concern; maitake may strengthen their effects, risking low blood pressure or low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is worth a conversation with your pharmacist if you're on warfarin, blood pressure meds, or diabetes drugs — maitake mushroom may intensify their effects. If you're not on any of those, it's generally well tolerated, though stomach upset is possible.

Because evidence for its effectiveness isn't established for the conditions listed, check with your doctor first about whether it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake Mushroom 1500 mg, straight from the product label.

Brand HMS Nutrition
Barcode (UPC) 860003543856
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255589
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake Mushroom 1500 mg by HMS Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
860003543856
IngredientAmount% DV
Maitake Mushroom1500 mg--

Other ingredients: Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules daily with food, or as directed by a physician.

Precautions

Caution: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in the USA Manufactured in an FDA inspected facility GMP Good Manufacturing Practice Quality Assured

Formulation

Supports a healthy immune system and overall well-being

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake Mushroom 1500 mg by HMS Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake Mushroom 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake Mushroom 1500 mg by HMS Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Maitake Mushroom

Interacts with
260 drugs
1500 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom monograph & interactions

Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake Mushroom 1500 mg by HMS Nutrition Drug Interactions

Want to check YOUR meds against Maitake Mushroom 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake Mushroom 260

Individual Drug Interactions

The ingredients in Maitake Mushroom 1500 mg interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake Mushroom 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Maitake Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake Mushroom 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake Mushroom 1500 mg, from the product label.

HMS Nutrition

See all HMS Nutrition products
Name
HMS Nutrition LLC
Street Address
501 Silverside Rd, Suite 341
City
Wilmington
State
DE
ZipCode
19809
Pharmacist Counseling Corner

Maitake Mushroom 1500 mg by HMS Nutrition: Common Questions

Does Maitake Mushroom 1500 mg by HMS Nutrition interact with any medications?
Yes. Based on its ingredients, Maitake Mushroom 1500 mg has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake Mushroom 1500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without checking with your pharmacist first. Maitake mushroom may increase warfarin's blood-thinning effects and raise your clotting time — one patient's levels spiked dangerously high after taking it for just a week. Your doctor or pharmacist needs to know before you start.
Will this help with my chronic fatigue?
The evidence isn't there yet. We rate maitake mushroom as having insufficient reliable evidence for chronic fatigue syndrome, so we can't say whether it works for that. Talk with your doctor about whether it's worth trying.
What are the side effects?
Most people tolerate it fine. Stomach upset — diarrhea, belly pain, and occasionally nausea — is the main risk, though it only showed up in a small number of people in trials. One person reported a rash that went away on its own.
Is it safe in pregnancy?
The safety data advises against it. There isn't enough research on concentrated supplements during pregnancy, so talk with your doctor or midwife before taking it.
Can I take this while breastfeeding?
The safety data advises against it. Not enough is known about concentrated maitake supplements and breastfeeding, so check with your doctor or pharmacist first.
What is maitake mushroom?
It's a fungus that's been used in traditional medicine for centuries. This supplement gives you 1500 mg of maitake mushroom per capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake Mushroom 1500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake Mushroom 1500 mg label
Go deeper

The Full Monographs Behind Maitake Mushroom 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake Mushroom 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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