Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Twelve Rivers Mycomedic Ingredients & Drug Interactions

by Raw Forest Foods

Twelve Rivers Mycomedic label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Twelve Rivers Mycomedic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Twelve Rivers Mycomedic is a dietary supplement by Raw Forest Foods with 8 active ingredients. Its ingredients are commonly taken for immune support, antioxidant support, general wellness/tonic.Based on those ingredients, 895 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fu Ling Fruiting Body Extract, Reishi Fruiting Body Extract, Chaga Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Twelve Rivers Mycomedic by Raw Forest Foods

Ask about any prescription or over-the-counter medication and we check it for interactions with Twelve Rivers Mycomedic by Raw Forest Foods — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Twelve Rivers Mycomedic by Raw Forest Foods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Twelve Rivers Mycomedic is a powder blend of eight mushroom fruiting body extracts. The active ingredients are Chaga, Cordyceps, Fu Ling (poria mushroom), Maitake, Reishi, Royal Sun Agaricus, Turkey Tail, and Willow Bracket.

Each is included as a concentrated extract rather than whole mushroom material. The product contains no other listed inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Deep comprehensive immune support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Bronchitis, Cancer, Cancer-related fatigue, Chemotherapy-induced anemia — and 4 related terms.
  • The closest evidence on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Chemotherapy-induced anemia, Laryngeal cancer, Chronic fatigue syndrome (CFS), and more.

The evidence base for most of these mushrooms is limited. Cordyceps is rated possibly ineffective for athletic performance.

Reishi is rated possibly ineffective for high cholesterol (hyperlipidemia). For the remaining conditions studied—including cardiovascular disease, diabetes, COVID-19, sexual dysfunction, asthma, chronic fatigue, and various forms of cancer—the data we hold shows insufficient reliable evidence to rate whether these mushrooms work.

This doesn't mean they don't work; it means the evidence isn't yet established well enough for us to say.

The evidence, ingredient by ingredient Chaga Cordyceps Poria Mushroom Maitake Mushroom Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chaga, Cordyceps, Fu Ling, Maitake, and Reishi are generally well tolerated short-term, though long-term safety data are limited for all of them. Chaga carries a specific concern: excessive consumption can cause kidney damage due to its high oxalate content; two cases of kidney failure and one of acute kidney injury have been reported.

Cordyceps, Maitake, and Reishi may cause gastrointestinal upset—diarrhea, constipation, abdominal discomfort, nausea, and stomach upset—though these were uncommon in trials and sometimes resolved when the mushroom was taken with food. Reishi may also cause dizziness, dry mouth, itching, rash, sore throat, or runny nose.

One case of liver inflammation (cholestatic hepatitis) was reported with a cordyceps product, though whether cordyceps itself was the cause is unclear. Allergic reactions, including allergic rhinitis and allergic asthma, have been reported rarely with poria mushroom, and one case of rash and itching occurred with Maitake.

The safety data for Royal Sun Agaricus, Turkey Tail, and Willow Bracket are not on file.

Side effects, ingredient by ingredient Chaga Cordyceps Poria Mushroom Maitake Mushroom Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Poria Mushroom, Maitake Mushroom, Cordyceps, Reishi Mushroom, Chaga.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 895 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Twelve Rivers Mycomedic, check it against blood thinners (anticoagulants) and antiplatelet drugs like warfarin and aspirin—moderate risk of increased bleeding. Also double-check immunosuppressants, diabetes medications, blood pressure drugs, sedatives, anticholinergic drugs, cholinergic drugs, and testosterone products.

Three of the eight ingredients—Royal Sun Agaricus, Turkey Tail, and Willow Bracket—have not been checked for interactions, so your pharmacist may find additional concerns in the medical literature outside our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-mushroom blend that may interact with blood thinners, diabetes medications, blood pressure drugs, immunosuppressants, sedatives, and hormone therapies. If you take any of those—or any prescription medication—check your exact drugs against the tool on this page before you start.

It's generally well tolerated short-term, but long-term safety isn't well studied, and pregnant or nursing people should avoid it. Talk with your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Twelve Rivers Mycomedic, straight from the product label.

Brand Raw Forest Foods
Barcode (UPC) 850004627365
Net contents 2.47 Ounce(s); 70 Gram(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309829
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Twelve Rivers Mycomedic by Raw Forest Foods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
35
UPC/BARCODE
850004627365
IngredientAmount% DV
Chaga Fruiting Body Extract250 mg--
Cordyceps Fruiting Body Extract250 mg--
Fu Ling Fruiting Body Extract250 mg--
Maitake Fruiting Body Extract250 mg--
Reishi Fruiting Body Extract250 mg--
Royal Sun Agaricus Fruiting Body Extract250 mg--
Turkey Tail Fruiting Body Extract250 mg--
Willow Bracket Fruiting Body Extract250 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Formulated by master herbalists

Wisdom of the forest Founded in 2010, RAW Forest Foods is the destination for adaptogenic, pro-androgenic, and tonic phyto-therapeutic herbs and supplements. Born in tradition and steeped in science, we professionally - and - artfully craft these products using premier, hand-selected ingredients and master formulations. We invite you to discover the infinite power within.

Welcome to the trail family.

Formula

Advanced mushroom complex

Fruiting body 30% polysaccharides extract powders

Formulation

Restore & fortify Deep comprehensive immune support

Prepared Ready to use

This product is GMO free, vegan /vegetarian, and has been manufactured in the US with global ingredients in a certified organic & FDA cGMP registered facility. Formulated by master herbalists.

This product is GMO free, vegan /vegetarian, and has been manufactured in the US with global ingredients in a certified organic & FDA cGMP registered facility. No fillers, no drying agents, and never irradiated.

This product is GMO free, vegan /vegetarian, and has been manufactured in the US with global ingredients in a certified organic & FDA cGMP registered facility.

Non GMO

Vegan

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Serving instructions: These expertly prepared extract powders are ready to use: Simply add the desired amount to several ounces of warm or hot water, stir to dissolve, and enjoy. Suggested usage: as a dietary supplement, adults take 2 grams (roughly ¾ tsp) 1 – 2 times daily, preferably on an empty stomach. As with all dietary supplements, please consult a qualified health care practitioner prior to use.

Precautions

May contain traces of maltodextrin (occurring as part of the extraction process).

Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Twelve Rivers Mycomedic by Raw Forest Foods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Twelve Rivers Mycomedic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Twelve Rivers Mycomedic by Raw Forest Foods

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container35 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chaga Fruiting Body Extract

Interacts with
327 drugs
250 mg per serving Form: Polysaccharides

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Chaga Fruiting Body Extract monograph & interactions

Cordyceps Fruiting Body Extract

Interacts with
249 drugs
250 mg per serving Form: Cordyceps militaris Fruiting Body Extract, Polysaccharides

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Fruiting Body Extract monograph & interactions

Fu Ling Fruiting Body Extract

Interacts with
417 drugs
250 mg per serving Form: Poria cocos Fruiting Body Extract, Polysaccharides

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scient...

Fu Ling Fruiting Body Extract monograph & interactions

Maitake Fruiting Body Extract

Interacts with
260 drugs
250 mg per serving Form: Polysaccharides

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Fruiting Body Extract monograph & interactions

Reishi Fruiting Body Extract

Interacts with
375 drugs
250 mg per serving Form: Ganoderma lucidum Fruiting Body Extract, Polysaccharides

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Fruiting Body Extract monograph & interactions

Royal Sun Agaricus Fruiting Body Extract

250 mg per serving Form: Polysaccharides

Turkey Tail Fruiting Body Extract

250 mg per serving Form: Trametes versicolor Fruiting Body Extract, Polysaccharides

Willow Bracket Fruiting Body Extract

250 mg per serving Form: Polysaccharides
Interaction report

Twelve Rivers Mycomedic by Raw Forest Foods Drug Interactions

Want to check YOUR meds against Twelve Rivers Mycomedic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
895Drugs
887 Moderate 8 Minor

Ingredients driving the most interactions

Fu Ling Fruiting Body Extract 417
Reishi Fruiting Body Extract 375
Chaga Fruiting Body Extract 327
Maitake Fruiting Body Extract 260
Cordyceps Fruiting Body Extract 249

Individual Drug Interactions

The ingredients in Twelve Rivers Mycomedic interact with 895 drugs. Click any drug to see the details.

5 of the 8 ingredients in Twelve Rivers Mycomedic interact with drugs. Each result below shows which ingredient is responsible. Fu Ling Fruiting Body Extract Reishi Fruiting Body Extract Chaga Fruiting Body Extract Maitake Fruiting Body Extract Cordyceps Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Twelve Rivers Mycomedic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fu Ling Fruiting Body Extract3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Fu Ling Fruiting Body Extract full monograph & interactions

Reishi Fruiting Body Extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Fruiting Body Extract full monograph & interactions

Chaga Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Fruiting Body Extract full monograph & interactions

Maitake Fruiting Body Extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Fruiting Body Extract full monograph & interactions

Cordyceps Fruiting Body Extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Twelve Rivers Mycomedic, from the product label.

Raw Forest Foods

See all Raw Forest Foods products
Name
RAW Forest Foods LLC
Street Address
11 Elmwood Ave, STE 102
City
BTV
State
VT
ZipCode
05402
Phone Number
(802) 349-1347
Web Address
www.rawforestfoods.com
Pharmacist Counseling Corner

Twelve Rivers Mycomedic by Raw Forest Foods: Common Questions

Does Twelve Rivers Mycomedic by Raw Forest Foods interact with any medications?
Yes. Based on its ingredients, Twelve Rivers Mycomedic has a known interaction with 895 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Twelve Rivers Mycomedic contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take if I'm on a blood thinner like warfarin?
Not without checking with your pharmacist first. Chaga, Cordyceps, Maitake, and Reishi all have documented moderate-severity interactions with blood thinners. One patient on warfarin actually developed an abnormally high level of anticoagulation after taking Maitake. Your pharmacist needs to review your dose and type before you add this product.
Can I take this if I have diabetes and use diabetes medication?
You'll need to check with your pharmacist or doctor. Chaga, Maitake, and Reishi may theoretically lower blood sugar further, increasing the risk of low blood sugar (hypoglycemia). Maitake especially has clinical evidence of this effect, so dosing adjustments might be needed.
What is Cordyceps used for in this blend?
Cordyceps is included as an immune-supporting and energy-supporting ingredient, though the evidence we hold rates it possibly ineffective for athletic performance. The blend does not specify a single intended use; it's marketed as a broad mushroom formula.
Are there any common side effects from taking this?
The most common are gastrointestinal—diarrhea, constipation, abdominal discomfort, nausea, and stomach upset. Reishi may also cause dizziness, dry mouth, itching, or rash. These are generally uncommon and often resolve if you take it with food. Allergic reactions are rare but have been reported.
Can I take this while pregnant or breastfeeding?
The safety data advise against it. There isn't enough information to know whether these mushroom extracts are safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist for personalized guidance.
Does this actually work for anything?
The evidence is mixed and limited. Cordyceps is rated possibly ineffective for athletic performance, and Reishi is rated possibly ineffective for high cholesterol. For most other uses—cardiovascular health, diabetes, fatigue, cancer—the evidence we hold is insufficient to say whether it works. That's different from saying it doesn't; it means we don't have enough reliable data yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Twelve Rivers Mycomedic label
Go deeper

The Full Monographs Behind Twelve Rivers Mycomedic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Twelve Rivers Mycomedic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 51 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
  8. Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
  9. Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed

See these in context on the Chaga monograph →

Cordyceps 14 references
  1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
  3. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
  4. Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
  5. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
  6. Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
  7. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
  8. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
  9. Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
  10. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
  11. Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
  12. Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
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See these in context on the Cordyceps monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
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See these in context on the Poria Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
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  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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