Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Udo's Oil High Lignan 3-6-9 Blend Ingredients & Drug Interactions

by Flora

Udo's Oil High Lignan 3-6-9 Blend label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Udo's Oil High Lignan 3-6-9 Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Udo's Oil High Lignan 3-6-9 Blend is a dietary supplement by Flora with 3 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Udo's Oil High Lignan 3-6-9 Blend by Flora

Ask about any prescription or over-the-counter medication and we check it for interactions with Udo's Oil High Lignan 3-6-9 Blend by Flora — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Udo's Oil High Lignan 3-6-9 Blend by Flora

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a 5-ingredient blend of essential fatty acids and oils. The active components include oleic acid (a monounsaturated fat), linoleic acid, alpha-linolenic acid, and other polyunsaturated and monounsaturated fats — the building blocks your body needs for cell structure and hormone production.

The formula also contains a lignan-rich fiber blend and is rounded out with inactive oils (flax, sunflower, sesame, coconut, evening primrose, rice bran, and oat bran oils) plus soy lecithin and mixed tocopherols (a form of vitamin E) as preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: essential fatty acids for cell structure and health.
  • We looked for evidence on: Coronary heart disease (CHD), Hypercholesterolemia, Hypertension, Stroke, cardiovascular health, inflammation — and 1 related terms.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Stroke.

Oleic acid, the one ingredient in this product we could evaluate, is rated possibly effective for lowering cholesterol (hypercholesterolemia) and reducing risk of coronary heart disease. That means early evidence points in a promising direction, but larger or better-designed studies are needed to be sure.

The effectiveness of the other fatty acids in this blend — linoleic acid and alpha-linolenic acid — isn't established in the data we hold.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid from food sources like olive oil is generally recognized as safe in normal dietary amounts. However, concentrated supplement doses haven't been well studied in pregnancy or breastfeeding, so the safety data advises caution at higher levels during those times.

The product contains no reported adverse effects in our data. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist about whether this oil blend is right for you.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (insulin, metformin, sulfonylureas, or other blood-sugar-lowering medications), alert your doctor or pharmacist before you start this product — oleic acid may increase their effect and lower your blood sugar more than expected. For all other medications, check the search tool on this page with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Udo's Oil is a source of omega fatty acids that may help with cholesterol and heart health, but it can potentially boost the effect of antidiabetes medications. If you take insulin or other blood-sugar-lowering drugs, check with your doctor or pharmacist before starting — you may need dose adjustments or closer monitoring.

Anyone else should run their full medication list through the interaction checker below before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Udo's Oil High Lignan 3-6-9 Blend, straight from the product label.

Brand Flora
Barcode (UPC) 061998679944
Net contents 8.5 fl. Oz.; 250 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218259
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Udo's Oil High Lignan 3-6-9 Blend by Flora, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
16
UPC/BARCODE
061998679944
IngredientAmount% DV
Calories120 Calorie(s)--
Saturated Fat1.5 Gram(s)8%
Polyunsaturated Fat9 Gram(s)--
Total Fat14 Gram(s)18%
Monounsaturated Fat2.5 Gram(s)--
Linoleic Acid3 Gram(s)--
Oleic Acid2.5 Gram(s)--
Alpha-Linolenic Acid6 Gram(s)--

Other ingredients: organic Flax seed Oil, organic Sunflower seed Oil, organic Fiber Blend, organic Sesame seed Oil, organic Coconut Oil, organic Evening Primrose seed Oil, organic Rice Bran oil, organic Soy Lecithin, organic Oat Bran oil, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Udo's Oil High Lignan 3-6-9 Blend provides a balanced 2:1 ratio of omega-3 (6 g) to omega-6 (3 g) essential fatty acids per serving, for people who want one product that gives them all of the good fats they need, without any of the bad fats they should avoid.

Made with organic flax, sesame, and sunflower seed oils

Kosher Check

Plant based Omega-3 Fish Free

What is in Udo's Oil? Flax (omega-3) Sesame (omega-6, omega-9) Sunflower (omega-6) Coconut (omega-9 & MCT)

General Statements

Every cell, tissue, gland, and organ is dependent upon the presence of essential fatty acids. They are the main structural component of cell membranes and are important for cell growth and division.

Udo's Oil is formulated by Udo Erasmus, PhD, an internationally acclaimed authority on the subject of essential fatty acids and author of the groundbreaking book Fats That Heal Fats That Kill.

Formulated by: Udo Erasmus, PhD.

Udo's Choice

1 Award winning formula

Sustainable forestry initiative Certified sourcing www.sfiprogram.org SFI This box contains 100% recyclable material This box is 100% recyclable

Glass bottle

Formulation

Lignans exhibit antioxidant properties and can be used as part of a healthy diet.

Udo's Oil blend is fresh-pressed in a state-of-the-art, low heat, light- and oxygen-free environment and packaged in an environmentally friendly glass bottle.

Gluten free

Certified organic

Provides a balanced 2:1:1 ratio of omega fatty acids

Non GMO Project Verified nongmoproject.org

Certified Organic By QAI

Vegan

Suggested/Recommended/Usage/Directions

Udo's Oil has a pleasant, nutty, buttery taste and can be added unheated to foods such as cereal, salad, pasta, or stir-fried vegetables, and even poured over dessert.

Suggested use: The cloudy layer in the oil is unique to this blend. To obtain its benefits, shake bottle before each use (lignans may settle and should be stirred often). Take 1 tbsp. or more a day with meals (up to 1 tbsp. per 50 lb. of body weight per day). For best results, substitute other sources of dietary fat with Udo's Oil.

Once opened, use within 2 months.

Serving Suggestions: You can easily supply your body with the essential fatty acids it needs by incorporating Udo's Oil High Lignan 3-6-9 Blend into your meals. The pleasant nutty, buttery flavor of this oil is a great addition to all types of recipes. Just remember not to heat the oil. Try some of our favorite serving suggestions below or just be creative. Stir into cottage cheese, applesauce, protein shakes, juices, and homemade soup (after cooking). Drizzle it over steamed vegetables, rice, pasta, and baked or mashed potatoes. Blend it with extra virgin olive oil in dishes such as hummus and tabouleh, or serve with balsamic vinegar for dipping. Combine it with fresh vegetable or fruit juices and the Flora Green Blend, for a nutritious, energy-boosting drink.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

USDA Organic

Non GMO Project Verified nongmoproject.org

Kosher Check

Quality Assurance International Certified Organic

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: Manufactured in a facility that also processes mustard and wheat.

Do not heat or use for frying.

Security sealed for your protection. Do not use if seal is missing or damaged.

Storage

For optimum freshness, keep refrigerated.

Udo's Oil can be frozen to maintain freshness for longer periods.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Udo's Oil High Lignan 3-6-9 Blend by Flora label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Udo's Oil High Lignan 3-6-9 Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Udo's Oil High Lignan 3-6-9 Blend by Flora

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Linoleic Acid

3 Gram(s) per serving

Oleic Acid

Interacts with
86 drugs
2.5 Gram(s) per serving

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...

Oleic Acid monograph & interactions

Alpha-Linolenic Acid

6 Gram(s) per serving

Other (inactive) ingredients: Organic Flax seed Oil, Organic Sunflower seed Oil, Organic Fiber Blend, Organic Sesame seed Oil, Organic Coconut Oil, Organic Evening Primrose seed Oil, Organic Rice Bran oil, Organic Soy Lecithin, Organic Oat Bran oil, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Udo's Oil High Lignan 3-6-9 Blend by Flora Drug Interactions

Want to check YOUR meds against Udo's Oil High Lignan 3-6-9 Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Udo's Oil High Lignan 3-6-9 Blend interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Udo's Oil High Lignan 3-6-9 Blend interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Udo's Oil High Lignan 3-6-9 Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Udo's Oil High Lignan 3-6-9 Blend, from the product label.

Flora

See all Flora products
Name
Flora, Inc.
Street Address
805 E. Badger Rd.
City
Lynden
State
WA
ZipCode
98264
Phone Number
1.800.446.2110
Web Address
www.florahealth.com
Pharmacist Counseling Corner

Udo's Oil High Lignan 3-6-9 Blend by Flora: Common Questions

Does Udo's Oil High Lignan 3-6-9 Blend by Flora interact with any medications?
Yes. Based on its ingredients, Udo's Oil High Lignan 3-6-9 Blend has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Udo's Oil High Lignan 3-6-9 Blend contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on oleic acid supplements at this dose during pregnancy or breastfeeding, even though small food amounts are considered safe. Talk with your doctor or pharmacist for personalized advice.
What are lignan-rich fibers, and why are they in this product?
Lignans are plant compounds found in seeds and whole grains that act as fiber. We hold no specific data on their benefits or interactions in this product, but they're included as part of the blend's nutritional profile.
Does this really help with cholesterol and heart disease?
The oleic acid in it is rated possibly effective for both, meaning early evidence is encouraging but not conclusive. You'd want to pair it with diet and lifestyle changes and talk with your doctor about whether it fits your heart-health plan.
I'm on a blood-sugar medication — is this safe for me?
Not without checking first. Oleic acid may make your antidiabetes drug work harder, which could lower your blood sugar too much. Check with your doctor or pharmacist before starting.
What's the difference between the oils listed as ingredients and the inactive oils?
The active ingredients (oleic acid, linoleic acid, alpha-linolenic acid, and the polyunsaturated/monounsaturated fats) are what the product is designed for. The inactive oils and other listed items are excipients — they help deliver the actives and preserve the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Udo's Oil High Lignan 3-6-9 Blend is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Udo's Oil High Lignan 3-6-9 Blend label
Go deeper

The Full Monographs Behind Udo's Oil High Lignan 3-6-9 Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Udo's Oil High Lignan 3-6-9 Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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