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Dietary supplement

Ultimate EFA Ingredients & Drug Interactions

by Youngevity

Ultimate EFA label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate EFA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate EFA is a dietary supplement by Youngevity with 1 active ingredient.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate EFA by Youngevity

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate EFA by Youngevity — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultimate EFA by Youngevity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (714 mg) without saying how much of each component you get.
  • “Typical Average Fatty Acid Profile” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Ultimate EFA is a 7-ingredient softgel that delivers essential fatty acids—the fats your body needs but can't make on its own. The active ingredients include omega-3 fatty acids (docosahexaenoic acid), omega-6 fatty acids (gamma-linolenic acid and linoleic acid), and monounsaturated and polyunsaturated fats, along with oleic acid and alpha-linolenic acid.

The softgels also contain inactive ingredients like flax seed oil, fish oil, borage oil, gelatin, glycerin, and mixed tocopherols.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cardiovascular health.
  • We looked for evidence on: Coronary heart disease (CHD), Hypertension, Hypercholesterolemia, Stroke, atherosclerosis, dyslipidemia.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Stroke.

Oleic acid, one of this product's active components, is rated possibly effective for high cholesterol (hypercholesterolemia) and coronary heart disease based on research showing that diets rich in oleic acid from olive oil can improve cholesterol levels and heart health markers. The evidence data we hold does not establish effectiveness ratings for the other fatty acid ingredients in this product.

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid is generally recognized as safe when you consume it in normal food amounts from sources like olive oil. However, concentrated supplement doses haven't been well studied in pregnancy or while breastfeeding—the research just isn't there to know either way.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist about whether this product is right for you.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs or blood sugar medications, check with your doctor or pharmacist before taking this product—oleic acid may increase their effects and lower your blood sugar more than intended. We were unable to check most of the other ingredients in this product for drug interactions, so ask your pharmacist to review your complete medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Ultimate EFA may be worth considering if you're looking to support heart health and cholesterol levels through essential fatty acids. If you take diabetes medication, blood pressure medication, or any other prescription drugs, check your specific medications with your doctor or pharmacist before starting—especially because we couldn't check most of this product's ingredients for interactions.

A conversation with your healthcare provider will help you figure out if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate EFA, straight from the product label.

Brand Youngevity
Barcode (UPC) 21832
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 240049
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate EFA by Youngevity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
21832
IngredientAmount% DV
Calories9 Calorie(s)--
Calories from Fat8 Calorie(s)--
Total Fat1 Gram(s)1%
Docosahexaenoic Acid16 mg--
Gamma-Linolenic Acid4 mg--
Monounsaturated Fat1 Gram(s)--
Total Omega-3 Fatty Acids714 mg--
Saturated Fat1 Gram(s)1%
Linoleic Acid110 mg--
Oleic Acid137 mg--
Alpha-Linolenic Acid447 mg--
Polyunsaturated Fat1 Gram(s)--
Typical Average Fatty Acid Profile0 NP--

Other ingredients: organic Flax seed Oil, Gelatin, Glycerin, Fish Oil, purified Water, Borage Oil, Carob extract, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ultimate EFA is a proprietary blend of essential fatty acids from Borage, Flax and fish oils. Used as part of a healthy diet, essential fatty acids may support the body in many ways, especially cardiovascular health.

Essential fatty acid Blend of flax seed, borage and fish oils

Precautions

Warning: If you are pregnant, nursing or taking medications, consult your healthcare professional before using this product.

This product contains ingredients derived from tuna.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Directions: Take 1 soft gel, three times a day, or as directed by your healthcare professional.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Manufactured in the U.S.A.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate EFA by Youngevity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate EFA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate EFA by Youngevity

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Total Omega-3 Fatty Acids

714 mg per serving
  • › Typical Average Fatty Acid Profile

Other (inactive) ingredients: Organic Flax seed Oil, Gelatin, Glycerin, Fish Oil, Purified Water, Borage Oil, Carob extract, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate EFA by Youngevity Drug Interactions

Want to check YOUR meds against Ultimate EFA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Ultimate EFA interact with 86 drugs. Click any drug to see the details.

0 of the 1 ingredient in Ultimate EFA interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate EFA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Ultimate EFA, from the product label.

Youngevity

See all Youngevity products
Name
Youngevity
Street Address
2400 Boswell Road
City
Chula Vista
State
CA
ZipCode
91914
Phone Number
1.800.982.3189
Web Address
www.youngevity.com
Pharmacist Counseling Corner

Ultimate EFA by Youngevity: Common Questions

Does Ultimate EFA by Youngevity interact with any medications?
Yes. Based on its ingredients, Ultimate EFA has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate EFA contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data we have isn't clear enough to say yes or no. Oleic acid in normal food amounts is fine, but concentrated supplement doses haven't been well studied during pregnancy or breastfeeding. Talk with your doctor or pharmacist—they can help you decide what's best for you and your baby.
What's oleic acid and why is it in this product?
Oleic acid is a type of monounsaturated fat found in foods like olive oil and avocado. It's included because research suggests it may help support healthy cholesterol levels and heart health.
Does this product actually work for cholesterol or heart health?
The oleic acid in this product is rated possibly effective for high cholesterol and coronary heart disease based on studies showing that diets rich in oleic acid improve cholesterol markers. We don't have effectiveness data for the other fatty acid ingredients.
Why do I see warnings about diabetes medications?
Early research suggests oleic acid might boost the effects of blood sugar medications, which could lower your blood sugar too much. If you take diabetes drugs, your doctor or pharmacist should review this product with you first.
Are there any side effects I should know about?
We don't have adverse effect data on file for this product. If you have questions about how you feel after taking it, talk with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate EFA is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate EFA label
Sources

Sources & How We Checked

Ultimate EFA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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