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Dietary supplement

Uva Ursi 500 mg Ingredients & Drug Interactions

by Supreme Nutrition Products

Uva Ursi 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi 500 mg is a dietary supplement by Supreme Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva-ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi 500 mg by Supreme Nutrition Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi 500 mg by Supreme Nutrition Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi 500 mg by Supreme Nutrition Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: uva-ursi (also called bearberry), a plant extract traditionally used for urinary tract health. The capsule itself is made from vegetable cellulose.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, cystitis, urinary frequency.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence for uva ursi is mixed. For urinary tract infections (UTIs), it's rated possibly ineffective — meaning the data doesn't show it works for that purpose.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence to say either way. If you're considering this for a specific condition, talk with your doctor or pharmacist about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated at low doses for short-term use. The most common side effects are mild — diarrhea, nausea, stomach upset, and vomiting.

However, it can be toxic at high doses or with prolonged use; very high amounts (30 grams or more of the dried herb) have been reported as potentially fatal, and doses around 20 grams may cause serious effects like convulsions, delirium, and breathing problems. Don't use this product during pregnancy — it may stimulate the uterus and safety data is lacking.

There isn't enough information to say it's safe while breastfeeding either, so avoid it then as well. Keep doses low and use only short-term.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on any drugs processed by your liver's CYP2C19 or CYP3A4 enzymes (a large group including many blood pressure drugs, antidepressants, and immunosuppressants), lithium, glucuronidated medications, or urinary acidifying agents. Use the search tool on this page to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi is an option if you're interested in traditional urinary tract support, but the evidence it actually works for UTIs is weak. If you take any prescription medication — especially for liver metabolism or mood — check it against the interaction tool first.

Don't use it long-term, avoid it in pregnancy and while breastfeeding, and talk with your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi 500 mg, straight from the product label.

Brand Supreme Nutrition Products
Barcode (UPC) 794504890761
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 252155
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi 500 mg by Supreme Nutrition Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
794504890761
IngredientAmount% DV
Uva-ursi1000 mg--

Other ingredients: Vegetable Cellulose Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1-2 capsules 2 times daily between meals or as directed by a physician.

Precautions

This product is contraindicated if pregnant, nursing, or have kidney or retinal disease.

Do not take if under 12 years of age.

Do not take more than 14 days in a row unless instructed by your physician.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent or cure any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi 500 mg by Supreme Nutrition Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi 500 mg by Supreme Nutrition Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Uva-ursi

Interacts with
803 drugs
1000 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva-ursi monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi 500 mg by Supreme Nutrition Products Drug Interactions

Want to check YOUR meds against Uva Ursi 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva-ursi 803

Individual Drug Interactions

The ingredients in Uva Ursi 500 mg interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi 500 mg interact with drugs. Each result below shows which ingredient is responsible. Uva-ursi

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva-ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva-ursi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi 500 mg, from the product label.

Supreme Nutrition Products

See all Supreme Nutrition Products products
Name
Supreme Nutrition Products
Street Address
1019 Regents Blvd #203
City
Tacoma
State
WA
ZipCode
98466
Web Address
www.SupremeNutritionProducts.com
Pharmacist Counseling Corner

Uva Ursi 500 mg by Supreme Nutrition Products: Common Questions

Does Uva Ursi 500 mg by Supreme Nutrition Products interact with any medications?
Yes. Based on its ingredients, Uva Ursi 500 mg has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is uva ursi used for?
Traditionally it's been used for urinary tract health, but the evidence that it actually works for UTIs is weak. The data for bronchitis and enlarged prostate isn't strong enough to say whether it helps.
Are there any side effects I should watch for?
At normal doses, the most common side effects are mild — diarrhea, nausea, stomach upset, and vomiting. At very high doses (30 grams or more), it can cause serious effects like convulsions and breathing problems. Keep doses low and don't use it long-term.
Is it safe to take while pregnant or breastfeeding?
No. Avoid it during pregnancy because it may stimulate the uterus and safety data is missing. There also isn't enough information to say it's safe while breastfeeding, so skip it then too.
Why does uva ursi have so many drug interactions?
Uva ursi appears to affect how your liver and kidneys process medications. Specifically, it may slow down enzymes (CYP2C19 and CYP3A4) that clear many common drugs, and it may affect how your body handles lithium. These interactions haven't been confirmed in humans yet, but the lab evidence suggests caution.
Can I take this with vitamin C or acidifying supplements?
It's not a good idea. Uva ursi works best in alkaline urine, so medications or supplements that acidify your urine may reduce its effectiveness for urinary tract health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva Ursi 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi 500 mg label
Go deeper

The Full Monographs Behind Uva Ursi 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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