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Dietary supplement

Uva Ursi Ingredients & Drug Interactions

by Nutricost

Uva Ursi label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Uva Ursi by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi by Nutricost — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Uva Ursi by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Uva Ursi by Nutricost contains one active ingredient: uva ursi leaf extract. This is a plant-based ingredient traditionally used for urinary tract support.

The capsule also contains inactive ingredients — hypromellose, rice flour, and magnesium stearate — that help hold the capsule together and allow it to break down in your stomach.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Uva Ursi product and its label doesn't state a use — see Uva Ursi's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

For urinary tract infections (UTIs), uva ursi is rated possibly ineffective, meaning the evidence we hold doesn't support its use for this purpose. For bronchitis and benign prostatic hyperplasia (BPH), there isn't enough reliable evidence to rate whether it works.

If you're considering uva ursi for any of these, talk with your doctor about what the current evidence shows and whether other options might be better for you.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated at low doses when used short-term. The most common side effects are gastrointestinal — diarrhea, nausea, stomach upset, and vomiting.

At very high doses (20 grams or more of dried herb), serious effects like convulsions, delirium, and shortness of breath have been reported, and doses of 30 grams or more may be fatal; however, typical supplement doses are much lower. Uva ursi should be avoided during pregnancy because it may stimulate the uterus and lacks safety data.

It should also be avoided while breastfeeding due to insufficient safety information. Because prolonged use can be toxic, this supplement is meant for short-term use only.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Uva Ursi, check with your doctor or pharmacist if you're on lithium (a Moderate interaction), drugs processed by liver enzymes CYP2C19 or CYP3A4 (Moderate), medications metabolized through glucuronidation (Moderate), urinary acidifying agents (Moderate), or any drug transported by P-glycoprotein (Minor). These are the main drug types documented to interact with uva ursi.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi may be considered for short-term urinary tract support, though evidence for UTIs is limited. You should be careful if you take lithium, drugs processed by your liver's CYP2C19 or CYP3A4 enzymes, or medications that change your urine's acidity — and avoid it entirely if you're pregnant or breastfeeding.

Talk with your doctor or pharmacist before starting, especially if you're on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi, straight from the product label.

Brand Nutricost
Barcode (UPC) 810014671802
Net contents 240 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306397
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
240
UPC/BARCODE
810014671802
IngredientAmount% DV
Uva Ursi Leaf Extract450 mg--

Other ingredients: Hypromellose, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional.

Formulation

Third Party Tested

Non-GMO Gluten-free

Made and quality tested in the USA with globally sourced ingredients.

Non-GMO product

Vegetarian product

Precautions

Warning: For healthy individuals 18 years and older. Keep out of reach of children.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Nutricost Guaranteed GMP GMP Compliant Facility

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Uva Ursi 4,500 mg equivalent per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

Uva Ursi Leaf Extract

Interacts with
803 drugs
450 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi Leaf Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi by Nutricost Drug Interactions

Want to check YOUR meds against Uva Ursi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva Ursi Leaf Extract 803

Individual Drug Interactions

The ingredients in Uva Ursi interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi Leaf Extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Uva Ursi by Nutricost: Common Questions

Does Uva Ursi by Nutricost interact with any medications?
Yes. Based on its ingredients, Uva Ursi has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Uva Ursi if I'm pregnant?
No — uva ursi is rated likely unsafe in pregnancy because it may stimulate the uterus and there isn't enough safety data. Talk with your doctor before taking it if you're pregnant or planning to become pregnant.
Can I breastfeed while taking Uva Ursi?
The safety data isn't there to say it's okay. Avoid uva ursi while breastfeeding, and check with your doctor or pharmacist if you have questions about alternatives.
Does Uva Ursi actually work for UTIs?
The evidence we hold rates it possibly ineffective for urinary tract infections. If you're dealing with a UTI, your doctor can recommend treatments with better evidence behind them.
What are the most common side effects?
At typical doses, uva ursi is generally well tolerated. Stomach issues — diarrhea, nausea, upset stomach, and vomiting — are the most common side effects reported.
How long can I take Uva Ursi?
Uva ursi is meant for short-term use only. Prolonged use can be toxic, so don't take it long-term without talking to your doctor.
What's in the capsule besides the active ingredient?
The capsule contains hypromellose, rice flour, and magnesium stearate — all inactive ingredients that help the capsule hold together and break down in your stomach.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva Ursi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi label
Go deeper

The Full Monographs Behind Uva Ursi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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