Valerian Root 475 mg Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking Valerian Root 475 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root 475 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root 475 mg by Swanson
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root 475 mg by Swanson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root 475 mg by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: valerian, a root extract, at 475 mg per capsule. Valerian has been traditionally used to promote relaxation and sleep.
The capsule itself is made with gelatin and microcrystalline cellulose, which are inactive ingredients that serve as the capsule shell and filler.
Does it work?
Moderate evidence
The data shows that valerian is possibly effective for insomnia. The evidence for other uses—restless legs syndrome, anxiety before a procedure, stress, and menstrual cramps—is insufficient, so we can't say whether it works for those purposes based on the data we have.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term, but long-term safety hasn't been well studied. The most common side effects are dizziness, drowsiness, and mental slowness; some people also report headache, stomach upset, excitement, and vivid dreams.
If you've taken it for a while and then stop suddenly, you may experience withdrawal symptoms like a racing heartbeat, anxiety, irritability, and trouble sleeping—so taper slowly after extended use rather than stopping abruptly. Rare cases of liver problems have been reported with multi-ingredient products containing valerian, though a single-ingredient product carries less risk.
Valerian's safety during pregnancy has not been established, so it should be avoided. There isn't enough safety information for breastfeeding either, so avoid it then as well.
Talk with your pharmacist or doctor about whether it's right for your situation.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications against these drug types: CNS depressants (sleep aids, anxiety drugs, pain relievers), alcohol, alprazolam (Xanax), and glucuronidated drugs—a large group including some pain relievers and anti-cancer medications. Valerian is also listed as a Minor concern with CYP2D6 and CYP3A4 substrates, though it's unlikely to cause meaningful effects on those.
Run your exact medications through the checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may help you sleep if insomnia is your concern, but it's a sedating herb. If you take any medication—especially sleep aids, anxiety drugs, pain relievers, or alcohol—check with us first.
It's safest short-term, and if you stop after regular use, taper slowly to avoid withdrawal symptoms.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root 475 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root 475 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian | 950 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Promotes a feeling of calmness and relaxation Supports restful, restorative sleep May help promote relaxation and ease nervous tension Science-backed quality since 1969
Brain health 475 mg per capsule
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take one to two capsules with water one hour prior to bedtime.
Precautions
Warning: For adults only. May cause drowsiness. Do not use while driving or operating heavy equipment.
Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are taking prescription medication, especially sedatives or tranquilizers, or if you have a medical condition.
Keep out of reach of children.
Do not use if seal is broken.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root 475 mg by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root 475 mg by Swanson
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Valerian
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
Valerian Root 475 mg by Swanson Drug Interactions
HelloPharmacist Interaction Report
Swanson's Valerian Root 475 mg does interact with several medication types, so you'll want to check your prescriptions before starting it.
Read the full breakdown — every affected drug type, severity by severity
The most serious interactions are Moderate in severity. Valerian can add to the sedative effects of CNS depressants—drugs that slow your brain and nervous system, like sleep aids, anxiety medications, and pain relievers.
It also interacts with alcohol the same way, so mixing valerian with a drink can cause too much drowsiness. If you take alprazolam (Xanax), valerian may increase its sedative effects and possibly raise its levels in your blood, though the level increase is unlikely to be clinically important.
Valerian may also affect how your body processes glucuronidated drugs—a large group that includes some pain relievers, anti-cancer drugs, and other medications. The interaction is Moderate in severity and works through a weak inhibition of an enzyme involved in drug metabolism.
Two other drug types show Minor interactions: drugs metabolized by the liver enzymes CYP2D6 and CYP3A4. Research suggests valerian is unlikely to meaningfully affect these.
Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root 475 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root 475 mg interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root 475 mg interact with drugs. Each result below shows which ingredient is responsible. Valerian
BrexanoloneZulresso
How Brexanolone interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Brexanolone interactionBromazepamLectopam
How Bromazepam interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Bromazepam interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Buprenorphine interactionBuprenorphine HydrochlorideBelbuca, Probuphine
How Buprenorphine Hydrochloride interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Buprenorphine Hydrochloride interactionBuprenorphine Hydrochloride, Naloxone HydrochlorideBunavail
How Buprenorphine Hydrochloride, Naloxone Hydrochloride interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBuprenorphine, NaloxoneCassipa, Zubsolv
How Buprenorphine, Naloxone interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Buprenorphine, Naloxone interactionBuprenorphine/naloxoneSuboxone
How Buprenorphine/naloxone interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Buprenorphine/naloxone interactionButabarbital SodiumButisol Sodium, Sarisol #2
How Butabarbital Sodium interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Butabarbital Sodium interactionButabarbital, Phenobarbital, SecobarbitalS.B.P.
How Butabarbital, Phenobarbital, Secobarbital interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Butabarbital, Phenobarbital, Secobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Butalbital, Phenobarbital, Secobarbital interactionButorphanolStadol
How Butorphanol interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Butorphanol interactionCabotegravirApretude
How Cabotegravir interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Cabotegravir interactionCabotegravir SodiumVocabria
How Cabotegravir Sodium interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Cabotegravir Sodium interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Cabotegravir, Rilpivirine interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Cannabidiol (prescription Drug) interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Carbamazepine interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Carbidopa, Levodopa, Entacapone interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Celecoxib, Tramadol interactionCenobamateXcopri
How Cenobamate interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Cenobamate interactionCetirizineCetirizine, Quzyttir, Zyrtec
How Cetirizine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Cetirizine interactionChloral HydrateChloral Hydrate
How Chloral Hydrate interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Chloral Hydrate interactionChlordiazepoxideLibrium
How Chlordiazepoxide interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Chlordiazepoxide interactionChlordiazepoxide, Clidinium BromideLibrax
How Chlordiazepoxide, Clidinium Bromide interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Chlordiazepoxide, Clidinium Bromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Chlorpheniramine Polistirex, Codeine Polistirex interactionChlorpheniramine, Hydrocodone, PseudoephedrineTussend
How Chlorpheniramine, Hydrocodone, Pseudoephedrine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian + Chlorpheniramine, Hydrocodone, Pseudoephedrine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Chlorpromazine interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with Valerian Root 475 mg — through 1 ingredient. Tap an ingredient for the detail:
ValerianCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Clobazam interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root 475 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root 475 mg, from the product label.
Swanson
See all Swanson products- Name
- Swanson Health Products
- City
- Fargo
- State
- ND
- ZipCode
- 58104
- Phone Number
- 1-800-437-4148
- Web Address
- swanson.com
Valerian Root 475 mg by Swanson: Common Questions
Does Valerian Root 475 mg by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take valerian if I'm pregnant or breastfeeding?
What are the most common side effects?
Does valerian really help you sleep?
Is valerian safe to take long-term?
Can I mix valerian with alcohol?
What's in this capsule besides valerian?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Valerian Root 475 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Valerian Root 475 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root 475 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
- Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
- Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
- Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
- Lefebvre T, Foster BC, Drouin CE, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharmaceut Sci 2004;7:265-73.
- Yuan CS, Mehendale S, Xiao Y, et al. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg 2004;98:353-8. PubMed
- Donovan JL, DeVane CL, Chavin KD, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32:1333-6. PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
- Gutierrez S, Ang-Lee MK, Walker DJ, Zacny JP. Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. Pharmacol Biochem Behav 2004;78:57-64. PubMed
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