Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Vision Ingredients & Drug Interactions

by Performance Lab

Vision label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vision against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vision is a dietary supplement by Performance Lab with 7 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 1,137 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Saffron, Bilberry Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vision by Performance Lab

Ask about any prescription or over-the-counter medication and we check it for interactions with Vision by Performance Lab — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Vision by Performance Lab

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Performance Lab Vision contains seven active ingredients. Lutein and zeaxanthin are carotenoids (plant pigments) that concentrate in your eye's macula and help protect it from age-related wear.

Astaxanthin is another carotenoid with antioxidant properties. Bilberry fruit extract, black currant (freeze-dried and as an extract), and saffron are botanical ingredients traditionally linked to eye and cognitive health.

The product also contains two inactive ingredients — pullulan and Nu-Flow — which are used as capsule material and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye and vision health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein and zeaxanthin both have possibly effective evidence for age-related macular degeneration (AMD) and cataracts. For the other ingredients in this product, the evidence we hold isn't yet established: astaxanthin, bilberry fruit extract, black currant, and saffron all show insufficient reliable evidence for their listed uses in our data.

Saffron does show possibly effective evidence for Alzheimer disease and chemotherapy-induced peripheral neuropathy, but those aren't vision-focused claims. The bottom line is that lutein and zeaxanthin have the strongest evidence for supporting eye health in aging.

The evidence, ingredient by ingredient Lutein Astaxanthin Zeaxanthin Black Currant Bilberry Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein is generally well tolerated; doses up to 20 mg daily haven't caused adverse effects in trials. Astaxanthin, bilberry, and saffron are also generally well tolerated in studies, though long-term safety data for astaxanthin are limited.

The most common side effects are mild: astaxanthin may cause abdominal pain, diarrhea, or red-colored stools; bilberry may cause dark-colored stools, flatulence, or mild gastrointestinal discomfort; saffron may cause nausea, gastrointestinal complaints, or sedation. A small number of trial participants taking saffron reported anxiety or agitation.

Black currant concentrate is less studied than the whole berry, though in one trial a few participants on black currant seed oil reported mild diarrhea early in treatment. For pregnancy, lutein is rated likely safe.

Zeaxanthin is also likely safe, but supplement safety in pregnancy isn't well studied, so check with your doctor. Astaxanthin should be avoided in pregnancy due to insufficient safety data.

Black currant, bilberry, and saffron all lack adequate pregnancy safety data — saffron in particular is rated likely unsafe because it may stimulate the uterus. For breastfeeding, astaxanthin and saffron should be avoided; lutein, zeaxanthin, black currant, and bilberry all lack sufficient data.

Talk with your pharmacist or doctor if you're pregnant or nursing.

Side effects, ingredient by ingredient Lutein Astaxanthin Zeaxanthin Black Currant Bilberry Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Bilberry, Saffron, Astaxanthin, Black Currant, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,138 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Vision, double-check if you're on CNS depressants (sedating drugs), blood thinners or antiplatelet drugs (like warfarin or aspirin), antidiabetes medications, antihypertensive drugs (blood pressure medications), certain cancer drugs like erlotinib, or caffeine supplements — all have Moderate-severity interactions documented with one or more ingredients here. Use the medication checker on this page to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vision is a multi-ingredient eye-support formula with the strongest evidence behind lutein and zeaxanthin for age-related eye health. If you take blood thinners, antidiabetes drugs, or sedating medications, you'll need to check your specific drugs with the tool below — the product has several Moderate-severity interactions.

Pregnant or breastfeeding? Talk with your pharmacist first, especially about the saffron content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vision, straight from the product label.

Brand Performance Lab
Barcode (UPC) 617401625062
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 331706
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vision by Performance Lab, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 NutriCap(s)
Maximum serving Sizes:
1 NutriCap(s)
Servings per container
30
UPC/BARCODE
617401625062
IngredientAmount% DV
Lutein10 mg--
Astaxanthin4 mg--
Zeaxanthin2 mg--
Black Currant, Freeze-Dried300 mg--
Black Currant Fruit Extract25 mg--
Bilberry Fruit Extract25 mg--
Saffron10 mg--

Other ingredients: Pullulan, Nu-Flow

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Suitable for vegans.

Contains no soy, egg, fish, shellfish, dairy, peanuts, tree nuts, wheat, or other allergens. Non-GMO and non-irradiated. Free of gluten, caffeine, synthetic additives, artificial colors and preservatives. BPA free

GMP Certified Manufacturing

Vegan Approved Vegetarian Society

Performance Lab supplements are formulated in the UK, and manufactured under license in the USA, by Performance Lab Group Ltd. We uphold superior quality standards to deliver the best targeted nutrition to support your performance goals.

Brand IP Statement(s)

NutriCaps are registered trademarks of Performance Lab Group Ltd. Copyright Performance Lab Ltd. All rights reserved.

Performance Lab Upgrade Yourself

General Statements

Please recycle

For advanced usage guidelines visit www.performancelab.com/advanced

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule a day with food containing source of fat.

Precautions

Warning: Do not use if pregnant, nursing or under the age of 18. Consult with your doctor before taking this or any supplement if you have or suspect a medical condition and are taking any medication.

Warning: Do not use if pregnant, nursing or under the age of 18. Keep out of reach of children.

If you experience any adverse reactions from taking this product discontinue immediately, contact your doctor and report to 908-280-1066. Do not use if safety seal is broken or missing.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

NutriGenesis

Seals/Symbols

Vegan Approved Vegetarian Society

Certified B Corporation

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vision by Performance Lab label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vision label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vision by Performance Lab

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 NutriCap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
10 mg per serving Form: Marigold Flower Extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Astaxanthin

Interacts with
671 drugs
4 mg per serving Form: Haematococcus pluvialis Algae Extract

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Zeaxanthin

Interacts with
86 drugs
2 mg per serving Form: Marigold Flower Extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Black Currant, Freeze-Dried

Interacts with
140 drugs
300 mg per serving

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjo...

Black Currant, Freeze-Dried monograph & interactions

Black Currant Fruit Extract

Interacts with
140 drugs
25 mg per serving Form: Anthocyanin, Cyanidin 3-Glucoside

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjo...

Black Currant Fruit Extract monograph & interactions

Bilberry Fruit Extract

Interacts with
275 drugs
25 mg per serving Form: Anthocyanosides

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry Fruit Extract monograph & interactions

Saffron

Interacts with
521 drugs
10 mg per serving Form: Safranal

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron monograph & interactions

Other (inactive) ingredients: Pullulan, Nu-Flow. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vision by Performance Lab Drug Interactions

Want to check YOUR meds against Vision?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,137Drugs
1,137 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Saffron 521
Bilberry Fruit Extract 275
Black Currant, Freeze-Dried 140
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Vision interact with 1,137 drugs. Click any drug to see the details.

5 of the 7 ingredients in Vision interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Saffron Bilberry Fruit Extract Black Currant, Freeze-Dried Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Vision with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Saffron4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron full monograph & interactions

Bilberry Fruit Extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry Fruit Extract full monograph & interactions

Black Currant, Freeze-Dried2 drug types · 140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.
Gamma-linolenic acid (GLA), a constituent of black currant seed oil, appears to have antiplatelet effects.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures.

Likelihood Possible Evidence D
Black Currant, Freeze-Dried full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vision, from the product label.

Performance Lab

See all Performance Lab products
Name
Performance Lab Group Ltd.
Street Address
7 Clarendon Place
City
Royal Leamington Spa
State
Warwickshire
ZipCode
CV32 5QL
Phone Number
908-280-1066
Pharmacist Counseling Corner

Vision by Performance Lab: Common Questions

Does Vision by Performance Lab interact with any medications?
Yes. Based on its ingredients, Vision has a known interaction with 1,137 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vision contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my aging eyes or AMD?
Lutein and zeaxanthin both have possibly effective evidence for age-related macular degeneration and cataracts. The other ingredients — astaxanthin, bilberry, black currant, and saffron — don't have established evidence in our data for eye conditions specifically, though some show promise for other health areas.
Is saffron safe to take while I'm pregnant?
No — saffron is rated likely unsafe in pregnancy because it may stimulate the uterus. Lutein and zeaxanthin are likely safe, but you should still talk with your doctor or pharmacist before starting any supplement in pregnancy.
What are the side effects I should watch for?
Most ingredients are well tolerated. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stools. Bilberry may cause dark stools or mild gas. Saffron may cause nausea, drowsiness, or, rarely, anxiety. Black currant concentrate is less studied, but a few people reported mild diarrhea early on. If you notice anything unusual, stop and talk to your pharmacist.
Can I take this if I'm on blood thinners?
Bilberry and black currant both contain compounds that may theoretically increase bleeding risk with blood thinners — this is a Moderate-severity interaction. You need to check your exact medication below or talk with your pharmacist before starting.
Does this product have any fillers?
The capsules themselves are made of pullulan and Nu-Flow, which are inactive ingredients used for the capsule material and flow. The seven active ingredients are the botanicals and nutrients listed.
What does each ingredient do in this formula?
Lutein and zeaxanthin are plant pigments that protect your eye's center (macula). Astaxanthin is an antioxidant carotenoid. Bilberry, black currant, and saffron are traditional botanicals with antioxidant compounds — though evidence for their specific eye benefits isn't established in our data. Together, they're meant to support eye health as you age.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vision is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vision label
Go deeper

The Full Monographs Behind Vision’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Black Currant

Interacts with 140 drugs

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjoyed safely as a food and is popular as a...

Read the full Black Currant monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Vision's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 51 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Black Currant 6 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. Fa-lin Z, Zhen-yu W, Yan H, et al. Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment. Phytother Res 2010;24 Suppl 2:S209-13. PubMed
  3. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  4. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  5. Norred, C. L. and Brinker, F. Potential coagulation effects of preoperative complementary and alternative medicines. Alt Ther 2001;7(6):58-67.
  6. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Black Currant monograph →

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
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  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
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  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

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See these in context on the Saffron monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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