Selenium Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Selenium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Selenium is a dietary supplement by Performance Lab with 1 active ingredient. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are NutriGenesis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Selenium by Performance Lab
Ask about any prescription or over-the-counter medication and we check it for interactions with Selenium by Performance Lab — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Selenium by Performance Lab
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: selenium as NutriGenesis. Selenium is an essential mineral your body uses for antioxidant protection, thyroid function, and immune support.
The capsule itself is made from pullulan and includes a flow agent — these are inactive ingredients that help the product work as a capsule.
Does it work?
Strong evidence
The evidence we hold shows selenium is likely effective for treating selenium deficiency. It's rated possibly effective for Kashin-Beck disease (a joint and bone disorder), pre-eclampsia (high blood pressure in pregnancy), and autoimmune thyroiditis (thyroid inflammation).
For dyslipidemia (abnormal blood fat levels), the evidence suggests it's ineffective. Your actual results depend on whether you're truly deficient and the specific condition you're taking it for — talk with your doctor about what to expect.
How safe is it?
Well-documented data
Selenium is generally well tolerated at recommended doses that stay below 400 mcg daily. At normal dietary amounts, it's considered fine.
The most common side effects at standard doses are mild: gastric discomfort, headache, and rash. However, excess selenium is toxic and can cause hair loss, skin inflammation, nail damage, fatigue, nausea, vomiting, and weight loss.
In rare cases, very high doses have caused multi-organ failure. Long-term high doses may also increase the risk of certain skin cancers and potentially affect nerve health.
We have no pregnancy or breastfeeding data on file for this ingredient — talk with your doctor or pharmacist before use if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you use blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — selenium may increase bleeding risk. Also verify with your doctor if you take barbiturates (sedating medications), immunosuppressants, or niacin.
No interactions are documented for the ingredients we could not check.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Selenium is a good choice if you have a true selenium deficiency or are interested in supporting your thyroid and immune health at normal doses. Be careful if you take blood thinners, antiplatelet drugs, warfarin, barbiturates, or immunosuppressants — those interactions are Moderate-severity.
Stick to recommended doses and don't exceed 400 mcg daily unless your doctor says otherwise. Check your medications with the tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Selenium, straight from the product label.
| Brand | Performance Lab |
|---|---|
| Barcode (UPC) | 860010777176 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 335010 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Selenium by Performance Lab, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| NutriGenesis | 100 mcg | 182% |
Other ingredients: NutriCaps Pullulan capsule, Nu-Flow
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Suitable for vegans: Contains no soy, egg, fish, shellfish, dairy, peanut, tree nuts, wheat, or other allergens.
Suitable for vegans: Contains no soy, egg, fish, shellfish, dairy, peanut, tree nuts, wheat, or other allergens. Non-GMO and non-irradiated. Free of gluten, caffeine, synthetic additives, artificial colors and preservatives. BPA-free
GMP Certified Manufacturing
Vegan Vegetarian Society Approved
Performance Lab supplements are formulated in the UK, and manufactured under license in the EU, by Performance Lab Group Ltd.
We uphold superior quality standards to deliver the best targeted nutrition to support your performance goals.
Brand IP Statement(s)
NutriCaps & NutriGenesis are registered trademarks of Performance Lab Group Ltd. Copyright Performance Lab Group Ltd. All rights reserved.
Performance Lab Upgrade Yourself
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Please Recycle
For advanced usage guidelines visit www.performancelab.com/advanced
Learn more about Performance Lab NutriGenesis nutrients at www.performancelab.com/nutrigenesis.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule a day with food. For best results use daily and consistently.
Precautions
Warning: Do not use if pregnant, nursing or under the age of 18. Consult with your doctor before taking this or any supplement if you have, or suspect, a medical condition and are taking any medication.
Warning: Do not use if pregnant, nursing or under the age of 18. Keep out of reach of children.
Do not exceed the stated recommended daily dose. If you experience adverse events from taking this product discontinue immediately, contact your doctor and call 908-280-1066. Do not use if safety seal is broken or missing.
Storage
Store in a cool dry place.
Formula
NutriGenesis
Seals/Symbols
Vegan Vegetarian Society Approved Certified B Corporation
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Selenium by Performance Lab label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Selenium by Performance Lab
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 NutriCap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
NutriGenesis
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
NutriGenesis monograph & interactionsOther (inactive) ingredients: NutriCaps Pullulan capsule, Nu-Flow. These complete the product’s ingredient list but are not active constituents.
Selenium by Performance Lab Drug Interactions
HelloPharmacist Interaction Report
Performance Lab Selenium has documented interactions with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants and antiplatelet agents). Selenium may increase bleeding risk by boosting a compound called prostacyclin, which reduces how well platelets clump to form clots — this is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Selenium also carries Moderate-severity interactions with immunosuppressants (drugs that calm an overactive immune system), barbiturates (sedating medications), and warfarin specifically. With immunosuppressants, selenium may reduce how well they work by stimulating your immune system.
With barbiturates, it may prolong their sedating effects. Warfarin's activity could be altered through several mechanisms — selenium may displace it from its binding sites, slow its breakdown, or affect vitamin K-dependent clotting factors.
There's also a Minor-severity interaction with contraceptive drugs (which may increase your selenium levels, though the clinical meaning isn't clear) and niacin, where selenium might blunt niacin's beneficial effect on HDL cholesterol.
Altogether, these interactions span 317 individual medications. Use the medication checker on this page to look up any prescription or over-the-counter drugs you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Selenium?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Selenium interact with 321 drugs. Click any drug to see the details.
1 of the 1 ingredient in Selenium interact with drugs. Each result below shows which ingredient is responsible. NutriGenesis
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Alemtuzumab interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Aminophylline, Amobarbital, Ephedrine interactionAmobarbitalAmytal
How Amobarbital interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Nutrigenesis + Amobarbital, Secobarbital interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nutrigenesis + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Selenium — through 1 ingredient. Tap an ingredient for the detail:
NutrigenesisImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Nutrigenesis + Anifrolumab-fnia interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Selenium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
NutriGenesis
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Selenium, from the product label.
Performance Lab
See all Performance Lab products- Name
- Performance Lab Group Ltd.
- Street Address
- 7 Clarendon Place
- City
- Royal Leamington Spa
- State
- Warwickshire
- ZipCode
- CV32 5QL
- Phone Number
- 908-280-1066
- Web Address
- www.performancelab.com
Selenium by Performance Lab: Common Questions
Does Selenium by Performance Lab interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
How much selenium is safe to take daily?
What happens if I take too much selenium?
Can I take this if I'm pregnant or breastfeeding?
Does selenium actually work for thyroid health?
What are the side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Selenium is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Selenium’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Selenium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
- Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
- Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
- Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
- Kumpulainen, J., Salmenpera, L., Siimes, M. A., Koivistoinen, P., and Perheentupa, J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am.J Clin.Nutr. 1985;42(5):829-835. PubMed
- Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107(11):870-871.
- Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127. PubMed
- Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469.
- Sudfeld CR, Aboud S, Kupka R, et al. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. Nutrition 2014;30(9):1081-4. PubMed
- Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD009671. PubMed
- Thompson PA, Ashbeck EL, Roe DJ, et al. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016;108(12). PubMed
- Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid 2016;26(12):1681-92. PubMed
- Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Sep;33(9):789-810. Epub 2018 Jul 5. Review. PubMed
- Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3. PubMed
- Malpas CB, Vivash L, Genc S, et al. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):223-232. PubMed
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