Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ionic Selenium Ingredients & Drug Interactions

by AM Angstrom Minerals

Liquid Category: Mineral
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Ionic Selenium is a dietary supplement by AM Angstrom Minerals with 2 active ingredients. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Ionic Selenium by AM Angstrom Minerals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: selenium, an essential mineral your body needs for thyroid health, immune function, and antioxidant defense. The rest is just purified water — there are no other active ingredients or fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Ionic selenium for absorption and nutrient supplementation.
  • We looked for evidence on: Selenium deficiency, Thyroid cancer, Autoimmune thyroiditis, Hypothyroidism, Hyperthyroidism, Male infertility — and 3 related terms.
  • The strongest evidence on file: Selenium is rated "Likely Effective" for Selenium deficiency (Natural Medicines).
  • Also on file: Selenium is rated "Possibly Effective" for Autoimmune thyroiditis.
  • Also on file: Selenium is rated "Insufficient Reliable Evidence To Rate" for Hyperthyroidism, Hypothyroidism, Thyroid cancer, Male infertility.

Selenium appears likely effective for treating selenium deficiency itself. For Kashin-Beck disease (a joint and bone disorder linked to selenium lack), pre-eclampsia (high blood pressure in pregnancy), and autoimmune thyroiditis (thyroid inflammation), the evidence rates as possibly effective — meaning there's some promise, but we need stronger studies.

For high cholesterol (dyslipidemia), the evidence suggests it's probably ineffective.

The evidence, ingredient by ingredient Selenium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Selenium is generally well tolerated at normal dietary amounts and doses up to 400 mcg daily. The most common side effects at these levels are mild — gastric discomfort, headache, and rash.

However, excess selenium is toxic. High doses can cause hair loss, nail damage, nausea, vomiting, fatigue, and in rare severe cases, organ failure.

Long-term exposure to high selenium levels may also raise the risk of certain skin cancers and may affect nerve health. Stay within the daily upper limit of 400 mcg unless your doctor directs otherwise, and don't use high-dose supplements on your own.

Side effects, ingredient by ingredient Selenium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Selenium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 321 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, check your medications if you're on blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of bleeding), immunosuppressants (Moderate risk of reduced effect), barbiturates or other sedatives (Moderate risk of prolonged drowsiness), oral contraceptives (Minor — may raise selenium levels), or niacin for cholesterol (Minor — may weaken its HDL benefit).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ionic Selenium works if you're deficient — it's one of the few supplements with solid evidence for a real deficiency state. It may help with thyroid inflammation or pre-eclampsia, though the data is still building.

If you take blood thinners, immunosuppressants, sedatives, or oral contraceptives, check with your pharmacist first. Keep doses reasonable — selenium's benefit flips to harm if you take too much.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ionic Selenium, straight from the product label.

Brand AM Angstrom Minerals
Barcode (UPC) 759675387373
Net contents 16 Fluid Ounce(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337040
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ionic Selenium by AM Angstrom Minerals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Teaspoon(s)
Maximum serving Sizes:
1 Teaspoon(s)
Servings per container
96
UPC/BARCODE
759675387373
IngredientAmount% DV
Calories0 Gram(s), 0 Gram(s)--
Total Carbohydrates0 Gram(s), 0 Gram(s)--
Total Fat0 Gram(s), 0 Gram(s)--
Protein0 Gram(s), 0 Gram(s)--
Selenium100 mcg, 200 mcg181.5%, 363%

Other ingredients: Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Angstrom Selenium is ionic selenium for best absorption.

Angstrom Minerals are: Cell ready Sub lingual Bio available

Liquid minerals Ionic minerals

Ionic Selenium 40 mg/L

Formulation

No colors No flavors No fillers

Suggested/Recommended/Usage/Directions

Directions: Adults take 1/2-1 teaspoon daily with food by placing under tongue for 30 seconds.

Precautions

Consult a health care practitioner for use with all individuals especially those under age 14.

Consult a health care practitioner if pregnant or lactating.

Keep out of reach of children

Brand IP Statement(s)

As with any nutritional product, to receive the desired benefit, this product should be used in conjunction with a well balanced diet and exercise program. Please consult a physician before beginning any nutritional program. Caution: Do not use if tamper-evident seal is either broken or missing.

Storage

Keep tightly closed.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Serving/container 192 96

See for yourself

Ionic Selenium by AM Angstrom Minerals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Ionic Selenium by AM Angstrom Minerals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 Teaspoon(s) Dosage formLiquid Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

0 Gram(s) per serving

Selenium

Interacts with
321 drugs
100 mcg per serving Form: Sodium Selenate

Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...

Selenium monograph & interactions

Other (inactive) ingredients: Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ionic Selenium by AM Angstrom Minerals Drug Interactions

Want to check YOUR meds against Ionic Selenium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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321Drugs
288 Moderate 33 Minor

Ingredients driving the most interactions

Selenium 321

Each ingredient & the kinds of drugs it affects

For each ingredient in Ionic Selenium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Selenium6 drug types · 321 drugs

Anticoagulant/Antiplatelet Drugs

Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.

Likelihood Possible Evidence D
Barbiturates

Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.

Likelihood Possible Evidence D
Contraceptive Drugs

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.

Likelihood Possible Evidence B
Niacin

Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
The maker

Brand information

Manufacturer and brand details for Ionic Selenium, from the product label.

AM Angstrom Minerals

See all AM Angstrom Minerals products
Phone Number
855-743-5485
Web Address
Angstrom-minerals.com
Pharmacist Counseling Corner

Ionic Selenium by AM Angstrom Minerals: Common Questions

Does Ionic Selenium by AM Angstrom Minerals interact with any medications?
Yes. Based on its ingredients, Ionic Selenium has a known interaction with 321 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ionic Selenium contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this hurt my thyroid medication?
The data we hold doesn't show an interaction between selenium and thyroid drugs. However, selenium does support thyroid health overall — if you have autoimmune thyroiditis, there's some evidence it may help. Talk to your pharmacist about whether it's right alongside your specific thyroid medication.
What's the safest dose?
The safe upper limit is 400 mcg daily. Below that, side effects are rare and mild. If you're thinking of a higher dose, check with your doctor first — selenium becomes toxic in large amounts.
Can I take this if I'm pregnant?
We don't have safety data on file for selenium in pregnancy. There is some research suggesting it may help prevent pre-eclampsia, but you'll need to talk with your doctor or midwife about whether it's right for you — this is a decision tailored to your individual situation.
What if I take too much by accident?
Excess selenium can cause nausea, vomiting, hair loss, nail damage, and fatigue. In rare cases of severe overdose, it's caused organ failure. If you've taken a very large amount, call your doctor or poison control right away.
Does selenium really help with skin cancer risk?
No — research actually shows selenium does not prevent basal cell carcinoma and may increase the risk of squamous cell carcinoma and other nonmelanoma skin cancers. Don't rely on selenium as a cancer preventive.
Why is this a liquid instead of a pill?
The product facts don't explain the form choice. What matters is that you follow the dose directions and stay under 400 mcg daily — the form itself doesn't change that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ionic Selenium is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ionic Selenium label
Sources

Sources & How We Checked

Ionic Selenium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Selenium 36 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  2. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  3. Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
  4. Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
  5. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  6. Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
  7. Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
  8. Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
  9. Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
  10. Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
  11. Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
  12. Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
  13. Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
  14. Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
  15. Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
  16. Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
  17. Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
  18. Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
  19. Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
  20. Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
  21. Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
  22. Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
  23. Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
  24. Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
  25. Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
  26. Kumpulainen, J., Salmenpera, L., Siimes, M. A., Koivistoinen, P., and Perheentupa, J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am.J Clin.Nutr. 1985;42(5):829-835. PubMed
  27. Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107(11):870-871.
  28. Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127. PubMed
  29. Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469.
  30. Sudfeld CR, Aboud S, Kupka R, et al. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. Nutrition 2014;30(9):1081-4. PubMed
  31. Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD009671. PubMed
  32. Thompson PA, Ashbeck EL, Roe DJ, et al. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016;108(12). PubMed
  33. Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid 2016;26(12):1681-92. PubMed
  34. Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Sep;33(9):789-810. Epub 2018 Jul 5. Review. PubMed
  35. Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3. PubMed
  36. Malpas CB, Vivash L, Genc S, et al. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):223-232. PubMed

See these in context on the Selenium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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