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Dietary supplement

Vitamin D3 1000 IU Gummies Mixed Berry Ingredients & Drug Interactions

by NaturesPlus

Gummy Or Jelly Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Vitamin D3 1000 IU Gummies Mixed Berry is a dietary supplement by NaturesPlus with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin D. This is a nutrient your body needs to absorb calcium, build and maintain bone strength, and support immune and muscle function.

The remaining ingredients are inactive — glucose syrup, sugar, water, pectin, citric acid, and colorants — that make the gummy form and add flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune support and strong bones.
  • We looked for evidence on: Fall prevention, Fractures, Osteomalacia, Muscle strength, Physical performance, Child growth — and 4 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Osteomalacia (Natural Medicines).
  • Also on file: Vitamin D is rated "Effective" for Rickets, Vitamin D deficiency.
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Fractures.

Vitamin D in this form is effective for treating and preventing rickets, osteomalacia (soft bone disease), familial hypophosphatemia, renal bone disease (osteodystrophy), and hypoparathyroidism. These are specific medical conditions treated under a doctor's guidance.

If you're taking this product for general bone health or immune support in a healthy person, the evidence on file does not address that use.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses — the 1000 IU in each gummy is a modest amount. However, very high doses over time can cause vitamin D toxicity with symptoms of elevated blood calcium.

Rare serious adverse effects from excessive doses include calcific conjunctivitis and photophobia (light sensitivity), as well as decreased growth in children and osteoporosis in adults. Pregnancy and breastfeeding: this product is often used at recommended doses during pregnancy, but only under a doctor's guidance.

Breastfeeding at recommended doses is generally considered acceptable, but check with your doctor before taking higher amounts.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use thiazide diuretics (for blood pressure), verapamil or diltiazem (for heart rhythm), digoxin (for heart strength), atorvastatin (for cholesterol), calcipotriene (topical for psoriasis), or any medications broken down by the liver enzyme CYP3A4 — all are documented to interact with vitamin D. Even though your dose is below the usual threshold for concern, your pharmacist can confirm whether your specific medications are compatible.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This low-dose vitamin D supplement is appropriate for correcting specific vitamin D deficiency conditions under medical care. If you take medications for blood pressure, heart rhythm, heart strength, or cholesterol — or use any topical vitamin D product — you'll want to check your specific medications before starting.

Talk to your pharmacist or doctor before use if you're pregnant, breastfeeding, or have kidney disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin D3 1000 IU Gummies Mixed Berry, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467104044
Net contents 60 Gummy(ies)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 318946
Product type Vitamin
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gummy(ies)
Maximum serving Sizes:
1 Gummy(ies)
Servings per container
60
UPC/BARCODE
097467104044
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--
Vitamin D25 mcg125%

Other ingredients: Glucose Syrup, Sugar, Water, Pectin, Citric Acid, Black Carrot Concentrate, Trisodium Citrate, Natural Flavors, Chlorophyll, Paprika extract, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vitamin D may be your single most important supplement nutrient. Required for calcium absorption, vitamin D promotes strong bones and it vital support for a healthy immune system. NaturesPlus D3 1000 IU provides all the important benefits of vitamin D in a fun and tasty gummy!

Mixed berry flavored with other natural flavors

Formulation

Vegetarian

Gluten free Non-GMO Free from synthetic: colors, flavor. Free from milk, egg, crustacean shellfish, tree nuts, peanut, wheat, soy and sesame.

Immune support Bone support Joint support Muscle support

Precautions

Manufactured in a facility that also processes fish gelatin.

Keep out of reach of children.

Storage

Keep tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one gummy daily.

General Statements

Div. of Natural Organics, Inc.

Brand IP Statement(s)

Copyright Natural Organics

See for yourself

Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gummy(ies) Dosage formGummy Or Jelly Servings per container60 Amounts shown are per serving.

Vitamin D

Interacts with
715 drugs
25 mcg per serving Form: Cholecalciferol, Vitamin D3

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Glucose Syrup, Sugar, Water, Pectin, Citric Acid, Black Carrot Concentrate, Trisodium Citrate, Natural Flavors, Chlorophyll, Paprika extract, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus Drug Interactions

Want to check YOUR meds against Vitamin D3 1000 IU Gummies Mixed Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin D3 1000 IU Gummies Mixed Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Vitamin D3 1000 IU Gummies Mixed Berry, from the product label.

NaturesPlus

See all NaturesPlus products
Name
NaturesPlus
Street Address
548 Broadhollow Rd.
City
Melville
State
New York
ZipCode
11747
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus: Common Questions

Does Vitamin D3 1000 IU Gummies Mixed Berry by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Vitamin D3 1000 IU Gummies Mixed Berry has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin D3 1000 IU Gummies Mixed Berry contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this affect my blood pressure or heart medication?
Possibly, yes. Vitamin D interacts with several heart and blood pressure medications — thiazide diuretics, verapamil, diltiazem, and digoxin — because high-dose vitamin D can raise your blood calcium and reduce how well these drugs work. Your 1000 IU dose is low, but check with your pharmacist about your specific medications before starting.
Is this safe if I'm pregnant?
Vitamin D is often used during pregnancy at recommended amounts, but only under your doctor's guidance. The data doesn't tell us whether this specific dose is right for you. Talk to your doctor or pharmacist before taking it.
Can I take this with my cholesterol medication?
Vitamin D may reduce how much atorvastatin your body absorbs — a study showed levels can drop by up to 55%. If you take Lipitor or atorvastatin, check with your pharmacist before adding this supplement.
What is vitamin D for in this product?
Vitamin D helps your body absorb calcium and build strong bones. This supplement is effective for treating rickets, soft bone disease, and certain parathyroid and kidney bone disorders — conditions your doctor would diagnose. If you're taking it for general bone health without a diagnosed deficiency, the evidence doesn't confirm whether this dose helps.
Can too much vitamin D hurt me?
Very high doses over time can cause vitamin D toxicity. Serious symptoms — rare but possible — include elevated blood calcium, light sensitivity, and in children, slowed growth or osteoporosis. At 1000 IU per gummy, you're well below the adult upper limit of 4000 IU daily, but don't exceed that without a doctor's direction.
Are there any fillers in these gummies?
The gummies contain inactive ingredients — glucose syrup, sugar, water, pectin, citric acid, food colorants, flavors, and wax — that give them their form and taste. These aren't harmful, but if you're avoiding added sugars or have sensitivities to any of these, check the full ingredient list.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin D3 1000 IU Gummies Mixed Berry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin D3 1000 IU Gummies Mixed Berry label
Go deeper

The Full Monographs Behind Vitamin D3 1000 IU Gummies Mixed Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Vitamin D3 1000 IU Gummies Mixed Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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