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Dietary supplement

Vitrix Ingredients & Drug Interactions

by Nutrex Research Black Series

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Vitrix is a dietary supplement by Nutrex Research Black Series with 3 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 507 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris extract, LJ100 Eurycoma longifolia extract, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Vitrix by Nutrex Research Black Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Vitrix Natural Testosterone Booster” is listed as a grouped ingredient — the label gives one combined amount (850 mg) without saying how much of each component you get.

Vitrix contains three active ingredients. L-citrulline is an amino acid that your body converts to L-arginine, which plays a role in blood vessel relaxation and blood flow.

LJ100 Eurycoma longifolia extract is derived from the roots of a Southeast Asian plant traditionally used for sexual performance and athletic function. Tribulus terrestris is an herbal extract from a plant fruit, also marketed for sexual and athletic support.

The product also contains several inactive ingredients — vegetable cellulose, glycerol, purified water, and chlorophyllin — which serve as the capsule, thickener, solvent, and color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports sexual performance and testosterone levels.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual desire, Sexual dysfunction — and 3 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility.

Of the three active ingredients, L-citrulline is possibly effective for athletic performance, but possibly ineffective for sarcopenia (age-related muscle loss). The evidence for its use in cardiovascular disease, heart failure, diabetes, and Reye syndrome is insufficient to rate.

Eurycoma longifolia is possibly effective for sexual desire but possibly ineffective for athletic performance; evidence for back pain, osteoporosis, and diabetes is insufficient. Tribulus terrestris is possibly effective for sexual dysfunction and possibly ineffective for athletic performance; evidence for benign prostatic hyperplasia is insufficient.

The evidence, ingredient by ingredient L-citrulline Eurycoma Longifolia Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three ingredients are generally well tolerated in the short term, but long-term safety data are limited or uncertain for each. The most common side effects reported for L-citrulline are gastrointestinal discomfort and heartburn.

Eurycoma longifolia, if it does raise testosterone levels, could theoretically increase the risk of acne, insulin resistance, and liver problems. Tribulus terrestris is usually well tolerated orally, though rare serious effects including liver and kidney injury, seizures, and chronic painful erection have been reported; gastrointestinal complaints like nausea, cramping, and diarrhea can occur but were similar to placebo in one trial.

Regarding pregnancy, L-citrulline and Eurycoma longifolia have insufficient data and are best avoided in pregnancy. Tribulus terrestris is rated possibly unsafe in pregnancy due to potential hormonal effects.

For breastfeeding, safety data are insufficient or absent for all three, so supplemental use is not recommended while nursing.

Side effects, ingredient by ingredient L-citrulline Eurycoma Longifolia Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Tribulus, Eurycoma Longifolia, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 507 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Vitrix, double-check with your doctor or pharmacist if you take antihypertensive drugs (blood pressure medications) — L-citrulline and Tribulus terrestris may increase their effects and lower your blood pressure too much. Also check if you're on antidiabetes medications (Tribulus may lower blood sugar further), phosphodiesterase-5 inhibitors like sildenafil (L-citrulline may add to their blood vessel effects), lithium (Tribulus may raise its levels), propranolol (Eurycoma may reduce its effectiveness), or any drugs metabolized by liver enzymes CYP1A2, CYP2C19, or CYP2A6.

If you don't take any of these, no interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Vitrix is marketed toward men interested in sexual performance and athletic support. If you take any blood pressure medication, diabetes medication, a phosphodiesterase-5 inhibitor (ED drug), lithium, or propranolol, you should check with your own doctor or pharmacist before adding this product — the interactions documented here could affect how your medications work or your blood pressure and blood sugar.

Those not pregnant or breastfeeding who are generally healthy should discuss this supplement with their healthcare provider before starting, especially given the limited long-term safety information.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitrix, straight from the product label.

Brand Nutrex Research Black Series
Barcode (UPC) 857839006105
Net contents 80 Liquid Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176478
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitrix by Nutrex Research Black Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Liquid Capsule(s)
Maximum serving Sizes:
2 Liquid Capsule(s)
Servings per container
40
UPC/BARCODE
857839006105
IngredientAmount% DV
L-Citrulline0 NP--
LJ100 Eurycoma longifolia extract0 NP--
Vitrix Natural Testosterone Booster850 mg--
Tribulus terrestris extract0 NP--

Other ingredients: Vegetable Cellulose, Glycerol, purified Water, Chlorophyllin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Vitrix Product Highlights Supports sexual performance by elevating testosterone levels Increases libido and sexual function Renews vitality, energy and stamina Promotes overall wellbeing and hormonal balance Fast-acting liquid capsules

LJ100 is the registered trademark of HP ingredients. Worldwide Patent: WO/02/17946 Bioactive Fraction of Eurycoma longifolia.

Formula

Vitrix is an all-natural product that supports sexual performance and raises free testosterone levels in Men.

Male performance booster

LJ100

General Statements

Normal high free testosterone levels support libido, vitality and sexual activity. Vitrix is your perfect choice for fast-acting results and maximum performance when it matters the most.

Libido support Fast-acting

Regular exercise and proper nutrition are essential for achieving you physique goals. As individuals vary so may results from using this product.

Precautions

Warning: This product is intended to be used by normal healthy adults and should not be taken by anyone with any known medical conditions.

Do not use if pregnant or nursing.

Keep out of reach of children.

General

LBL-VITRIX-80CT-V5-US

FDA Statement of Identity

Dietary Supplement

Formulation

This product utilizes only natural capsules that are free of animal products.

Suggested/Recommended/Usage/Directions

Recommended Use: Take 2 liquid capsules twice a day with water, morning and evening. This product can be taken with or without food. Use daily for best results.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Vitrix by Nutrex Research Black Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vitrix by Nutrex Research Black Series

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Liquid Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitrix Natural Testosterone Booster

850 mg per serving

Other (inactive) ingredients: Vegetable Cellulose, Glycerol, Purified Water, Chlorophyllin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitrix by Nutrex Research Black Series Drug Interactions

Want to check YOUR meds against Vitrix?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
507Drugs
265 Moderate 242 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitrix with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D

LJ100 Eurycoma longifolia extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Vitrix, from the product label.

Nutrex Research Black Series

See all Nutrex Research Black Series products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-368-8739
Web Address
Nutrex.com
Pharmacist Counseling Corner

Vitrix by Nutrex Research Black Series: Common Questions

Does Vitrix by Nutrex Research Black Series interact with any medications?
Yes. Based on its ingredients, Vitrix has a known interaction with 507 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitrix contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Vitrix actually help with sexual performance?
Tribulus and Eurycoma longifolia are both possibly effective for sexual desire and sexual dysfunction according to the evidence we hold, while L-citrulline's effectiveness for that purpose isn't rated in our data. That said, the evidence is mixed and not overwhelming, so results vary between people.
Can I take this if I'm trying to build muscle or improve athletic performance?
L-citrulline is possibly effective for athletic performance, but both Eurycoma longifolia and Tribulus terrestris are rated possibly ineffective for that goal. If muscle growth is your main aim, Vitrix may not be your best choice.
What are the most common side effects?
L-citrulline most often causes gastrointestinal discomfort and heartburn. Tribulus is generally well tolerated, though some people report nausea, cramping, or diarrhea — though one study found these rates were similar to placebo. Serious side effects are rare but have been reported with Tribulus at very high doses.
Is it safe to take while pregnant or breastfeeding?
No. L-citrulline and Eurycoma longifolia should be avoided in pregnancy due to insufficient safety data. Tribulus terrestris is rated possibly unsafe in pregnancy because of potential hormonal effects. For breastfeeding, safety information is lacking or absent for all three ingredients, so supplemental use is not recommended.
Does Vitrix raise testosterone levels?
Eurycoma longifolia, specifically the LJ100 extract in this product, has been shown in clinical studies to increase total testosterone in aging men with low levels. This could be a benefit for some, but if testosterone rises beyond normal, it may increase risks of acne, insulin resistance, and other hormone-related effects.
How long does it take to see results?
The data we hold doesn't specify how quickly users might notice effects. That timing likely varies by person and by which benefit you're seeking — results in clinical trials took weeks to months, but individual experiences differ.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitrix label
Sources

Sources & How We Checked

Vitrix's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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