Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Volcano Extreme Ingredients & Drug Interactions

by Force Factor

Volcano Extreme label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Volcano Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Volcano Extreme is a dietary supplement by Force Factor with 6 active ingredients. Its ingredients are commonly taken for antioxidant support, heart and circulation health, vein problems (such as varicose veins).Based on those ingredients, 1,139 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape seed extract, Toothed Clubmoss, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Volcano Extreme by Force Factor

Ask about any prescription or over-the-counter medication and we check it for interactions with Volcano Extreme by Force Factor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Volcano Extreme by Force Factor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Nitric Oxide Strength Matrix” is a proprietary blend — the label gives one combined amount (3,150 mg) without saying how much of each component you get.
  • “Mind-Muscle Optimization Blend” is a proprietary blend — the label gives one combined amount (105 mg) without saying how much of each component you get.

Volcano Extreme contains 6 active ingredients. Grape seed extract is a plant compound studied for circulation and venous health.

L-Citrulline is an amino acid your body converts to another amino acid (arginine) to support blood vessel function and athletic performance. AlphaSize is a form of alpha-GPC, a compound related to brain and cognitive support.

CON-CRET Creatine HCl is a muscle-support ingredient. Nitrosigine and Toothed Clubmoss (which contains huperzine A) round out the formula.

The product also contains inactive ingredients—fillers, binders, and capsule materials like dicalcium phosphate, magnesium stearate, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle building and workout performance.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle strength, Muscle soreness, Cognitive function, Age-related cognitive decline — and 4 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength, Cerebral creatine deficiency syndromes.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Evidence for grape seed extract in chronic venous insufficiency (poor circulation in the legs) is rated Possibly Effective, but it's rated Possibly Ineffective for nausea from chemotherapy, hay fever, and weight loss. L-Citrulline is Possibly Effective for athletic performance but Possibly Ineffective for muscle loss (sarcopenia); evidence for heart health and diabetes is insufficient.

Creatine is Possibly Effective for muscle strength, athletic performance, and a rare genetic condition (cerebral creatine deficiency syndromes), but Possibly Ineffective for Huntington disease and weak bones. AlphaSize is Possibly Effective for Alzheimer disease; evidence for other cognitive and brain conditions is insufficient.

We hold no effectiveness ratings for Nitrosigine or Toothed Clubmoss in our data.

The evidence, ingredient by ingredient Grape L-citrulline Creatine Alpha-gpc Toothed Clubmoss

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Grape seed extract is generally well tolerated, though abdominal pain, diarrhea, dry mouth, heartburn, headache, joint pain, and nausea can occur. A rare but serious allergic reaction (anaphylaxis) to grape skin has been reported.

L-Citrulline is generally well tolerated in healthy adults, but long-term safety isn't fully studied; side effects may include gastrointestinal discomfort and heartburn. Creatine is generally well tolerated but can cause dehydration, diarrhea, upset stomach, muscle cramps, and water retention; rare serious cases of kidney injury and muscle breakdown have been reported in case reports.

AlphaSize is generally well tolerated, though dizziness, headache, and insomnia are rare; one concern is a rare elevated stroke risk with use of 2 months or longer. Toothed Clubmoss may cause dizziness, nausea, and sweating from its huperzine A content, and product quality varies widely.

Side effects, ingredient by ingredient Grape L-citrulline Creatine Alpha-gpc Toothed Clubmoss

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Toothed Clubmoss, Grape, Alpha-gpc, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 1,140 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Volcano Extreme, double-check these medication types with your pharmacist: blood pressure medications (antihypertensives), blood thinners or antiplatelet drugs, erectile dysfunction medications (phosphodiesterase-5 inhibitors), cyclosporine, midazolam, anticholinergic drugs, and cholinergic drugs like donepezil. Grape seed extract can affect how your body processes many enzyme-dependent drugs (CYP1A2, CYP2D6, CYP3A4, and CYP2E1 substrates), so the list is long—use the medication checker on this page with your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient workout and circulation support product best suited for people not taking blood pressure medications, blood thinners, or erectile dysfunction drugs. If you take any regular medications—especially those affecting enzymes, blood pressure, or the nervous system—you'll want to check with your pharmacist before starting.

Talk to us before taking this if you have kidney issues or are considering long-term use of the AlphaSize component.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Volcano Extreme, straight from the product label.

Brand Force Factor
Barcode (UPC) 818594013944
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 260320
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Volcano Extreme by Force Factor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
30
UPC/BARCODE
818594013944
IngredientAmount% DV
Grape seed extract150 mg--
L-Citrulline750 mg--
AlphaSize100 mg--
CON-CRET Creatine HCl750 mg--
Nitrosigine1500 mg--
Nitric Oxide Strength Matrix3150 mg--
Mind-Muscle Optimization Blend105 mg--
Toothed Clubmoss5 mg--

Other ingredients: Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silica, Hydroxypropyl Methylcellulose, Propylene Glycol, Triacetin, Titanium Dioxide, FD&C Yellow #6, FD&C Red #27

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Expect extreme performance You've come to expect consistent, unwavering results from every Force Factor supplement, VolcaNO Extreme ushers in a new generation of muscle-building science, we raises the bar once again, with a fully disclosed formula that goes way beyond other nitric oxide boosters. While most N.O. boosters are designed solely to improve blood flow and pump during weight training, Volcano Extreme provides distinct pre-, intra-, and post-workout benefits for complete workout support. Carefully selected ingredients in Volcano Extreme produce incredible pre-workout energy and focus, quickly getting you amped up and dialed in. Intra-workout optimization of blood flow and nutrient delivery gives you healthier, longer-lasting pumps to help you maximize your weightlifting results. Endurance and strength gains ensure you are able to take full advantage of your sessions, and the critically important mind-muscle connection is fortified so that every rep matters. It's a rookie mistake to overlook the vital post-workout period when muscle tissue regenerates, but most N.O. boosters do it regardless. In the hours immediately following weightlifting, your muscles need food -- not just proteins, but key vitamins, minerals, amino acids, and pure oxygen.

Unleash your potential Nitric oxide boosters are designed to dilate blood vessels, allowing more oxygen and nutrients to flood your muscles during weight training. This provides the coveted pump you crave so you can max out your reps and build definition, VolcaNO Extreme produces a premium pump, but doesn't stop there.

Serious weightlifters know that the mind-muscle connection is critical to maximizing results. Alphasize is a highly bioavailable choline donor ingredient that has been clinically shown to optimize muscle power output through enhanced control of muscle fiber activation and contraction. It also helps sharpen agility and delay the onset of mental fatigue. Overall, Volcano Extreme was scientifically engineered to deliver the most explosive weight-training workouts imaginable, helping you build impressive muscle and strength and Unleash Your Potential.

Intense NOx-Boosting muscle builder Max strength & power Potent mind-muscle synergy Relentless pump & endurance

Formula

Nitrosigine, a key ingredient in VolcaNO Extreme, works to guarantee your muscles are optimally fed during this pivotal post-workout window.

Most N.O. boosters contain either L-arginine or L-citrulline to increase nitric oxide, VolcaNO Extreme contains time-tested L-citrulline plus a potent N.O. catalyst called Nitrosigine, which has been clinically shown to start working in as little as 15 minutes and last up to 6 hours.

Nitrosigine also delivers a powerful cognitive boost, helping you zone in on workouts with extreme focus and concentration. Enhanced mental acuity combines with incredible energy and endurance for ultimate weightlifting sessions unlike anything you may have experienced.

Con-Cret, an ultra-refined form of creatine HCl, helps maximize power output and strength, enabling the production of rock-hard muscle with optimal tone and definition — exactly what you want.

Select ingredients Nitrosigine Bonded Arginine Silicate Con-Cret Reinforced AlphaSize

Alphasize is a highly bioavailable choline donor ingredient that has been clinically shown to optimize muscle power output through enhanced control of muscle fiber activation and contraction. It also helps sharpen agility and delay the onset of mental fatigue.

Suggested/Recommended/Usage/Directions

Select series stacking To take your weight training results to a whole new level, consider stacking Volcano Extreme with Test X180 Ignite Pro. Test X180 Ignite Pro's free testosterone boost and advanced thermogenesis, combined with VolcaNO Extreme's superior strength and power gains, will help you pack on pounds of rock-hard lean muscle quickly and efficiently. Directions: Workout Days: Take 3 tablets 30-45 minutes before working out. Rest Days: Take 3 tablets with breakfast or lunch.

FDA Statement of Identity

Dietary Supplement

Precautions

Keep out of reach of children.

For adult use only.

Allergen Warning: Manufactured by equipment which processes products containing milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts, and peanut flavor.

Precautions: Use only as directed.

Consult a healthcare professional before use if you are pregnant or nursing, have a medical condition or use prescription medications.

Storage

Store in a cool, dry place. Protect from heat, light, and moisture.

Brand IP Statement(s)

Nitrosigine is a registered trademark of Nutrition 21, LLC, Con-Cret and Con-Cret Reinforced are registered trademarks of ProMera Health, LLC. AlphaSize is a registered trademark of Chemi Nutra, LLC.

General Statements

Speak with one of our experts 1-800-216-0033

Seals/Symbols

Proudly manufactured in the U.S. from foreign and domestic ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Volcano Extreme by Force Factor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Volcano Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Volcano Extreme by Force Factor

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nitric Oxide Strength Matrix

3150 mg per serving

Mind-Muscle Optimization Blend

105 mg per serving

Other (inactive) ingredients: Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silica, Hydroxypropyl Methylcellulose, Propylene Glycol, Triacetin, Titanium Dioxide, FD&C Yellow #6, FD&C Red #27. These complete the product’s ingredient list but are not active constituents.

Interaction report

Volcano Extreme by Force Factor Drug Interactions

Want to check YOUR meds against Volcano Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,139Drugs
1,106 Moderate 33 Minor

Ingredients driving the most interactions

Grape seed extract 910
Toothed Clubmoss 219
L-Citrulline 178
AlphaSize 16

Individual Drug Interactions

The ingredients in Volcano Extreme interact with 1,139 drugs. Click any drug to see the details.

4 of the 6 ingredients in Volcano Extreme interact with drugs. Each result below shows which ingredient is responsible. Grape seed extract Toothed Clubmoss L-Citrulline AlphaSize

Each ingredient & the kinds of drugs it affects

For each ingredient in Volcano Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape seed extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape seed extract full monograph & interactions

Toothed Clubmoss2 drug types · 219 drugs

Anticholinergic Drugs

In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine. Theoretically, concurrent use of anticholinergic drugs and toothed clubmoss might decrease the effectiveness of toothed clubmoss or the anticholinergic drug.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Cholinergic Drugs

Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties. Theoretically, concurrent use of toothed clubmoss with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Toothed Clubmoss full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

AlphaSize1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
AlphaSize full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Volcano Extreme, from the product label.

Force Factor

Name
Force Factor, LLC
City
Boston
State
MA
ZipCode
02210
Phone Number
1-800-216-0033
Web Address
www.forcefactor.com
Pharmacist Counseling Corner

Volcano Extreme by Force Factor: Common Questions

Does Volcano Extreme by Force Factor interact with any medications?
Yes. Based on its ingredients, Volcano Extreme has a known interaction with 1,139 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Volcano Extreme contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Grape seed extract is rated Likely Safe in pregnancy. However, L-Citrulline, creatine, AlphaSize, and Toothed Clubmoss all lack enough safety data—the facts advise against supplemental use during pregnancy and breastfeeding for these ingredients. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
What's L-Citrulline and what does it do?
L-Citrulline is an amino acid your body converts to L-arginine, which supports blood vessel function and nitric oxide production. It's rated Possibly Effective for athletic performance, though evidence for heart and metabolic benefits is still being studied.
What are the most common side effects?
Grape seed extract may cause abdominal pain, diarrhea, dry mouth, heartburn, or headache. Creatine commonly causes water retention, dehydration, diarrhea, or muscle cramps. L-Citrulline and AlphaSize may cause gastrointestinal upset or headache. Toothed Clubmoss may cause dizziness, nausea, or sweating.
Is this safe if I have kidney problems?
Creatine requires caution if you have kidney issues, since it's processed through the kidneys. Talk with your doctor or pharmacist before taking this product if you have kidney disease or reduced kidney function.
Why does grape seed extract matter if I take my blood pressure medication?
Grape seed extract can affect how your liver breaks down many medications and may also lower blood pressure on its own. Combined with a blood pressure drug, that could cause your blood pressure to drop too low. Your pharmacist needs to review your exact medication list.
What does AlphaSize do?
AlphaSize is alpha-GPC, a compound rated Possibly Effective for Alzheimer disease. It's generally well tolerated, though rare side effects include dizziness and headache. One concern is a rare elevated stroke risk if used for 2 months or longer—discuss long-term use with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Volcano Extreme label
Go deeper

The Full Monographs Behind Volcano Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

Read the full Toothed Clubmoss monograph →
Sources

Sources & How We Checked

Volcano Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 135 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
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