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Dietary supplement

Whole Seed African Mango Ingredients & Drug Interactions

by aProvenProduct

Whole Seed African Mango label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Whole Seed African Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Whole Seed African Mango is a dietary supplement by aProvenProduct with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are African Mango. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Whole Seed African Mango by aProvenProduct

Ask about any prescription or over-the-counter medication and we check it for interactions with Whole Seed African Mango by aProvenProduct — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Whole Seed African Mango by aProvenProduct

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: African mango (Irvingia gabonensis), derived from the seed. The capsule itself is a vegetable capsule, which is an inactive ingredient.

African mango has been studied for potential effects on blood sugar, cholesterol, weight, and metabolic health, though the evidence for these uses isn't well established in our data.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: whole seed African mango nutritional nourishment.
  • We looked for evidence on: Obesity, Diabetes, Hypercholesterolemia, Metabolic syndrome, Weight management, Metabolic health.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for African mango in our data is rated as insufficient to reliably establish whether it works for diabetes, high cholesterol, obesity, or metabolic syndrome. While some studies have been done, there isn't enough quality research to say the supplement is effective for these purposes.

If you're interested in this product, talk with your pharmacist about whether the available research matches what you're hoping to achieve.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

African mango is generally well tolerated short-term in studies, though long-term safety and product quality aren't well established. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One case of acute hepatitis (liver inflammation) has been reported after supplement use — a rare event, but something to know about. During pregnancy, the safety data advises against use.

There isn't enough safety information to know either way during breastfeeding, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you're on antidiabetes drugs (blood sugar medications) — there's a Moderate risk of low blood sugar. Also double-check if you use testosterone therapy, where additive effects are possible.

Run your exact medications through the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient supplement may be right for you if you're curious about African mango and have no drug interactions to worry about. But if you take antidiabetes medications or testosterone therapy, you'll need to discuss this with your pharmacist or doctor first.

The evidence for what it actually does isn't strong, so be clear on your own health goals before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Whole Seed African Mango, straight from the product label.

Brand aProvenProduct
Barcode (UPC) 852597002093
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2012
DSLD ID 16882
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Whole Seed African Mango by aProvenProduct, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
852597002093
IngredientAmount% DV
African Mango1000 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Deep in the heart of the African jungle, natives rely on the seeds of African Mango for nourishment. Here, they eat the whole nut, never just a processed extract.

Whole Seeds...NOT Extracts

Brand IP Statement(s)

Whole Seed African Mango(TM) delivers the same nutritional benefit Africans enjoy. It's as close as you can come to eating these amazing seeds without traveling.

Precautions

CAUTION: Do not use if seal is broken.

As with all dietary supplements, consult a medical professional before using if you are pregnant, breastfeeding, or have an existing medical condition.

KEEP OUT OF REACH OF CHILDREN.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

aPP Certified

Suggested/Recommended/Usage/Directions

Suggested Use: As dietary supplement, take two capsules twice per day with water.

Storage

Storage: Keep tightly closed in a cool, dry place in the original container. Do not expose to excessive heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Whole Seed African Mango by aProvenProduct label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Whole Seed African Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Whole Seed African Mango by aProvenProduct

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

African Mango

Interacts with
94 drugs
1000 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Whole Seed African Mango by aProvenProduct Drug Interactions

Want to check YOUR meds against Whole Seed African Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

African Mango 94

Individual Drug Interactions

The ingredients in Whole Seed African Mango interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Whole Seed African Mango interact with drugs. Each result below shows which ingredient is responsible. African Mango

Each ingredient & the kinds of drugs it affects

For each ingredient in Whole Seed African Mango with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

African Mango2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Whole Seed African Mango, from the product label.

aProvenProduct

See all aProvenProduct products
Name
aProvenProduct
Street Address
2901 Richmond Rd., Ste. 130-185
City
Lexington
State
KY
ZipCode
40509
Pharmacist Counseling Corner

Whole Seed African Mango by aProvenProduct: Common Questions

Does Whole Seed African Mango by aProvenProduct interact with any medications?
Yes. Based on its ingredients, Whole Seed African Mango has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Whole Seed African Mango contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's African mango supposed to do?
African mango has been studied for blood sugar control, cholesterol, weight management, and metabolic health. However, we don't have enough reliable evidence in our data to say it actually works for any of these uses. Talk with your pharmacist about whether it might fit your health goals.
What are the side effects?
The most common ones reported are flatulence, headache, insomnia, and nausea. It's generally well tolerated short-term, but long-term safety isn't well established. One rare case of liver inflammation has been reported, so if you develop yellowing of the skin, abdominal pain, or unusual fatigue, stop the supplement and call your doctor right away.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy. During breastfeeding, there isn't enough information to know either way — talk with your doctor or pharmacist for personalized advice.
Can I take this with my blood sugar medication?
African mango can lower blood sugar on its own, and combining it with antidiabetes drugs raises the risk of low blood sugar (hypoglycemia). You'll need close monitoring of your blood glucose, and your medication dose might need adjusting. Check with your pharmacist or doctor before starting this supplement.
Does this product have fillers or other additives?
It contains vegetable capsules as the inactive ingredient — that's the capsule shell itself. There's nothing else added.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Whole Seed African Mango is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Whole Seed African Mango label
Go deeper

The Full Monographs Behind Whole Seed African Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Whole Seed African Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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