Major interaction on record — check this product against your medications before combining. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Black Label Krill Oil Ingredients & Drug Interactions

by aProvenProduct

Black Label Krill Oil label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Label Krill Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Black Label Krill Oil is a dietary supplement by aProvenProduct with 6 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 1,051 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Astaxanthin Esterified, Vitamin A, Premium Plus Krill Oil Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Black Label Krill Oil by aProvenProduct

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Label Krill Oil by aProvenProduct — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Black Label Krill Oil by aProvenProduct

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

Black Label Krill Oil contains 6 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (two omega-3 fatty acids from Antarctic krill), vitamin A, a krill oil blend, phospholipids, and astaxanthin esterified. The omega-3s and krill oil are the main active components; vitamin A and astaxanthin are antioxidants.

The product also contains inactive ingredients including gelatin, glycerin, and fish oil as carriers, along with medium-chain triglyceride oil and plant-derived antioxidants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: strengthen brain, heart and eyes with antioxidant support.
  • We looked for evidence on: Age-related cognitive decline, Age-related macular degeneration (AMD), Alzheimer disease, Cardiovascular disease (CVD), Cataracts, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Krill Oil is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Vitamin A is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Cognitive function, Coronary artery bypass graft (CABG) surgery.
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Age-related macular degeneration (AMD), Alzheimer disease.

Evidence for this product's benefits is limited. The krill oil ingredient is possibly effective for dry eye, but evidence is insufficient to rate its use for skin aging, Alzheimer disease, cancer, high cholesterol, or cognitive function.

Vitamin A is effective for vitamin A deficiency and possibly effective for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia. Astaxanthin lacks reliable evidence for age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome — we don't have the data to know whether it works for those purposes.

The evidence, ingredient by ingredient Vitamin A Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well tolerated at recommended amounts but becomes toxic at high doses because it builds up in your body — toxicity can cause liver damage, headache, blurred vision, and serious problems in rare cases. At very high doses, it has caused pseudotumor cerebri (dangerous fluid pressure in the skull), liver failure, even coma and death.

Krill oil is generally well tolerated in doses up to 4 grams daily and causes fewer stomach side effects than fish oil, though bloating, diarrhea, fishy burps, nausea, and heartburn do occur in some people. Astaxanthin is generally well tolerated, though abdominal pain, diarrhea, and red-colored stools have been reported.

Avoid this product if you have a shellfish allergy. For pregnancy and breastfeeding: vitamin A is rated possibly unsafe in pregnancy (high doses can cause birth defects), and astaxanthin should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Krill oil has insufficient safety data for pregnancy and breastfeeding — talk with your doctor before using it during either.

Side effects, ingredient by ingredient Vitamin A Krill Oil Astaxanthin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin A, Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,052 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take retinoid drugs (isotretinoin, tretinoin), blood thinners like warfarin, antiplatelet drugs (like clopidogrel), diabetes medications, tetracycline antibiotics, or any drugs metabolized by your liver's CYP3A4 or CYP2B6 pathways. The most serious risk is with retinoids.

Avoid this product entirely if you have a shellfish allergy or a bleeding disorder.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Black Label Krill Oil is a multi-ingredient supplement where the evidence for most claimed benefits is weak or absent. If you're considering it, the biggest caution is interactions with blood thinners, diabetes medications, tetracycline antibiotics, and especially prescription retinoids — and the theoretical effect on how your liver processes certain drugs.

If you take any prescription medications, check them against the medication tool on this page before starting. Talk with your doctor or pharmacist about whether this product makes sense for you and your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Label Krill Oil, straight from the product label.

Brand aProvenProduct
Barcode (UPC) 852597002369
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 24, 2014
DSLD ID 29802
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Label Krill Oil by aProvenProduct, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
852597002369
IngredientAmount% DV
Calories7 {Calories}--
Calories from Fat7 {Calories}--
Eicosapentaenoic Acid150 mg--
Docosahexaenoic Acid90 mg--
Vitamin A100 IU2%
Total Omega-3 Fatty Acids300 mg--
Premium Plus Krill Oil Blend1000 mg--
Phospholipids420 mg--
Astaxanthin Esterified2.5 mg--

Other ingredients: 100% Pure Euphausia superba Antarctic Krill Oil, Fish Oil, Gelatin, Glycerin, purified Water, Medium Chain Triglyceride Oil, Haematococcus pluvialis Astaxanthin Oleo Resin, Plant Derived Antioxidants

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Black Label krill Oil(TM) delivers the highest quality Antarctic Krill Oil, with added Astaxanthin for maximum benefits to your health.

General Statements

Strengthen you brain, heart and eyes while combating the stress of aging and free radical damage. Every cell in your body will thank you!

Lot number: 13001 Expires: 1/2015

NEW name, same great product!

Approximately 2/3 of Omega-3 is bonded to phospholipids; remainder is bonded to triglycerides or is in free fatty acid form.

Made in the U.S.A.

Precautions

NOTE: If you are pregnant or nursing, consult with your physician before taking this product.

Keep out of reach of children.

WARNING: Consult with your physician before using this product if you are allergic to seafood, suffer from a blood clotting disorder, use blood thinners (such as Coumadin) or other medications, or anticipate surgery.

Contains Euphausia superba krill oil extract, fish oil extract, Medium Chain Triglycerides, and astaxathin extract from Haematococcus algae.

WARNING: Consult with your physician before using this product if you are allergic to seafood, suffer from a blood clotting disorder, use blood thinners (such as Coumadin) or other medications, or anticipate surgery.

FDA Statement of Identity

+This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Dietary Supplement

Formula

Contains Euphausia superba krill oil extract, fish oil extract, Medium Chain Triglycerides, and astaxathin extract from Haematococcus algae.

with MORE Astaxanthin

Suggested/Recommended/Usage/Directions

SUGGESTED USE 2 softgels daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Label Krill Oil by aProvenProduct label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Label Krill Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Label Krill Oil by aProvenProduct

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
100 IU per serving

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Total Omega-3 Fatty Acids

300 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Premium Plus Krill Oil Blend

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Premium Plus Krill Oil Blend monograph & interactions

Phospholipids

420 mg per serving Form: Omega-3 Fatty Acids

Astaxanthin Esterified

Interacts with
671 drugs
2.5 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin Esterified monograph & interactions

Other (inactive) ingredients: 100% Pure Euphausia superba Antarctic Krill Oil, Fish Oil, Gelatin, Glycerin, Purified Water, Medium Chain Triglyceride Oil, Haematococcus pluvialis Astaxanthin Oleo Resin, Plant Derived Antioxidants. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Label Krill Oil by aProvenProduct Drug Interactions

Want to check YOUR meds against Black Label Krill Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,051Drugs
9 Major 1,042 Moderate

Ingredients driving the most interactions

Astaxanthin Esterified 671
Vitamin A 387
Premium Plus Krill Oil Blend 208

Individual Drug Interactions

The ingredients in Black Label Krill Oil interact with 1,051 drugs. Click any drug to see the details.

3 of the 6 ingredients in Black Label Krill Oil interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Esterified Vitamin A Premium Plus Krill Oil Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Label Krill Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin Esterified2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin Esterified full monograph & interactions

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Premium Plus Krill Oil Blend2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Premium Plus Krill Oil Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Label Krill Oil, from the product label.

aProvenProduct

See all aProvenProduct products
Name
aProven Product
Street Address
2111 Capstone Dr., Ste. 150
City
Lexington
State
KY
ZipCode
40511
Phone Number
1-877-577-2772
Pharmacist Counseling Corner

Black Label Krill Oil by aProvenProduct: Common Questions

Does Black Label Krill Oil by aProvenProduct interact with any medications?
Yes. Based on its ingredients, Black Label Krill Oil has a known interaction with 1,051 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Label Krill Oil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does krill oil really help with dry eyes?
Krill oil is rated possibly effective for dry eye based on the evidence we have, meaning some research suggests it may help but isn't conclusive. Whether it'll work for you is an individual question — your eye doctor or pharmacist can tell you more.
Is vitamin A in this product a problem if I'm already taking retinoid acne cream?
Yes — this is a major interaction. Retinoids are vitamin A derivatives, and taking them alongside vitamin A supplements can cause toxic buildup. Never combine them without explicit approval from your doctor.
Can I take this if I'm on warfarin?
Not without checking with your doctor first. Both the vitamin A and the krill oil in this product could theoretically increase your bleeding risk when paired with warfarin. Your doctor needs to know you're considering it.
What stomach side effects might I get?
The krill oil may cause bloating, diarrhea, fishy burps, heartburn, nausea, or stomach upset — though these tend to be milder and less frequent than with regular fish oil. Astaxanthin may cause abdominal pain or changes in stool color.
Is this safe to take while pregnant?
The vitamin A in this product is rated possibly unsafe in pregnancy at high doses (it can cause birth defects), and astaxanthin should be avoided — there isn't enough safety data. Krill oil also lacks enough pregnancy data. Talk with your doctor before taking this during pregnancy.
Can this product make my diabetes medications less effective?
The krill oil might theoretically lower blood sugar, which could increase hypoglycemia risk if you're on diabetes drugs — though the evidence is mixed. Talk with your doctor if you're diabetic before starting this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Black Label Krill Oil is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Label Krill Oil label
Go deeper

The Full Monographs Behind Black Label Krill Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Black Label Krill Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team