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Dietary supplement

Wild Yam Powder Ingredients & Drug Interactions

by BulkSupplements.com

Wild Yam Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam Powder is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam Powder by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam Powder by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam Powder by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: wild yam root powder. Wild yam is a plant traditionally used in herbal medicine, though its effectiveness for most purposes hasn't been firmly established in clinical trials.

The powder comes with no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Yam product and its label doesn't state a use — see Wild Yam's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for wild yam is limited. It's rated possibly ineffective for menopausal symptoms — meaning the available studies don't show it works for hot flashes or other menopausal complaints.

For gallbladder disease, sexual dysfunction, period pain, and infertility, there isn't enough reliable evidence to know whether it works or not. If you're considering this for one of those uses, the science doesn't back it up yet.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam powder is generally well tolerated when taken by mouth for a short time in healthy adults, but we don't have good data on how safe it is over the long term. The most common side effects are fever, headache, upset stomach, and vomiting — especially at higher doses.

A rare but serious reaction is anaphylaxis (a sudden, severe allergic reaction). Don't use this during pregnancy or while breastfeeding.

There isn't enough safety information to know whether it's okay, and the caution is to avoid it until we know more. Talk to your pharmacist or doctor if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before you buy — especially estrogen-based drugs. Estrogen therapy and hormone replacement are Moderate-severity concerns.

Altogether, these interactions span 41 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild yam powder is one to be cautious with if you take any estrogen-based medication — the powder could shift how your body handles that drug. It's generally well tolerated short-term in healthy adults, but the evidence that it actually works for common uses like menopausal symptoms is weak.

If you're pregnant, breastfeeding, or on hormone therapy, check with your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam Powder, straight from the product label.

Brand BulkSupplements.com
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294308
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam Powder by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
800 mg
Maximum serving Sizes:
800 mg
Servings per container
625
IngredientAmount% DV
Wild Yam, Powder800 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten, additives

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 800 mg (about 1/3 tsp) once or twice daily with a meal, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam Powder by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam Powder by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size800 mg Dosage formPowder Servings per container625 Amounts shown are per serving.

Wild Yam, Powder

Interacts with
41 drugs
800 mg per serving Form: Dioscorea opposita

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam, Powder monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam Powder by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Wild Yam Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam, Powder 41

Individual Drug Interactions

The ingredients in Wild Yam Powder interact with 41 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Yam Powder interact with drugs. Each result below shows which ingredient is responsible. Wild Yam, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam, Powder1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam Powder, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Wild Yam Powder by BulkSupplements.com: Common Questions

Does Wild Yam Powder by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Wild Yam Powder has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does wild yam actually help with hot flashes or menopausal symptoms?
The evidence says it's possibly ineffective — meaning studies haven't shown it works for menopausal symptoms. If that's why you're looking at it, the data doesn't support that use.
What are the most common side effects?
Fever, headache, upset stomach, and vomiting — they tend to happen more at higher doses. A rare but serious reaction is anaphylaxis. Most people tolerate it fine short-term.
Is it safe to use if I'm trying to get pregnant or am pregnant?
No, not enough safety data exists. Avoid it during pregnancy and while breastfeeding. Talk to your doctor or pharmacist about safer options.
Why does wild yam interact with estrogen medications?
Wild yam has both estrogenic and anti-estrogenic properties in lab studies. That means it could theoretically amp up or dial down how your body handles estrogen therapy — unpredictably.
How long is it safe to take this?
Short-term use in healthy adults is likely fine, but long-term safety hasn't been well studied. If you're thinking of taking it regularly, ask your pharmacist how long is reasonable for you.
Does it work for period pain or sexual dysfunction?
There isn't enough reliable evidence to know. The science on these uses just isn't there yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam Powder label
Go deeper

The Full Monographs Behind Wild Yam Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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