Women's Vitality Spore Probiotic Ingredients & Drug Interactions
by Probiogen
What is this page for?
First and foremost: checking Women's Vitality Spore Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Women's Vitality Spore Probiotic is a dietary supplement by Probiogen with 6 active ingredients. Its ingredients are commonly taken for candida and yeast overgrowth, gut health support, antimicrobial.Based on those ingredients, 1,048 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry (Vaccinium macrocarpon) whole fruit concentrate, Caprylic Acid, Lactobacillus acidophilus DDS-1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Women's Vitality Spore Probiotic by Probiogen
Ask about any prescription or over-the-counter medication and we check it for interactions with Women's Vitality Spore Probiotic by Probiogen — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Women's Vitality Spore Probiotic by Probiogen
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 6 ingredients: four live probiotic organisms (Lactobacillus acidophilus DDS-1, Bacillus coagulans HC, Bacillus subtilis HU58, and Bacillus clausii), plus caprylic acid — a short-chain fatty acid — and cranberry whole fruit concentrate. The probiotics are meant to support digestive and vaginal health, while caprylic acid and cranberry are included for their own roles in the formula.
The capsule itself is made from plant-based materials (hydroxypropyl methylcellulose and cellulose fiber), so there are no animal-derived fillers.
Does it work?
Moderate evidence
The probiotics here show the most established evidence. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori.
Bacillus coagulans is possibly effective for constipation and IBS. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea.
Cranberry is possibly effective for urinary tract infections. Caprylic acid's evidence is weaker — we hold insufficient data to rate it for epilepsy or essential tremor.
Several other uses listed here (athletic performance, cancer, nonalcoholic fatty liver disease, age-related cognitive decline) lack reliable evidence as well.
How safe is it?
Well-documented data
The probiotics are generally well tolerated in healthy adults. Lactobacillus acidophilus and the Bacillus strains can cause mild gastrointestinal side effects — bloating, gas, abdominal discomfort, diarrhea — though these are uncommon.
In rare cases, live probiotics have been linked to serious infections (sepsis, bacteremia) in severely immunocompromised patients or those with central catheters, but this risk is very low in people with healthy immune systems. Caprylic acid's most common side effects are mild abdominal discomfort and taste changes; it's generally well tolerated short-term, though supplement doses haven't been extensively studied.
Cranberry is well tolerated; the most common side effects are diarrhea and gastrointestinal discomfort. Pregnancy and lactation safety data for most ingredients is either absent or limited — talk with your doctor before using this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check before taking this product if you use antibiotics (all three probiotic strains lose potency), blood thinners like warfarin, antihypertensive (blood pressure) medications, statin cholesterol drugs like atorvastatin, the heart medication nifedipine, NSAIDs, or CYP3A4-metabolized drugs (cranberry may raise their levels). The probiotic strains need to be separated from antibiotics to work — your pharmacist can help time them properly.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is worth considering if you're managing IBS, constipation, or urinary tract infections and want multiple targeted ingredients. However, if you take blood pressure medications, anticoagulants (blood thinners), statins, NSAIDs, or antibiotics, you'll need to check your exact drugs against our interaction tool first — the timing and your individual risk matter.
Talk with your pharmacist before starting, especially if you're on regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Women's Vitality Spore Probiotic, straight from the product label.
| Brand | Probiogen |
|---|---|
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 24, 2023 |
| DSLD ID | 288733 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult Female (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Women's Vitality Spore Probiotic by Probiogen, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Caprylic Acid | 100 mg | -- |
| Lactobacillus acidophilus DDS-1 | 0 NP | -- |
| Bacillus coagulans HC | 0 NP | -- |
| Bacillus subtilis HU58 | 0 NP | -- |
| Bacillus clausii | 0 NP | -- |
| Cranberry (Vaccinium macrocarpon) whole fruit concentrate | 600 mg | -- |
| Women's Probiotic Blend | 57.5 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Cellulose plant fiber
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Why Probiotics? Poor diet, pollutants and antibiotics can all wreak havoc in our gut. Probiotics provide "friendly" bacteria that regulate your inner ecosystem to keep you feeling your best. Probiotics are naturally found in the body and in the environment. Spore probiotics are among the most effective strains that nature has to offer.
Maintains healthy vaginal flora Supports a healthy urinary tract Digestive health & nutrient absorption Healthy immune system support
Microbiologist formulated & clinically proven to outlive the leading probiotics and yogurt
Supports digestive + immune health
100% better survival DNA verified strains Smart Spore Technology
Dairy free Gluten free Soy free Non GMO
Science-backed formula
Made in the USA with domestic and selectively imported ingredients
Contains No: GMO, dairy, wheat, gluten, soy, added artificial colors or flavors.
The Probiogen advantage Survives 100x better vs. yogurt and other leading brands
With probiotics, it's quality over quantity Many leading brands with up to 200+ billion CFUs only guarantee potency at the time of manufacture. Probiogen provides live, viable CFUs that live and thrive in the gut, colonizing to provide true benefits when you need them most. Feel the Probiogen difference. Smart Spore Technology Spores are nature's best probiotics. Unlike other popular strains, spore-formers make it past the harsh gastric system to colonize in the gut for better digestive and overall health.
Formula
Probiotic + key women's health nutrients
HU 58 Guaranteed potency probiotic with DNA verified strains
Storage
Plus no refrigeration needed
Store in a cool, dry place.
General Statements
Aren't high quality probiotics refrigerated? If a probiotic needs to be refrigerated, how will it survive a much warmer and more intense environment like your gastric system? Likely - it won't. Learn more about probiogen spore probiotics
Complete study available at Probiogen.com
Brand IP Statement(s)
Probiogen Probiotics that thrive!
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Take 2 capsules twice daily after a meal or as directed by your physician.
Precautions
Warning: If you are pregnant or lactating, consult a healthcare professional before using this product.
Do not use this product if the safety seal on the bottle is broken.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Women's Vitality Spore Probiotic by Probiogen label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Women's Vitality Spore Probiotic by Probiogen
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Caprylic Acid
Interacts with262 drugs
Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While...
Caprylic Acid monograph & interactionsCranberry (Vaccinium macrocarpon) whole fruit concentrate
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry (Vaccinium macrocarpon) whole fruit concentrate monograph & interactionsWomen's Probiotic Blend
- › Lactobacillus acidophilus DDS-1
- › Bacillus coagulans HC
- › Bacillus subtilis HU58
- › Bacillus clausii
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Cellulose plant fiber. These complete the product’s ingredient list but are not active constituents.
Women's Vitality Spore Probiotic by Probiogen Drug Interactions
HelloPharmacist Interaction Report
Women's Vitality Spore Probiotic by Probiogen contains several ingredients that interact with medications.
Caprylic acid is the source of the most serious documented interactions — it may increase blood pressure-lowering effects (hypotension risk) when combined with blood pressure medications (antihypertensives), and theoretically may raise levels of blood thinners like warfarin and nonsteroidal anti-inflammatory drugs (NSAIDs) by displacing them from protein binding sites, though these effects haven't been confirmed in humans.
Read the full breakdown — every affected drug type, severity by severity
Three probiotic strains in this product — Lactobacillus acidophilus, Bacillus coagulans, and Bacillus subtilis — can all lose effectiveness if taken at the same time as antibiotics, since the drugs may kill the live organisms. Cranberry concentrate is moderately interactive with several heart and cholesterol medications: it may increase levels of certain statin cholesterol drugs (like atorvastatin), the blood pressure medication nifedipine, and the blood thinner warfarin.
It also carries minor interactions with CYP2C9 substrates and diclofenac, though clinical evidence on the latter two is mixed.
We couldn't check Bacillus clausii — we hold no interaction data for it. Altogether, these interactions span 1,037 individual medications.
Use the medication checker on this page to look up your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Women's Vitality Spore Probiotic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Women's Vitality Spore Probiotic interact with 1,048 drugs. Click any drug to see the details.
5 of the 6 ingredients in Women's Vitality Spore Probiotic interact with drugs. Each result below shows which ingredient is responsible. Cranberry (Vaccinium macrocarpon) whole fruit concentrate Caprylic Acid Lactobacillus acidophilus DDS-1 Bacillus coagulans HC Bacillus subtilis HU58
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Caprylic AcidAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Caprylic Acid + Acebutolol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Caprylic AcidNonsteroidal Anti-inflammatory Drugs (nsaids) Moderate
Interaction Summary
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
Read the full Caprylic Acid + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Women's Vitality Spore Probiotic — through 2 ingredients. Tap an ingredient for the detail:
Caprylic AcidNonsteroidal Anti-inflammatory Drugs (nsaids) Moderate
Interaction Summary
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
Read the full Caprylic Acid + Acetaminophen, Aspirin, Caffeine interactionCranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Women's Vitality Spore Probiotic — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) Whole Fruit ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Whole Fruit Concentrate + Acetaminophen, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Women's Vitality Spore Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry (Vaccinium macrocarpon) whole fruit concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Caprylic Acid
Antihypertensive Drugs
Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that caprylic acid might have positive inotropic effects, resulting in reduced arterial pressure and vascular resistance and increased cardiac output.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
In vitro research suggests that caprylic acid might displace NSAIDs from binding sites on albumin. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, caprylic acid might increase plasma concentrations of warfarin.
In vitro research suggests that high doses of caprylic acid might displace warfarin from albumin binding sites. This effect has not been reported in humans.
Lactobacillus acidophilus DDS-1
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Bacillus coagulans HC
Antibiotic Drugs
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.
Bacillus subtilis HU58
Antibiotic Drugs
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.
Brand information
Manufacturer and brand details for Women's Vitality Spore Probiotic, from the product label.
Probiogen
See all Probiogen products- Name
- Probiogen
- Street Address
- 9160 E. Bahia Dr.
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85260
- Web Address
- probiogen.com
Women's Vitality Spore Probiotic by Probiogen: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Women's Vitality Spore Probiotic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Caprylic Acid
Interacts with 262 drugsCaprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While laboratory studies show it has antimicro...
Read the full Caprylic Acid monograph → Herb & supplement monographCranberry
Interacts with 712 drugsCranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...
Read the full Cranberry monograph → Herb & supplement monographLactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBacillus Coagulans
Interacts with 182 drugsBacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...
Read the full Bacillus Coagulans monograph → Herb & supplement monographBacillus Subtilis
Interacts with 182 drugsBacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...
Read the full Bacillus Subtilis monograph →Sources & How We Checked
Women's Vitality Spore Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 83 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Caprylic Acid 5 references
- Massolini G, Aubry AF, McGann A, Wainer IW. Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. Biochem Pharmacol 1993 PubMed
- Kristev A, Mitkov D, Lukanov Y, Chapkynov P. The effect of octanoic fatty acid on the cardiovascular system of the guinea pig. Cor Vasa 1989;31(4):321-7.
- Hayball PF, Holman JW, Nation RL. Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. J Chromatogr B Biomed App PubMed
- Noctor TA, Wainer IW, Hage DS. Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. J Chromatogr 1992;5 PubMed
- Voller B, Lines E, McCrossin G, et al. Dose-escalation study of octanoic acid in patients with essential tremor. J Clin Invest. 2016;126(4):1451-7. PubMed
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bacillus Coagulans 20 references
- Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
- Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
- Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
- Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
- Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
- Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
- MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
- Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
- De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
- Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
- Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
- Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
- Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
- Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
- Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
- Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed
Bacillus Subtilis 10 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
- La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
- Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
- Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
- Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
- Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
- Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
- Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
- Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC