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Dietary supplement

Xanthohumol 150 mg Ingredients & Drug Interactions

by SuperSmart

Xanthohumol 150 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Xanthohumol 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Xanthohumol 150 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hops Flower Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Xanthohumol 150 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Xanthohumol 150 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Xanthohumol 150 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: hops flower extract, standardized to deliver 150 mg of xanthohumol per capsule. Xanthohumol is a flavonoid compound found naturally in hops that researchers have studied for various health effects.

The capsules also contain acacia gum and white rice flour as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hops product and its label doesn't state a use — see Hops's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on hops for the conditions this product may be marketed for — age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion, and insomnia — does not establish that it works. All of those uses are rated as having insufficient reliable evidence to rate.

That doesn't mean hops won't help you; it means the research to back those claims isn't solid enough yet.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops is generally well tolerated in the short term, but drowsiness can occur — so be cautious if you drive or operate machinery. Long-term safety hasn't been well studied, so we don't know what happens if you take this for months or years.

The safety data advises against use during pregnancy and breastfeeding due to insufficient information. Occupational exposure to hops dust is linked to chronic respiratory symptoms like cough and bronchitis in workers; supplements taken by mouth carry a different exposure profile, but it's worth noting.

In a small number of reported cases, supplements combining hops and soy have been tied to postmenopausal bleeding, though it's unclear whether hops, soy, or the combination is responsible.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this if you take any sedative drugs, anti-anxiety medications, or sleep aids (Moderate-severity interaction — additive drowsiness is possible). Also double-check if you're on estrogen-based hormone replacement therapy or any medications broken down by your liver's CYP3A4 or CYP1A2 pathways (Minor-severity interactions).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product might be worth considering if you're exploring herbal options for sleep or anxiety — but the evidence isn't strong yet. If you take sedatives, sleep aids, or hormone replacement therapy, talk with your pharmacist first.

Avoid it during pregnancy and breastfeeding. Check your exact medications with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Xanthohumol 150 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003827849
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332549
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Xanthohumol 150 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
5453003827849
IngredientAmount% DV
Hops Flower Extract150 mg--

Other ingredients: Acacia Gum, white rice flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Xanthohumol 150 mg per day

Each vegetarian capsule contains 50 mg of hop flower extract standardized to 10% Xanthohumol.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take 2 to 3 capsules a day.

Precautions

Precautions: Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied diet.

Store out of reach of young children.

As with any food supplement, always consult your healthcare professional before consuming if you are pregnant, lactating or if you have any other health condition.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Xanthohumol 150 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Xanthohumol 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Xanthohumol 150 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Hops Flower Extract

Interacts with
863 drugs
150 mg per serving Form: Xanthohumol

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Hops Flower Extract monograph & interactions

Other (inactive) ingredients: Acacia Gum, White rice flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Xanthohumol 150 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Xanthohumol 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Hops Flower Extract 863

Individual Drug Interactions

The ingredients in Xanthohumol 150 mg interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in Xanthohumol 150 mg interact with drugs. Each result below shows which ingredient is responsible. Hops Flower Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Xanthohumol 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hops Flower Extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops Flower Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Xanthohumol 150 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, LDA
Street Address
Avenida Do Infante 66 Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Xanthohumol 150 mg by SuperSmart: Common Questions

Does Xanthohumol 150 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Xanthohumol 150 mg has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Xanthohumol 150 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Hops has sedative properties, so drowsiness is possible — especially if you're also taking sleeping pills or sedatives. The data shows it's generally well tolerated short-term, but if you do feel drowsy, don't drive or operate machinery.
Can I take this if I'm on hormone replacement therapy?
You need to check with your pharmacist first. Hops might theoretically interfere with how your hormone therapy works, though most hops extracts contain only small amounts of the constituents involved. This isn't a blanket 'no,' but it needs a conversation with your healthcare provider.
Is this safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking of taking it for months, that's a conversation to have with your pharmacist or doctor.
Does this actually work for sleep or anxiety?
The evidence we hold rates hops as having insufficient reliable evidence for insomnia and anxiety. That means research hasn't established that it works — not that it definitely won't help you, just that we don't have solid proof yet.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety information, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor if you're in either situation.
What is xanthohumol?
Xanthohumol is a flavonoid compound naturally found in hops. It's the main active ingredient researchers have studied, and this product is standardized to deliver 150 mg of it per capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Xanthohumol 150 mg label
Go deeper

The Full Monographs Behind Xanthohumol 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Xanthohumol 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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