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Dietary supplement

XF XanthoForce Hop Extract 50 mg Ingredients & Drug Interactions

by Swanson

XF XanthoForce Hop Extract 50 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking XF XanthoForce Hop Extract 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

XF XanthoForce Hop Extract 50 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are XanthoForce Hop extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against XF XanthoForce Hop Extract 50 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with XF XanthoForce Hop Extract 50 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of XF XanthoForce Hop Extract 50 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

XanthoForce Hop Extract contains one active ingredient: 50 mg of a hops extract (standardized as XanthoForce). Hops is a plant traditionally used in herbal medicine.

The product also contains inactive ingredients — brown rice flour, hypromellose (a capsule material), and diatomite — to make up the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hops product and its label doesn't state a use — see Hops's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for hops extract is not established in the data we hold. Effectiveness ratings show insufficient reliable evidence for age-related cognitive decline, sexual dysfunction, anxiety, ADHD, dyspepsia (indigestion), and insomnia.

That means studies haven't yet built a solid case for or against it for these uses — it's not a judgment that it doesn't work, only that the evidence isn't there yet.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops extract is generally well tolerated in the short term, but long-term safety hasn't been well studied, and it may cause drowsiness. Occupational exposure to hops dust (particularly in harvest workers) has been linked to chronic respiratory symptoms like dry cough and chronic bronchitis, though this is less relevant to taking a supplement capsule.

Rare cases of postmenopausal bleeding have been reported with supplements containing hops and soy together, though it's unclear whether hops, soy, or the combination was responsible. Topical contact with fresh hops or hops dust can trigger allergic reactions and contact dermatitis in some people.

Pregnancy: There isn't enough safety information; the data advises against use during pregnancy. Breastfeeding: Safety is unknown, so avoid use while breastfeeding.

Talk with your doctor or pharmacist about whether this product is appropriate for your situation.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take XanthoForce Hop Extract, double-check with your doctor or pharmacist if you use sedative or sleeping medications — hops may increase drowsiness (Moderate severity). Also confirm if you're on estrogen-containing drugs or hormone replacement therapy, as hops theoretically may interfere with them (Moderate severity).

Medications broken down by the CYP3A4 or CYP1A2 pathways present Minor concerns, though real-world impact is uncertain at typical doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient hops supplement is most relevant if you're curious about traditional herbal use, but the evidence for its effectiveness isn't established yet. If you take sedatives, estrogen-containing medications, or have any prescriptions at all, check them against the interaction tool on this page before starting — hops can add to drowsiness and may interfere with how your body handles certain drugs.

Pregnant or breastfeeding? The safety data advises against it.

Run any questions or concerns past your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about XF XanthoForce Hop Extract 50 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614027722
Net contents 30 Veggie Cap(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 185068
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for XF XanthoForce Hop Extract 50 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614027722
IngredientAmount% DV
XanthoForce Hop extract50 mg--

Other ingredients: Brown Rice Flour, Hypromellose, Diatomite, May contain one or both of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule per day with water.

Brand IP Statement(s)

XanthoForce is a trademark of Berg Imports, LLC.

Precautions

Warning: For adults only.

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

SWU772 Rev 0 05 08 18

General Statements

Antioxidant Support

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

XF XanthoForce Hop Extract 50 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

XF XanthoForce Hop Extract 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in XF XanthoForce Hop Extract 50 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

XanthoForce Hop extract

Interacts with
863 drugs
50 mg per serving Form: Xanthohumol

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

XanthoForce Hop extract monograph & interactions

Other (inactive) ingredients: Brown Rice Flour, Hypromellose, Diatomite, May contain one or both of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

XF XanthoForce Hop Extract 50 mg by Swanson Drug Interactions

Want to check YOUR meds against XF XanthoForce Hop Extract 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

XanthoForce Hop extract 863

Individual Drug Interactions

The ingredients in XF XanthoForce Hop Extract 50 mg interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in XF XanthoForce Hop Extract 50 mg interact with drugs. Each result below shows which ingredient is responsible. XanthoForce Hop extract

Each ingredient & the kinds of drugs it affects

For each ingredient in XF XanthoForce Hop Extract 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

XanthoForce Hop extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
XanthoForce Hop extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for XF XanthoForce Hop Extract 50 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swanson.com
Pharmacist Counseling Corner

XF XanthoForce Hop Extract 50 mg by Swanson: Common Questions

Does XF XanthoForce Hop Extract 50 mg by Swanson interact with any medications?
Yes. Based on its ingredients, XF XanthoForce Hop Extract 50 mg has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
XF XanthoForce Hop Extract 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Hops can cause drowsiness, especially if you're taking sedative medications. Start cautiously and see how it affects you, and avoid driving or operating machinery until you know your response.
Can I take this if I'm on birth control or hormone replacement therapy?
Hops theoretically may interfere with estrogen-containing medications, though the effect depends on the dose and extract type. Check with your doctor or pharmacist about your specific medication before you start.
Is this safe long-term?
Short-term safety is generally good, but long-term safety hasn't been well studied. If you're thinking of using it regularly, discuss it with your healthcare provider.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against use during pregnancy, and safety is unknown while breastfeeding — talk with your doctor about alternatives.
Does hops actually work for anxiety or sleep?
The evidence isn't established in the data we hold. Hops has been used traditionally, but studies haven't yet built a solid case for it for these purposes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

XF XanthoForce Hop Extract 50 mg label
Go deeper

The Full Monographs Behind XF XanthoForce Hop Extract 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

XF XanthoForce Hop Extract 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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