Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

XymoZyme HCl Ingredients & Drug Interactions

by XYMOGEN

XymoZyme HCl label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking XymoZyme HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

XymoZyme HCl is a dietary supplement by XYMOGEN with 8 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian Root Extract, Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against XymoZyme HCl by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with XymoZyme HCl by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of XymoZyme HCl by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 8 active ingredients.
  • “Pancreatin 10X” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

XymoZyme HCl contains 8 active ingredients, most of them digestive enzymes. Amylase, Protease, Lipase, Chymotrypsin, and Trypsin are all enzymes that help break down food — they're designed to support your digestive process.

Betaine Hydrochloride is a compound that increases stomach acid to aid digestion. Gentian Root Extract is an herbal ingredient traditionally used to support digestive function.

Pancreatin 10X is a blend of pancreatic enzymes listed separately as its component ingredients above. The capsule also contains inactive ingredients like Hypromellose, water, ascorbyl palmitate, hydroxypropyl cellulose, and silica — these are binders and fillers that make the capsule work.

This is a comprehensive enzyme formula aimed at supporting the full digestive process from start to finish.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: comprehensive digestive support.
  • We looked for evidence on: Dyspepsia, Flatulence, Postoperative swelling, Sprains, Wound healing, Exercise-induced muscle soreness — and 4 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Flatulence, Wound healing.

The evidence on these ingredients is limited. Chymotrypsin is rated Effective for cataracts, though this product is a digestive supplement, not an eye product.

For the digestive purposes this supplement appears intended for — like dyspepsia (indigestion) and general digestive support — the ingredients Lipase, Betaine Hydrochloride, Trypsin, and Gentian Root Extract all carry an Insufficient Reliable Evidence To Rate rating. That means we don't hold enough quality data to say whether they work for those uses.

Protease and Chymotrypsin also lack evidence for most digestive conditions. In short, the evidence backing this product's digestive benefit hasn't been established in our data.

The evidence, ingredient by ingredient Betaine Hydrochloride Gentian Proteolytic Enzymes (proteases) Lipase Chymotrypsin Trypsin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated in supplement form, though a few cautions stand out. Betaine Hydrochloride can irritate your stomach and is not safe if you have ulcers, gastritis, or true acid reflux.

Protease is generally well tolerated but rarely people have shown allergic reactions, including hypersensitivity to airborne proteolytic enzymes. Chymotrypsin, an animal-derived enzyme, can rarely cause anaphylaxis (a severe allergic reaction).

Trypsin when combined with other enzymes may cause mild-to-moderate gastrointestinal symptoms like nausea, heartburn, and stomach pain. For pregnancy: Betaine Hydrochloride, Chymotrypsin, and Trypsin should be avoided — there isn't enough safety information.

Protease, Lipase, and Gentian Root Extract also should be avoided unless prescribed by your doctor because safety data is limited or absent. For breastfeeding, the same caution applies — there is little to no reliable safety data, so talk with your healthcare provider before using this product.

Side effects, ingredient by ingredient Betaine Hydrochloride Gentian Proteolytic Enzymes (proteases) Lipase Chymotrypsin Trypsin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 6 matched ingredients can interact with medications — Betaine Hydrochloride, Gentian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start XymoZyme HCl, double-check if you take blood pressure medications (antihypertensive drugs) — Gentian Root Extract in this product may lower your pressure further, and Betaine Hydrochloride's stomach-acid boost could reduce their effect. Also check if you take acid-suppressing medications: H2-blockers like famotidine, antacids, or PPIs like omeprazole — Betaine Hydrochloride may work against them.

Use the medication checker on this page to verify your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

XymoZyme HCl is a multi-enzyme digestive formula that works best for adults without ulcers or acid reflux. If you take blood pressure medications, antacids, H2-blockers, or PPIs, check your exact medications with our tool before starting.

Pregnant or breastfeeding? Talk with your pharmacist first — the safety data isn't there yet.

For most healthy adults looking to support digestion, your pharmacist can help you figure out if this is the right fit.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about XymoZyme HCl, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 722537512565
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 303620
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for XymoZyme HCl by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
722537512565
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Betaine Hydrochloride300 mg--
Chymotrypsin0 NP--
Trypsin0 NP--
Gentian Root Extract20 mg--
Ox Bile150 mg--
Pancreatin 10X100 mg--

Other ingredients: Hypromellose, Water, Ascorbyl Palmitate, Hydroxypropyl Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule with meals, or use as directed by your healthcare professional.

Precautions

Consult your healthcare professional before use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

XymoZyme HCI combines key ingredients to aid each phase of digestion. This formula is designed for individuals who can benefit from comprehensive digestive support or who experience unpleasant after-meal symptoms associated with digestion.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Broad-Spectrum Digestive Support

Vegetarian Caps

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Seals/Symbols

Vegetarian Caps

ePV (ePedigree Verification) Third-Party Verified GMP Compliant

Brand IP Statement(s)

Copyright 2023 Xymogen

Xymogen Exclusive Professional Formulas

FDA Statement of Identity

Dietary Supplement

General Statements

Scan to Learn more! This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

XymoZyme HCl by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

XymoZyme HCl label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in XymoZyme HCl by XYMOGEN

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Gentian Root Extract

Interacts with
172 drugs
20 mg per serving Form: Gentiana lutea Root Extract

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian Root Extract monograph & interactions

Ox Bile

150 mg per serving Form: Cholic Acid

Pancreatin 10X

100 mg per serving Form: Porcine

Other (inactive) ingredients: Hypromellose, Water, Ascorbyl Palmitate, Hydroxypropyl Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

XymoZyme HCl by XYMOGEN Drug Interactions

Want to check YOUR meds against XymoZyme HCl?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
172 Moderate 36 Minor

Ingredients driving the most interactions

Gentian Root Extract 172
Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in XymoZyme HCl interact with 208 drugs. Click any drug to see the details.

2 of the 8 ingredients in XymoZyme HCl interact with drugs. Each result below shows which ingredient is responsible. Gentian Root Extract Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in XymoZyme HCl with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian Root Extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian Root Extract full monograph & interactions

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for XymoZyme HCl, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

XymoZyme HCl by XYMOGEN: Common Questions

Does XymoZyme HCl by XYMOGEN interact with any medications?
Yes. Based on its ingredients, XymoZyme HCl has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
XymoZyme HCl contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the digestive enzymes in this supplement doing?
Amylase, Protease, Lipase, Chymotrypsin, and Trypsin are all enzymes that break down different parts of food — carbs, proteins, and fats — to help your digestive system absorb them better. Betaine Hydrochloride boosts stomach acid to support that process. Together, they're meant to aid the full digestive chain.
Is this safe if I have a sensitive stomach or reflux?
No. Betaine Hydrochloride increases stomach acid, so this product is not safe if you have ulcers, gastritis, or true acid reflux — it could make those conditions worse. Talk with your pharmacist before using it.
Can I take this while pregnant?
There isn't enough safety information to know whether it's safe during pregnancy. Betaine Hydrochloride, Chymotrypsin, and Trypsin should be avoided unless your doctor prescribes them. Talk with your healthcare provider or pharmacist about whether this product is right for you.
What side effects might I notice?
Most people tolerate it well, but some may experience mild gastrointestinal symptoms like nausea, heartburn, or stomach pain — especially when enzymes are combined. Rarely, allergic reactions including anaphylaxis have been reported. Stop and contact your healthcare provider if you notice difficulty breathing, swelling, or severe reactions.
Does this actually work for indigestion or poor digestion?
The evidence isn't established in our data. Most of the active ingredients — including the enzymes and Gentian Root — haven't been studied well enough to prove they work for digestive complaints. Your pharmacist can discuss whether enzyme supplements may help in your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if XymoZyme HCl is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

XymoZyme HCl label
Go deeper

The Full Monographs Behind XymoZyme HCl’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Chymotrypsin

Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelling and support healing after injury or s...

Read the full Chymotrypsin monograph → Herb & supplement monograph

Trypsin

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chymotrypsin and bromelain) for swelling and...

Read the full Trypsin monograph →
Sources

Sources & How We Checked

XymoZyme HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 34 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Chymotrypsin 6 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Shaw PC. The use of a trypsin-chymotrypsin formulation in fractures of the hand. Br J Clin Pract 1969;23:25-6. DOI
  5. McCue FC, Webster TM, Gieck J. Clinical effects of proteolytic enzymes after reconstructive hand surgery. Int Surg 1972;57:479-82.
  6. Sun HJ, Xiao JQ, Qiao QH, et al. Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. Int J Oral Maxillofac Surg 2017;46(7):877-82. doi: 10.1016/j.ijom.2017.02.1267. PubMed

See these in context on the Chymotrypsin monograph →

Trypsin 17 references
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. PubMed
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp
  5. Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. PubMed
  6. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  7. Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. PubMed
  8. Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. PubMed
  9. US Department of Justice. U.S. Files Complaint Against Texas-Based Healthpoint Ltd. Under the False Claims Act. https://www.justice.gov/opa/pr/us-files-complaint-against-texas-based-healthpoint-ltd-under-false-claims-act. (Accessed June 19, 2019).
  10. Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. PubMed
  11. Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. PubMed
  12. Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47 Suppl:S23-8. PubMed
  13. Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. PubMed
  14. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. PubMed
  15. Popiela T, Kulig J, Klek S, Wachol D, Bock PR, Hanisch J. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek. 2000;57 Suppl 5:142.
  16. Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac S PubMed
  17. Comparison of Chronic Wound Care Products. Pharmacist's Letter/Prescriber's Letter 2008;12(3):1203.

See these in context on the Trypsin monograph →

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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