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Dietary supplement

Zeaxanthin + Lutein Ingredients & Drug Interactions

by EyePromise

Zeaxanthin + Lutein label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zeaxanthin + Lutein against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zeaxanthin + Lutein is a dietary supplement by EyePromise with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zeaxanthin + Lutein by EyePromise

Ask about any prescription or over-the-counter medication and we check it for interactions with Zeaxanthin + Lutein by EyePromise — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zeaxanthin + Lutein by EyePromise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

EyePromise Zeaxanthin + Lutein contains 2 active ingredients: lutein and zeaxanthin, both carotenoids (natural pigments) that concentrate in the eye. They're delivered in a softgel capsule with inactive ingredients including extra virgin olive oil, glycerin, carrageenan, and plant extracts like paprika and marigold flower.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health and macular protection.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, two common eye conditions tied to aging. Zeaxanthin is also possibly effective for AMD.

For other uses we have on file—including retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, and several neurological or other conditions—the evidence is either insufficient or points toward ineffectiveness. The data we hold doesn't cover every possible benefit people ask about; talk with your eye care provider about whether this product fits your specific situation.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both lutein and zeaxanthin are generally well tolerated at typical supplement doses. Lutein at doses up to 20 mg daily has not caused adverse effects in the studies we have.

Neither ingredient carries safety warnings for pregnancy or breastfeeding—both are rated likely safe—though the safety data on concentrated supplement doses during pregnancy and lactation is limited. If you're pregnant or nursing, check with your doctor or pharmacist before starting, since food sources are well studied but supplements are less so.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antidiabetes medications (drugs that lower blood sugar) before taking this product—zeaxanthin may theoretically increase the risk of low blood sugar. Use the search tool on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward people concerned about age-related eye health, particularly macular degeneration and cataracts. If you take diabetes medications, check with us or your pharmacist first—zeaxanthin may theoretically lower your blood sugar further.

Generally well tolerated, but pregnant or breastfeeding individuals should discuss it with their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zeaxanthin + Lutein, straight from the product label.

Brand EyePromise
Barcode (UPC) 185656000281
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 321845
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zeaxanthin + Lutein by EyePromise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Softgel(s)
Maximum serving Sizes:
1 Vegetarian Softgel(s)
Servings per container
180
UPC/BARCODE
185656000281
IngredientAmount% DV
Lutein10 mg--
Zeaxanthin10 mg--

Other ingredients: Extra Virgin Olive Oil, Food Starch, Modified, Glycerin, Carrageenan, Water, Purified, Maltitol Syrup, Canola Oil, Safflower Oil, Paprika extract, Marigold Flower Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

ZeaGold FloraGLO Lutein

Suggested/Recommended/Usage/Directions

Directions: Adults take 1 softgel with a meal up to twice daily, or as directed by your eye care professional.

Storage

Store at room temperature: 59 degrees - 77 degrees F (15 degrees - 25 degrees C). Do not expose to excessive heat.

General Statements

Recommended by doctors. Trusted by professional athletes.

E 60-day money-back guarantee

Formulation

Guaranteed to improve MPOD score.

The optimal ratio of essential nutrients for healthy vision. Eye health

Yeast/gluten free.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: If you are pregnant or nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if seal under cap is broken or missing,

Keep out of reach of children.

Brand IP Statement(s)

EyePromise Upgrade your eyes.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

NSF Contents Certified Manufactured in the U.S.A. with domestic and imported ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zeaxanthin + Lutein by EyePromise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zeaxanthin + Lutein label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zeaxanthin + Lutein by EyePromise

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
10 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
10 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Extra Virgin Olive Oil, Food Starch, Modified, Glycerin, Carrageenan, Water, Purified, Maltitol Syrup, Canola Oil, Safflower Oil, Paprika extract, Marigold Flower Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zeaxanthin + Lutein by EyePromise Drug Interactions

Want to check YOUR meds against Zeaxanthin + Lutein?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Zeaxanthin + Lutein interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Zeaxanthin + Lutein interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Zeaxanthin + Lutein with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zeaxanthin + Lutein, from the product label.

EyePromise

See all EyePromise products
Name
ZeaVision Holdings, Inc.
City
St. Louis
State
MO
ZipCode
63005
Phone Number
866-833-2800
Web Address
EyePromise.com
Pharmacist Counseling Corner

Zeaxanthin + Lutein by EyePromise: Common Questions

Does Zeaxanthin + Lutein by EyePromise interact with any medications?
Yes. Based on its ingredients, Zeaxanthin + Lutein has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zeaxanthin + Lutein contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help with macular degeneration?
Both lutein and zeaxanthin are possibly effective for age-related macular degeneration based on the evidence we have. That means the research supports benefit, but it's not ironclad. Talk with your eye doctor about whether it's right for you and what dose makes sense.
What exactly are lutein and zeaxanthin?
They're carotenoids—natural pigments found in plants and in your eye tissue. Your body doesn't make them, so you get them from food (like leafy greens and eggs) or supplements. They're thought to protect your eye cells from age-related damage.
Is it safe to take while pregnant?
Both lutein and zeaxanthin are rated likely safe in pregnancy. That said, the safety data on concentrated supplement doses during pregnancy is limited—food sources are much better studied. Check with your doctor or pharmacist for personalized advice.
Can I take this if I'm breastfeeding?
Both ingredients are rated likely safe during breastfeeding. Lutein naturally shows up in breast milk. But safety data on concentrated supplement doses while nursing is thin, so talk with your doctor or pharmacist to decide what's best for you.
What are the inactive ingredients?
The softgel contains extra virgin olive oil, glycerin, carrageenan, and plant extracts including paprika and marigold flower, among others. If you have sensitivities to any of these, check the full list on the label.
Has this been studied for cataracts?
Lutein is possibly effective for cataracts based on the evidence we hold. As with macular degeneration, that means research supports benefit but it's not definitive. Your eye doctor can tell you whether it fits into your cataract prevention plan.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zeaxanthin + Lutein is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zeaxanthin + Lutein label
Go deeper

The Full Monographs Behind Zeaxanthin + Lutein’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Zeaxanthin + Lutein's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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