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Dietary supplement

Zembrin Powder Ingredients & Drug Interactions

by Nootropics Depot

Zembrin Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zembrin Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zembrin Powder is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, low mood, mental focus and cognition.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zembrin (Sceletium tortuosum) (aerial parts) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zembrin Powder by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Zembrin Powder by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zembrin Powder by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Zembrin Powder contains one active ingredient: Sceletium tortuosum extract from the aerial parts of the plant. There are no other inactive ingredients (no fillers or binders) in this product.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sceletium's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: mood and stress support.
  • We looked for evidence on: Anxiety, Stress, Depression, mood elevation, emotional wellness.
  • The closest evidence on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Depression, Stress.

The evidence for sceletium doesn't yet support a clear rating for any condition we've checked. For anxiety, depression, stress, alcohol use disorder, obesity, and athletic performance, the data we hold shows insufficient reliable evidence to rate how well it works.

That doesn't mean it's ineffective—it means the research so far hasn't been robust enough to make a solid call.

The evidence, ingredient by ingredient Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sceletium appears generally well tolerated in small studies, but long-term safety hasn't been established, so we don't have a full picture of how safe it is over months or years. The most commonly reported side effects from trials include anxiety, headache, insomnia, irritability, and nausea.

There are also anecdotal reports of depression and listlessness with chewing, euphoric effects at high doses, and elevated blood pressure. The safety data advises against use during pregnancy.

Safety data are also lacking for breastfeeding, so avoid it while nursing. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Zembrin, check whether you're on any CNS depressants—sedatives, sleep aids, anti-anxiety medications, or certain pain relievers—because sceletium may add to their sedative effects. If you're unsure whether your medications fall into this category, use the checker on this page or ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Zembrin is a single-ingredient extract with limited evidence for the conditions it's marketed toward, so it's hard to say whether it'll work for your situation. The main thing to watch for is its Moderate interaction with CNS depressants—if you take sleep aids, sedatives, or other downers, check with your doctor or pharmacist before adding this.

Avoid it if you're pregnant or breastfeeding. Talk it over with your healthcare provider to see if it fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zembrin Powder, straight from the product label.

Brand Nootropics Depot
Net contents 0.07 Ounce(s); 2 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232702
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zembrin Powder by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 mg
Maximum serving Sizes:
25 mg
Servings per container
80
IngredientAmount% DV
Zembrin (Sceletium tortuosum) (aerial parts) extract25 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Zembrin of HG&H Pharmaceuticals (Pty) Limited. U.S. Patents 6,288,104, 8,552,051 and 8,980,338

FDA Statement of Identity

Dietary Supplement

General Statements

Disclaimer: Transfer scoops are not accurate forms of measurement. A milligram scale is needed to accurately measure dosages.

Precautions

Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

Do not take if under 18, pregnant/nursing, have any medical conditions or taking Rx/OTC drugs.

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 25mg once daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zembrin Powder by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zembrin Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zembrin Powder by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 mg Dosage formPowder Servings per container80 Amounts shown are per serving.

Zembrin (Sceletium tortuosum) (aerial parts) extract

Interacts with
248 drugs
25 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Zembrin (Sceletium tortuosum) (aerial parts) extract monograph & interactions
Interaction report

Zembrin Powder by Nootropics Depot Drug Interactions

Want to check YOUR meds against Zembrin Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Zembrin (Sceletium tortuosum) (aerial parts) extract 248

Individual Drug Interactions

The ingredients in Zembrin Powder interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Zembrin Powder interact with drugs. Each result below shows which ingredient is responsible. Zembrin (Sceletium tortuosum) (aerial parts) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Zembrin Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zembrin (Sceletium tortuosum) (aerial parts) extract1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Zembrin (Sceletium tortuosum) (aerial parts) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zembrin Powder, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Pharmacist Counseling Corner

Zembrin Powder by Nootropics Depot: Common Questions

Does Zembrin Powder by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Zembrin Powder has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zembrin Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Zembrin if I'm pregnant or breastfeeding?
The safety data advises against it during pregnancy. Safety data are lacking for breastfeeding too, so avoid it while nursing. Talk with your doctor or pharmacist about personalized advice for your situation.
What are the most common side effects?
In trials, the most reported side effects were anxiety, headache, insomnia, irritability, and nausea. There are also anecdotal reports of depression, listlessness, elevated blood pressure, and euphoric effects at higher doses.
How long has sceletium been studied for safety?
It appears generally well tolerated in small studies, but long-term safety hasn't been established yet—we don't have solid data on what happens with years of use.
Does Zembrin actually work for anxiety or depression?
The evidence so far is insufficient to rate how well it works for either condition. That means research hasn't been robust enough yet to make a clear call, not that it's definitely ineffective—but don't assume it will help.
What is sceletium and what does it do?
Sceletium tortuosum is a plant extract used in traditional practices. Some evidence suggests it has sedative properties, but the data on its specific effects and benefits in humans is still limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zembrin Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zembrin Powder label
Go deeper

The Full Monographs Behind Zembrin Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Zembrin Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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