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Dietary supplement

Zhi Zi Alcohol Free Ingredients & Drug Interactions

by Hawaii Pharm

Zhi Zi Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zhi Zi Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zhi Zi Alcohol Free is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for liver and digestive complaints, fever and inflammation, anxiety, restlessness, and trouble sleeping.Based on those ingredients, 21 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gardenia jasminoides Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zhi Zi Alcohol Free by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Zhi Zi Alcohol Free by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zhi Zi Alcohol Free by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: gardenia jasminoides fruit extract in dry form. Gardenia is a plant used in traditional medicine.

The liquid is made with glycerin and water as inactive ingredients — no alcohol, as the name suggests.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gardenia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: liver and digestive health with calming support.
  • We looked for evidence on: Anxiety, Insomnia, Liver function, Digestive health, Inflammation.
  • The closest evidence on file: Gardenia is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gardenia is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence we have for gardenia doesn't yet establish it as effective for the conditions it's sometimes used for — anxiety, dementia, depression, diabetes, high blood pressure, or influenza. The data shows insufficient reliable evidence for each of these uses.

The evidence, ingredient by ingredient Gardenia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for gardenia are limited, and large or long-term use hasn't been well studied. The facts show caution is warranted.

Pregnancy and breastfeeding: there isn't enough safety information available. The data advises against using this product during pregnancy or while breastfeeding — talk with your doctor or pharmacist if you're in either situation and considering it.

Adverse effects are uncommon but documented. When applied to skin, it can cause allergic contact dermatitis in sensitive people.

Orally, there's a rare case report of blue-gray skin discoloration linked to long-term use of a multi-ingredient product containing gardenia; the discoloration gradually resolved after the person stopped.

Side effects, ingredient by ingredient Gardenia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gardenia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 21 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any stimulant laxatives — over the counter or prescription — double-check this product with your pharmacist first. Gardenia may increase both the effects and side effects of these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient supplement is primarily a concern if you take stimulant laxatives — check those medications first. The evidence doesn't currently support gardenia for anxiety, depression, diabetes, high blood pressure, or the other uses listed here.

If you're pregnant, breastfeeding, or considering long-term use, talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zhi Zi Alcohol Free, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253659446
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Aug 24, 2023
DSLD ID 300846
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zhi Zi Alcohol Free by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253659446
IngredientAmount% DV
Gardenia jasminoides Fruit Extract, Dry1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

C2H5OH Alcohol free USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Gardenia jasminoides

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

C2H5OH Alcohol free

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zhi Zi Alcohol Free by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zhi Zi Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zhi Zi Alcohol Free by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Gardenia jasminoides Fruit Extract, Dry

Interacts with
21 drugs
1156 mg per serving

Gardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are...

Gardenia jasminoides Fruit Extract, Dry monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zhi Zi Alcohol Free by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Zhi Zi Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
21Drugs
21 Moderate

Ingredients driving the most interactions

Gardenia jasminoides Fruit Extract, Dry 21

Individual Drug Interactions

The ingredients in Zhi Zi Alcohol Free interact with 21 drugs. Click any drug to see the details.

1 of the 1 ingredient in Zhi Zi Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Gardenia jasminoides Fruit Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Zhi Zi Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gardenia jasminoides Fruit Extract, Dry1 drug type · 21 drugs

Stimulant Laxatives

Theoretically, gardenia might increase the effects and adverse effects of stimulant laxatives.
Animal research shows that geniposide, a glucoside found in gardenia fruit, may function as a laxative and cause diarrhea when taken orally.

Likelihood Possible Evidence D
Gardenia jasminoides Fruit Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zhi Zi Alcohol Free, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Zhi Zi Alcohol Free by Hawaii Pharm: Common Questions

Does Zhi Zi Alcohol Free by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Zhi Zi Alcohol Free has a known interaction with 21 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zhi Zi Alcohol Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not based on the safety data we have. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you if you're in either situation.
Does gardenia actually help with anxiety, depression, or any of the conditions listed?
According to our data, there isn't enough reliable evidence yet to say gardenia works for anxiety, depression, dementia, diabetes, high blood pressure, or influenza. More research is needed.
What are the side effects?
Adverse effects aren't common, but gardenia can trigger allergic skin reactions in sensitive people. There's one rare case report of blue-gray skin discoloration tied to very long-term use of a multi-ingredient product containing gardenia; the discoloration improved after stopping. Overall, human safety data are limited.
Why is this called 'Alcohol Free' if it's a liquid?
Because many liquid herbal extracts use alcohol as a preservative. This one uses glycerin and water instead.
Is this safe to use long-term?
We don't have enough data on long-term use to say it's safe. The facts note that large or long-term amounts haven't been well studied. If you're thinking of using it long-term, check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zhi Zi Alcohol Free is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zhi Zi Alcohol Free label
Go deeper

The Full Monographs Behind Zhi Zi Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gardenia

Interacts with 21 drugs

Gardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are interesting, strong human evidence for i...

Read the full Gardenia monograph →
Sources

Sources & How We Checked

Zhi Zi Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gardenia 5 references
  1. Kubo, Y., Nonaka, S., and Yoshida, H. Allergic contact dermatitis from gardenia fruit. Contact Dermatitis 1990;22(2):65-7. PubMed
  2. Yamauchi, K., Fujimoto, N., Kuwano, S., Inouye, H., and Inoue, K. The mechanism of purgative action of geniposide, an iridoid glucoside of the fruit of Gardenia, in mice. Planta Med 1976;30(1):39-47.
  3. Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers. Contact Dermatitis 1998;39(4):166-170. PubMed
  4. Mizawa M, Andoh T, Shimizu T. Gardenia fruit-related blue-gray skin pigmentation. JAMA Dermatol. 2020. PubMed
  5. Tong T, Fu J, Kong Y. Recurrent Abdominal Pain in a 61-Year-Old Woman. Gastroenterology 2023;164(6):887-890. PubMed

See these in context on the Gardenia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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