Major interaction on record — check this product against your medications before combining. Based on 8 of 16 ingredients. Check your meds →
Dietary supplement

Yin Chao Junior Ingredients & Drug Interactions

by Health Concerns

Yin Chao Junior label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yin Chao Junior against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Yin Chao Junior is a dietary supplement by Health Concerns with 16 active ingredients. Its ingredients are commonly taken for liver and digestive complaints, fever and inflammation, anxiety, restlessness, and trouble sleeping.Based on those ingredients, 1,055 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Bitter Orange, Forsythia, White Mulberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Yin Chao Junior by Health Concerns

Ask about any prescription or over-the-counter medication and we check it for interactions with Yin Chao Junior by Health Concerns — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Yin Chao Junior by Health Concerns

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 16 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Yin Chao Junior contains 16 ingredients, most traditional Chinese herbs. The active ingredients include gardenia, forsythia, bitter orange, chrysanthemum, perilla, white mulberry leaf, and chinese mint (also called Japanese mint), along with several others we list but have limited interaction data for: peucedanum, pinellia, platycodon, loquat, zhejiang fritillary, ligusticum wallichii, trichosanthes, and chinese eupatorium.

The formula also contains rice and a proprietary blend container. The inactive ingredients are water, glycerin, alcohol, and blackberry juice concentrate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Children's health and immune support formula.
  • We looked for evidence on: Common cold, Influenza, Cough, Asthma, Bronchitis, Headache — and 4 related terms.
  • The closest evidence on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Asthma (Natural Medicines).
  • Also on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Headache, Common cold, Cough.
  • Also on file: Japanese Mint is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Headache, Common cold.

The evidence on whether Yin Chao Junior's ingredients work for their intended purposes is not established in the data we hold. Gardenia, forsythia, bitter orange, chrysanthemum, perilla, white mulberry leaf, and chinese mint all carry "Insufficient Reliable Evidence To Rate" for the conditions they're traditionally used for — meaning we don't have strong clinical studies backing specific uses.

That doesn't mean the formula won't help you feel better, but we can't point to solid proof that it will for any particular condition.

The evidence, ingredient by ingredient Gardenia Forsythia Bitter Orange Chrysanthemum Perilla White Mulberry Japanese Mint Chinese Cucumber

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients carry cautions or require avoidance in pregnancy and while breastfeeding. Gardenia and forsythia should be avoided in both pregnancy and lactation due to limited safety data.

Bitter orange is rated possibly unsafe while breastfeeding and should be avoided during pregnancy due to its stimulant effects. Chrysanthemum, perilla, white mulberry leaf, and chinese mint also lack sufficient safety data during pregnancy and lactation — talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Gardenia, chrysanthemum, perilla, and chinese mint can trigger allergic reactions in sensitive people, ranging from contact dermatitis to hives and, rarely, asthma or anaphylaxis. White mulberry leaf commonly causes temporary bloating, gas, loose stools, or constipation in some users, though these often fade over time.

Bitter orange may cause dizziness, difficulty concentrating, or syncope (fainting).

Side effects, ingredient by ingredient Gardenia Forsythia Bitter Orange Chrysanthemum Perilla White Mulberry Japanese Mint Chinese Cucumber

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Chinese Cucumber, Bitter Orange, Forsythia, White Mulberry, Gardenia.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,056 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Yin Chao Junior, check with your pharmacist if you take any of these: MAOIs (older antidepressants), midazolam (a sedative), QT-prolonging heart drugs, stimulant drugs, blood thinners (anticoagulants), antiplatelet drugs like aspirin or clopidogrel, antidiabetes drugs, CYP3A4 substrates (including many statins and immunosuppressants), dextromethorphan (cough medicine), stimulant laxatives, or azithromycin (an antibiotic). Bitter orange is the primary driver of these interactions, so the concern is especially high if you take any medication that affects heart rhythm, blood pressure, or bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, antidepressants (especially MAOIs), antidiabetes drugs, or sedatives like midazolam, talk to your pharmacist before using Yin Chao Junior — bitter orange and other ingredients pose real concerns. People with high blood pressure or heart rhythm issues should also check first, especially if they consume caffeine.

The product's effectiveness for specific conditions isn't established in our data, and several ingredients lack solid pregnancy and breastfeeding safety information. Use the interaction checker below with your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yin Chao Junior, straight from the product label.

Brand Health Concerns
Net contents 1 Fluid Ounce(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 73660
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yin Chao Junior by Health Concerns, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
30 Drop(s)
Maximum serving Sizes:
30 Drop(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend0 NP--
Gardenia0 NP--
Forsythia0 NP--
Bitter Orange0 NP--
Peucedanum0 NP--
Chrysanthemum0 NP--
Pinellia0 NP--
Platycodon0 NP--
Loquat0 NP--
Perilla0 NP--
White Mulberry0 NP--
Zhejiang Fritillary0 NP--
Chinese Mint0 NP--
Ligusticum wallichii0 NP--
Trichosanthes0 NP--
Chinese eupatorium0 NP--
Rice0 NP--

Other ingredients: Water, Glycerin, Alcohol, Blackberry juice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 ml. (30 drops) every 4 hours. Can be added to juice or warm water. Shake well before using.

Precautions

Notice: This product is not intended for use by pregnant women.

General Statements

Made in the U.S.A.

Brand IP Statement(s)

Chinese traditional formulas

Combining modern research and ancient wisdom

FDA Statement of Identity

Dr. Fung's Dietary Supplement for Children

Formula

Dr. Fung's Dietary Supplement for Children

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yin Chao Junior by Health Concerns label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yin Chao Junior label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yin Chao Junior by Health Concerns

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size30 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Water, Glycerin, Alcohol, Blackberry juice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yin Chao Junior by Health Concerns Drug Interactions

Want to check YOUR meds against Yin Chao Junior?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,055Drugs
10 Major 981 Moderate 64 Minor

Ingredients driving the most interactions

Bitter Orange 957
Forsythia 123
White Mulberry 87
Trichosanthes 86
Gardenia 21

Individual Drug Interactions

The ingredients in Yin Chao Junior interact with 1,055 drugs. Click any drug to see the details.

5 of the 16 ingredients in Yin Chao Junior interact with drugs. Each result below shows which ingredient is responsible. Bitter Orange Forsythia White Mulberry Trichosanthes Gardenia

Each ingredient & the kinds of drugs it affects

For each ingredient in Yin Chao Junior with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bitter Orange13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Bitter Orange full monograph & interactions

Forsythia2 drug types · 123 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking forsythia with anticoagulant or antiplatelet drugs might increase the risk of bleeding due to decreased platelet aggregation. Forsythia might reduce platelet aggregation by inhibiting platelet activating factor. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Unlikely Evidence D
Azithromycin (Zithromax)

Theoretically, taking forsythia with azithromycin might increase the risk of adverse effects. Animal research in rats shows that taking a single dose of forsythia with azithromycin decreases the clearance and increases the area under the curve of both forsythiaside, a constituent of forsythia, and azithromycin. The mechanism of this interaction is not well understood.

Likelihood Unlikely Evidence D
Forsythia full monograph & interactions

White Mulberry2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
White Mulberry full monograph & interactions

Trichosanthes1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects. Monitor blood glucose levels closely, dose adjustment may be needed.

Likelihood Possible Evidence D
Trichosanthes full monograph & interactions

Gardenia1 drug type · 21 drugs

Stimulant Laxatives

Theoretically, gardenia might increase the effects and adverse effects of stimulant laxatives.
Animal research shows that geniposide, a glucoside found in gardenia fruit, may function as a laxative and cause diarrhea when taken orally.

Likelihood Possible Evidence D
Gardenia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yin Chao Junior, from the product label.

Health Concerns

See all Health Concerns products
Name
Health Concerns
Street Address
8001 Capwell Drive
City
Oakland
State
CA
ZipCode
94621
Pharmacist Counseling Corner

Yin Chao Junior by Health Concerns: Common Questions

Does Yin Chao Junior by Health Concerns interact with any medications?
Yes. Based on its ingredients, Yin Chao Junior has a known interaction with 1,055 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yin Chao Junior contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Yin Chao Junior while pregnant or breastfeeding?
The safety data for most ingredients in this formula are limited during pregnancy and lactation. Gardenia and forsythia specifically should be avoided during both. Bitter orange should be avoided during pregnancy due to stimulant effects. Talk with your doctor or pharmacist before using this product if you're pregnant, planning to become pregnant, or breastfeeding — they can help you weigh any potential benefits against the lack of solid safety information.
Does this supplement work for colds or cough?
Several ingredients — forsythia, chrysanthemum, and chinese mint — are traditionally used for respiratory symptoms like cough and colds, but the clinical evidence we hold for them is rated as insufficient to prove they work for these purposes. It doesn't mean they won't help you feel better, but we can't point to solid proof.
What are the most common side effects?
White mulberry leaf can cause temporary bloating, gas, loose stools, or constipation in about half of people who take it, though these effects often ease over time. Gardenia, chrysanthemum, perilla, and chinese mint can trigger allergic skin reactions like contact dermatitis or hives, especially in sensitive people. Bitter orange may cause dizziness or difficulty concentrating.
Can I take this with caffeine?
No — bitter orange in this formula can raise blood pressure and heart rate when combined with caffeine, and the combination increases the risk of serious heart problems. Avoid caffeine while taking Yin Chao Junior.
Is this product safe if I have high blood pressure?
Bitter orange has stimulant effects and can raise blood pressure and heart rate, so check with your pharmacist first if you have high blood pressure or heart conditions. The same caution applies if you take blood pressure or heart rhythm medications.
What's in the proprietary blend?
The product contains a proprietary blend container, but all of its component ingredients are listed separately on the label — peucedanum, pinellia, platycodon, loquat, and zhejiang fritillary. A proprietary blend just means the exact proportions of each ingredient aren't disclosed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yin Chao Junior label
Go deeper

The Full Monographs Behind Yin Chao Junior’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gardenia

Interacts with 21 drugs

Gardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are interesting, strong human evidence for i...

Read the full Gardenia monograph → Herb & supplement monograph

Forsythia

Interacts with 123 drugs

Forsythia is a traditional Chinese herb, used mainly for cold and flu symptoms and as part of multi-herb formulas. Most evidence comes from laboratory, animal, and traditional use rather tha...

Read the full Forsythia monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Chrysanthemum

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for t...

Read the full Chrysanthemum monograph → Herb & supplement monograph

Perilla

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it...

Read the full Perilla monograph → Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph → Herb & supplement monograph

Japanese Mint

Japanese mint is a menthol-rich plant used mainly for its essential oil in topical rubs, inhalants, and digestive remedies. There is some support for menthol's soothing and cooling effects,...

Read the full Japanese Mint monograph → Herb & supplement monograph

Chinese Cucumber

Interacts with 86 drugs

Chinese cucumber (Trichosanthes kirilowii) is a plant used in traditional Chinese medicine, and a protein from its root called trichosanthin (Compound Q) has been studied as an injectable dr...

Read the full Chinese Cucumber monograph →
Sources

Sources & How We Checked

Yin Chao Junior's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 96 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gardenia 5 references
  1. Kubo, Y., Nonaka, S., and Yoshida, H. Allergic contact dermatitis from gardenia fruit. Contact Dermatitis 1990;22(2):65-7. PubMed
  2. Yamauchi, K., Fujimoto, N., Kuwano, S., Inouye, H., and Inoue, K. The mechanism of purgative action of geniposide, an iridoid glucoside of the fruit of Gardenia, in mice. Planta Med 1976;30(1):39-47.
  3. Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers. Contact Dermatitis 1998;39(4):166-170. PubMed
  4. Mizawa M, Andoh T, Shimizu T. Gardenia fruit-related blue-gray skin pigmentation. JAMA Dermatol. 2020. PubMed
  5. Tong T, Fu J, Kong Y. Recurrent Abdominal Pain in a 61-Year-Old Woman. Gastroenterology 2023;164(6):887-890. PubMed

See these in context on the Gardenia monograph →

Forsythia 3 references
  1. Kong XT, Fang HT, Jiang GQ, et al. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis Child 1993;68:468-71. PubMed
  2. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  3. Li XG, Ni J, Shen S, Wang XP, Tian JC. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats. Chin J Nat Med 2020;18(3):234-240. PubMed

See these in context on the Forsythia monograph →

Bitter Orange 47 references
  1. Penzak SR, Jann MW, Cold JA, et al. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol 2001;41:1059-63. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Calapai G, Firenzuoli F, Saitta A, et al. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report. Fitoterapia 1999;70:586-92. DOI
  4. Keogh AM, Baron DW. Sympathomimetic abuse and coronary artery spasm. Br Med J 1985;291:940.
  5. Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69:14-23. PubMed
  6. Pellati F, Benvenuti S, Melegari M, Firenzuoli F. Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J Pharm Biomed Anal 2002;29:1113-9. . PubMed
  7. Colker CM, Kalman DS, Torina GC, et al. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res 1999;60:145-153. DOI
  8. Penzak SR, Acosta EP, Turner M, et al. Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J Clin Pharmacol 2002;42:1165-70. PubMed
  9. Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-44. PubMed
  10. Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life Sci 2002;71:1149-60. PubMed
  11. Visentin V, Morin N, Fontana E, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther 2001;299:96-104.
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See these in context on the Bitter Orange monograph →

Chrysanthemum 25 references
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See these in context on the Chrysanthemum monograph →

Perilla 4 references
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See these in context on the Perilla monograph →

White Mulberry 6 references
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See these in context on the White Mulberry monograph →

Japanese Mint 2 references
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See these in context on the Japanese Mint monograph →

Chinese Cucumber 4 references
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See these in context on the Chinese Cucumber monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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