Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Zymetane Ingredients & Drug Interactions

by Wonder Laboratories

Zymetane label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zymetane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Zymetane is a dietary supplement by Wonder Laboratories with 6 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zymetane by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Zymetane by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zymetane by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (97 mg) without saying how much of each component you get.

Zymetane contains six active ingredients, all working on digestion. Three are digestive enzymes: protease (breaks down protein), lipase (breaks down fat), and pepsin (another protein-digesting enzyme).

Betaine hydrochloride boosts stomach acid to help these enzymes do their job. The sixth ingredient is pancreatin, a blend of multiple enzymes from the pancreas.

Two other ingredients on the label—amylase and ammonium chloride—we couldn't fully assess for interactions, but they're part of the formula's digestive support design. The tablet also contains inactive ingredients like calcium carbonate, cellulose, stearic acid, silica, and vanillin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Nutritionally supports digestive health.
  • We looked for evidence on: Dyspepsia, Inflammatory bowel disease (IBD), Indigestion, Bloating and gas.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD) (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for what Zymetane does isn't established in the data we hold. Betaine hydrochloride, lipase, and protease have all been studied for conditions like indigestion (dyspepsia), food sensitivities, and inflammatory bowel disease, but the research so far is insufficient to rate whether they actually work.

That doesn't mean they don't help—it means we just don't have strong enough studies yet to say one way or the other. If you're considering this for a specific digestive issue, your pharmacist or doctor can help you weigh what limited evidence exists against your own situation.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The enzymes in here—protease and pepsin—are generally well tolerated, though a small number of people may experience digestive upset or allergic reactions. Pepsin is found in laundry detergents, and rarely, people exposed to airborne pepsin have developed allergy symptoms like rhinitis or asthma.

Betaine hydrochloride is the caution ingredient: it can irritate your stomach and isn't safe if you have ulcers, gastritis, or true acid reflux. Lipase is also generally well tolerated but should be used with medical guidance if you have serious digestive conditions.

During pregnancy, betaine hydrochloride should be avoided—there isn't enough safety data. Protease, pepsin, and lipase also lack solid safety data in pregnancy and should only be used if your doctor advises it.

For breastfeeding, there's little data on any of these, so check with your healthcare provider first before taking this product.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Zymetane, check if you're on H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (PPIs like omeprazole). Betaine hydrochloride in this product raises stomach acid and could reduce how well these medications work.

We also weren't able to check amylase and ammonium chloride for interactions, so mention all three of those ingredient names to your pharmacist when you ask.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Zymetane is a digestive enzyme blend with a stomach-acid booster. It's generally well tolerated for digestive support in adults, but if you take acid-reducing medications for heartburn or ulcers, you'll want to double-check with your pharmacist first—betaine hydrochloride could work against them.

Avoid it in pregnancy and talk to your doctor before breastfeeding. Run your medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zymetane, straight from the product label.

Brand Wonder Laboratories
Barcode (UPC) 099528295036
Net contents 300 Tablet(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 315271
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zymetane by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
300
UPC/BARCODE
099528295036
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Betaine Hydrochloride178 mg--
Pepsin97 mg--
Ammonium Chloride10 mg--
Pancreatin97 mg--

Other ingredients: Calcium Carbonate, Cellulose, Stearic Acid, Silica, Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a food enzyme dietary supplement, take one tablet with each meal and if necessary at bedtime. Don't hesitate to use two servings (two tablets) with each meal and at bedtime if needed.

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Contains milk ingredients.

Formulation

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs) Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability. Made in USA

Nutritionally supports digestive health

Gluten free

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Formula

Food enzyme

FDA Statement of Identity

Dietary Supplement

General Statements

Formula 295 Reorder # 2953

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zymetane by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zymetane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zymetane by Wonder Laboratories

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container300 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
178 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pepsin

No known
interactions
97 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Ammonium Chloride

10 mg per serving

Pancreatin

97 mg per serving

Other (inactive) ingredients: Calcium Carbonate, Cellulose, Stearic Acid, Silica, Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zymetane by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Zymetane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Zymetane interact with 36 drugs. Click any drug to see the details.

1 of the 6 ingredients in Zymetane interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Zymetane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zymetane, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Zymetane by Wonder Laboratories: Common Questions

Does Zymetane by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Zymetane has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zymetane contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Zymetane work if I'm taking an acid reducer?
Betaine hydrochloride—one of the active ingredients—increases stomach acid, which is the opposite of what your acid-reducing drug is trying to do. They could work against each other. Talk to your pharmacist about timing or whether this product is right for you if you're on an H2-blocker, antacid, or PPI.
Is it safe to take during pregnancy?
Betaine hydrochloride should be avoided in pregnancy—there isn't enough safety data. The enzymes (protease, pepsin, and lipase) also lack solid pregnancy data, so they're best used only if your doctor advises it. Talk with your doctor before starting this if you're pregnant or planning to be.
Can I take it while breastfeeding?
Safety data during breastfeeding is limited for all the active ingredients in Zymetane. Check with your healthcare provider first before you use it—they know your situation and can give you personalized advice.
What are the digestive enzymes actually supposed to do?
Protease breaks down protein, lipase breaks down fat, and pepsin is another protein-digesting enzyme—they help your digestive system process food. The betaine hydrochloride boosts stomach acid to help these enzymes work better. However, we don't have strong evidence yet that they actually improve indigestion or other digestive problems.
Does Zymetane have a lot of fillers?
Besides the six active digestive ingredients, the tablet contains calcium carbonate, cellulose, stearic acid, silica, and vanillin as inactive ingredients—these are common binders and texture agents used in tablets.
What if I have an ulcer or acid reflux?
Betaine hydrochloride can irritate your stomach and isn't safe for people with ulcers, gastritis, or true acid reflux—it actually raises acid rather than calming it. Skip this product and talk to your pharmacist about digestive support that's safer for your condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zymetane label
Go deeper

The Full Monographs Behind Zymetane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Zymetane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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