Interactions on record — worth a quick check against your medications. Based on 2 of 8 ingredients. Check your meds →
Dietary supplement

Zypan Ingredients & Drug Interactions

by SP Standard Process

Zypan label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zypan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Zypan is a dietary supplement by SP Standard Process with 8 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zypan by SP Standard Process

Ask about any prescription or over-the-counter medication and we check it for interactions with Zypan by SP Standard Process — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zypan by SP Standard Process

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (595 mg) without saying how much of each component you get.

Zypan contains 8 ingredients total, including a proprietary blend. The active components that we have data for are betaine hydrochloride (which increases stomach acid), pepsin (a protein-digesting enzyme), and pancreatin (a blend of digestive enzymes from the pancreas).

The product also contains bovine and ovine spleen extracts, plus bovine pancreas extract. Two inactive ingredients — cellulose and calcium stearate — are also present as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Enzyme digestive support.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating, Protein digestion.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for betaine hydrochloride's effectiveness is insufficient. The data we hold does not establish reliable evidence that it works for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, or allergic rhinitis (hay fever).

We have no effectiveness ratings for pepsin or any of the other ingredients in this product.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride is not safe for people with ulcers, gastritis, or true acid reflux — it can irritate the stomach and potentially trigger heartburn. It should be avoided during pregnancy and breastfeeding because there isn't enough safety data.

Pepsin is generally well tolerated in most adults, but it may cause digestive upset or allergic reactions. In rare cases, occupational exposure to pepsin has led to allergic reactions of the nose and eyes or asthma.

Pepsin should be avoided during pregnancy unless prescribed by a doctor, and use during breastfeeding is not recommended without medical advice. We hold no safety data for the other ingredients.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take H2-blockers, antacids, or proton pump inhibitors (PPIs) — betaine hydrochloride in Zypan can reduce how well these acid-reducing drugs work. No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Zypan is a digestive enzyme supplement, but the evidence that it actually works for its intended uses isn't established in the data we hold. If you take medications to reduce stomach acid — H2-blockers, antacids, or PPIs — this product could make them less effective.

Talk to your pharmacist or doctor before starting, especially if you have a history of ulcers, acid reflux, or if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zypan, straight from the product label.

Brand SP Standard Process
Barcode (UPC) 812122012379
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 340302
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zypan by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
45
UPC/BARCODE
812122012379
IngredientAmount% DV
Proprietary Blend595 mg--
Stearic Acid0 NP--
Betaine Hydrochloride0 NP--
Ammonium Chloride0 NP--
Pepsin0 NP--
Pancreatin0 NP--
Bovine Spleen0 NP--
Ovine Spleen0 NP--
Bovine Pancreas Cytosol extract0 NP--

Other ingredients: Cellulose, Calcium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Enzyme digestive support

Non-Dairy GF (Gluten Free)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Two tablets with each meal, or as directed.

Precautions

Caution: Chewing this product is not recommended.

This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, and shellfish.

General Statements

Whole Food Supplements Since 1929

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zypan by SP Standard Process label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zypan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zypan by SP Standard Process

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

595 mg per serving
  • › Stearic Acid
  • › Betaine Hydrochloride
  • › Ammonium Chloride
  • › Pepsin
  • › Pancreatin
  • › Bovine Spleen
  • › Ovine Spleen
  • › Bovine Pancreas Cytosol extract

Other (inactive) ingredients: Cellulose, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zypan by SP Standard Process Drug Interactions

Want to check YOUR meds against Zypan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Zypan interact with 36 drugs. Click any drug to see the details.

1 of the 8 ingredients in Zypan interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Zypan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zypan, from the product label.

SP Standard Process

See all SP Standard Process products
Name
Standard Process Inc.
Street Address
1200 West Royal Lee Drive
City
Palmyra
State
WI
ZipCode
53156
Pharmacist Counseling Corner

Zypan by SP Standard Process: Common Questions

Does Zypan by SP Standard Process interact with any medications?
Yes. Based on its ingredients, Zypan has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zypan contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Zypan supposed to do?
Zypan is a digestive enzyme supplement. It contains pepsin and pancreatin, which are enzymes that help break down proteins and other nutrients in food. However, the evidence that these ingredients actually work for the conditions listed (like indigestion, diarrhea, or food allergies) isn't established in the data we have.
Can I take Zypan if I'm pregnant?
No — betaine hydrochloride should be avoided during pregnancy because there isn't enough safety data. Pepsin also should be avoided during pregnancy unless prescribed by your doctor. Talk to your doctor or pharmacist for personalized advice before taking this product.
Is Zypan safe while breastfeeding?
No — both betaine hydrochloride and pepsin should be avoided during breastfeeding. Betaine hydrochloride has not been studied enough to know it's safe, and pepsin use is not recommended without medical advice. Speak with your doctor or pharmacist before using this product if you're nursing.
What are the side effects of Zypan?
Betaine hydrochloride can irritate the stomach and cause heartburn, especially in people with ulcers or acid reflux. Pepsin may cause digestive upset or allergic reactions. In rare cases, pepsin exposure has caused nasal/eye allergies or asthma in occupational settings.
Can I take Zypan with my H2-blocker or PPI?
Not without talking to your pharmacist first. Betaine hydrochloride in Zypan increases stomach acid, which can reduce how well acid-reducing medications like famotidine, ranitidine, omeprazole, or similar drugs work. Check your exact medications below before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zypan label
Go deeper

The Full Monographs Behind Zypan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Zypan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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