FDA-filed SPL labeling · retrieved through openFDA

Amoxicillin / Clavulanate

Amoxicillin/clavulanate is a combination antibiotic used to treat bacterial infections of the respiratory tract, ears, sinuses, skin, and urinary tract in adults and children.

Brand names Augmentin Es-600Augmentin
Drug classes ⓘ Penicillin-class Antibacterial
Rx Forms 4 Route Oral
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 201 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJul 7, 2026
Clinical labels in scope ⓘ201
AvailabilityRx
Earliest approval/marketing year ⓘ1990
FDA-listed product records ⓘ572
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026
⭐ Amoxicillin / Clavulanate at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Amoxicillin/clavulanate is an effective combination antibiotic that can tackle bacteria resistant to amoxicillin alone. Take it at the start of a meal to reduce stomach upset and improve clavulanate absorption, and always complete the full prescribed course. Watch for signs of an allergic reaction, severe rash, or persistent diarrhea, and contact your doctor right away if any of these occur.
How we write & review this content — our editorial policy →

📖 Amoxicillin / Clavulanate: Patient Information Guide

A plain-language walkthrough of Amoxicillin / Clavulanate — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Amoxicillin/clavulanate is a combination antibiotic used to treat a range of bacterial infections across several formulations in both adults and children. Not every form is approved for every use — see product-specific notes below.

  • Lower respiratory tract infections — tablets, chewable tablets, and oral suspensions (including Augmentin)
  • Acute bacterial otitis media (ear infections) — tablets, chewable tablets, and oral suspensions (including Augmentin); Augmentin ES-600 and similar 600 mg/42.9 mg per 5 mL suspensions are specifically for recurrent or persistent ear infections in children aged 3 months to 12 years weighing ≤40 kg with certain risk factors (recent antibiotic use, age ≤2 years, or daycare attendance)
  • Sinusitis — tablets, chewable tablets, and oral suspensions (including Augmentin); Amoxicillin and Clavulanate Potassium Extended-Release Tablets treat acute bacterial sinusitis in adults and pediatric patients ≥40 kg who can swallow tablets
  • Community-acquired pneumonia — Amoxicillin and Clavulanate Potassium Extended-Release Tablets only, for adults and pediatric patients ≥40 kg who can swallow tablets
  • Skin and skin structure infections — tablets, chewable tablets, and oral suspensions (including Augmentin)
  • Urinary tract infections — tablets, chewable tablets, and oral suspensions (including Augmentin)
⚙️How it works▾

Amoxicillin is a penicillin-class antibiotic that kills bacteria by interfering with their ability to build a stable cell wall — without a working cell wall, bacteria cannot survive. Clavulanate potassium is a beta-lactamase inhibitor: it blocks the enzyme (beta-lactamase) that some bacteria use to break down and inactivate amoxicillin, restoring amoxicillin's ability to fight those resistant bacteria.

The antibacterial effect depends on keeping amoxicillin levels above the bacteria's minimum inhibitory concentration (the lowest drug level needed to stop bacterial growth) for as much of the dosing period as possible. This is why the timing and frequency of doses matters.

💊How it's taken▾

Amoxicillin/clavulanate is taken by mouth in tablet, chewable tablet, or liquid suspension form. It is generally dosed two or three times daily depending on the specific product and condition being treated — follow your prescriber's schedule exactly. Taking each dose at the start of a meal is strongly recommended: food improves absorption of the clavulanate component and helps prevent stomach upset.

  • Tablets and suspensions can technically be taken without food, but starting a meal before each dose is preferred
  • Augmentin ES-600 and similar high-dose suspensions should always be taken at the start of a meal
  • Finish the full prescribed course even if you feel better — stopping early can allow the infection to return or bacteria to develop resistance
🤒Side effects — in detail▾

The most commonly reported side effects include:

  • Diarrhea or loose stools (most common — more likely with higher doses)
  • Nausea
  • Vomiting
  • Skin rash or hives
  • Vaginitis

Serious reactions are less common but require immediate medical attention: severe allergic reactions (including anaphylaxis), dangerous skin reactions like Stevens-Johnson syndrome, liver problems (jaundice, hepatitis), and a gut infection called C. difficile — which can cause severe, persistent diarrhea and may appear weeks after finishing antibiotics.

⚠️Warnings & precautions▾
  • Serious allergic reactions: Anaphylaxis (a life-threatening whole-body allergic reaction) has occurred. Risk is higher in people with a penicillin or cephalosporin allergy. Stop the medication and get emergency help immediately if you have trouble breathing, swelling, or a sudden drop in blood pressure.
  • Severe skin reactions: Rarely, this drug can cause Stevens-Johnson syndrome, toxic epidermal necrolysis, or DRESS — all serious, potentially life-threatening skin conditions. Stop taking the drug and call your doctor if a rash starts to blister, peel, or spread.
  • Liver problems: Hepatitis and cholestatic jaundice (bile backup causing yellowing of the skin) have been reported — rarely fatal. Watch for yellow skin or eyes, dark urine, or unusual abdominal pain.
  • C. difficile diarrhea (CDAD): Antibiotics can disrupt normal gut bacteria and allow C. difficile to overgrow, causing severe diarrhea or colitis — even weeks after finishing the course. Seek care for any persistent or bloody diarrhea.
  • Mononucleosis: A very high proportion of patients with mono who take amoxicillin-containing products develop a skin rash. Do not use this medication if you have mono.
  • Phenylketonuria (PKU): Chewable tablets and some oral suspensions contain phenylalanine and must be used cautiously in people with PKU.
🔀What it interacts with▾

Amoxicillin/clavulanate can interact with several medications — tell your prescriber and pharmacist about everything you take:

  • Probenecid (gout medication): raises amoxicillin blood levels; co-use is not recommended
  • Oral anticoagulants (blood thinners like warfarin): can increase bleeding risk by prolonging clotting time; more frequent INR monitoring and possible dose adjustment may be needed
  • Allopurinol (gout medication): substantially increases the risk of skin rash when combined with amoxicillin
  • Oral contraceptives (birth control pills): this antibiotic may reduce their effectiveness by affecting gut bacteria that help recycle estrogen — consider a backup contraceptive method

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Tell your doctor if you have ever had a serious allergic reaction (especially anaphylaxis or a severe skin reaction) to penicillin, cephalosporins, or any beta-lactam antibiotic
  • Do not take this medication if you have previously had jaundice or liver problems caused specifically by amoxicillin/clavulanate
  • Inform your doctor if you have mononucleosis (mono) — use should be avoided due to high risk of rash
  • Tell your doctor if you have kidney disease — dose adjustment is recommended for severe kidney impairment
  • Tell your doctor if you have liver disease — regular liver function monitoring is recommended during treatment
  • If you are pregnant or breastfeeding, discuss risks and benefits with your prescriber before use
  • People with phenylketonuria (PKU) should note that some chewable tablets and oral suspensions contain phenylalanine
🚑If you take too much▾

Taking too much amoxicillin/clavulanate most commonly causes stomach and abdominal pain, vomiting, and diarrhea; rash, hyperactivity, or drowsiness have also been reported in some patients. In rare cases, overdose has been associated with crystalluria (crystals in the urine) and kidney problems, so staying well-hydrated is important. If you suspect an overdose, stop the medication and contact a poison control center or seek emergency care right away.

📡Pharmacodynamics — effects in the body▾

The antibacterial effect of amoxicillin/clavulanate depends on how long amoxicillin blood levels remain above the minimum concentration needed to stop bacterial growth — a concept called %fT>MIC (percentage of time the free drug exceeds the minimum inhibitory concentration). Clavulanate does not directly kill bacteria; instead, it protects amoxicillin by blocking beta-lactamase enzymes that certain bacteria produce to destroy it, effectively extending amoxicillin's reach to bacteria that would otherwise be resistant.

🔬Pharmacokinetics — how your body processes it▾

After an oral dose, both amoxicillin and clavulanate are absorbed from the gut — peak blood levels occur roughly 1 to 1.5 hours after dosing. Neither component binds tightly to blood proteins (amoxicillin is about 18% bound, clavulanate about 25%), and amoxicillin spreads readily into most body tissues and fluids, though not into the brain or spinal fluid. Amoxicillin has a half-life of about 1.3 hours and clavulanate about 1 hour, both cleared mainly by the kidneys — 50–70% of amoxicillin and 25–40% of clavulanate are excreted unchanged in urine within the first 6 hours. Taking the medication with food enhances clavulanate absorption, though it has little effect on amoxicillin levels.

📦How to store it▾

Dispense in tight container . Store tablets and dry powder at or below 25°C (77°F). Store reconstituted suspension under refrigeration.

📄 Written from Amoxicillin / Clavulanate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Amoxicillin / Clavulanate — the kind of thing our pharmacy team would talk through with you at the counter.

What infections does amoxicillin/clavulanate actually treat? ▾
This antibiotic is used for a range of common bacterial infections — ear infections, sinus infections, lower respiratory tract infections, skin infections, and urinary tract infections. The extended-release tablet form is also approved specifically for community-acquired pneumonia. Your prescriber chose it because it can fight bacteria that have developed resistance to plain amoxicillin on its own.
Should I take this with food or on an empty stomach? ▾
Taking it at the start of a meal is the best approach. Food doesn't affect amoxicillin much, but it does meaningfully improve how much clavulanate your body absorbs. More importantly, taking it with food significantly reduces the chance of nausea, vomiting, and stomach upset — which are the most common complaints with this antibiotic.
I'm getting a lot of diarrhea — is that normal, and when should I be worried? ▾
Some diarrhea or loose stools are common with amoxicillin/clavulanate and are the most frequently reported side effect. It tends to be worse at higher doses. However, if your diarrhea is severe, watery, bloody, or persists even after you finish the course, that's a reason to call your doctor. There's a small risk of a serious gut infection called C. difficile that can cause dangerous colitis, and it's worth ruling that out.
What allergy symptoms should I watch for, and how serious can they be? ▾
Mild reactions like a minor rash aren't unusual, but you should stop the medication and get emergency help right away if you develop hives, swelling of the face or throat, difficulty breathing, or feel lightheaded — those can be signs of anaphylaxis, a life-threatening allergic reaction. Also watch for a rash that blisters, peels, or spreads rapidly — that needs urgent medical attention too. If you've ever had a serious reaction to penicillin or a related antibiotic, make sure your doctor knows before you start.
Can this antibiotic affect my birth control pills? ▾
Yes, there's a concern that amoxicillin/clavulanate can reduce the effectiveness of combined oral contraceptives by affecting the gut bacteria that help your body recycle estrogen. To be safe, use a backup method of contraception — like condoms — for the duration of your antibiotic course and check with your prescriber or pharmacist for guidance.
Do I really need to finish the full course even if I feel better? ▾
Yes, absolutely. Feeling better usually means the antibiotic is working, but it doesn't mean all the bacteria are gone. Stopping early allows surviving bacteria — which may be the harder-to-kill ones — to rebound and potentially develop resistance. Finishing the full prescribed course protects you and helps keep antibiotics effective for everyone.
Is Amoxicillin / Clavulanate available over the counter? ▾
Amoxicillin / Clavulanate is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Amoxicillin / Clavulanate first available? ▾
Amoxicillin / Clavulanate has been available in the United States since at least 1990, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Amoxicillin / Clavulanate? ▾
Amoxicillin / Clavulanate is supplied by 44 manufacturers listed in the FDA NDC Directory, including NuCare Pharmaceuticals,Inc., A-S Medication Solutions, Preferred Pharmaceuticals Inc..

💬 Answers drafted from Amoxicillin / Clavulanate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

🌿Drug & Supplement CheckerAmoxicillin / Clavulanate vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Amoxicillin / Clavulanate NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Amoxicillin / Clavulanate comes

Amoxicillin / Clavulanate is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Amoxicillin and Clavulanate Potassium Tablets treat lower respiratory tract infections, acute bacterial otitis media, sinusitis, skin and skin structure infections, and urinary tract infections in adults and pediatric patients
  • Indicated only when bacteria are confirmed or suspected to produce beta-lactamase enzymes
Important instructions
  • Amoxicillin and Clavulanate Potassium Tablets may be taken with or without food, but taking them at the start of a meal improves clavulanate absorption and reduces stomach upset
  • Swallow tablets whole — do not crush or split
Available strengths 4 strengths
125 mg / 875 mg 250 mg / 125 mg 500 mg / 125 mg 875 mg / 125 mg
353 FDA-listed product records ⓘ

Oral suspension

By mouth
Brands Augmentin Augmentin Es-600
How this form is used
What it may be used for
  • Augmentin oral suspension treats lower respiratory tract infections, ear infections, sinusitis, skin and skin structure infections, and urinary tract infections in adults and pediatric patients
  • Augmentin ES-600 oral suspension is specifically indicated for recurrent or persistent acute otitis media in children aged 3 months to 12 years weighing 40 kg or less, with specific risk factors such as recent antibiotic use or daycare attendance
  • Amoxicillin and Clavulanate Potassium oral suspension is indicated for pediatric patients weighing less than 40 kg and for adults or children who cannot swallow tablets, for lower respiratory tract infections, sinusitis, ear infections, skin infections, and urinary tract infections
Important instructions
  • Augmentin ES-600 and other 600 mg/42.9 mg per 5 mL suspensions should be taken at the start of a meal to reduce stomach upset and improve clavulanate absorption
  • Augmentin oral suspension and Amoxicillin and Clavulanate Potassium oral suspension can be taken with or without food, but starting a meal before dosing is recommended
  • Shake the suspension well before each use and follow your pharmacist's instructions for storage and any discard date after reconstitution
Available strengths 12 strengths
AMOXICILLIN 125 mg/5 mL; CLAVULANATE POTASSIUM 31.25 mg/5 mL AMOXICILLIN 200 mg/5 mL; CLAVULANATE POTASSIUM 28.5 mg/5 mL AMOXICILLIN 200 mg/5 mL; CLAVULANIC ACID 28.5 mg/5 mL AMOXICILLIN 250 mg/5 mL; CLAVULANATE POTASSIUM 62.5 mg/5 mL AMOXICILLIN 400 mg/5 mL; CLAVULANATE POTASSIUM 57 mg/5 mL AMOXICILLIN 400 mg/5 mL; CLAVULANIC ACID 57 mg/5 mL
Show 6 more strengths Show fewer strengths
AMOXICILLIN 600 mg/5 mL; CLAVULANATE POTASSIUM 42.9 mg/5 mL 125; 31.25 mg/5 mL; mg/5 mL 200; 28.5 mg/5 mL; mg/5 mL 250; 62.5 mg/5 mL; mg/5 mL 400; 57 mg/5 mL; mg/5 mL 600; 42.9 mg/5 mL; mg/5 mL
202 FDA-listed product records ⓘ

Chewable tablet

By mouth
How this form is used
What it may be used for
  • Chewable tablets are indicated for lower respiratory tract infections, acute bacterial otitis media, sinusitis, skin and skin structure infections, and urinary tract infections in adults and pediatric patients
Important instructions
  • Chewable tablets may be taken with or without food, but taking them at the start of a meal is recommended to improve clavulanate absorption and minimize stomach upset
  • People with phenylketonuria (PKU) should know that chewable tablets contain phenylalanine — check with your doctor or pharmacist before use
Available strengths 2 strengths
200 mg / 28.5 mg 400 mg / 57 mg
10 FDA-listed product records ⓘ

Extended-release tablet

By mouth
How this form is used
What it may be used for
  • Amoxicillin and Clavulanate Potassium Extended-Release Tablets treat community-acquired pneumonia in adults and pediatric patients weighing at least 40 kg who can swallow tablets
  • Amoxicillin and Clavulanate Potassium Extended-Release Tablets treat acute bacterial sinusitis in adults and pediatric patients weighing at least 40 kg who can swallow tablets
Important instructions
  • Amoxicillin and Clavulanate Potassium Extended-Release Tablets are for patients who weigh at least 40 kg and are able to swallow tablets
  • Follow your prescriber's instructions for timing and duration of the full course
Available strengths 3 strengths
62.5 mg / 562.5 mg / 437.5 mg 562.5 mg / 437.5 mg / 62.5 mg 562.5 mg / 62.5 mg / 437.5 mg
6 FDA-listed product records ⓘ

📊 Amoxicillin / Clavulanate across the U.S. market

How Amoxicillin / Clavulanate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

4
Dose forms ⓘ
44
Manufacturers
3
Brand names
572
FDA-listed product records ⓘ
1990
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

NuCare Pharmaceuticals,Inc.13%
A-S Medication Solutions9%
Preferred Pharmaceuticals Inc.7%
Remedyrepack Inc.6%
Proficient Rx LP5%
Aurobindo Pharma Limited5%
Other makers54%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Amoxicillin / Clavulanate is used

A general measure of how commonly Amoxicillin / Clavulanate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Amoxicillin / Clavulanate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

5,453,053
Medicaid prescriptions filled (Q1–Q4 2025)
$82.1M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Amoxicillin / Clavulanate prescribed? Of the 1,596 medications we measure, Amoxicillin / Clavulanate ranks #37 by Medicaid prescriptions — more than 98% of them.

Where Amoxicillin / Clavulanate ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #37 of 1,596
#32 Pantoprazole 5,789,599 Rx #33 Quetiapine 5,743,048 Rx #34 Triamcinolone 5,724,276 Rx #35 Methylphenidate 5,663,940 Rx #36 Semaglutide Injection 5,616,018 Rx #37 Amoxicillin / Clavulan... 5,453,053 Rx #38 Prednisone 5,404,950 Rx #39 Montelukast 5,399,653 Rx #40 Azithromycin 5,254,152 Rx #41 Loratadine 5,204,681 Rx #42 Buspirone 5,180,004 Rx

Utilization by Amoxicillin / Clavulanate product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 875 mg / 125 mg oral tablet is the most-dispensed Amoxicillin / Clavulanate product — about 65% of these Medicaid prescriptions.

amoxicillin 875 MG / clavulanate 125 MG Oral Tablet Most dispensed

3,546,182 Medicaid prescriptions (Q1–Q4 2025) 65% of Amoxicillin / Clavulanate prescriptions shown $45.4M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 14 of 318 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 562508

amoxicillin 120 MG/ML / clavulanate 8.58 MG/ML Oral Suspension

863,689 Medicaid prescriptions (Q1–Q4 2025) 16% of Amoxicillin / Clavulanate prescriptions shown $14.2M gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 20 of 59 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617993

amoxicillin 80 MG/ML / clavulanate 11.4 MG/ML Oral Suspension

487,345 Medicaid prescriptions (Q1–Q4 2025) 9% of Amoxicillin / Clavulanate prescriptions shown $8.2M gross reimbursement (before rebates) ≈ $17 per prescription (gross)

Summed across the 13 of 46 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617430

amoxicillin 500 MG / clavulanate 125 MG Oral Tablet

425,470 Medicaid prescriptions (Q1–Q4 2025) 8% of Amoxicillin / Clavulanate prescriptions shown $5.8M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 8 of 140 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617296

amoxicillin 50 MG/ML / clavulanate 12.5 MG/ML Oral Suspension

101,464 Medicaid prescriptions (Q1–Q4 2025) 2% of Amoxicillin / Clavulanate prescriptions shown $7.4M gross reimbursement (before rebates) ≈ $73 per prescription (gross)

Summed across the 12 of 22 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617322

amoxicillin 40 MG/ML / clavulanate 5.7 MG/ML Oral Suspension

19,154 Medicaid prescriptions (Q1–Q4 2025) <1% of Amoxicillin / Clavulanate prescriptions shown $285,473 gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 11 of 32 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617423

12 HR amoxicillin 1000 MG / clavulanate 62.5 MG Extended Release Oral Tablet

5,048 Medicaid prescriptions (Q1–Q4 2025) <1% of Amoxicillin / Clavulanate prescriptions shown $688,726 gross reimbursement (before rebates) ≈ $136 per prescription (gross)

Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 617995

amoxicillin 250 MG / clavulanate 125 MG Oral Tablet

4,679 Medicaid prescriptions (Q1–Q4 2025) <1% of Amoxicillin / Clavulanate prescriptions shown $201,386 gross reimbursement (before rebates) ≈ $43 per prescription (gross)

Summed across the 5 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 562251

Other Amoxicillin / Clavulanate products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

22 Medicaid prescriptions (Q1–Q4 2025) <1% of Amoxicillin / Clavulanate prescriptions shown $830 gross reimbursement (before rebates) ≈ $38 per prescription (gross)

Summed across the 1 of 34 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Amoxicillin / Clavulanate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 86 of 677 listed Amoxicillin / Clavulanate NDCs with Medicaid activity.

🔍 Compare Amoxicillin / Clavulanate products

A representative set of FDA-listed product records for Amoxicillin / Clavulanate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 572 products — FDA National Drug Code Directory. See every product, package size and price: browse all 572 Amoxicillin / Clavulanate NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.

Multiple ingredients (MIN) Amoxicillin / Clavulanate RxCUI 19711 4 dose forms · 22 strengths
  1. Dose form (SCDF) Chewable Tablet RxCUI 562252 In current FDA listings
    Clinical drug / strength (SCD) amoxicillin 100 MG / clavulanate 25 MG RxCUI 2105786 amoxicillin 125 MG / clavulanate 31.2 MG RxCUI 562253 amoxicillin 200 MG / clavulanate 28.5 MG RxCUI 617309 amoxicillin 200 MG / clavulanate 50 MG RxCUI 2105792 amoxicillin 250 MG / clavulanate 62.5 MG RxCUI 617304 amoxicillin 300 MG / clavulanate 75 MG RxCUI 2105795 amoxicillin 400 MG / clavulanate 57 MG RxCUI 617316 amoxicillin 50 MG / clavulanate 12.5 MG RxCUI 2105798
  4. Dose form (SCDF) Oral Tablet RxCUI 562250 In current FDA listings
    Clinical drug / strength (SCD) amoxicillin 100 MG / clavulanate 25 MG RxCUI 2105776 amoxicillin 200 MG / clavulanate 50 MG RxCUI 1810270 amoxicillin 250 MG / clavulanate 125 MG RxCUI 562251 amoxicillin 300 MG / clavulanate 75 MG RxCUI 1810273 amoxicillin 50 MG / clavulanate 12.5 MG RxCUI 1810268 amoxicillin 500 MG / clavulanate 125 MG RxCUI 617296 amoxicillin 800 MG / clavulanate 125 MG RxCUI 617996 amoxicillin 875 MG / clavulanate 125 MG RxCUI 562508

Look up RxCUI 19711 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Augmentin Es-600 Augmentin

🏭 Manufacturers & labelers

NuCare Pharmaceuticals,Inc. 73 A-S Medication Solutions 53 Preferred Pharmaceuticals Inc. 41 Remedyrepack Inc. 33 Proficient Rx LP 30 Aurobindo Pharma Limited 29 Sandoz Inc 28 PD-Rx Pharmaceuticals, Inc. 26 RPK Pharmaceuticals, Inc. 24 Chartwell RX, LLC 21 USAntibiotics, LLC 20 Teva Pharmaceuticals USA, Inc. 19 NorthStar Rx LLC 18 Bryant Ranch Prepack 16 Micro Labs Limited 14 Hikma Pharmaceuticals USA Inc. 12 Asclemed USA, Inc. 12 Northstar RxLLC 11 NuCare Pharmaceuticals, Inc. 9 Preferred Pharmaceuticals, Inc. 9 Sportpharm LLC 8 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 7 Bionpharma Inc. 6 Medsource Pharmaceuticals 6

…and 16 more on the FDA NDC directory.

RxNorm drug class

Amoxicillin / Clavulanate belongs to the beta Lactamase Inhibitor class.

Pharmacologic class beta Lactamase Inhibitor
How it works beta Lactamase Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 7, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Amoxicillin / Clavulanate.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Amoxicillin / Clavulanate after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
201
NDC products indexed
572
Distinct labelers/manufacturers represented
44
Linked representative label ⓘ
USAntibiotics, LLC
Linked label effective
Jul 7, 2026
Composite sections available
23
Linked SPL Set ID
c4a6deb5-0bcd-4fa3-b19b-a82fa1dd14f3
Linked SPL Document ID
5249ea78-ae6d-a83a-e063-6394a90ada30
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 201 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. USAntibiotics, LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.