FDA-filed SPL labeling · retrieved through openFDA

Somatropin

Somatropin is a synthetic human growth hormone used to treat growth failure in children and growth hormone deficiency in adults, available under several brand names including Humatrope, Norditropin, Omnitrope, and others.

Brand names AccretropinGenotropinHumatropeNorditropinNutropin AQ Nuspin +11 more
Drug class Recombinant Human Growth Hormone
Rx/OTC Forms 3 Routes Subcutaneous · Intramuscular; Subcutaneous · Intramuscular, Subcutaneous · Topical
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJul 7, 2025
Clinical labels in scope 5
AvailabilityRx/OTC
Earliest approval/marketing year 1986
FDA-listed product records 110
Boxed warningNone found in compared labels
How we combine label and product data →
Somatropin at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Somatropin is a prescription growth hormone replacement used to treat growth failure in children and growth hormone deficiency in adults. It requires regular injections and ongoing monitoring by a specialist for blood sugar, thyroid function, and other potential side effects. It is an effective therapy when used for the right conditions — but it carries real risks, especially in children with Prader-Willi Syndrome and people with serious illness, so close medical supervision is essential.

📖 Somatropin: Patient Information Guide

A plain-language walkthrough of Somatropin — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Somatropin is a synthetic growth hormone used across several brand-name products to treat conditions where the body cannot make enough growth hormone on its own.

  • Growth failure in children caused by growth hormone deficiency (GHD) — supported by Humatrope, Norditropin, and Omnitrope, among others
  • Prader-Willi Syndrome in children — supported by Norditropin and Omnitrope
  • Short stature in children born small for gestational age (SGA) who don't catch up by age 2 — supported by Humatrope, Norditropin, and Omnitrope
  • Turner Syndrome in girls — supported by Humatrope, Norditropin, and Omnitrope
  • Idiopathic short stature (ISS) — unexplained short stature not caused by another treatable condition — supported by Humatrope, Norditropin, and Omnitrope
  • SHOX gene deficiency causing short stature — supported by Humatrope
  • Noonan Syndrome in children — supported by Norditropin
  • Growth hormone deficiency in adults, whether the deficiency began in childhood or developed in adulthood — supported by Humatrope, Norditropin, and Omnitrope
⚙️How it works

Somatropin is identical in structure to the growth hormone your pituitary gland naturally produces. It activates growth hormone receptors throughout the body, prompting the liver and other tissues to release IGF-1 (insulin-like growth factor-1). IGF-1 is the main driver of bone lengthening in children, increasing both the number and size of muscle cells, and supporting protein building throughout the body. In adults with deficiency, somatropin helps shift body composition — reducing fat mass (especially around the abdomen) and increasing lean muscle — while also improving how the body handles fats and cholesterol.

Somatropin also affects how the body manages carbohydrates and minerals. It can reduce insulin sensitivity at higher doses and promotes retention of potassium, phosphorus, and sodium as part of normal cell growth. In children with low blood sugar related to pituitary problems, it can help stabilize glucose levels — but large doses may impair glucose tolerance.

💊How it's taken

Somatropin is given as a subcutaneous injection — just under the skin — and is never taken by mouth. Children typically receive injections 6 to 7 days per week, with the weekly dose divided into daily injections. Adults usually inject once daily, often at bedtime. Injection sites (abdomen, thigh, upper arm, or buttock) should be rotated every time to prevent skin changes.

  • Dosing is highly individualized — your prescriber will adjust the dose based on your response and lab results over time
  • Never change your dose or schedule without talking to your doctor first
  • Follow the specific preparation and storage instructions for your brand — some products require reconstitution before use
🤒Side effects — in detail

Like all medications, somatropin can cause side effects — some common and manageable, others requiring medical attention.

  • Upper respiratory infections, sore throat, and fever
  • Headache
  • Ear infections (especially in children with Turner Syndrome)
  • Swelling in the hands, feet, or body (fluid retention)
  • Joint pain, muscle aches, or back pain
  • Numbness or tingling — including carpal tunnel syndrome (nerve compression in the wrist)
  • Increased blood sugar or glucose intolerance
  • Skin dimpling at the injection site (lipoatrophy) if the same spot is used repeatedly

More serious reactions — such as severe allergic reactions, signs of increased brain pressure (bad headache, vision changes, nausea), a child limping or reporting hip pain, or persistent severe stomach pain — require prompt medical attention. Contact your doctor right away if any of these occur.

⚠️Warnings & precautions
  • Prader-Willi Syndrome in children: Children with this condition who are severely obese or have breathing problems (including sleep apnea) face a risk of sudden death. A thorough evaluation for airway and breathing problems is required before starting somatropin, and treatment should be stopped if new breathing issues develop.
  • Critically ill patients: Somatropin is not safe for people in intensive care recovering from major surgery, serious trauma, or acute respiratory failure — clinical studies showed significantly higher death rates in this setting.
  • Active cancer: Somatropin must not be used if there is any active malignancy. Patients with a history of brain tumors or cancer should be monitored carefully for any recurrence during treatment.
  • Blood sugar changes: Somatropin can reduce insulin sensitivity and may unmask type 2 diabetes. Regular blood sugar monitoring is essential, especially in people with risk factors like obesity or Turner Syndrome.
  • Intracranial hypertension (raised pressure in the skull): Can develop, usually in the first 8 weeks of treatment. Symptoms include severe headache, vision changes, nausea, or vomiting. An eye exam is recommended before starting treatment.
  • Slipped capital femoral epiphysis: A hip growth plate injury that can occur in children on somatropin — report any new limp or hip/knee pain immediately.
  • Benzyl alcohol: Some somatropin formulations contain benzyl alcohol as a preservative, which can be dangerous for premature infants and low-birth-weight babies. Preservative-free options should be used in these situations.
🔀What it interacts with

Somatropin can interact with several medications, affecting how well they work or increasing the risk of side effects.

  • Glucocorticoids (steroids like prednisone or cortisone acetate): Somatropin lowers cortisol levels — people on steroid replacement therapy may need higher doses. High-dose steroids can also blunt somatropin's growth effects in children.
  • Insulin and diabetes medications: Somatropin reduces the body's response to insulin, so blood sugar medications may need dose adjustments.
  • Oral estrogen: Taken by mouth, estrogen can reduce the IGF-1 response to somatropin — higher somatropin doses may be needed for women on oral estrogen replacement.
  • CYP450-metabolized drugs: Somatropin speeds up the liver's processing of many medications. If you take drugs that are broken down by liver enzymes, your doctor may need to monitor levels more closely.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it
  • Do not use somatropin if you have an active cancer or malignancy of any kind
  • Do not use during acute critical illness — including after major heart or abdominal surgery, serious trauma, or acute respiratory failure
  • Children with Prader-Willi Syndrome who are severely obese, have sleep apnea, or have significant breathing problems should not use somatropin
  • Do not use if you have active proliferative or severe non-proliferative diabetic retinopathy (serious eye damage from diabetes)
  • Not for use in children whose growth plates (epiphyses) are already closed — it won't promote further height and is not indicated
  • Tell your doctor if you have diabetes, thyroid disease, a history of cancer, scoliosis, or adrenal gland problems
  • Older adults are more sensitive to somatropin's effects — lower starting doses are generally recommended
  • If you are pregnant or breastfeeding, discuss this with your doctor; some formulations contain benzyl alcohol, which should be avoided — preservative-free alternatives or reconstitution with saline may be recommended
  • Known allergy to somatropin or any ingredient in the product is a contraindication
🚑If you take too much

Taking too much somatropin in the short term can first cause low blood sugar (hypoglycemia) and then high blood sugar (hyperglycemia), along with fluid retention (swelling). Over a long period, excessive doses could lead to abnormal bone and tissue growth — the kinds of changes seen with too much growth hormone, such as gigantism in children or acromegaly (thickening of bones and enlargement of hands, feet, and facial features) in adults. If you suspect an overdose, contact your healthcare provider or poison control right away.

📡Pharmacodynamics — effects in the body

Somatropin's primary action is stimulating linear (height) growth in children by acting on the cartilaginous growth plates at the ends of long bones. It does this mainly through IGF-1, which it triggers the liver and kidneys to produce. Beyond growth, somatropin increases muscle cell number and size, promotes protein synthesis, stimulates fat breakdown (reducing body fat stores and lowering LDL cholesterol in people with GHD), and affects how the body retains minerals like potassium and phosphorus. It also increases red blood cell mass and influences the size of internal organs.

🔬Pharmacokinetics — how your body processes it

When injected subcutaneously (under the skin), about 80% of a somatropin dose reaches the bloodstream — a high absorption rate compared to an intravenous dose used as a reference. Peak blood levels are reached roughly 5 to 6 hours after a subcutaneous injection. The drug has a relatively short half-life: about 0.4 hours when given directly into a vein, but around 3 hours after a subcutaneous injection, because it is absorbed gradually from the injection site. Somatropin is broken down primarily in the liver and kidneys through normal protein metabolism, and some breakdown products are returned to the bloodstream before being cleared.

📦How to store it

Store ZOMACTON vials refrigerated at 36° to 46°F (2° to 8°C) in the original carton to protect from light. Avoid freezing the accompanying diluent. store ZOMACTON 5 mg vials that have been reconstituted with co-packaged Bacteriostatic Sodium Chloride Injection, USP (with 0.

📄 Written from Somatropin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Somatropin — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is somatropin and why has my doctor prescribed it?
Somatropin is a lab-made version of the growth hormone your body naturally produces. Your doctor has likely prescribed it because your body — or your child's body — isn't making enough on its own. That can happen for a variety of reasons, from a problem with the pituitary gland to being born with a genetic condition like Turner Syndrome or Prader-Willi Syndrome. In children, it helps them grow closer to a normal height. In adults with deficiency, it helps improve body composition, energy, and how the body handles fat.
How do I give the injection, and does it hurt?
You'll inject it just under the skin — not into a vein or deep muscle. Common spots are the belly, thigh, upper arm, or buttock. The most important habit to get into is rotating your injection site every time, because using the same spot repeatedly can cause the skin to dimple or lose fat tissue underneath. Most people find the injections manageable with practice. Your care team will walk you through the technique for your specific brand and device — for example, Omnitrope cartridges require a specific pen device.
What side effects should I expect, and which ones should make me call the doctor right away?
Common side effects include some swelling (especially in the hands or feet), joint or muscle aches, headache, and upper respiratory infections. These often ease up as your body adjusts. What you should call your doctor about immediately: a child who starts limping or complaining of hip or knee pain, a bad headache with vision changes or vomiting, severe stomach pain that doesn't go away, or any signs of an allergic reaction like swelling of the face or trouble breathing. Also watch for increased thirst or frequent urination, which could signal blood sugar changes.
Will somatropin affect my blood sugar or my diabetes medications?
Yes, this is something to keep a close eye on. Somatropin can reduce your body's sensitivity to insulin, which means blood sugar can run higher than usual. If you already have diabetes or prediabetes, your insulin or medication dose may need to be adjusted after starting somatropin. Even if you don't have diabetes, your doctor will likely check your blood sugar periodically during treatment — especially if you have risk factors like obesity or Turner Syndrome.
Are there any medications or supplements I should tell my doctor about before starting somatropin?
Definitely. A few interactions are worth knowing about. If you take steroid medications like prednisone, your dose may need to go up because somatropin can lower your cortisol levels. If you're on oral estrogen, you may actually need a higher dose of somatropin to get the same effect. And if you take any medications that are processed by the liver, your doctor may want to monitor those more closely since somatropin can affect how quickly the liver clears certain drugs.
Is somatropin safe during pregnancy or breastfeeding?
The available data don't show a direct link between somatropin and birth defects or miscarriage, and it doesn't appear to cross the placenta or significantly raise levels in breast milk. That said, there's a practical concern: some somatropin formulations — including certain Zomacton products — contain benzyl alcohol as a preservative, which should be avoided during pregnancy and breastfeeding. If you need somatropin during this time, your doctor can recommend a preservative-free formulation or reconstituting with saline instead. Always let your doctor know if you're pregnant, planning to become pregnant, or nursing.
Is Somatropin available over the counter?
Both — Somatropin is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Somatropin first available?
Somatropin has been available in the United States since at least 1986, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Somatropin?
Somatropin is supplied by 15 manufacturers listed in the FDA NDC Directory, including Pfizer Laboratories Div Pfizer Inc, Eli Lilly and Company, EMD Serono, Inc..

💬 Answers drafted from Somatropin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Somatropin comes

Somatropin is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

By injection · Under the skin
Brands Norditropin Nutropin AQ NuSpin 5 Nutropin AQ NuSpin 10 Nutropin AQ NuSpin 20 Omnitrope
How this form is used
What it may be used for
  • Humatrope is used for growth failure due to GHD, Turner Syndrome, idiopathic short stature, SHOX deficiency, SGA, and adult GHD
  • Norditropin is used for GHD, Noonan Syndrome, Turner Syndrome, SGA, ISS, Prader-Willi Syndrome, and adult GHD
  • Omnitrope is used for growth failure in children due to GHD, Prader-Willi Syndrome, SGA, Turner Syndrome, and ISS, as well as adult GHD
  • All subcutaneous injection products are given by injection just under the skin, with injection sites rotated to prevent skin changes
Important instructions
  • Inject subcutaneously into the abdomen, thigh, upper arm, or buttock — rotate sites every time to avoid skin dimpling
  • Omnitrope cartridges (5 mg/1.5 mL and 10 mg/1.5 mL) must be used with the corresponding Omnitrope Pen 5 or Pen 10 delivery device
  • Children generally receive injections 6 to 7 days per week; adults typically inject once daily — follow your prescriber's schedule exactly
  • Treatment must be supervised by a physician experienced in diagnosing and managing the condition being treated
Available strengths 8 strengths
Show 2 more strengths Show fewer strengths
17 FDA-listed product records

Topical cream, ointment or gel

On the skin
Brands Viiva
Available strengths 1 strength
1 FDA-listed product record

📊 Somatropin across the U.S. market

How Somatropin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

3
Dose forms
15
Manufacturers
13
Brand names
110
FDA-listed product records
1986
First marketed

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Kit (85) · Powder (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Pfizer Laboratories Div Pfizer Inc33%
Eli Lilly and Company11%
EMD Serono, Inc.11%
Pharmacia and Upjohn Company LLC11%
Ferring Pharmaceuticals Inc.10%
Novo Nordisk7%
Other makers17%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Somatropin is used

A general measure of how commonly Somatropin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Somatropin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

142,879
Medicaid prescriptions filled (Q1–Q4 2025)
$800.8M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Somatropin prescribed? Of the 1,596 medications we measure, Somatropin ranks #444 by Medicaid prescriptions — more than 72% of them.

Where Somatropin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Somatropin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1.5 mL / 6.67 mg/mL pen injector is the most-dispensed Somatropin product — about 31% of these Medicaid prescriptions.

1.5 ML somatropin 6.67 MG/ML Pen Injector Most dispensed

43,983 Medicaid prescriptions (Q1–Q4 2025) 31% of Somatropin prescriptions shown $226.3M gross reimbursement (before rebates) ≈ $5,146 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1736329

1.5 ML somatropin 10 MG/ML Pen Injector

39,503 Medicaid prescriptions (Q1–Q4 2025) 28% of Somatropin prescriptions shown $291M gross reimbursement (before rebates) ≈ $7,366 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 847243

1 ML somatropin 12 MG/ML Cartridge

19,609 Medicaid prescriptions (Q1–Q4 2025) 14% of Somatropin prescriptions shown $134.3M gross reimbursement (before rebates) ≈ $6,851 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 996558

1 ML somatropin 5 MG/ML Cartridge

11,237 Medicaid prescriptions (Q1–Q4 2025) 8% of Somatropin prescriptions shown $38.6M gross reimbursement (before rebates) ≈ $3,433 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 763488

1.5 ML somatropin 3.33 MG/ML Pen Injector

7,983 Medicaid prescriptions (Q1–Q4 2025) 6% of Somatropin prescriptions shown $20.6M gross reimbursement (before rebates) ≈ $2,585 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1736262

1.5 ML somatropin 6.67 MG/ML Cartridge

7,234 Medicaid prescriptions (Q1–Q4 2025) 5% of Somatropin prescriptions shown $40.9M gross reimbursement (before rebates) ≈ $5,659 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1736337

somatropin 10 MG/ML Injectable Solution

2,302 Medicaid prescriptions (Q1–Q4 2025) 2% of Somatropin prescriptions shown $5.3M gross reimbursement (before rebates) ≈ $2,315 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 284989

somatropin 5 MG/ML Injectable Solution

2,127 Medicaid prescriptions (Q1–Q4 2025) 1% of Somatropin prescriptions shown $4.6M gross reimbursement (before rebates) ≈ $2,169 per prescription (gross)

Summed across the 2 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 241975

somatropin 12 MG Cartridge

1,779 Medicaid prescriptions (Q1–Q4 2025) 1% of Somatropin prescriptions shown $10.7M gross reimbursement (before rebates) ≈ $6,006 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 582969

1.5 ML somatropin 3.3 MG/ML Cartridge

1,415 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $4M gross reimbursement (before rebates) ≈ $2,845 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1736267

0.25 ML somatropin 2.4 MG/ML Prefilled Syringe

1,061 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $2.6M gross reimbursement (before rebates) ≈ $2,479 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762837

somatropin 6 MG Cartridge

964 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $2.8M gross reimbursement (before rebates) ≈ $2,862 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 729232

0.25 ML somatropin 1.6 MG/ML Prefilled Syringe

815 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $1.3M gross reimbursement (before rebates) ≈ $1,631 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762834

0.25 ML somatropin 0.8 MG/ML Prefilled Syringe

601 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $497,285 gross reimbursement (before rebates) ≈ $827 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762830

somatropin 24 MG Cartridge

600 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $6M gross reimbursement (before rebates) ≈ $9,992 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 582974

0.25 ML somatropin 3.2 MG/ML Prefilled Syringe

492 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $1.6M gross reimbursement (before rebates) ≈ $3,217 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762841

0.25 ML somatropin 4 MG/ML Prefilled Syringe

365 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $4,164 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762873

somatropin 6 MG Injection

224 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $4.4M gross reimbursement (before rebates) ≈ $19,517 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 249453

0.25 ML somatropin 4.8 MG/ML Prefilled Syringe

215 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $5,171 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762846

0.25 ML somatropin 5.6 MG/ML Prefilled Syringe

166 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $964,241 gross reimbursement (before rebates) ≈ $5,809 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762850

0.25 ML somatropin 8 MG/ML Prefilled Syringe

109 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $941,943 gross reimbursement (before rebates) ≈ $8,642 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762895

0.25 ML somatropin 6.4 MG/ML Prefilled Syringe

95 Medicaid prescriptions (Q1–Q4 2025) <1% of Somatropin prescriptions shown $633,529 gross reimbursement (before rebates) ≈ $6,669 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 762857

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Somatropin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 23 of 37 listed Somatropin NDCs with Medicaid activity.

🔍 Compare Somatropin products

A representative set of FDA-listed product records for Somatropin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 110 of 110 products — FDA National Drug Code Directory. See every product, package size and price: browse all 110 Somatropin NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Somatropin RxCUI 61148 5 dose forms · 32 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 373935 In current FDA listings
    Clinical drug / strength (SCD) 4.4 MG/ML RxCUI 542438 5 MG/ML RxCUI 241975 8 MG/ML RxCUI 248288 8.8 MG/ML RxCUI 284019 10 MG/ML RxCUI 284989
  2. Dose form (SCDF) Injection RxCUI 1734076 In current FDA listings
    Clinical drug / strength (SCD) 5 MG RxCUI 346494 6 MG RxCUI 249453
  3. Dose form (SCDF) Prefilled Syringe RxCUI 727641 No current FDA listing

Look up RxCUI 61148 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Accretropin Genotropin Humatrope Norditropin Nutropin AQ Nuspin Omnitrope Saizen Serostim Zomacton Zorbtive Nutropin Nutropin AQ NuSpin 10 Nutropin AQ NuSpin 20 Nutropin AQ NuSpin 5 saizenprep Viiva

🏭 Manufacturers & labelers

Pfizer Laboratories Div Pfizer Inc 36 Eli Lilly and Company 12 EMD Serono, Inc. 12 Pharmacia and Upjohn Company LLC 12 Ferring Pharmaceuticals Inc. 11 Novo Nordisk 8 Sandoz Inc 6 Genentech, Inc. 4 Jilin Qijian Bio-Pharmaceutical Co.,Ltd. 2 Novartis Pharmaceuticals Corporation 2 Bio-Technology General (Israel) Ltd. 1 Boehringer Ingelheim RCV GmbH & Co KG 1 Hefei Xinzhu Biological Technology Co., Ltd. 1 Viiva LLC 1 Wasserburger Arzneimittelwerk GmbH 1

RxNorm drug class

Somatropin belongs to the Recombinant Human Growth Hormone class.

Pharmacologic class Recombinant Human Growth Hormone
Drug family (ATC) Somatropin and somatropin agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 7, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Somatropin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Somatropin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
5
NDC products indexed
110
Distinct labelers/manufacturers represented
15
Linked representative label
Novo Nordisk
Linked label effective
Jul 7, 2025
Composite sections available
26
Linked SPL Set ID
1058e17c-9261-459c-a3e6-fae38d196c14
Linked SPL Document ID
b67c2419-4feb-4ce1-b97e-88760a8e1aee
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 5 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Novo Nordisk is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.