SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops, 30 vials — NDC 0065-1437-04 (Billing 00065-1437-04)
This is a package of 30 vials of SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops from Alcon Laboratories, Inc., marketed since Feb 2020 and currently FDA-listed; retail pharmacies pay about $0.3763 per vial (NADAC). It is the main listing for this product, which comes in 2 package sizes.
NDC database record
One package, one record: these facts belong to NDC 0065-1437-04 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0065 labeler · 1437 product · 04 package
- Package marketed since
- Feb 1, 2020
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Billing quantity
- 30 EA per package
- Barcode (UPC-A, from the NDC)
- 3 0065143704 1
- Medicaid fills, this package
- 4,285 prescriptions in the last four reported quarters
- FDA record last changed
- Jul 24, 2026
Other active recalls for Polyethylene Glycol 400 And Propylene Glycol (different manufacturers) — 1 · tap to view
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 058288
- GCN: 23696
- GPI-14 (Medi-Span): 86209902482022
- HICL (First Databank): 038529
- AHFS class code: 52:92.00.00
- RxCUI (RxNorm): 477589
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
Clinical
Systane Hydration PF is an over-the-counter eye drop solution marketed as a preservative-free lubricant. It contains polyethylene glycol 400 and propylene glycol, which are humectant ingredients commonly used in artificial tear products to help lubricate and moisturize the eye surface. This type of product is typically used to relieve dryness and provide temporary comfort to dry or irritated eyes.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per ea | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.376 | $11.29 / 30 vials |
| Medicaid paysCMS SDUD · 12 mo | $0.7608 | $22.82 / 30 vials |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file · file of Sep 30, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Marketing end | Status |
|---|---|---|---|---|---|---|
| 00065-1437-04 You're viewing this Main listing | 30 VIAL, SINGLE-DOSE in 1 CARTON / .7 mL in 1 VIAL, SINGLE-DOSE | $0.3763 / ea | $11.29 | 2020-02-01 | — | Active |
| 00065-1437-05 0065-1437-05 | 5 VIAL, SINGLE-DOSE in 1 CARTON / .7 mL in 1 VIAL, SINGLE-DOSE | — | — | 2020-02-01 | — | Active |
In Medicaid, this is the most-dispensed pack of this product — about 100% of fills over the last four reported quarters. See all packs ↓
Pack size FAQ
What quantity is in this package?
How does this package differ from NDC 00065-1437-05?
What NDC number is used to bill for this package of SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
Therapeutic equivalents
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Sep 30, 2026
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Where does this data come from?
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from Alcon Laboratories, Inc. labeler code 00065
- BSS PLUS balanced salt solution enriched with bicarbonate, dextrose, and glutathione Kit NDC 0065-0800-50
- PATADAY ONCE DAILY RELIEF OLOPATADINE HYDROCHLORIDE 7 mg/mL Solution NDC 0065-0816-01
- atropine sulfate 10 mg/mL Solution NDC 0065-0817-01
- Systane Ultra Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1431-01
- Systane ULTRA polyethylene glycol 400 and propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1432-04
- Systane Balance propylene glycol .06 mg/mL Emulsion NDC 0065-1433-02
- Systane Day and Night Value Pack Polyethylene Glycol 400, Propylene Glycol 0.3% Kit NDC 0065-1502-10
- Systane Ultra Preservative Free Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1507-82
- Systane COMPLETE PF propylene glycol .06 mg/mL Emulsion NDC 0065-1509-28
- SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1510-00
- Systane COMPLETE PF propylene glycol .06 mg/mL Emulsion NDC 0065-1530-01
- BSS balanced salt solution 6.4 mg/mL; .75 mg/mL; .48 mg/mL; .3 mg/mL; 3.9 mg/mL; 1.7 mg/mL Solution NDC 0065-1795-04
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses for use as a protectant against further irritation or to relieve dryness of the eye
⏱️ Dosage and Administration ▾
Directions put 1 or 2 drops in the affected eye(s) as needed.
⚠️ Warnings ▾
Warnings For external use only
🧪 Active Ingredient ▾
Active Ingredients Purpose Polyethylene Glycol 400 0.4% Lubricant Propylene Glycol 0.3% Lubricant
🧪 Inactive Ingredients ▾
Inactive ingredients aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium borate, sodium chloride, sodium hyaluronate, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
🎯 Purpose ▾
Active Ingredients Purpose Polyethylene Glycol 400 0.4% Lubricant Propylene Glycol 0.3% Lubricant
📄 Do Not Use ▾
Do not use if this product changes color or becomes cloudy if you are sensitive to any ingredient in this product
📄 When Using This Product ▾
When using this product do not touch tip of container to any surface to avoid contamination do not reuse once opened, discard
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if you experience any of the following: eye pain changes in vision continued redness or irritation of the eye condition worsens or persists for more than 72 hours
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Other Information ▾
Other information store at room temperature
📄 Questions or Comments ▾
Questions? In the U.S. call 1-800-757-9195 www.systane.com [email protected]
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL SYSTANE ® Lubricant Eye Drops HYDRATION PF PRESERVATIVE-FREE DRY EYE RELIEF Convenient Single Vials On-the-Go Extra moisturizing for sensitive eyes Longer lasting hydration* VOTED PRODUCT OF THE YEAR Consumer Survey of Product Innovation 2021 ± Hydro Boost TECHNOLOGY Alcon STERILE 30 Vials 0.7 mL (0.02 FL OZ) Experience preservative-free relief that’s extra moisturizing for sensitive eyes Common Dry Eye Symptoms • Burning or stinging • Fluctuating vision • Irritation • Watery eyes TAMPER EVIDENT: For your protection, do not use if vial is damaged or opened at time of purchase.
1 Based on a survey of eye care professionals. Data on file. * vs SYSTANE ® ULTRA Lubricant Eye Drops ± Winner Eye Care Category. Survey of 40,000 people by Kantar. www.alconpatents.com Made in France 436272-0221 SYSTANE ® Lubricant Eye Drops HYDRATION PF PRESERVATIVE-FREE DRY EYE RELIEF DIRECTIONS: Make sure container is intact before use.
To open, COMPLETELY TWIST OFF TAB. Do not pull off. Put 1 or 2 drops in the affected eye(s) as needed.
Throw away container. Do not reuse. ALCON Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA LOT: EXP.: