Systane Ultra Preservative Free Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops — NDC 0065-1507-82 (Billing 00065-1507-82)
This is a package of Systane Ultra Preservative Free Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops from Alcon Laboratories, Inc., marketed since Feb 2022 and currently FDA-listed; retail pharmacies pay about $1.16 per mL (NADAC). It is the main listing for this product, which comes in 2 package sizes.
NDC database record
One package, one record: these facts belong to NDC 0065-1507-82 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0065 labeler · 1507 product · 82 package
- Package marketed since
- Feb 15, 2022
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Barcode (UPC-A, from the NDC)
- 3 0065150782 9
- Medicaid fills, this package
- 989 prescriptions in the last four reported quarters
- FDA record last changed
- Jul 24, 2026
Other active recalls for Polyethylene Glycol 400 And Propylene Glycol (different manufacturers) — 1 · tap to view
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 081958
- GCN: 49228
- HICL (First Databank): 038529
- AHFS class code: 52:92.00.00
- RxCUI (RxNorm): 477589
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 8, 2026
Clinical
Systane Ultra Preservative Free is an over-the-counter eye drop solution containing two active ingredients: polyethylene glycol 400 and propylene glycol. These lubricating agents are typically used to temporarily relieve dryness and irritation of the eye surface. The product is formulated without preservatives and is marketed as an OTC monograph drug, meaning it follows established FDA guidelines for this category of eye lubricants.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $1.155 | $11.55 / 10 ml |
| Medicaid paysCMS SDUD · 12 mo | $1.57 | $15.68 / 10 ml |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file · file of Oct 7, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Marketing end | Status |
|---|---|---|---|---|---|---|
| 00065-1507-82 You're viewing this Main listing | 1 BOTTLE, DROPPER in 1 CARTON / 10 mL in 1 BOTTLE, DROPPER | $1.16 / mL | $11.55 | 2022-02-15 | — | Active |
| 00065-1507-92 0065-1507-92 | 2 BOTTLE, DROPPER in 1 CARTON / 10 mL in 1 BOTTLE, DROPPER | — | — | 2023-04-11 | — | Active |
In Medicaid, this is the most-dispensed pack of this product — about 100% of fills over the last four reported quarters. See all packs ↓
Pack size FAQ
What quantity is in this package?
What NDC number is used to bill for this package of Systane Ultra Preservative Free Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
Therapeutic equivalents
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Oct 7, 2026
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII LU49E6626Q
A synthetic organic compound used as a pH buffer and neutralizing agent in medicines. It helps maintain the proper acidity level in liquid formulations to improve stability and comfort.
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UNII R57ZHV85D4
Boric acid is a weak acid derived from boron. In medicines, it typically serves as a buffer to help maintain the product's pH level and may act as a preservative in certain formulations.
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UNII 3A1I7376TC
A natural gum derived from guar seeds, used as a thickener and binder in medicines. It increases viscosity to improve texture and help hold ingredients together in liquid or semi-solid formulations.
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UNII QTT17582CB
A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
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UNII 660YQ98I10
Potassium chloride is a mineral salt used in medicines as a buffer and to help maintain the proper pH balance and stability of the formulation during storage and use.
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UNII 451W47IQ8X
Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
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UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII 506T60A25R
Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
9 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 6, 2026
- FDA openFDA NDC Directory · synced Oct 8, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from Alcon Laboratories, Inc. labeler code 00065
- atropine sulfate 10 mg/mL Solution NDC 0065-0817-01
- Systane Ultra Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1431-01
- Systane ULTRA polyethylene glycol 400 and propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1432-04
- Systane Balance propylene glycol .06 mg/mL Emulsion NDC 0065-1433-02
- SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1437-04
- Systane Day and Night Value Pack Polyethylene Glycol 400, Propylene Glycol 0.3% Kit NDC 0065-1502-10
- Systane COMPLETE PF propylene glycol .06 mg/mL Emulsion NDC 0065-1509-28
- SYSTANE HYDRATION PF PRESERVATIVE FREE Polyethylene Glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-1510-00
- Systane COMPLETE PF propylene glycol .06 mg/mL Emulsion NDC 0065-1530-01
- BSS balanced salt solution 6.4 mg/mL; .75 mg/mL; .48 mg/mL; .3 mg/mL; 3.9 mg/mL; 1.7 mg/mL Solution NDC 0065-1795-04
- Systane Complete PF Propylene Glycol Emulsion .06 mg/mL Emulsion NDC 0065-2509-18
- Systane Pro PF Propylene Glycol 6 mg/mL Emulsion NDC 0065-3290-03
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses for the temporary relief of burning and irritation due to dryness of the eye for the temporary relief of discomfort due to minor irritations of the eye or to exposure to wind or sun
⏱️ Dosage and Administration ▾
Directions shake well before using put 1 or 2 drops in the affected eye(s) as needed see side of carton for directions for use
Directions for Use: Hold the bottle just below the cap and twist the cap to open. BEFORE FIRST USE , hold the bottle upside down and dispense one drop of product to discard. Shake the bottle downward to remove residual product (see picture).
Place 1 or 2 drops in the affected eye(s) as needed and blink. After use, shake the bottle downward to remove residual product that may be left on the tip (see picture above). Replace cap after use.
Discard 90 days after opening.
⚠️ Warnings ▾
Warnings For external use only
🧪 Inactive Ingredients ▾
Inactive ingredients Aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
🎯 Purpose ▾
Active Ingredients Purpose Polyethylene Glycol 400 0.4% Lubricant Propylene Glycol 0.3% Lubricant
📄 Do Not Use ▾
Do not use if this product changes color or becomes cloudy if you are sensitive to any ingredient in this product
📄 When Using This Product ▾
When using the product do not touch tip of container to any surface to avoid contamination replace cap after each use
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if you experience any of the following: eye pain changes in vision continued redness or irritation of the eye condition worsens or persists for more than 72 hours
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Other Information ▾
Other Information Store at room temperature
📄 Questions or Comments ▾
Questions? In the U.S. call 1-800-757-9195 [email protected] www.systane.com
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL Preservative-Free Systane ® LUBRICANT EYE DROPS ULTRA PF FAST ACTING DRY EYE RELIEF Moisture Rich Formula Instantly Hydrates Preservative-Free Bottle DOCTOR RECOMMENDED #1 BRANDS 1 Alcon STERILE 10 mL (0.34 FL OZ) LOT: EXP.: SIDE PANEL: TAMPER EVIDENT: For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase. 1 Based on a survey of eye care professionals.
Data on file. Alcon Laboratories, Inc. Fort Worth, TX 76134 USA Country of Origin United States U.S.
Pat.: www.alconpatents.com 300068254-0824 Actual Size TWIN VALUE PACK Preservative-Free Systane ® LUBRICANT EYE DROPS ULTRA PF FAST ACTING DRY EYE RELIEF Moisture Rich Formula Instantly Hydrates Preservative-Free Bottles DOCTOR RECOMMENDED #1 BRANDS 1 Alcon STERILE Two 10 mL (0.34 FL OZ) Bottles LOT: EXP.: SIDE PANEL: TAMPER EVIDENT: For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase. 1 Based on a survey of eye care professionals.
Data on file. Preservative-Free Fast Acting Relief for Sensitive Eyes Alcon Laboratories, Inc. Fort Worth, TX 76134 USA Country of Origin USA U.S.
Pat.: www.alconpatents.com ACTUAL SIZE 300068255-0824 Preservative-Free Systane ® LUBRICANT EYE DROPS ULTRA PF FAST ACTING DRY EYE RELIEF Moisture Rich Formula Instantly Hydrates Preservative-Free Bottle DOCTOR RECOMMENDED #1 BRANDS 1 Alcon STERILE 10 mL (0.34 fl oz) LOT: EXP.: SIDE PANEL: TAMPER EVIDENT: For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase. 1 Based on a survey of eye care professionals.
Data on file. Alcon Laboratories, Inc. Fort Worth, TX 76134 USA Country of Origin: Singapore U.S.
Pat.: www.alconpatents.com 300072082-0525 Actual Size Systane ® LUBRICANT EYE DROPS ULTRA PF FAST ACTING DRY EYE RELIEF 10 mL (0.34 FL OZ) STERILE Only for use in the eye. Store at room temperature. Discard 90 days after opening.
TAMPER EVIDENT: For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase. Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA See Carton for Directions For Use. Country of Origin: USA LOT: EXP: 300068258-0824