ADAPALENE 1 mg/g Gel — NDC 0536-1412-26 (Billing 00536-1412-26)
This is a package of ADAPALENE 1 mg/g Gel from RUGBY LABORATORIES, INC., marketed since Feb 2024 and currently FDA-listed; retail pharmacies pay about $0.3365 per g (NADAC). It is the main listing for this product, which comes in 2 package sizes.
NDC database record
One package, one record: these facts belong to NDC 0536-1412-26 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0536 labeler · 1412 product · 26 package
- Package marketed since
- Feb 20, 2024
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2027
- Barcode (UPC)
- 0305361412265
- Medicaid fills, this package
- 22,408 prescriptions in the last four reported quarters
- FDA record last changed
- Jul 24, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 026436
- GCN: 29300
- GPI-14 (Medi-Span): 90050003004010
- HICL (First Databank): 011233
- AHFS class code: 84:28.00.00
- RxCUI (RxNorm): 307731
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Retinoid class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
Adapalene is used to treat acne in adults and children 12 years of and older. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin.
Read the full MedlinePlus article ↗- It treats acne vulgaris, the common type of acne. Some products are labeled for ages 12 and up. Ask a doctor before using it in younger children.
- Use it once a day, usually in the evening, on clean, dry skin. Apply a thin layer to the whole affected area and keep it away from your eyes, lips and inside of your mouth or nose....
- Give it about 8 to 12 weeks. Acne can seem to flare in the early weeks, which is not a reason to stop. If you see no improvement after 12 weeks, talk to your prescriber.
- Redness, dryness, peeling and some burning or stinging are the most common, especially in the first month. They are usually mild to moderate and often ease. A moisturizer can help....
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.337 | $15.14 / 45 g |
| Medicaid paysCMS SDUD · 12 mo | $0.4787 | $21.54 / 45 g |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file · file of Sep 30, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Marketing end | Status |
|---|---|---|---|---|---|---|
| 00536-1412-20 0536-1412-20 | 1 TUBE in 1 CARTON / 15 g in 1 TUBE | $0.4655 / g | $6.98 | 2024-02-20 | — | Active |
| 00536-1412-26 You're viewing this Main listing | 1 TUBE in 1 CARTON / 45 g in 1 TUBE | $0.3365 / g | $15.14 | 2024-02-20 | — | Active |
This pack has the lowest per-g cost of the 2 priced pack sizes ($0.3365 NADAC).
In Medicaid, this is the most-dispensed pack of this product — about 62% of fills over the last four reported quarters. See all packs ↓
Pack size FAQ
What quantity is in this package?
What NDC number is used to bill for this package of ADAPALENE 1 mg/g Gel?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Adapalene 1 mg/gthis 00536-1412-26 | RUGBY | 1 tube | $0.336 | — | Availability likely | — |
| Adapalene 1 mg/g 46122-0768-36 | AMERISOURCE | 1 tube | $0.466 | — | Availability likely | +38% |
| Adapalene 1 mg/g 51672-2150-01 | Sun | 1 tube | $0.466 | — | Availability likely | +38% |
| Adapalene 1 mg/g 70000-0666-01 | Cardinal | 1 tube | $0.466 | — | Availability likely | +38% |
| Adapalene 1 mg/g 00168-0424-46 | E. | 1 tube | $2.855 | AB | Availability likely | +748% |
| Differin 1 mg/g 00299-4910-00 | Galderma | 1 tube | — | — | FDA listed | — |
| PanOxyl 1 mg/g 00316-0143-15 | CROWN | 1 tube | — | — | FDA listed | — |
| PanOxyl 1 mg/g 00316-0284-15 | CROWN | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 00363-0888-05 | Walgreens | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 00363-1401-05 | Walgreens | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 00363-4110-05 | Walgreens | 1 tube | — | — | FDA listed | — |
| Proactiv MD Adapalene Acne Treatment .1 g/100g 11410-0958-15 | Alchemee, | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 11822-0062-01 | RITE | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 21130-0754-05 | Safeway, | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 30142-0725-05 | The | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 36800-0088-05 | TOP | 1 tube | — | — | Discontinued | — |
| Adapalene 1 mg/g 41250-0288-05 | MEIJER, | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 49967-0354-01 | LOreal | 1 tube | — | — | FDA listed | — |
| Effaclar 1 mg/g 49967-0591-01 | LOreal | 1 tube | — | — | FDA listed | — |
| Effaclar 1 mg/g 49967-0592-01 | LOreal | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 51316-0114-05 | CVS | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 55910-0880-05 | Dolgencorp, | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 59726-0114-05 | P | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 59726-0888-05 | P | 1 tube | — | — | Discontinued | — |
| Adapalene 1 mg/g 69842-0088-05 | CVS | 1 tube | — | — | FDA listed | — |
| Neutrogena Adapalene 0.1% Acne Treatment 1 mg/g 69968-0826-01 | Kenvue | 1 tube | — | — | FDA listed | — |
| Neutrogena Evenly Clear Retinoid Adapalene Gel 0.1% Acne Treatment 1 mg/g 69968-0945-02 | Kenvue | 1 tube | — | — | FDA listed | — |
| Neutrogena Evenly Clear Retinoid Adapalene Gel 0.1% Acne Treatment 1 mg/g 69968-1004-02 | Kenvue | 1 tube | — | — | FDA listed | — |
| Curist Acne Relief .1 g/100g 72559-0015-13 | Little | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 72657-0158-15 | GLENMARK | 1 bottle | — | — | FDA listed | — |
| Adapalene 1 mg/g 73581-0019-06 | YYBA | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 73581-0214-06 | YYBA | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 73581-0215-45 | YYBA | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 73581-0216-45 | YYBA | 1 tube | — | — | FDA listed | — |
| Adapalene Gel 0.1% .1 g/100g 73715-0003-01 | MOHNARK | 30 g | — | — | Discontinued | — |
| Adapalene 1 mg/g 76162-0114-05 | Topco | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 79481-1140-05 | Meijer | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 79903-0338-05 | Wal-Mart | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 82442-0105-01 | Target | 1 tube | — | — | FDA listed | — |
| Adapalene 1 mg/g 72162-1048-02 | Bryant | 1 tube | — | AB | FDA listed | — |
| Adapalene 1 mg/g 63629-8791-01 | Bryant | 1 tube | — | AB | FDA listed | — |
| Adapalene Paraben Free 1 mg/g 76162-0221-05 | Topco | 1 tube | — | — | FDA listed | — |
| Adapalene Paraben Free 1 mg/g 79481-2210-05 | Meijer | 1 tube | — | — | FDA listed | — |
| Adapalene Paraben Free 1 mg/g 30142-0542-05 | The | 1 tube | — | — | FDA listed | — |
| Adapalene Paraben Free 1 mg/g 51316-0219-05 | CVS | 1 tube | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Sep 30, 2026
Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
🧪 Avoiding an ingredient? See Adapalene inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII 4Q93RCW27E
A synthetic polymer made from acrylic acid that's crosslinked for stability. It acts as a thickener and gelling agent in creams and gels, helping the medicine spread evenly and maintain its texture.
-
UNII 7FLD91C86K
Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
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UNII HIE492ZZ3T
Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
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UNII JX0HIX6OAG
Poloxamer 182 is a synthetic polymer made from ethylene oxide and propylene oxide. It acts as a solubilizer and emulsifier, helping mix water and oil-based ingredients together in liquid medications.
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UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
-
UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
7 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from RUGBY LABORATORIES, INC. labeler code 00536
- Rugby Carboxymethylcellulose Sodium 0.5% Eye Drops .5 g/100mL Solution/ Drops NDC 0536-1386-35
- Rugby Lubricant Eye Drops Carboxymethylcellulose sodium .5 g/100mL Solution/ Drops NDC 0536-1387-92
- Mucus Relief Guaifenesin 1200 mg Tablet, Extended Release NDC 0536-1392-88
- Hydrocortisone Cream with Aloe 1 g/100g Cream NDC 0536-1407-95
- Rugby Polyvinyl Alcohol 1.4% Lubricating Eye Drops 1.4 g/100mL Solution/ Drops NDC 0536-1408-94
- Rugby Phenazopyridine HCl Urinary Tract Analgesic PHENAZOPYRIDINE HYDROCHLORIDE 95 mg Tablet NDC 0536-1411-07
- Acetaminophen 500 mg Tablet, Film Coated NDC 0536-1413-48
- Gas Relief Simethicone 180 mg Capsule, Liquid Filled NDC 0536-1421-08
- Rugby Miconazole 3 Miconazole nitrate Kit NDC 0536-1425-41
- rugby infants acetaminophen 160 mg/5mL Suspension NDC 0536-1426-77
- Docosanol 100 mg/g Cream NDC 0536-1427-04
- Rugby Mucus and Chest Congestion 541 Guaifenesin 200 mg/10mL Liquid NDC 0536-1430-97
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Use For the treatment of acne
⏱️ Dosage and Administration ▾
Directions Adults and children 12 years of age and older: use once daily clean the skin gently and pat dry before applying the product cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation. Children under 12 years of age: ask a doctor
⚠️ Warnings ▾
Warnings For external use only Do not use on damaged skin (cuts, abrasions, eczema, sunburn) if you are allergic to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors do not wax to remove hair in areas where the product has been applied during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use if using more than one topical acne medication at a time but irritation usually lessens with continued use of this product it may take up to 3 months of once daily use to see results avoid product contact with eyes, lips, and mouth.
If contact occurs, immediately flush the area with water. wash hands after use Stop use and ask doctor if you become pregnant, or are planning to become pregnant, while using the product you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath) irritation becomes severe you see no improvement after 3 months of once daily use Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other information TAMPER EVIDENT: DO NOT USE IF THE SEAL ON THE TUBE IS PUNCTURED OR NOT VISIBLE. store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. protect from freezing
🧪 Active Ingredient ▾
Active ingredient Adapalene USP, 0.1% (retinoid) read consumer information leaflet
🧪 Inactive Ingredients ▾
Inactive ingredients carbomer homopolymer type C, edetate disodium, phenoxyethanol, poloxamer 182, propylene glycol, purified water, sodium hydroxide.
🎯 Purpose ▾
Purpose Acne treatment
📄 Do Not Use ▾
Do not use on damaged skin (cuts, abrasions, eczema, sunburn) if you are allergic to adapalene or any of the ingredients in this product.
📄 When Using This Product ▾
When using this product limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors do not wax to remove hair in areas where the product has been applied during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use if using more than one topical acne medication at a time but irritation usually lessens with continued use of this product it may take up to 3 months of once daily use to see results avoid product contact with eyes, lips, and mouth.
If contact occurs, immediately flush the area with water. wash hands after use
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask doctor if you become pregnant, or are planning to become pregnant, while using the product you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath) irritation becomes severe you see no improvement after 3 months of once daily use
🤰 If Pregnant or Breast-Feeding ▾
If pregnant or breast-feeding, ask a doctor before use.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions? 1-866-923-4914
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL - 45 g Tube carton Rugby ® NDC 0536-1412-26 Compare to the active ingredient in Differin ® Gel † Adapalene Gel USP, 0.1% Acne Treatment Previously available only by prescription FDA approved Dermatologist developed Once Daily Topical Retinoid* *Read consumer information leaflet before use NET WT