propofol 10 mg/mL Injection, Emulsion — NDC 16714-528-10 (Billing 16714-0528-10)
by NorthStar Rx LLC · 10 VIAL in 1 CARTON / 20 mL in 1 VIAL
This is a package of propofol 10 mg/mL Injection, Emulsion from NorthStar Rx LLC, marketed since Jul 2022 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.
NDC 16714-0528-10
🏷️ FDA NDC (as labeled)
16714-528-10
billing pads the product segment with a zero
This package
Contains20 mL in 1 vial
Medicaid pays$1.08 / unit · 12 mo
Per package$215.10 / 200 ml · Medicaid
Pack sizes2 compare ↓
Main listing for product 16714-528 · Also comes in:
20 vials 16714-528-20
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
NDC database record
One package, one record: these facts belong to NDC 16714-528-10 alone.
- Record
- FDA NDC Directory package listing · Human prescription drug
- Code segments
- 16714 labeler · 528 product · 10 package
- Package marketed since
- Jul 1, 2022
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2027
- Barcode (UPC-A, from the NDC)
- 3 1671452810 6
- Medicaid fills, this package
- 3,645 prescriptions in the last four reported quarters
- FDA record last changed
- Oct 8, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
16714-528-10
Product NDC
16714-528
11-digit billing NDC
16714052810
NCPDP billing unit
ML — per mL (volume)
Application #
ANDA206408
SPL Set ID
562acb1a-ccd2-4b98-b4fd-807f2c3ee038
Established class (EPC)
General Anesthetic
Physiologic effect
General Anesthesia
DEA schedule
Non-controlled
Marketing category
ANDA
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2022-07-01
Route
INTRAVENOUS
Dosage form
INJECTION, EMULSION
Substance
PROPOFOL
TE code (Orange Book)
AB · RLD · RS
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
GCN Seq No
016796
GCN
14021
HICL code
004842
Ingredient (HICL)
Propofol In Lipid Emulsions
HIC1 code
H
Therapeutic class — broad (HIC1)
Nervous System (Except Autonomic)
HIC2 code
H2
Therapeutic class — intermediate (HIC2)
Psychoactive Drugs
HIC3 code
H2C
Therapeutic class — specific (HIC3)
General Anesthetics,Injectable
AHFS code
28:04.08.00
AHFS class
Non-Barbiturates
FDB label name
PROPOFOL 200 MG/20 ML VIAL
FDB brand name
Propofol
Legend status
F — Federal legend — prescription drug or device
Quick answers
- GSN (GCN sequence number): 016796
- GCN: 14021
- HICL (First Databank): 004842
- AHFS class code: 28:04.08.00
Why two NDCs?
The FDA registers this code as 16714-528-10 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 16714-0528-10. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
Clinical
Label name PROPOFOL 200 MG/20 ML VIAL Ingredient Propofol In Lipid Emulsions
📖 What it is MedlinePlus · NLM
Propofol is used to begin and maintain general anesthesia (you are unconscious and unaware of what is happening) during surgery in adults and children. It is also used to provide sedation (you are relaxed, sleepy or in some cases asleep) in adults during surgical or other medical procedures. Propofol is also used to provide sedation for adults in intensive care units that are receiving mechanical ventilation (a machine that takes over the work of breathing). Propofol is in a class of medications called anesthetic agents. It works by changing the activity of certain substances in the brain.
Read the full MedlinePlus article ↗📗 Our plain-language guide HelloPharmacist
- Propofol is given through a vein to put you under general anesthesia or to provide sedation during procedures. It is also used to sedate adults in the ICU who are on a breathing ma...
- Some people feel burning, stinging, or pain at the IV site, and this is one of the more common effects. Your team can reduce it by using a larger vein or giving lidocaine first. An...
- Low blood pressure, a slower heart rate, and a short pause in breathing are the most common. Your team watches for these and treats them. You may also get a rash, itching, or invol...
- Yes. Tell them if you have ever had a severe allergic reaction to eggs, egg products, soybeans, or soy products, because propofol should not be used in that case. Also mention epil...
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Propofol — tap one for details:
1
Nutrient depletion considerations
Propofol may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
💬 Questions about propofol?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | $1.08 | $215.10 / 200 ml |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
| Medicare Part B allowsASP · J2704 | $0.089 / J2704 unit | — |
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Billing & reimbursement
FDA NDC (as labeled)16714-528-10
11-digit billing NDC16714-0528-10
Format5-3-2 as registered → padded to 5-4-2 for billing (zero added to the product segment)
HCPCS J-codeJ2704
DescriptorINJECTION, PROPOFOL, 10 MG
Billing units / pkg1 units
How the units are derivedThis package is 20 ML; the HCPCS unit is 10 MG, so one package = 1 billing unit.
Medicare Part B spend (2026 (Q1))$20,183 · 7,494 claims · $2.69 per claim (all NDCs under J2704)
Crosswalk sourcePDAC NDC-HCPCS crosswalk (DME MAC / DMEPOS)
Where does this data come from?
The HCPCS J-code crosswalk comes from the CMS ASP NDC-HCPCS crosswalk and the DMEPDAC (DME MAC) NDC-HCPCS crosswalk — free public CMS data. Billing units are derived from the code’s descriptor and the package amount.
- CMS ASP NDC-HCPCS crosswalk · refreshed Sep 22, 2026
- DMEPDAC NDC-HCPCS crosswalk
- openFDA NSDE billing units · refreshed Oct 7, 2026
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 16714-0528-10 You're viewing this Main listing | 10 VIAL in 1 CARTON / 20 mL in 1 VIAL | 2022-07-01 | — | Active |
| 16714-0528-20 16714-528-20 | 20 VIAL in 1 CARTON / 20 mL in 1 VIAL | 2022-07-01 | — | Active |
In Medicaid, this is the most-dispensed pack of this product — about 81% of fills over the last four reported quarters. See all packs ↓
Pack size FAQ
What quantity is in this package?
This package is listed by the FDA — 10 vial in 1 carton / 20 ml in 1 vial.
What NDC number is used to bill for this package of propofol 10 mg/mL Injection, Emulsion?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Propofol 10 mg/mL 00409-6010-25 | Hospira, | 25 vials | $0.171 | AB | Availability likely | — |
| propofol 10 mg/mL 25021-0608-20 | Sagent | 25 vials | $0.171 | AB | Availability likely | — |
| Propofol Injectable Emulsion 10 mg/mL 43598-0265-25 | Dr. | 25 vials | $0.171 | AB | Availability likely | — |
| propofol 10 mg/mL 71288-0730-51 | Meitheal | 10 vials | $0.171 | AB | Availability likely | — |
| Propofol 10 mg/mL 00409-1511-98 | Hospira, | 25 vials | $0.171 | AB | Availability likely | — |
| Propofol 10 mg/mL 00069-0209-10 | Pfizer | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00641-6194-10 | Hikma | 10 vials | — | AB | FDA listed | — |
| propofol 10 mg/mLthis 16714-0528-10 | NorthStar | 10 vials | — | AB | FDA listed | — |
| propofol 10 mg/mL 23155-0345-41 | Heritage | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 51662-1293-01 | HF | 20 ml | — | AB | FDA listed | — |
| Diprivan 10 mg/mL 63323-0269-59 | Fresenius | 20 vials | — | AB | FDA listed | — |
| Diprivan 10 mg/mL 65219-0800-10 | Fresenius | 10 vials | — | AB | FDA listed | — |
| propofol 10 mg/mL 71288-0729-21 | Meitheal | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 72572-0590-10 | Civica, | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 80830-1188-07 | Amneal | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 83634-0603-20 | Avenacy, | 20 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00641-6195-20 | Hikma | 20 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00641-6196-10 | Hikma | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00069-0234-20 | Pfizer | 20 vials | — | AB | FDA listed | — |
| propofol 10 mg/mL 16714-0690-10 | NorthStar | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 51662-1471-01 | HF | 50 ml | — | AB | FDA listed | — |
| Propofol 10 mg/mL 51662-1470-01 | HF | 100 ml | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00409-4699-24 | Hospira, | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 80830-2364-08 | Amneal | 20 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 80830-2365-07 | Amneal | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 72572-0612-10 | Civica, | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00069-0248-10 | Pfizer | 10 vials | — | AB | FDA listed | — |
| propofol 10 mg/mL 16714-0977-20 | NorthStar | 20 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 72572-0601-20 | Civica, | 20 vials | — | AB | FDA listed | — |
| propofol 10 mg/mL 71288-0731-53 | Meitheal | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 83854-0018-10 | Anthea | 10 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00409-0501-98 | Hospira, | 20 vials | — | AB | FDA listed | — |
| Propofol 10 mg/mL 00409-0010-98 | Hospira, | 10 vials | — | AB | FDA listed | — |
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
2022
On the market since
Jul 2022
📍
2026
Currently FDA-listed
4 years listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
🧪 Avoiding an ingredient? See Propofol inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.
Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.- FDA label on DailyMed · label index refreshed Oct 6, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerNorthStar Rx LLC
Application holderAVET LIFESCIENCES LTD
FDA applicationANDA206408 (ANDA)
Labeler code16714
First marketedJul 2022
Product typeHuman Prescription Drug
Portfolio415 products on file
More NDCs from NorthStar Rx LLC labeler code 16714
- Etodolac 600 mg Tablet, Extended Release NDC 16714-499-01
- Diltiazem Hydrochloride 120 mg Capsule, Extended Release NDC 16714-523-01
- Diltiazem Hydrochloride 180 mg Capsule, Extended Release NDC 16714-524-01
- Diltiazem Hydrochloride 240 mg Capsule, Extended Release NDC 16714-525-01
- Ipratropium Bromide 21 ug Spray, Metered NDC 16714-526-01
- Ipratropium Bromide 42 ug Spray, Metered NDC 16714-527-01
- Bisoprolol Fumarate 5 mg Tablet, Film Coated NDC 16714-529-01
- Bisoprolol Fumarate 10 mg Tablet, Film Coated NDC 16714-530-01
- Emtricitabine and tenofovir disoproxil fumarate 200 mg; 300 mg Tablet, Film Coated NDC 16714-534-01
- Posaconazole 100 mg Tablet, Delayed Release NDC 16714-535-01
- Levetiracetam 750 mg Tablet, Film Coated NDC 16714-537-01
- Lacosamide 50 mg Tablet NDC 16714-548-01
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
Full prescribing information FDA SPL
The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 FDA label ▾
No FDA label is on file for this product yet. Labels load from openFDA / DailyMed and refresh weekly.
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
Medicaid utilization & spend
📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
3.6K
Units reimbursed last 4 qtrs
53.5K
Gross reimbursed last 4 qtrs
$57.5K
Avg / prescription
$15.79
Avg / unit
$1.0755
Latest quarter Q1 2026
876Rx
Fee-for-service vs managed care ⓘ
Fee-for-service · 813 Rx Managed care · 2,832 Rx
State Medicaid map
Units reimbursed · per 100k residents
8.3300
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
Prescriptions—
Units—
Reimbursed—
🏆 Top states by units · per 100k residents
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
Medicaid utilization by pack size
Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
Drug total (last 4 qtrs): 4,497 Rx · 64,408 units · $158,840 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.
About this NDC listing & data coverage
Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | — Not published for this NDC No photo available yet for this listing. |
| Inactive ingredients (structured) | — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available. |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | ✓ Available |
| HCPCS J-code billing crosswalk | ✓ Available |
| Medicaid utilization (CMS SDUD) | ✓ Available |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by NorthStar Rx LLC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 20 vials (16714-0528-20). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
NorthStar Rx LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
Does this product have a billing J-code?
Yes — this NDC cross-references HCPCS code J2704 for medical-claim billing (typically used when a product is administered in a clinical setting rather than dispensed at a retail pharmacy). See the Billing section on this page.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.