Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.
Gas Relief Ultra Strength Simethicone 180 mg Capsule, Liquid Filled — NDC 21130-073-60 (Billing 21130-0073-60)
by Safeway, Inc. · 60 BLISTER PACK in 1 CARTON / 1 CAPSULE, LIQUID FILLED in 1 BLISTER PACK
This is a package of Gas Relief Ultra Strength Simethicone 180 mg Capsule, Liquid Filled from Safeway, Inc., marketed since Sep 2020 and currently FDA-listed. It is this product's only package size.
NDC 21130-0073-60
🏷️ FDA NDC (as labeled)
21130-073-60
billing pads the product segment with a zero
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
21130-073-60
Product NDC
21130-073
11-digit billing NDC
21130007360
RxCUI
252294
UNII
92RU3N3Y1O
UPC
0321130789673
Application #
M002
SPL Set ID
8927d9eb-65b2-40f3-846c-dc9cd2884dea
Physiologic effect
Skin Barrier Activity
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2020-09-30
Route
ORAL
Dosage form
CAPSULE, LIQUID FILLED
Substance
DIMETHICONE
Quick answers
- RxCUI (RxNorm): 252294
Why two NDCs?
The FDA registers this code as 21130-073-60 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 21130-0073-60. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
Clinical
📖 What it is MedlinePlus · NLM
Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Read the full MedlinePlus article ↗📗 Our plain-language guide HelloPharmacist
- It relieves the discomfort of gas. For adults, that means pressure, bloating and fullness. Infant drops are for baby gas, often caused by swallowed air or certain formulas or foods...
- Shake the bottle well. Use only the syringe or dropper that came with it. Dispense it slowly toward the inner cheek. You can also mix it with 1 oz. of cool water, formula or anothe...
- Doses can be repeated as needed after meals and at bedtime. Do not go over 12 doses in a day. Follow your product’s label and your doctor’s advice.
- If you can, use your child’s weight. If not, use age. Check the chart on your product, and ask me or your doctor if you are unsure.
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Simethicone — tap one for details:
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
💬 Questions about Simethicone?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 2, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 21130-0073-60 You're viewing this Main listing | 60 BLISTER PACK in 1 CARTON / 1 CAPSULE, LIQUID FILLED in 1 BLISTER PACK | 2020-09-30 | — | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense gas relief 180 mg 00113-0657-72 | L. | 60 capsules | $0.054 | — | Availability likely | — |
| Gas Relief Ultra Strength 180 mg 00536-1306-08 | Rugby | 60 capsules | $0.054 | — | Availability likely | — |
| Gas Relief 180 mg 00536-1421-08 | Rugby | 60 capsules | $0.054 | — | Availability likely | — |
| Gas Relief 180 mg 46122-0769-64 | AmerisourceBergen | 60 capsules | $0.054 | — | Availability likely | — |
| Gas Relief 180 mg 70677-1093-01 | Strategic | 60 capsules | $0.054 | — | Availability likely | — |
| Gas Relief 180 mg 70677-1254-01 | Strategic | 60 capsules | $0.054 | — | Availability likely | — |
| Phazyme 180 mg 00132-0208-12 | C.B. | 12 capsules | $0.228 | — | FDA listed | — |
| Gas-X Ultra Strength AntiGas Softgels 180 mg 00067-6274-18 | Haleon | 9 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 00363-0833-50 | Walgreens | 1 capsule | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 00363-0932-20 | Walgreens | 1 capsule | — | — | FDA listed | — |
| Gas Relief 180 mg 00363-1510-20 | Walgreens | 1 capsule | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 00363-8730-20 | Walgreens | 1 capsule | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 00363-8740-20 | Walgreens | 1 capsule | — | — | FDA listed | — |
| Ultra Strength Gas Relief 180 mg 00363-9941-09 | Walgreen | 10 capsules | — | — | FDA listed | — |
| Ultra Strength Gas Relief 180 mg 00363-9942-22 | Walgreen | 60 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mgthis 21130-0073-60 | Safeway, | 1 capsule | — | — | FDA listed | — |
| Gas Relief 180 mg 21130-0446-60 | Safeway, | 60 capsules | — | — | FDA listed | — |
| Ultra Strength Gas Relief 180 mg 21130-0717-06 | BETTER | 60 capsules | — | — | FDA listed | — |
| Simethicone 180 mg 35916-1939-01 | SOFTGEL | 1000 capsules | — | — | Discontinued | — |
| Gas Relief Ultra Strength 180 mg 36800-0324-05 | TOPCO | 25 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 37808-0874-60 | H | 60 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 41163-0773-60 | United | 60 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 41163-0832-60 | United | 60 capsules | — | — | FDA listed | — |
| Ultra Strength Gas Relief 180 mg 41226-0717-30 | KROGER | 60 capsules | — | — | FDA listed | — |
| Care One Gas Relief 180 mg 41520-0657-72 | American | 60 capsules | — | — | FDA listed | — |
| Ultra Strength Gas Relief 180 mg 49035-0585-21 | Wal-Mart | 50 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 50090-6088-00 | A-S | 1440 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 51316-0152-20 | CVS | 1 capsule | — | — | FDA listed | — |
| Ultrastrength Gas Relief 180 mg 51316-0621-76 | CVS | 50 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 410 180 mg 53345-0003-03 | Humanwell | 25000 capsules | — | — | FDA listed | — |
| Simethicone 180 mg 53345-0036-01 | Humanwell | 25000 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 56062-0657-72 | Publix | 60 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 59726-0152-60 | P | 60 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 59726-0773-20 | P | 1 capsule | — | — | FDA listed | — |
| Gas Relief 180 mg 63941-0152-60 | Best | 60 capsules | — | — | FDA listed | — |
| Anti-Gas Ultra Strength 180 mg 63941-0773-60 | Best | 60 capsules | — | — | FDA listed | — |
| good sense gas relief 180 mg 68788-4101-03 | Preferred | 30 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 68788-7890-03 | Preferred | 30 capsules | — | — | Discontinued | — |
| Gas Relief 180 mg 69168-0433-06 | Allegiant | 120 capsules | — | — | FDA listed | — |
| ultra strength gas relief 180 mg 69452-0543-83 | BIONPHARMA | 300 capsules | — | — | FDA listed | — |
| Gas Relief Ultra Strength 180 mg 69842-0832-20 | CVS | 20 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 70000-0668-01 | CARDINAL | 60 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 72090-0015-01 | Pioneer | 180 capsules | — | — | FDA listed | — |
| basic care gas relief 180 mg 72288-0657-72 | Amazon.com | 60 capsules | — | — | FDA listed | — |
| Curist Gas Relief 180 mg/180mg 72559-0041-48 | Little | 365 mg | — | — | FDA listed | — |
| Simethicone 180 mg 73629-0002-18 | AMZ789 | 180 capsules | — | — | FDA listed | — |
| ULTRA STRENGTH Gas Relief Softgels 180 mg 76162-0840-05 | Topco | 25 capsules | — | — | FDA listed | — |
| meijer ULTRA STRENGTH Gas Relief SOFTGEL 180 mg 79481-0814-05 | Meijer, | 25 capsules | — | — | FDA listed | — |
| Gas Relief 180 mg 83455-0152-60 | United | 60 capsules | — | — | FDA listed | — |
| Gas Relief Simethicone 180mg Softgel 180 mg 84324-0015-01 | NUVICARE | 100 capsules | — | — | FDA listed | — |
| Simethicone 180 MG 85786-0401-24 | Farmacias | 24 capsules | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
2020
On the market since
Sep 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Sep 3, 2026
What it looks like
Color
orange
ShapeOval
Imprint05A
Size12 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.
- FDA label on DailyMed · label index refreshed Oct 1, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII WZB9127XOA
A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
-
UNII H77VEI93A8
A synthetic yellow dye used to color medications. It helps identify the drug and make it visually distinctive, with no effect on how the medicine works.
-
UNII 2G86QN327L
Gelatin is a protein derived from animal collagen, commonly used in medicines as a gelling agent and capsule material. It helps create soft or hard capsule shells that hold and release medication, and can also thicken liquid formulations.
-
UNII PDC6A3C0OX
Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
4 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesFD&C red #40, FD&C yellow #6, gelatin, glycerin
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerSafeway, Inc.
FDA applicationM002 (OTC MONOGRAPH DRUG)
Labeler code21130
First marketedSep 2020
Product typeHuman Otc Drug
Portfolio75 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
📦 Storage and Handling
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
📄 Stop Use and Ask a Doctor If
🤰 If Pregnant or Breast-Feeding
📄 Keep Out of Reach of Children
📄 Questions or Comments
📄 Package Label / Principal Display Panel
🎯 Indications and Usage ▾
Uses relieves bloating, pressure, or fullness commonly referred to as gas
⏱️ Dosage and Administration ▾
Directions swallow one or two softgels as symptoms occur do not exceed two softgels per 24 hours except under the advice and supervision of a physician
⚠️ Warnings ▾
Warnings Stop use and ask a doctor if condition persists If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.
📦 Storage and Handling ▾
Other information store between 15-30°C (59-86°F) protect from heat and moisture
🧪 Active Ingredient ▾
Active ingredient (in each softgel) Simethicone 180 mg
🧪 Inactive Ingredients ▾
Inactive ingredients FD&C red #40, FD&C yellow #6, gelatin, glycerin
🎯 Purpose ▾
Purpose Antigas
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if condition persists
🤰 If Pregnant or Breast-Feeding ▾
If pregnant or breast-feeding, ask a health professional before use.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children.
📄 Questions or Comments ▾
Questions or comments? Call 1-877-753-3935 Monday-Friday 9AM-5PM EST
📄 Package Label / Principal Display Panel ▾
Principal Display Panel COMPARE TO Phazyme® Ultra Strength active ingredient† Ultra Strength Gas Relief SIMETHICONE 180 mg antiflatulent (Antigas Fast Relief of: Gas Pressure Bloating Discomfort SOFTGELS †This product is not manufactured or distributed by C.B. Fleet Company, Inc., distributor of Phazyme® Ultra Strength. TAMPER EVIDENT: DO NOT USE IF BLISTER UNIT IS TORN, BROKEN OR SHOWS ANY SIGNS OF TAMPERING.
KEEP OUTER CARTON FOR COMPLETE WARNINGS AND PRODUCT INFORMATION. DISTRIBUTED BY BETTER LIBING BRANDS LLC P.O. BOX 99, PLEASANTON, CA 94566-0009 www.betterlivingbrandsllc.com
Package Label SIGNATURE CARE Ultra Strength Gas Relief Simethicone 180 mg
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Safeway, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Safeway, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.