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GNP Witch Hazel 855 mg/mL Liquid, 473 mL — NDC 46122-0335-43 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

GNP Witch Hazel 855 mg/mL Liquid, 473 mL — NDC 46122-335-43 (Billing 46122-0335-43)

by Amerisource Bergen · 473 mL in 1 BOTTLE

This is a package of 473 mL of GNP Witch Hazel 855 mg/mL Liquid from Amerisource Bergen, marketed since Jan 2016 and currently FDA-listed; retail pharmacies pay about $0.0076 per mL (NADAC). It is this product's only package size.

NDC 46122-0335-43
🏷️ FDA NDC (as labeled) 46122-335-43 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

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Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 46122-335-43 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
46122 labeler · 335 product · 43 package
Package marketed since
Jan 1, 2016
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Billing quantity
473 mL per package
Barcode (UPC)
0087701427336
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 46122-335-43
Product NDC 46122-335
11-digit billing NDC 46122033543
NCPDP billing unit ML — per mL (volume)
UNII 101I4J0U34
UPC 0087701427336
Application # M016
SPL Set ID 45ac839d-215d-4c5f-8ae5-5e111d170061
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2016-01-01
Route TOPICAL
Dosage form LIQUID
Substance WITCH HAZEL

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 90970035000900
GPI class GNP Witch Hazel
GCN Seq No 067539
GCN 30117
HICL code 021836
Ingredient (HICL) Witch Hazel
HIC1 code L
Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue
HIC2 code L4
Therapeutic class — intermediate (HIC2) Astringents
HIC3 code L4A
Therapeutic class — specific (HIC3) Astringents
AHFS code 84:12.00.00
AHFS class Astringents (84:12)
FDB label name GNP WITCH HAZEL 86% SOLUTION
FDB brand name Witch Hazel
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 067539
  • GCN: 30117
  • GPI-14 (Medi-Span): 90970035000900
  • HICL (First Databank): 021836
  • AHFS class code: 84:12.00.00
Why two NDCs? The FDA registers this code as 46122-335-43 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 46122-0335-43. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name GNP WITCH HAZEL 86% SOLUTION Ingredient Witch Hazel
🧪 What is this product?

GNP Witch Hazel is a topical liquid containing witch hazel, an herbal extract. This OTC monograph product is typically used to help soothe and cool minor skin irritation. Witch hazel is commonly applied directly to the skin as a topical astringent, meaning it may help tighten or tone skin tissue. It is frequently used on minor cuts, scrapes, insect bites, and other minor skin conditions.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.008 $3.59 / 473 ml
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Dec 2023 Feb 2026 May 2026 Sep 2026 $0.008 $0.006
▲ Up 38% over the last 11 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
46122-0335-43 You're viewing this Main listing 473 mL in 1 BOTTLE 2016-01-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Health Mart Witch Hazel 855 mg/mL 62011-0268-01 Strategic 473 ml $0.006 — FDA listed save 28%
Sunmark Witch Hazel 855 mg/mL 49348-0181-38 Strategic 473 ml $0.007 — Availability likely save 7%
GNP Witch Hazel 855 mg/mLthis 46122-0335-43 Amerisource 473 ml $0.008 — Availability likely —
Witch Hazel 842 mg/mL 70000-0615-01 Cardinal 473 ml $0.008 — Availability likely —
Witch Hazel 842 mg/mL 70677-1252-01 Strategic 473 ml $0.008 — Availability likely —
Witch Hazel 860 mg/mL 00363-0803-43 Walgreen 473 ml — — FDA listed —
Witch Hazel 86 g/100mL 10565-0040-16 Hydrox 473 ml — — FDA listed —
Witch Hazel 86 g/100mL 10733-0801-08 Medical 236 ml — — FDA listed —
Witch Hazel 860 mg/mL 11344-0822-43 Nice-Pak 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 21130-0822-43 Better 473 ml — — FDA listed —
Kroger Witch Hazel .86 g/mL 30142-0418-16 Kroger 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 30142-0822-43 The 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 37808-0822-43 H 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 41163-0822-43 United 473 ml — — FDA listed —
Witch Hazel 86 kg/100L 41250-0822-43 Meijer, 473 l — — FDA listed —
Witch Hazel 860 mg/mL 41520-0822-43 ADUSA 473 ml — — FDA listed —
Witch Hazel ReadyInCase 86 g/100mL 49580-0390-06 P 473 ml — — FDA listed —
TN Dickinsons Witch Hazel Astringent 86 g/100mL 52651-0001-04 Dickinson 3785 ml — — FDA listed —
Witch Hazel 860 mg/mL 55301-0822-43 Your 473 l — — FDA listed —
Witch Hazel 860 mg/mL 56062-0822-43 Publix 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 59779-0045-43 CVS 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 63941-0822-43 Valu 473 ml — — FDA listed —
Witch Hazel 86 g/100mL 70082-0008-16 DealMed 473 ml — — FDA listed —
Witch Hazel 86 g/100mL 71990-0001-01 Arcadia 473 ml — — FDA listed —
Witch Hazel 860 mg/mL 72288-0922-26 Amazon.com 118 ml — — Discontinued —
Witch Hazel 860 mg/mL 76162-0822-43 Topco 473 ml — — FDA listed —
Witch Hazel 855 mg/mL 82645-0903-16 Pharma 473 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2016
On the market since
Jan 2016
📍
2026
Currently FDA-listed
10 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

2 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesAlcohol 14% and purified water.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAmerisource Bergen
FDA applicationM016 (OTC MONOGRAPH DRUG)
Labeler code46122
First marketedJan 2016
Product typeHuman Otc Drug
Portfolio206 products on file

More NDCs from Amerisource Bergen labeler code 46122

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 15 words ▾

Indications For relief of minor skin Irritations due to minor cuts minor scraps insect bites

⏱️ Dosage and Administration 11 words ▾

Directions Apply liberally to the afflicted area as often as necessary

⚠️ Warnings 16 words ▾

Warnings For external use only avoid contact with eyes If contact occurs rinse thoroughly with water.

🧪 Active Ingredient 4 words ▾

Active Ingredient Witch Hazel

🧪 Inactive Ingredients 7 words ▾

Inactive ingredients Alcohol 14% and purified water.

🎯 Purpose 2 words ▾

Purpose Astringent

📄 Stop Use and Ask a Doctor If 23 words ▾

When using this product stop using and contact a doctor if condition persists or gets worse symptoms do not improve within 7 days

📄 Keep Out of Reach of Children 34 words ▾

Keep out of reach of children. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. In case of eye contact flush eyes with running water for 15 minutes.

📄 Package Label / Principal Display Panel 48 words ▾

Principal Display Panel NDC 46122-33 5 -43 Witch Hazel (Hamamelis Water) Distilled Extract A lcohol 14 % by volume 16 fl oz (1 pt) 473 mL Principal Display Panel NDC 46122-335-43 Witch Hazel (Hamamelis Water) Distilled Extract Alcohol 14% by volume 16 fl oz (1 pt) 473 mL

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 46122-0331-43 · Amerisource 46122-0337-65 · AmerisourceBergen →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.