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carboxymethylcellulose sodium 5 mg/mL Solution/ Drops, 70 vials — NDC 50268-0067-70 package photo

carboxymethylcellulose sodium 5 mg/mL Solution/ Drops, 70 vials

by AvPAK · 70 VIAL, SINGLE-USE in 1 CARTON (50268-067-70) / .4 mL in 1 VIAL, SINGLE-USE
NDC 50268-0067-70
🏷️ FDA NDC (as labeled) 50268-067-70 billing pads the product segment with a zero
This package
Contains70 vials Cost per ea$0.1549 NADAC Per package$10.84 / 70 vials Pack sizes3 compare ↓
Also comes in: 30 vials 50268-0067-30 50 vials 50268-0067-50
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Carboxymethylcellulose Sodium (different manufacturers) — 6 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Apr 23, 2025 — cGMP deviations and lack of assurance of sterility. (BRS Analytical Services, LLC) · FDA recall D-0406-2025
Class III · Dec 18, 2024 — LABELING: LABEL MIX-UP (AvKARE) · FDA recall D-0175-2025
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0291-2024
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0299-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0134-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0132-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

🆔 Identity & classification

FDA NDC (as labeled) 50268-067-70
Product NDC 50268-067
11-digit billing NDC 50268006770
NCPDP billing unit EA — each (per item)
RxCUI 1188426
UNII K679OBS311
Application # M018
SPL Set ID b478a695-ded0-2e5f-e053-2995a90ac45e
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-11-19
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance CARBOXYMETHYLCELLULOSE SODIUM
GPI-14 86200010102021
GPI class Carboxymethylcellulose Sod PF
GCN Seq No 030011
GCN 37384
HICL code 003843
Ingredient (HICL) Carboxymethylcellulose Sodium
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name CARBOXYMETHYLCELL 0.5% EYE DRP
FDB brand name Carboxymethylcellulose Sodium
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 50268-067-70 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 50268-0067-70. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerAvPAK
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code50268
First marketedNov 2020
Product typeHuman Otc Drug
Portfolio346 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name CARBOXYMETHYLCELL 0.5% EYE DRP Ingredient Carboxymethylcellulose Sodium
🧪 What is this product?

This is an over-the-counter eye drop solution containing carboxymethylcellulose sodium, a lubricating agent that functions as an artificial tear. It is marketed as an OTC monograph product, meaning it follows FDA's established safety and use guidelines for this category. The drops are typically used to relieve dry eye symptoms and provide temporary moisture and comfort to the eye surface.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII M4I0D6VV5M
    Calcium chloride is a salt compound that acts as a firming agent and source of calcium ions in medications. It's used in formulations to help maintain tablet structure, improve texture, or serve as a buffering agent.
  • UNII QTT17582CB
    A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
  • UNII 02F3473H9O
    A mineral salt used in medications as a source of magnesium. It helps bind ingredients together, improve texture, and maintain the product's stability during storage.
  • UNII 660YQ98I10
    Potassium chloride is a mineral salt used in medicines as a buffer and to help maintain the proper pH balance and stability of the formulation during storage and use.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII TU7HW0W0QT
    A salt derived from lactic acid, sodium lactate acts as a buffer and pH stabilizer in medicines. It helps maintain the product's acidity level and can also serve as a humectant to retain moisture.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesCalcium chloride; hydrochloric acid; magnesium chloride; potassium chloride; purified water; sodium chloride; sodium hydroxide and sodium lactate.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.155 $10.84 / 70 vials
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Jul 2025 Jun 2026 Jul 2026 Aug 2026 $0.155 $0.138
▲ Up 12% over the last 4 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
carboxymethylcellulose sodium 5 mg/mLthis 50268-0067-70 AvPAK 70 vials $0.155 — Availability likely —
Leader Lubricant Eye Drops .5 g/100mL 70000-0012-01 Cardinal 70 vials $0.155 — Availability likely —
Rugby Lubricant Eye Drops .5 g/100mL 00536-1387-92 Rugby 30 vials $0.221 — Availability likely +43%
Good Neighbor Pharmacy Lubricant Eye Drops .5 g/100mL 46122-0756-56 Amerisource 30 vials $0.221 — Availability likely +43%
Foster and Thrive Lubricant Eye Drops .5 g/100mL 70677-1190-01 Strategic 30 vials $0.221 — Availability likely +43%
Rugby Carboxymethylcellulose Sodium 0.5% Eye Drops .5 g/100mL 00536-1386-35 Rugby 2 bottles $0.275 — Availability likely +77%
Carboxymethylcellulose Sodium Eye Lubricant 5 mg/mL 42494-0448-05 Cameron 2 bottles $0.275 — Discontinued +77%
carboxymethylcellulose sodium 5 mg/mL 50268-0068-15 AvPAK 1 bottle $0.365 — Availability likely +136%
Leader Lubricant Eye Drops Soothing Relief .5 g/100mL 70000-0705-01 LEADER/Cardinal 1 bottle $0.365 — Availability likely +136%
Refresh Tears 5 mg/mL 00023-0798-01 Allergan, 2 bottles $0.412 — Availability likely +166%
Lubricant Drops 5 mg/mL 70000-0090-01 CARDINAL 1 bottle $0.498 — FDA listed +221%
Refresh Plus 5 mg/mL 00023-0403-05 Allergan, 5 vials — — FDA listed —
Refresh Tears 00023-0795-65 Allergan, 1 kit — — FDA listed —
Walgreens Lubricant Eye Drops Preservative Free .5 g/100mL 00363-8800-01 Walgreen 30 vials — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8832-15 Walgreen 2 bottles — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8833-15 Walgreen 1 bottle — — FDA listed —
Lubricant Eye 5 mg/mL 00536-1476-92 Rugby 30 ampules — — FDA listed —
Lubricant Eye Drops Preservative Free .5 g/100mL 11673-0150-01 Target 70 vials — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11673-0771-01 Target 2 bottles — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11716-0771-01 Hanlim 2 bottles — — FDA listed —
Auro-Cmc 5 mg/mL 16030-0401-10 Aurolab 10 ml — — FDA listed —
Carboxymethylcellulose Sodium Eye Drops 0.5% 5 mg/mL 16030-0501-05 Aurolab 5 ml — — FDA listed —
Gentle Eyes Lubricant Eye Drops 5 mg/mL 17312-0430-15 TRP 1 bottle — — FDA listed —
Signature Care Lubricant Eye Drops .5 g/100mL 21130-0705-01 Better 30 vials — — FDA listed —
Kroger Lubricant Eye .5 g/100mL 30142-0373-33 The 30 vials — — FDA listed —
HEB Lubricant Eye Drops .5 g/100mL 37808-0100-01 HEB 30 vials — — FDA listed —
Medi-First Lubricant Eye Drops .5 g/100mL 47682-0193-83 Unifirst 30 ampules — — FDA listed —
Green Guard Lubricant Eye Drops .5 g/100mL 47682-0194-83 UniFirst 30 ampules — — FDA listed —
Equate Lubricant Eye Drops Preservative-Free .5 g/100mL 49035-0245-01 Wal-Mart 25 vials — — FDA listed —
Equate Restore Plus Lubricant Eye Drops .5 g/100mL 49035-0389-01 Walmart, 70 vials — — FDA listed —
Good Sense Lubricating Plus Lubricant Eye Drops .5 g/100mL 50804-0700-01 GoodSense 30 bottles — — FDA listed —
Carboxymethylcellulose Sodium 0.5% 5 mg/mL 51407-0945-30 Golden 3 pouches — — FDA listed —
Discount Drug Mart Lubricant Eye Drops 5 mg/mL 53943-0510-01 Discount 5 bottles — — FDA listed —
Retaine CMC 5 mg/mL 54799-0460-30 OCuSOFT 30 vials — — FDA listed —
Medics Choice Lubricant Eye Drops .5 g/100mL 55651-0030-01 K.C. 5 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0105-05 KC 5 bottles — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0510-01 KC 5 bottles — — FDA listed —
Publix Moisturizing Relief Eye Drops .5 g/100mL 56062-0789-01 Publix 30 vials — — FDA listed —
TheraTears Dry and Tired 5 mg/mL 58790-0013-30 MEDTECH 6 pouches — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 5ct 5 mg/mL 65923-0575-05 United 1 vial — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 30ct 5 mg/mL 65923-0576-30 United 30 vials — — FDA listed —
Refresh Tears 5 mg/mL 66715-1073-00 Lil' 1 bottle — — Discontinued —
Refresh Tears Lubricant 5 mg/mL 67751-0130-01 Navajo 3 ml — — Discontinued —
Lubricating Tears 5 mg/mL 69618-0076-55 Reliable 1 bottle — — FDA listed —
CVS Lubricant Eye Drops .5 g/100mL 69842-0804-01 CVS 70 vials — — FDA listed —
CVS Lubricant Eye Drops 30 ct .5 g/100mL 69842-0993-01 CVS 30 vials — — FDA listed —
Lubricant Eye 5 mg/mL 70000-0751-01 CARDINAL 30 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 71105-0105-05 Redicare 5 bottles — — FDA listed —
TopCare Health Lubricant Eye Drops .5 g/100mL 76162-0089-30 Topcare 30 vials — — FDA listed —
Meijer Lubricant Eye Drops .5 g/100mL 79481-0066-01 Meijer 30 vials — — FDA listed —
Rain Renewal Eye Drops .5 g/100mL 79662-0001-30 Rain 30 bottles — — FDA listed —
Equate Moisturizing Comfort Lubricant Eye Drops .5 g/100mL 79903-0264-05 Walmart 1 bottle — — FDA listed —
Focus Tears PF 5 mg/mL 82724-0009-20 Covalent 30 vials — — FDA listed —
Eyes Alive Lubricating 5 mg/mL 83291-0200-00 RIVIERA 100 ampules — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2020
On the market since
Nov 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

💊 Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
30 vials50268-0067-30 171 Rx · $2,743
50 vials50268-0067-50 No Medicaid data
70 vials this page50268-0067-70 No Medicaid data
Drug total (last 4 qtrs): 171 Rx · 5,775 units · $2,743 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Carboxymethylcellulose sodium — the ingredient across all brands.

Top reported reactions

Eye Irritation1,560
Eye Pain1,462
Macular Degeneration966
Vision Blurred885
Cataract871
Dry Eye723
Ocular Hyperaemia722

Age at onset

Infant2
Child9
Adolescent6
Adult847
Elderly1,957

Reporter sex

13,009 reports
Male · 24%
Female · 76%
Unknown · 0%

Serious outcomes

Hospitalization2,077
Death382
Disabling229
Life-threatening135
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 1,439 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
50268-0067-30 30 VIAL, SINGLE-USE in 1 CARTON (50268-067-30) / .4 mL in 1 VIAL, SINGLE-USE $0.2213 / ea $6.64 2020-11-19 Active
50268-0067-50 50 VIAL, SINGLE-USE in 1 CARTON (50268-067-50) / .4 mL in 1 VIAL, SINGLE-USE $0.2548 / ea $12.74 2020-11-19 Active
50268-0067-70 You're viewing this 70 VIAL, SINGLE-USE in 1 CARTON (50268-067-70) / .4 mL in 1 VIAL, SINGLE-USE $0.1549 / ea $10.85 2020-11-19 Active

This pack has the lowest per-ea cost of the 3 priced pack sizes ($0.1549 NADAC).

This pack shows little to no recent Medicaid volume — a different pack size carries most fills. See all packs ↓

Pack size FAQ

What quantity is in NDC 50268-0067-70?
NDC 50268-0067-70 contains 70 vials — 70 vial, single-use in 1 carton / .4 ml in 1 vial, single-use.
What is the difference between NDC 50268-0067-70 and NDC 50268-0067-30?
Both are carboxymethylcellulose sodium 5 mg/mL Solution/ Drops — the drug itself is identical. NDC 50268-0067-70 is the 70 vials package, while NDC 50268-0067-30 is the 30 vials package. Per-ea NADAC also differs: $0.1549 here vs $0.2213 for the 30 vials pack.
What NDC number is used to bill for this package of carboxymethylcellulose sodium 5 mg/mL Solution/ Drops?
Bill NDC 50268-0067-70 — the 11-digit billing format is 50268006770. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 31 words ▾

Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.

⏱️ Dosage and Administration 24 words ▾

Directions To open, TWIST AND PULL TAB TO REMOVE . Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

⚠️ Warnings 95 words ▾

Warnings For use in the eyes only. To avoid contamination, do not touch tip of container to any surface. Do not reuse.

Once opened, discard. Do not touch unit-dose tip to eye. If solution changes color or becomes cloudy, do not use.

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away (1-800-222-1222).

🧪 Active Ingredient 5 words ▾

Active ingredient Carboxymethylcellulose sodium 0.5%

🧪 Inactive Ingredients 19 words ▾

Inactive ingredients Calcium chloride; hydrochloric acid; magnesium chloride; potassium chloride; purified water; sodium chloride; sodium hydroxide and sodium lactate.

🎯 Purpose 3 words ▾

Purpose Eye lubricant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 50268-0065-30 · AvPAK 50268-0068-15 · AvPAK →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.