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Naproxen Sodium 220 mg Tablet, Film Coated, 30-count — NDC 63187-0596-30 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Naproxen Sodium 220 mg Tablet, Film Coated, 30-count — NDC 63187-596-30 (Billing 63187-0596-30)

by Proficient Rx LP · 30 TABLET, FILM COATED in 1 BOTTLE

This is a package of 30 tablets of Naproxen Sodium 220 mg Tablet, Film Coated from Proficient Rx LP, marketed since Apr 2014 and currently FDA-listed.

NDC 63187-0596-30
🏷️ FDA NDC (as labeled) 63187-596-30 billing pads the product segment with a zero
This package
Contains30-count Pack sizes5 compare ↓
Product page 63187-0596-24 Also comes in: 24 tablets 63187-596-24 28 tablets 63187-596-28 60 tablets 63187-596-90 90 tablets 63187-596-60
OTC Generic On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Naproxen Sodium (different manufacturers) — 2 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Mar 13, 2025 — CGMP Deviations (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0346-2025
Class II · Nov 7, 2023 — Labeling: Label Mix-Up-Indomethacin bottles may be labeled as Naproxen (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0124-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 63187-596-30
Product NDC 63187-596
11-digit billing NDC 63187059630
NCPDP billing unit EA — each (per item)
RxCUI 849574
UNII 9TN87S3A3C
UPC 0363187596309
Application # ANDA074661
SPL Set ID e668c80f-dd53-4b82-8678-5e4fccb13023
Established class (EPC) Anti-Inflammatory Agents; Nonsteroidal Anti-inflammatory Drug
Mechanism of action Cyclooxygenase Inhibitors
Chemical class Non-Steroidal
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2014-04-11
Route ORAL
Dosage form TABLET, FILM COATED
Substance NAPROXEN SODIUM

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 66100060100303
GPI class Naproxen Sodium
GCN Seq No 021980
GCN 47132
HICL code 003726
Ingredient (HICL) Naproxen Sodium
HIC1 code S
Therapeutic class — broad (HIC1) Locomotor System
HIC2 code S2
Therapeutic class — intermediate (HIC2) Drugs Acting Principally On Joints
HIC3 code S2B
Therapeutic class — specific (HIC3) Nsaids, Cyclooxygenase Inhibitor Type Analgesics
AHFS code 28:08.04.04
AHFS class Reversible Cox-1/Cox-2 Inhibitors
FDB label name NAPROXEN SODIUM 220 MG TABLET
FDB brand name Naproxen Sodium
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 021980
  • GCN: 47132
  • GPI-14 (Medi-Span): 66100060100303
  • HICL (First Databank): 003726
  • AHFS class code: 28:08.04.04
  • RxCUI (RxNorm): 849574
Why two NDCs? The FDA registers this code as 63187-596-30 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 63187-0596-30. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Nonsteroidal Anti-inflammatory Drug class.

Pharmacologic class Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Propionic acid derivatives, Antiinflammatory products for vaginal administration, Antiinflammatory preparations, non-steroids for topical use
How it works Cyclooxygenase Inhibitors
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name NAPROXEN SODIUM 220 MG TABLET Ingredient Naproxen Sodium
📗 Our plain-language guide HelloPharmacist
  • It relieves pain, inflammation and fever. Prescription versions treat arthritis, tendonitis, bursitis, acute gout and painful periods. Over-the-counter versions handle minor aches...
  • Take it by mouth with a full glass of water. Over-the-counter products are taken every 8 to 12 hours while symptoms last, and you should use the smallest dose that works. For presc...
  • Headache, indigestion, heartburn, nausea and swelling are common. Call your doctor if you have black stools, vomit blood, a rash, yellow skin or eyes, or chest pain.
  • Usually not. Combining naproxen with other NSAIDs or aspirin raises bleeding risk with little added benefit. Naproxen can also interfere with low-dose aspirin taken for your heart,...
📖 Read our full Naproxen guide →
1
Nutrient depletion considerations

Naproxen Sodium may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Naproxen Sodium nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 24 tablets 28 tablets 60 tablets 90 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
63187-0596-24 63187-596-24 Main listing 24 TABLET, FILM COATED in 1 BOTTLE 2017-09-01 — Active
63187-0596-28 63187-596-28 28 TABLET, FILM COATED in 1 BOTTLE 2017-08-01 — Active
63187-0596-30 You're viewing this 30 TABLET, FILM COATED in 1 BOTTLE 2015-08-03 — Active
63187-0596-60 63187-596-60 90 TABLET, FILM COATED in 1 BOTTLE 2015-08-03 — Active
63187-0596-90 63187-596-90 60 TABLET, FILM COATED in 1 BOTTLE 2015-08-03 — Active

You're viewing one of 5 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This is a 30-count package — 30 tablet, film coated in 1 bottle.
How does this package differ from NDC 63187-0596-24?
Both are Naproxen Sodium 220 mg Tablet, Film Coated — the drug itself is identical. This page's package is the 30-count one, while NDC 63187-0596-24 is the 24 tablets package.
What NDC number is used to bill for this package of Naproxen Sodium 220 mg Tablet, Film Coated?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Naproxen Sodium 220 mg 45802-0490-71 Padagis 50 tablets $0.059 — Discontinued —
Leader All Day Pain Relief 220 mg 70000-0171-01 Cardinal 100 tablets $0.059 — Discontinued —
Rugby All Day Relief 220 mg 00536-1093-01 Rugby 100 tablets $0.063 — Discontinued —
rugby all day relief 220 mg 00536-1094-01 Rugby 100 tablets $0.065 — Discontinued —
Naproxen Sodium 220 mg 63868-0465-01 Chain 100 tablets $0.065 — FDA listed —
Good Sense Naproxen Sodium 220 mg 00113-0901-62 L. 24 tablets $0.067 — Availability likely —
Good Sense Naproxen Sodium 220 mg 00113-4368-62 L. 24 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0562-71 Amerisource 50 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0564-71 Amerisource 50 tablets $0.067 — Availability likely —
Naproxen sodium 220 mg 69230-0329-01 Camber 100 tablets $0.067 — Availability likely —
Leader All Day Pain Relief 220 mg 70000-0201-02 Cardinal 50 tablets $0.067 — Availability likely —
foster and thrive all day pain relief 220 mg 70677-1137-01 Strategic 50 tablets $0.067 — Availability likely —
good sense naproxen sodium 220 mg 00113-1412-71 L. 50 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0041-01 Bayer 175 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-0111-01 Bayer 10 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0112-01 Bayer 175 tablets — — FDA listed —
Aleve 220 mg 00280-0113-01 Bayer 10 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-0114-01 Bayer 200 tablets — — FDA listed —
Aleve Caplets Soft Grip Arthritis 220 mg 00280-0115-01 Bayer 270 tablets — — FDA listed —
Aleve Caplets Easy Open Arthritis 220 mg 00280-0130-01 Bayer 90 tablets — — FDA listed —
Aleve Easy Open Arthritis 220 mg 00280-0131-01 Bayer 200 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-6000-01 Bayer 24 tablets — — FDA listed —
Aleve 220 mg 00280-6010-01 Bayer 100 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6020-02 Bayer 90 tablets — — FDA listed —
Aleve Caplets - Easy Open Arthritis Cap 220 mg 00280-6050-01 Bayer 100 tablets — — FDA listed —
Aleve Easy Open Arthritis Cap 220 mg 00280-6060-20 Bayer 200 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6070-40 Bayer 40 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-6092-02 Bayer 130 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-8252-10 Bayer 10 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-0368-61 Walgreen 600 tablets — — Discontinued —
all day pain relief 200 mg 00363-0938-82 Walgreen 200 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-6099-01 WALGREENS 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-9608-01 WALGREENS 100 tablets — — FDA listed —
Back And Muscle Pain 220 mg 00363-9609-01 WALGREENS 100 tablets — — FDA listed —
Bayer Aleve 220 mg 00924-6000-00 Acme 1 tablet — — FDA listed —
up and up naproxen sodium 220 mg 11673-0368-71 Target 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 11673-0764-05 TARGET 50 tablets — — FDA listed —
up and up naproxen sodium 220 mg 11673-0909-75 Target 90 tablets — — FDA listed —
Back and Muscle Pain 220 mg 11822-4170-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 11822-4171-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 11822-6040-02 Rite 100 tablets — — Discontinued —
Naproxen Sodium 220 mg 21130-0061-05 Safeway, 50 tablets — — FDA listed —
Naproxen 220 mg 21130-0062-05 Safeway, 50 tablets — — FDA listed —
signature care naproxen sodium 220 mg 21130-0180-62 Safeway 24 tablets — — Discontinued —
Naproxen Sodium 220 mg 21130-0593-79 Safeway 400 tablets — — FDA listed —
Pain Relief 220 mg 21130-0608-05 BETTER 50 tablets — — FDA listed —
Naproxen 220 mg 21130-0674-52 Better 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0690-05 BETTER 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0856-52 Better 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 25000-0141-02 MARKSANS 3840 tablets — — FDA listed —
Naproxen Sodium 220 mg 25000-0144-02 MARKSANS 3840 tablets — — FDA listed —
Flanax 220 mg 27854-0160-00 Belmora 100 tablets — — Discontinued —
Flanax Menstrual Pain Reliever 220 mg 27854-0165-10 Belmora 10 tablets — — FDA listed —
AnaDent 220 mg 27854-0170-01 Belmora 24 tablets — — FDA listed —
Flanax Pain Reliever/Fever reducer 220 mg 27854-0505-01 Belmora 24 tablets — — FDA listed —
Belmora Flanax 220 mg 27854-0555-01 Belmora 24 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 27854-0700-01 Belmora 24 tablets — — FDA listed —
Ana-Dent PAIN RELIEF 220 mg 27854-0701-01 Belmora 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 30142-0954-10 Kroger 100 tablets — — FDA listed —
Topcare All Day Pain Relief 220 mg 36800-0140-82 Topco 200 tablets — — FDA listed —
TopCare All Day Pain Relief 220 mg 36800-0368-62 Topco 24 tablets — — FDA listed —
Topcare All Day Pain Relief 220 mg 36800-0490-62 Topco 24 tablets — — FDA listed —
topcare back and muscle pain 220 mg 36800-0696-75 Topco 90 tablets — — FDA listed —
All Day Pain Relief 220 mg 37808-0068-24 H 24 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0631-82 H 200 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0652-62 H 24 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0713-79 H 400 tablets — — FDA listed —
Naproxen Sodium 220 mg 37835-0594-01 Bi-Mart 100 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0511-62 United 24 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0707-71 United 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 41226-0609-05 Kroger 50 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0313-82 Meijer 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0477-62 Meijer 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0680-71 Meijer 50 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0818-62 Meijer 24 tablets — — FDA listed —
Care One Naproxen Sodium 220 mg 41520-0349-82 American 200 tablets — — FDA listed —
CareOne Naproxen Sodium 220 mg 41520-0507-48 American 90 tablets — — Discontinued —
Care One Naproxen Sodium 220 mg 41520-0533-71 American 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0245-01 HYVEE 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0844-01 HYVEE 24 tablets — — FDA listed —
First Aid Direct All Day Pain Relief 220 mg 42961-0122-02 Cintas 1 tablet — — FDA listed —
Naproxen Sodium 220 mg 43063-0909-20 PD-Rx 20 tablets — — FDA listed —
Naproxen Sodium Caplets 220 mg 43598-0058-29 Dr 200 tablets — — FDA listed —
Naproxen Sodium Headache Pain Caplets 220 mg 43598-0059-52 Dr.Reddy's 225 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain Caplets 220 mg 43598-0060-52 Dr.Reddy's 225 tablets — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0072-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0074-01 Dr.Reddy's 100 tablets — — FDA listed —
Belmora Flanax 220 mg 47682-0037-50 Unifirst 1 tablet — — FDA listed —
Medique Mediproxen 220 mg 47682-0237-33 Unifirst 1 tablet — — FDA listed —
Bayer Aleve 220 mg 47682-0488-50 Unifirst 50 tablets — — FDA listed —
Medique at Home Mediproxen 220 mg 47682-0737-50 Unifirst 1 tablet — — FDA listed —
Calmadol Pain Reliever 220 mg 48201-0007-24 GRANDALL 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 49483-0608-00 TIME 6500 tablets — — FDA listed —
Naproxen Sodium 220 mg 49483-0609-00 TIME 6500 tablets — — FDA listed —
Naproxen Sodium 220 mg 50090-0685-01 A-S 10 tablets — — FDA listed —
Medique Mediproxen 220 mg 50090-2388-00 A-S 1 tablet — — FDA listed —
rugby all day relief 220 mg 50090-3356-00 A-S 30 tablets — — FDA listed —
Naproxen 220 mg 50844-0261-08 L.N.K. 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 50844-0417-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Headache Pain 220 mg 50844-0471-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Sodium 220 mg 50844-0604-09 L.N.K. 5 tablets — — FDA listed —
Naproxen Back and Muscle Pain 220 mg 50844-0714-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0608-90 CVS 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0761-20 CVS 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0762-70 CVS 270 tablets — — FDA listed —
Back and Muscle Pain 220 mg 51316-0817-08 CVS 24 tablets — — FDA listed —
CAREALL Naproxen 220 mg 51824-0072-01 New 100 tablets — — FDA listed —
CAREALL Naproxen Sodium 220 mg 51824-0109-01 New 100 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 53185-0394-50 Athlete's 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 53185-0604-12 Athlete's 100 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 53329-0688-30 Medline 100 tablets — — Discontinued —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0191-05 Amneal 500 tablets — — FDA listed —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0192-05 Amneal 500 tablets — — FDA listed —
Naproxen 220 mg 53943-0144-02 DISCOUNT 50 tablets — — FDA listed —
Naproxen 220 mg 53943-0145-02 DISCOUNT 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0272-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0273-01 Dr. 100 tablets — — FDA listed —
exchange select naproxen sodium 220 mg 55301-0368-71 Army 50 tablets — — FDA listed —
Naproxen 220 mg 55319-0406-52 Family 90 tablets — — Discontinued —
Naproxen 220 mg 55319-0717-08 Family 24 tablets — — FDA listed —
Rapidol Naproxen 220 mg 55758-0048-24 Pharmadel 24 tablets — — FDA listed —
DG Health Naproxen Sodium 220 mg 55910-0481-62 Dolgencorp 24 tablets — — FDA listed —
DG Health Naproxen Sodium 220 mg 55910-0490-62 Dolgencorp 24 tablets — — FDA listed —
dg health naproxen sodium 220 mg 55910-0500-71 Dolgencorp 50 tablets — — Discontinued —
dg health naproxen sodium 220 mg 55910-0729-62 Dolgencorp 24 tablets — — FDA listed —
All Day Relief 220 mg 56062-0368-62 Publix 24 tablets — — FDA listed —
all day relief 220 mg 56062-0490-71 Publix 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 57344-0145-01 AAA 24 tablets — — FDA listed —
Naproxen 220 mg 57896-0954-01 Geri-Care 100 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0735-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0736-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0737-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0738-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0739-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0819-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0845-21 Aurohealth 100 tablets — — FDA listed —
Artridol 220 mg 59428-0604-08 Zapotol 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 59726-0169-15 P 15 tablets — — Discontinued —
naproxen sodium 220 mg 59779-0914-75 CVS 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 61504-0145-02 AMERIFOODS 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0327-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0328-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0728-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0729-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0761-42 Granules 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0762-42 Granules 50 tablets — — FDA listed —
Naproxen Sodium 220 mgthis 63187-0596-30 Proficient 30 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 63187-0794-20 Proficient 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 63868-0466-01 Chain 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0144-01 VALU 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0245-01 VALU 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0444-01 VALU 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0445-01 VALU 24 tablets — — FDA listed —
kirkland signature naproxen sodium 220 mg 63981-0368-79 Costco 400 tablets — — FDA listed —
Aleve 220 mg 66715-5103-00 Lil' 60 tablets — — FDA listed —
24/7 Life by 7-Eleven Naproxen Sodium 220 mg 66715-5428-04 Lil' 24 tablets — — FDA listed —
Aleve 220 mg 66715-6402-08 Lil' 30 tablets — — FDA listed —
Aleve, TRAVEL BASIX 220 mg 66715-6411-02 Lil' 2 tablets — — FDA listed —
Aleve 220 mg 66715-6502-02 Lil' 2 tablets — — FDA listed —
Aleve 220 mg 66715-9702-01 Lil' 1 tablet — — Discontinued —
Lil Drug Store Pain Relief All Day 220 mg 66715-9740-04 Lil' 12 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0138-50 WinCo 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0140-10 WinCo 100 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 67751-0125-01 Navajo 2 tablets — — FDA listed —
Aleve 220 mg 67751-0144-03 Navajo 1 tablet — — FDA listed —
Naproxen 220 mg 68071-5039-01 NuCare 21 tablets — — FDA listed —
Naproxen Sodium 220 mg 68196-0255-20 SAM'S 400 tablets — — FDA listed —
Berkley and Jensen Naproxen Sodium 220 mg 68391-0368-79 BJWC 400 tablets — — FDA listed —
Naproxen 220 mg 68788-7572-02 Preferred 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 68788-8443-02 Preferred 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 68998-0144-03 Marc 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 68998-0145-03 Marc 100 tablets — — FDA listed —
Naproxen Caplets All day relief for pain 220 mg 69168-0362-07 Allegiant 10 tablets — — FDA listed —
Naproxen Caplets 220 mg 69168-0394-24 Allegiant 24 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 69168-0395-17 Allegiant 300 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 69197-0394-24 Command 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 69517-0109-02 HealthLife 32 tablets — — FDA listed —
Proxen Np 660 220 mg 69729-0123-12 OPMX 12 tablets — — FDA listed —
Naproxen Sodium 220 mg 69842-0811-62 CVS 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 69848-0010-01 Granules 10 tablets — — FDA listed —
Aleve 220 mg 70264-0011-01 R 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 71141-0182-32 Lidl 100 tablets — — FDA listed —
Naproxen 220 mg 71205-0595-30 Proficient 30 tablets — — FDA listed —
Naproxen Sodium 220 mg 71335-1061-01 Bryant 20 tablets — — FDA listed —
Naproxen 220 mg 71335-1282-01 Bryant 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 71335-2584-01 Bryant 20 tablets — — FDA listed —
Rugby All Day Relief 220 mg 71335-3009-01 Bryant 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0144-01 Harris 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0145-01 Harris 24 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0331-62 Amazon.com 24 tablets — — Discontinued —
Amazon Basic Care Naproxen Sodium 220 mg 72288-0366-20 Amazon.com 200 tablets — — FDA listed —
basic care naproxen sodium 220 mg 72288-0368-75 Amazon.com 90 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0489-75 Amazon.com 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 72789-0543-14 PD-Rx 14 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0005-10 WALMART 40 tablets — — Discontinued —
Naproxen Sodium 220 mg 79903-0231-50 WALMART 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 79903-0232-90 WALMART 90 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0389-50 Walmart 50 tablets — — FDA listed —
All Day Back and Muscle Pain Relief 220 mg 79903-0609-09 Walmart 90 tablets — — FDA listed —
betr headache pain relief 220 mg 80267-0001-71 Live 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 81522-0045-05 FSA 200 tablets — — FDA listed —
Pain Relief 220 mg 82501-1576-01 Gobrands, 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0108-01 CHAIN 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0109-01 CHAIN 100 tablets — — FDA listed —
Aleve Caplets 220 mg 85237-1832-01 Select 1 tablet — — FDA listed —
Medique Mediproxen 220 mg 85766-0121-01 Sportpharm 1 tablet — — FDA listed —
Dr Simi All Day Pain Relief 220 mg 85786-0104-24 Farmacias 24 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 85828-0394-92 Grocery 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 00363-7510-20 Walgreens 20 tablets — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0071-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0073-01 Dr.Reddy's 100 tablets — — FDA listed —
naproxen sodium 220 mg 72288-0988-75 Amazon.com 90 tablets — — FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2014
On the market since
Apr 2014
📍
2026
Currently FDA-listed
12 years listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

Color Blue
ShapeRound
ImprintL490
Size1 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3NXW29V3WO
    Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII 3WJQ0SDW1A
    Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 7SEV7J4R1U
    A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
  • UNII 15FIX9V2JP
    Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.

7 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesFD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerProficient Rx LP
Application holderL PERRIGO CO
FDA applicationANDA074661 (ANDA)
Labeler code63187
First marketedApr 2014
Product typeHuman Otc Drug
Portfolio1,729 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 35 words ▾

Uses • temporarily relieves minor aches and pains due to: • minor pain of arthritis • muscular aches • backache • menstrual cramps • headache • toothache • the common cold • temporarily reduces fever

⏱️ Dosage and Administration 89 words ▾

Directions • do not take more than directed • the smallest effective dose should be used • drink a full glass of water with each dose Adults and children 12 years and older: • take 1 tablet every 8 to 12 hours while symptoms last • for the first dose you may take 2 tablets within the first hour • do not exceed 2 tablets in any 8- to 12-hour period • do not exceed 3 tablets in a 24-hour period Children under 12 years: • ask a doctor

⚠️ Warnings ~2 min read ▾

Warnings Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you: • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Do not use • if you have ever had an allergic reaction to any other pain reliever/fever reducer • right before or after heart surgery Ask a doctor before use if • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease • you are taking a diuretic • you have problems or serious side effects from taking pain relievers or fever reducers • you have asthma Ask a doctor or pharmacist before use if you are • under a doctor’s care for any serious condition • taking any other drug When using this product • take with food or milk if stomach upset occurs • the risk of heart attack or stroke may increase if you use more than directed or for longer than directed Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • you have difficulty swallowing • it feels like the pill is stuck in your throat • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use.

It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

(1-800-222-1222)

📦 Storage and Handling 23 words ▾

Other information • each tablet contains: sodium 21 mg • store at 20-25°C (68-77°F). Avoid high humidity and excessive heat above 40°C (104°F).

🧪 Active Ingredient 16 words ▾

Active ingredient (in each tablet) Naproxen sodium 220 mg (naproxen 200 mg) (NSAID)* *nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 19 words ▾

Inactive ingredients FD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

🎯 Purpose 4 words ▾

Purpose Pain reliever/fever reducer

📄 Do Not Use 25 words ▾

Do not use • if you have ever had an allergic reaction to any other pain reliever/fever reducer • right before or after heart surgery

📄 Ask a Doctor Before Use If 63 words ▾

Ask a doctor before use if • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease • you are taking a diuretic • you have problems or serious side effects from taking pain relievers or fever reducers • you have asthma

📄 Ask a Doctor or Pharmacist Before Use If 24 words ▾

Ask a doctor or pharmacist before use if you are • under a doctor’s care for any serious condition • taking any other drug

📄 When Using This Product 35 words ▾

When using this product • take with food or milk if stomach upset occurs • the risk of heart attack or stroke may increase if you use more than directed or for longer than directed

📄 Stop Use and Ask a Doctor If 90 words ▾

Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • you have difficulty swallowing • it feels like the pill is stuck in your throat • redness or swelling is present in the painful area • any new symptoms appear

🤰 If Pregnant or Breast-Feeding 48 words ▾

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

📄 Keep Out of Reach of Children 22 words ▾

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

📄 Questions or Comments 4 words ▾

Questions or comments? 1-800-719-9260

📄 Package Label / Principal Display Panel 25 words ▾

Principal Display Panel Compare to Aleve® active ingredient Naproxen Sodium Tablets 220 mg Pain Reliever/Fever Reducer (NSAID) Strength to Last 12 Hours 30 Tablets 63187-596-30

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Naproxen Sodium — the program that covers self-administered drugs. 4 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Naproxen Sodium. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$441.8K
Claims incl. refills
15.2K
Beneficiaries
11.4K
Spend / beneficiary
$38.70
Spend / claim
$29.13
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Proficient Rx LP. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 4 other package presentations of this same product, including 24 tablets (63187-0596-24), 28 tablets (63187-0596-28), 60 tablets (63187-0596-90). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Proficient Rx LP is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 63187-0591-20 · Proficient 63187-0597-30 · Proficient →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.