Desoximetasone 2.5 mg/g Cream — NDC 71656-087-60 (Billing 71656-0087-60)
This is a package of Desoximetasone 2.5 mg/g Cream from Saptalis Pharmaceuticals, LLC., marketed since May 2026 and currently FDA-listed; retail pharmacies pay about $0.3227 per g (NADAC).
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 007583
- GCN: 31181
- GPI-14 (Medi-Span): 90550040003710
- HICL (First Databank): 003309
- AHFS class code: 84:06.08.00
- RxCUI (RxNorm): 197574
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Corticosteroid class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
- It depends on the product. Creams, gels and ointments calm inflamed, itchy skin from conditions that respond to steroids. The spray is used for plaque psoriasis in adults 18 and ol...
- You put a thin film on the affected skin, usually twice a day, and rub it in gently. Don't cover the spray area with a bandage unless your doctor tells you to. Keep it away from yo...
- Stop when your skin is under control. The label doesn't recommend using the spray beyond 4 weeks. Avoid your face, armpits and groin, and don't use it on skin that has thinned.
- The most common are dryness, irritation and itching where you apply it. Call your doctor if you notice vision changes, thinning skin, stretch marks, or signs of infection.
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Desoximetasone — tap one for details:
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.323 | $1,161.72 / 3600 g |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · Q2 2026 | $0.7357 | $2,648.52 / 3600 g |
Where does this data come from?
- CMS NADAC weekly file · file of Sep 30, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 3, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Marketing end | Status |
|---|---|---|---|---|---|---|
| 71656-0087-15 71656-087-15 Main listing | 15 TUBE in 1 CARTON / 15 g in 1 TUBE | $0.3979 / g | $89.52 | 2026-05-07 | — | Active |
| 71656-0087-60 You're viewing this | 60 TUBE in 1 CARTON / 60 g in 1 TUBE | $0.3227 / g | $1,161.61 | 2026-05-07 | — | Active |
This pack has the lowest per-g cost of the 2 priced pack sizes ($0.3227 NADAC).
Pack size FAQ
What quantity is in this package?
What NDC number is used to bill for this package of Desoximetasone 2.5 mg/g Cream?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Desoximetasone 2.5 mg/gthis 71656-0087-60 | Saptalis | 60 tubes | $0.323 | AB | Availability likely | — |
| desoximetasone 2.5 mg/g 72578-0095-01 | Viona | 1 tube | $0.369 | AB | Availability likely | +14% |
| desoximetasone 2.5 mg/g 45802-0496-14 | Padagis | 1 tube | $0.369 | AB | Availability likely | +14% |
| Desoximetasone 2.5 mg/g 68180-0946-01 | Lupin | 1 tube | $0.369 | AB | Availability likely | +14% |
| Desoximetasone 2.5 mg/g 00472-0479-15 | Actavis | 1 tube | $0.369 | AB | Availability likely | +14% |
| Desoximetasone 2.5 mg/g 00472-0478-15 | Actavis | 1 tube | $0.394 | — | Discontinued | +22% |
| Desoximetasone 2.5 mg/g 45802-0495-35 | Padagis | 1 tube | $0.398 | AB | Availability likely | +23% |
| Desoximetasone 2.5 mg/g 68180-0950-01 | Lupin | 1 tube | $0.398 | AB | Availability likely | +23% |
| desoximetasone 2.5 mg/g 72578-0091-01 | Viona | 1 tube | $0.398 | AB | Availability likely | +23% |
| Desoximetasone 2.5 mg/g 51672-1270-01 | Sun | 1 tube | $0.410 | AB | Availability likely | +27% |
| Desoximetasone 2.5 mg/g 68462-0531-17 | Glenmark | 15 g | $0.680 | — | FDA listed | +111% |
| Desoximetasone 2.5 mg/g 51672-1262-01 | Sun | 1 tube | $0.680 | — | FDA listed | +111% |
| Desoximetasone 2.5 mg/g 50090-0597-00 | A-S | 1 tube | — | AB | FDA listed | — |
| Desoximetasone 2.5 mg/g 50090-5571-00 | A-S | 1 tube | — | AB | FDA listed | — |
| Desoximetasone 2.5 mg/g 63187-0646-15 | Proficient | 1 tube | — | AB | FDA listed | — |
| desoximetasone 2.5 mg/g 70771-1437-00 | Zydus | 1 tube | — | AB | FDA listed | — |
| Desoximetasone 2.5 mg/g 71205-0271-15 | Proficient | 1 tube | — | — | FDA listed | — |
| Desoximetasone 2.5 mg/g 72162-2330-02 | Bryant | 1 tube | — | AB | FDA listed | — |
| Desoximetasone 2.5 mg/g 40032-0024-60 | Novel | 1 tube | — | AB | FDA listed | — |
| desoximetasone 2.5 mg/g 63629-8641-01 | Bryant | 1 tube | — | AB | FDA listed | — |
| desoximetasone 2.5 mg/g 70771-1166-00 | Zydus | 1 tube | — | AB | FDA listed | — |
| desoximetasone 2.5 mg/g 63629-8642-01 | Bryant | 1 tube | — | AB | FDA listed | — |
| desoximetasone 2.5 mg/g 72162-1414-02 | Bryant | 1 tube | — | AB | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Sep 30, 2026
Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
What it looks like
Where does this data come from?
- FDA label on DailyMed · label index refreshed Oct 1, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII 2DMT128M1S
A waxy solid derived from plant or animal sources. It acts as an emulsifier to blend oil and water components, and also thickens the medicine to give it the right texture and consistency.
-
UNII 0RE8K4LNJS
Isopropyl myristate is an oily liquid made from coconut or palm oil. It's used in medicines as an emollient and penetration enhancer to help the medicine absorb through skin or improve spreadability in topical products.
-
UNII 884C3FA9HE
Lanolin alcohol is a waxy substance derived from sheep's wool. It functions as an emollient and emulsifier in medicines, helping blend oil and water-based ingredients while softening the product's texture.
-
UNII T5L8T28FGP
Mineral oil is a clear, odorless liquid derived from crude oil. It acts as a lubricant and emollient in medications, helping pills slide smoothly during manufacturing and aiding moisture retention in topical products.
-
UNII B6E5W8RQJ4
White petrolatum is a purified mineral oil product used as a lubricant and skin protectant in medications. It helps pills slide through manufacturing equipment and can soften or protect the skin when applied topically.
5 inactive ingredients listed in the exact product block matched to this NDC.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATIONS AND USAGE Desoximetasone cream, USP 0.25% is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION Apply a thin film of desoximetasone cream, USP 0.25% to the affected skin areas twice daily. Rub in gently.
⛔ Contraindications ▾
CONTRAINDICATIONS Desoximetasone cream, USP 0.25% is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation
⚠️ Warnings and Cautions ▾
WARNINGS Keep out of reach of children.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. In controlled clinical studies the incidence of adverse reactions was low (0.8%) for desoximetasone cream, USP 0.25% and included burning, folliculitis, and folliculo-pustular lesions.
To report SUSPECTED ADVERSE REACTIONS, contact Saptalis Pharmaceuticals, LLC at 1-833-727-8254 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
🆘 Overdosage ▾
OVERDOSAGE Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS).
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids.
There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED Desoximetasone cream, USP 0.25% is supplied in 15 gram (NDC 71656-087-15) and 60 gram (NDC 71656-087-60) tubes. Store at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Distributed by: Saptalis Pharmaceuticals, LLC Hauppauge, NY 11788 MADE IN USA Rev. 03/2024 PPM-0078
📋 Description ▾
For topical use only. Not for oral, ophthalmic, or intravaginal use. DESCRIPTION Desoximetasone cream, USP 0.25% contains the active synthetic corticosteroid desoximetasone.
The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Each gram of desoximetasone cream, USP 0.25% contains 2.5 mg of desoximetasone in an emollient cream base consisting of cetostearyl alcohol, isopropyl myristate, lanolin alcohols, mineral oil, purified water and white petrolatum. The chemical name of desoximetasone is Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16-methyl-, (11β, 16α)-.
Desoximetasone has the molecular formula C22H29FO4 and a molecular weight of 376.47. The CAS Registry Number is 382-67-2. The structural formula is: structure-2
⚠️ Precautions ▾
PRECAUTIONS
🧬 Pharmacokinetics ▾
Pharmacokinetics The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.
Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Pharmacokinetic studies in men with desoximetasone cream, USP 0.25% with tagged desoximetasone showed a total of 5.2% ± 2.9% excretion in urine (4.1% ± 2.3%) and feces (1.1% ± 0.6%) and no detectable level (limit of sensitivity: 0.005 μg/mL) in the blood when it was applied topically on the back followed by occlusion for 24 hours. Seven days after application, no further radioactivity was detected in urine or feces. The half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.
📄 Package Label / Principal Display Panel ▾
NDC 71656-087-015Desoximetasone Cream, USP 0.25%- 15g Carton carton-15gr2 Tube container-15g
NDC 71656-087-060Desoximetasone Cream, USP 0.25% -60 g Carton carton-60gr2 Tube container-60g