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Spironolactone 50 mg Tablet, 500-count — NDC 72162-2683-05 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Spironolactone 50 mg Tablet, 500-count — NDC 72162-2683-5 (Billing 72162-2683-05)

by Bryant Ranch Prepack · 500 TABLET in 1 BOTTLE

This is a package of 500 tablets of Spironolactone 50 mg Tablet from Bryant Ranch Prepack, marketed since Dec 2019 and currently FDA-listed.

NDC 72162-2683-05
🏷️ FDA NDC (as labeled) 72162-2683-5 billing pads the package segment with a zero
This package
Contains500-count Pack sizes3 compare ↓
Product page 72162-2683-00 Also comes in: 100 tablets 72162-2683-1 1000 tablets 72162-2683-0
Rx only Generic On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 72162-2683-5 alone.

Record
FDA NDC Directory package listing · Human prescription drug
Code segments
72162 labeler · 2683 product · 5 package
Package marketed since
Oct 2, 2026
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 7216226835 3
FDA record last changed
Oct 8, 2026
⚠️
Other active recalls for Spironolactone (different manufacturers) — 1 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Aug 5, 2025 — Presence of foreign substance: identified as aluminum. (SUN PHARMACEUTICAL INDUSTRIES INC) · FDA recall D-0574-2025
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 72162-2683-5
Product NDC 72162-2683
11-digit billing NDC 72162268305
Application # ANDA202187
SPL Set ID a32c43d3-a13b-4e6c-b2dd-5dc46fef5b00
Established class (EPC) Aldosterone Antagonist
Mechanism of action Aldosterone Antagonists
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2019-12-13
Route ORAL
Dosage form TABLET
Substance SPIRONOLACTONE
TE code (Orange Book) AB · RLD · RS
Why two NDCs? The FDA registers this code as 72162-2683-5 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 72162-2683-05. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

📗 Our plain-language guide HelloPharmacist
  • Spironolactone is used for a few different conditions depending on the form you're prescribed. Most commonly, it treats heart failure, high blood pressure, and fluid buildup (swell...
  • What is spironolactone actually used for?
  • Either is fine — but pick one and stick with it. Food can nearly double how much spironolactone your body absorbs, so if you take it with food some days and without food others, yo...
  • Should I take spironolactone with food or on an empty stomach?
📖 Read our full Spironolactone guide →
1
Nutrient depletion considerations

Spironolactone may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Spironolactone nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 100 tablets 1000 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
72162-2683-00 72162-2683-0 Main listing 1000 TABLET in 1 BOTTLE 2026-10-02 — Active
72162-2683-01 72162-2683-1 100 TABLET in 1 BOTTLE 2026-10-02 — Active
72162-2683-05 You're viewing this 500 TABLET in 1 BOTTLE 2026-10-02 — Active

You're viewing one of 3 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This is a 500-count package — 500 tablet in 1 bottle.
How does this package differ from NDC 72162-2683-01?
Both are Spironolactone 50 mg Tablet — the drug itself is identical. This page's package is the 500-count one, while NDC 72162-2683-01 is the 100 tablets package.
What NDC number is used to bill for this package of Spironolactone 50 mg Tablet?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Spironolactone 50 mg 69584-0853-10 Oxford 100 tablets $0.083 AB Availability likely —
spironolactone 50 mg 68382-0661-01 Zydus 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 00378-0243-01 Mylan 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 72603-0135-01 NorthStar 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 51079-0979-20 Mylan 1 tablet $0.083 AB Availability likely —
Spironolactone 50 mg 60687-0476-01 American 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 53489-0328-01 Sun 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 59746-0217-01 Jubilant 100 tablets $0.083 AB Availability likely —
spironolactone 50 mg 31722-0095-01 Camber 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 59651-0427-01 Aurobindo 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 53746-0514-01 Amneal 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 64980-0707-01 Rising 100 tablets $0.083 AB Availability likely —
Spironolactone 50 mg 16729-0226-01 Accord 100 tablets $0.089 AB Availability likely —
Spironolactone 50 mg 54348-0340-90 PharmPak, 90 tablets — AB FDA listed —
Spironolactone 50 mg 63187-0861-30 Proficient 30 tablets — AB FDA listed —
Spironolactone 50 mg 71610-0287-30 Aphena 30 tablets — AB FDA listed —
Spironolactone 50 mg 50090-6408-00 A-S 100 tablets — AB FDA listed —
Spironolactone 50 mg 50090-6600-00 A-S 90 tablets — AB FDA listed —
Spironolactone 50 mg 71205-0147-30 Proficient 30 tablets — AB FDA listed —
Spironolactone 50 mg 71205-0830-30 Proficient 30 tablets — AB FDA listed —
Spironolactone 50 mg 76420-0063-30 Asclemed 30 tablets — AB FDA listed —
Spironolactone 50 mg 76420-0557-01 Asclemed 100 tablets — AB FDA listed —
Spironolactone 50 mg 63629-1065-01 Bryant 100 tablets — AB FDA listed —
Spironolactone 50 mg 82804-0285-30 Proficient 30 tablets — AB FDA listed —
Spironolactone 50 mg 43063-0974-90 PD-Rx 90 tablets — AB FDA listed —
Spironolactone 50 mg 48433-0088-20 Safecor 1 tablet — AB FDA listed —
Spironolactone 50 mg 68788-8452-03 Preferred 30 tablets — AB FDA listed —
Spironolactone 50 mg 50090-7083-00 A-S 90 tablets — AB FDA listed —
Spironolactone 50 mg 65162-0514-03 Amneal 30 tablets — AB FDA listed —
Spironolactone 50 mg 68071-4374-03 NuCare 30 tablets — AB FDA listed —
Spironolactone 50 mg 72162-1626-05 Bryant 500 tablets — AB FDA listed —
Spironolactone 50 mg 50090-7082-00 A-S 100 tablets — AB FDA listed —
Spironolactone 50 mg 68071-3795-09 NuCare 90 tablets — AB FDA listed —
Spironolactone 50 mg 72162-1694-01 Bryant 100 tablets — AB FDA listed —
Spironolactone 50 mg 72189-0496-30 Direct_Rx 30 tablets — AB FDA listed —
Spironolactone 50 mg 82804-0976-00 Proficient 100 tablets — AB FDA listed —
Spironolactone 50 mg 63629-2438-01 Bryant 100 tablets — AB FDA listed —
spironolactone 50 mg 70771-1028-00 Zydus 1000 tablets — AB FDA listed —
Spironolactone 50 mg 00615-8452-39 NCS 30 tablets — AB FDA listed —
Spironolactone 50 mg 63629-1066-01 Bryant 500 tablets — AB FDA listed —
Spironolactone 50 mg 63629-1067-01 Bryant 30 tablets — AB Discontinued —
Spironolactone 50 mg 63629-5341-01 Bryant 30 tablets — AB FDA listed —
Aldactone 50 mg 00025-1041-31 Pfizer 100 tablets — AB FDA listed —
Spironolactone 50 mg 72789-0291-30 PD-Rx 30 tablets — AB FDA listed —
Spironolactone 50 mg 70518-3655-00 REMEDYREPACK 30 tablets — AB Discontinued —
Spironolactone 50 mg 71335-2207-01 Bryant 100 tablets — AB FDA listed —
Spironolactone 50 mg 76420-0926-00 Asclemed 1000 tablets — AB FDA listed —
Spironolactone 50 mg 50090-6458-00 A-S 100 tablets — AB FDA listed —
spironolactone 50 mg 70518-4468-00 REMEDYREPACK 1 tablet — AB FDA listed —
Spironolactone 50 mg 71335-0401-01 Bryant 30 tablets — AB Discontinued —
Spironolactone 50 mg 71335-2887-01 Bryant 100 tablets — AB FDA listed —
Spironolactone 50 mg 67046-0613-03 Coupler 30 tablets — AB FDA listed —
spironolactone 50 mg 51655-0861-26 Northwind 90 tablets — AB FDA listed —
Spironolactone 50 mg 67296-2285-09 Redpharm 90 tablets — AB FDA listed —
Spironolactone 50 mgthis 72162-2683-05 Bryant 500 tablets — AB FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2019
On the market since
Dec 2019
📍
2026
Currently FDA-listed
7 years listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

Color White
ShapeRound
ImprintSP;IT;50
Size9 mm
ScoringScored — splits in 2
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

🧪 Avoiding an ingredient? See Spironolactone inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII EWQ57Q8I5X
    Lactose monohydrate is a natural sugar derived from milk. It serves as a filler and binder in tablets and capsules, helping create the proper size, texture, and consistency of the medicine.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII AV092KU4JH
    A natural oil extracted from peppermint plants. It's used as a flavoring agent to mask bitter tastes and add a refreshing mint flavor to medicines, making them easier to take.
  • UNII 6OZP39ZG8H
    Polysorbate 80 is a synthetic emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together in medications and improves how the product disperses in the body.
  • UNII K0KQV10C35
    Povidone K25 is a synthetic polymer made from vinyl pyrrolidone. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in the stomach for better absorption.
  • UNII ETJ7Z6XBU4
    Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
  • UNII O8232NY3SJ
    A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.

7 inactive ingredients listed in the exact product block matched to this NDC.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerBryant Ranch Prepack
Application holderAUROBINDO PHARMA LTD
FDA applicationANDA202187 (ANDA)
Labeler code72162
First marketedDec 2019
Product typeHuman Prescription Drug
Portfolio4,442 products on file

More NDCs from Bryant Ranch Prepack labeler code 72162

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 FDA label
📄 FDA label 19 words ▾

No FDA label is on file for this product yet. Labels load from openFDA / DailyMed and refresh weekly.

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Spironolactone — the program that covers self-administered drugs. 15 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Spironolactone. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$23.96M
Claims incl. refills
2.6M
Beneficiaries
1.9M
Spend / beneficiary
$12.45
Spend / claim
$9.09
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

About this NDC listing & data coverage

Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data ✓ Available
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Bryant Ranch Prepack. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 100 tablets (72162-2683-01), 1000 tablets (72162-2683-00). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Bryant Ranch Prepack is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 72162-2682-00 · Bryant 72162-2684-03 · Bryant →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.