Eyes Alive Lubricating CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED 5 mg/mL Liquid, 72 ampules — NDC 83291-0200-72 package photo

Eyes Alive Lubricating CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED 5 mg/mL Liquid, 72 ampules

by RIVIERA PHARMA INC · 72 AMPULE in 1 CARTON (83291-200-72) / .6 mL in 1 AMPULE
NDC 83291-0200-72
🏷️ FDA NDC (as labeled) 83291-200-72 billing pads the product segment with a zero
This package
Contains72 ampules Pack sizes7 compare ↓
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

🆔 Identity & classification

FDA NDC (as labeled) 83291-200-72
Product NDC 83291-200
11-digit billing NDC 83291020072
RxCUI 1188426, 1603466
UNII K679OBS311
UPC 0383291000035
Application # M018
SPL Set ID b6966691-6884-438c-9f89-5924089226e1
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2023-06-01
Route INTRAOCULAR
Dosage form LIQUID
Substance CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED
GPI-14 86200010102021
GCN Seq No 030011
GCN 37384
HICL code 003843
Ingredient (HICL) Carboxymethylcellulose Sodium
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name EYES ALIVE LUB 0.5% EYE DROPS
FDB brand name Eyes Alive
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 83291-200-72 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 83291-0200-72. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerRIVIERA PHARMA INC
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code83291
First marketedJun 2023
Product typeHuman Otc Drug
Portfolio2 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name EYES ALIVE LUB 0.5% EYE DROPS Ingredient Carboxymethylcellulose Sodium
🧪 What is this product?

Eyes Alive Lubricating is an over-the-counter eye drop solution containing carboxymethylcellulose sodium, a lubricating ingredient typically used to relieve dry eye discomfort and irritation. The product is applied directly to the eye surface to help coat and moisturize the ocular tissues. Carboxymethylcellulose sodium functions as an artificial tear substitute, commonly used to temporarily soothe dryness and provide a protective layer on the eye.

Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII M4I0D6VV5M
    Calcium chloride is a salt compound that acts as a firming agent and source of calcium ions in medications. It's used in formulations to help maintain tablet structure, improve texture, or serve as a buffering agent.
  • UNII QTT17582CB
    A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
  • UNII 02F3473H9O
    A mineral salt used in medications as a source of magnesium. It helps bind ingredients together, improve texture, and maintain the product's stability during storage.
  • UNII 660YQ98I10
    Potassium chloride is a mineral salt used in medicines as a buffer and to help maintain the proper pH balance and stability of the formulation during storage and use.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII TU7HW0W0QT
    A salt derived from lactic acid, sodium lactate acts as a buffer and pH stabilizer in medicines. It helps maintain the product's acidity level and can also serve as a humectant to retain moisture.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesCalcium chloride, hydrochloric acid May or may not contain this ingredient to adjust pH., magnesium chloride, potassium chloride, purified water, sodium chloride, sodium hydroxide, and sodium lactate.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMedingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leader Lubricant Eye Drops .5 g/100mL 70000-0012-01 Cardinal 70 vials $0.155 Availability likely
Rugby Lubricant Eye Drops .5 g/100mL 00536-1387-92 Rugby 30 vials $0.221 Availability likely
Good Neighbor Pharmacy Lubricant Eye Drops .5 g/100mL 46122-0756-56 Amerisource 30 vials $0.221 Availability likely
carboxymethylcellulose sodium 5 mg/mL 50268-0067-30 AvPAK 30 vials $0.221 Availability likely
Foster and Thrive Lubricant Eye Drops .5 g/100mL 70677-1190-01 Strategic 30 vials $0.221 Availability likely
Rugby Carboxymethylcellulose Sodium 0.5% Eye Drops .5 g/100mL 00536-1386-35 Rugby 2 bottles $0.275 Availability likely
Carboxymethylcellulose Sodium Eye Lubricant 5 mg/mL 42494-0448-05 Cameron 2 bottles $0.275 Discontinued
carboxymethylcellulose sodium 5 mg/mL 50268-0068-15 AvPAK 1 bottle $0.365 Availability likely
Leader Lubricant Eye Drops Soothing Relief .5 g/100mL 70000-0705-01 LEADER/Cardinal 1 bottle $0.365 Availability likely
Refresh Tears 5 mg/mL 00023-0798-01 Allergan, 2 bottles $0.412 Availability likely
Lubricant Drops 5 mg/mL 70000-0090-01 CARDINAL 1 bottle $0.498 FDA listed
Refresh Plus 5 mg/mL 00023-0403-05 Allergan, 5 vials FDA listed
Refresh Tears 00023-0795-65 Allergan, 1 kit FDA listed
Walgreens Lubricant Eye Drops Preservative Free .5 g/100mL 00363-8800-01 Walgreen 30 vials FDA listed
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8832-15 Walgreen 2 bottles FDA listed
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8833-15 Walgreen 1 bottle FDA listed
Lubricant Eye 5 mg/mL 00536-1476-92 Rugby 30 ampules FDA listed
Lubricant Eye Drops Preservative Free .5 g/100mL 11673-0150-01 Target 70 vials FDA listed
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11673-0771-01 Target 2 bottles FDA listed
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11716-0771-01 Hanlim 2 bottles FDA listed
Auro-Cmc 5 mg/mL 16030-0401-10 Aurolab 10 ml FDA listed
Carboxymethylcellulose Sodium Eye Drops 0.5% 5 mg/mL 16030-0501-05 Aurolab 5 ml FDA listed
Gentle Eyes Lubricant Eye Drops 5 mg/mL 17312-0430-15 TRP 1 bottle FDA listed
Signature Care Lubricant Eye Drops .5 g/100mL 21130-0705-01 Better 30 vials FDA listed
Kroger Lubricant Eye .5 g/100mL 30142-0373-33 The 30 vials FDA listed
HEB Lubricant Eye Drops .5 g/100mL 37808-0100-01 HEB 30 vials FDA listed
Medi-First Lubricant Eye Drops .5 g/100mL 47682-0193-83 Unifirst 30 ampules FDA listed
Green Guard Lubricant Eye Drops .5 g/100mL 47682-0194-83 UniFirst 30 ampules FDA listed
Equate Lubricant Eye Drops Preservative-Free .5 g/100mL 49035-0245-01 Wal-Mart 25 vials FDA listed
Equate Restore Plus Lubricant Eye Drops .5 g/100mL 49035-0389-01 Walmart, 70 vials FDA listed
Good Sense Lubricating Plus Lubricant Eye Drops .5 g/100mL 50804-0700-01 GoodSense 30 bottles FDA listed
Carboxymethylcellulose Sodium 0.5% 5 mg/mL 51407-0945-30 Golden 3 pouches FDA listed
Discount Drug Mart Lubricant Eye Drops 5 mg/mL 53943-0510-01 Discount 5 bottles FDA listed
Retaine CMC 5 mg/mL 54799-0460-30 OCuSOFT 30 vials FDA listed
Medics Choice Lubricant Eye Drops .5 g/100mL 55651-0030-01 K.C. 5 ampules FDA listed
Lubricant Eye Drops 5 mg/mL 55651-0105-05 KC 5 bottles FDA listed
Lubricant Eye Drops 5 mg/mL 55651-0510-01 KC 5 bottles FDA listed
Publix Moisturizing Relief Eye Drops .5 g/100mL 56062-0789-01 Publix 30 vials FDA listed
TheraTears Dry and Tired 5 mg/mL 58790-0013-30 MEDTECH 6 pouches FDA listed
Family Care Single Use Lubricant Eye Drop 0.4mL 5ct 5 mg/mL 65923-0575-05 United 1 vial FDA listed
Family Care Single Use Lubricant Eye Drop 0.4mL 30ct 5 mg/mL 65923-0576-30 United 30 vials FDA listed
Refresh Tears 5 mg/mL 66715-1073-00 Lil' 1 bottle Discontinued
Refresh Tears Lubricant 5 mg/mL 67751-0130-01 Navajo 3 ml Discontinued
Lubricating Tears 5 mg/mL 69618-0076-55 Reliable 1 bottle FDA listed
CVS Lubricant Eye Drops .5 g/100mL 69842-0804-01 CVS 70 vials FDA listed
CVS Lubricant Eye Drops 30 ct .5 g/100mL 69842-0993-01 CVS 30 vials FDA listed
Lubricant Eye 5 mg/mL 70000-0751-01 CARDINAL 30 ampules FDA listed
Lubricant Eye Drops 5 mg/mL 71105-0105-05 Redicare 5 bottles FDA listed
TopCare Health Lubricant Eye Drops .5 g/100mL 76162-0089-30 Topcare 30 vials FDA listed
Meijer Lubricant Eye Drops .5 g/100mL 79481-0066-01 Meijer 30 vials FDA listed
Rain Renewal Eye Drops .5 g/100mL 79662-0001-30 Rain 30 bottles FDA listed
Equate Moisturizing Comfort Lubricant Eye Drops .5 g/100mL 79903-0264-05 Walmart 1 bottle FDA listed
Focus Tears PF 5 mg/mL 82724-0009-20 Covalent 30 vials FDA listed
Eyes Alive Lubricating 5 mg/mLthis 83291-0200-72 RIVIERA 72 ampules FDA listed
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2023
On the market since
Jun 2023
📍
2026
Currently FDA-listed
3 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
83291-0200-00 100 AMPULE in 1 CARTON (83291-200-00) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-02 2 AMPULE in 1 POUCH (83291-200-02) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-04 4 AMPULE in 1 POUCH (83291-200-04) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-08 8 AMPULE in 1 CARTON (83291-200-08) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-32 32 AMPULE in 1 CARTON (83291-200-32) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-52 52 AMPULE in 1 CARTON (83291-200-52) / .6 mL in 1 AMPULE 2023-06-01 Active
83291-0200-72 You're viewing this 72 AMPULE in 1 CARTON (83291-200-72) / .6 mL in 1 AMPULE 2023-06-01 Active

Pack size FAQ

What quantity is in NDC 83291-0200-72?
NDC 83291-0200-72 contains 72 ampules — 72 ampule in 1 carton / .6 ml in 1 ampule.
What is the difference between NDC 83291-0200-72 and NDC 83291-0200-02?
Both are Eyes Alive Lubricating CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED 5 mg/mL Liquid — the drug itself is identical. NDC 83291-0200-72 is the 72 ampules package, while NDC 83291-0200-02 is the 2 ampules package.
What NDC number is used to bill for this package of Eyes Alive Lubricating CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED 5 mg/mL Liquid?
Bill NDC 83291-0200-72 — the 11-digit billing format is 83291020072. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 83291-200-72, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 83291-0200-72, written without dashes as 83291020072. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 83291-0200-72, the first segment (83291) is the labeler code FDA assigned to RIVIERA PHARMA INC; the middle segment (0200) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (72) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by RIVIERA PHARMA INC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 6 other package presentations of this same product, including 2 ampules (83291-0200-02), 4 ampules (83291-0200-04), 8 ampules (83291-0200-08). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
RIVIERA PHARMA INC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage 34 words

Uses for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. may be used as a protectant against further irritation of the eye.

⏱️ Dosage and Administration 35 words

Directions TWIST AND REMOVE TAB Place 1 or 2 drops in the affected eye(s) as needed for relief and discard container. If used for post-operative (e.g., LASIK) dryness and discomfort, follow your eye doctors instructions.

⚠️ Warnings 99 words

Warnings For external use only Do not use is solution changes color or becomes cloudy. When using this product to avoid contamination, do not touch tip of container to any surface. Do not reuse.

Once open, discard. do not touch unit dose tip to eye Stop use and ask a doctor before use if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children if swallowed, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 27 words

Other information Use only if single use container is intact. Use before expiration date marked on container. Store at 59°-86°F (15°-30°C) RETAIN THIS CARTON FOR FUTURE REFERENCE.

🧪 Active Ingredient 5 words

Active ingredients Carboxymethylcellulose sodium 0.5%

🧪 Inactive Ingredients 31 words

Inactive ingredients Calcium chloride, hydrochloric acid May or may not contain this ingredient to adjust pH. , magnesium chloride, potassium chloride, purified water, sodium chloride, sodium hydroxide , and sodium lactate.

🎯 Purpose 3 words

Purpose Eye lubricant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.